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公开(公告)号:US20240294972A1
公开(公告)日:2024-09-05
申请号:US18473205
申请日:2023-09-22
发明人: Andrea Marziali , Milenko Despotovic , Joel Pel
IPC分类号: C12Q1/6832 , B01D29/05 , B01D35/027 , B01L3/00 , B01L7/00 , B03C5/00 , B03C5/02 , B62D5/06 , C12N15/10 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , F15B1/26 , F15B21/041
CPC分类号: C12Q1/6832 , B01D29/05 , B01D35/027 , B01D35/0273 , B01L3/502753 , B03C5/005 , B03C5/026 , B62D5/062 , C12N15/101 , C12Q1/6825 , C12Q1/6837 , F15B1/26 , F15B21/041 , B01L7/52 , B01L2200/0631 , B01L2300/1805 , B01L2400/0421 , B01L2400/0451 , B03C2201/18 , B03C2201/26 , C12Q1/6813
摘要: Methods and apparatus providing for the isolation of an unknown mutation from a sample comprising wild type nucleic acids and mutated nucleic acids through the application of time-varying driving fields and periodically varying mobility-altering fields to the sample within in an affinity matrix.
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公开(公告)号:US12065466B2
公开(公告)日:2024-08-20
申请号:US17326247
申请日:2021-05-20
发明人: Brian Reed , Manjula Pandey
CPC分类号: C07K14/00 , C07K14/003 , C07K2319/00 , C07K2319/70 , G01N33/6818
摘要: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides amino acid recognition molecules, such as amino acid binding proteins and fusion polypeptides thereof. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号:US20240272169A1
公开(公告)日:2024-08-15
申请号:US18598736
申请日:2024-03-07
发明人: Brian Reed , Jeremy Lackey , Haidong Huang
IPC分类号: G01N33/58 , C07K14/47 , C07K19/00 , C12Q1/6806 , G01N1/28 , G01N21/64 , G01N33/68 , G16B25/10 , G16B30/00 , G16B40/00 , G16B40/10 , G16B50/00 , G16B50/30
CPC分类号: G01N33/581 , C07K14/47 , C07K19/00 , C12Q1/6806 , G01N1/28 , G01N21/6428 , G01N33/58 , G01N33/582 , G01N33/6821 , G01N33/6824 , G16B25/10 , G16B40/00 , G16B40/10 , G16B50/30 , G01N2021/6439 , G01N2458/00 , G16B30/00 , G16B50/00
摘要: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号:US12055548B2
公开(公告)日:2024-08-06
申请号:US16709077
申请日:2019-12-10
发明人: Brian Reed , Jeremy Lackey , Haidong Huang
IPC分类号: A61K38/00 , C07K14/47 , C07K19/00 , C12Q1/6806 , G01N1/28 , G01N21/64 , G01N33/58 , G01N33/68 , G16B25/10 , G16B40/00 , G16B40/10 , G16B50/30 , G16B30/00 , G16B50/00
CPC分类号: G01N33/581 , C07K14/47 , C07K19/00 , C12Q1/6806 , G01N1/28 , G01N21/6428 , G01N33/58 , G01N33/582 , G01N33/6821 , G01N33/6824 , G16B25/10 , G16B40/00 , G16B40/10 , G16B50/30 , G01N2021/6439 , G01N2458/00 , G16B30/00 , G16B50/00
摘要: Aspects of the application provide methods of identifying and sequencing proteins, polypeptides, and amino acids, and compositions useful for the same. In some aspects, the application provides methods of obtaining data during a degradation process of a polypeptide, and outputting a sequence representative of the polypeptide. In some aspects, the application provides amino acid recognition molecules comprising a shielding element that enhances photostability in polypeptide sequencing reactions.
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公开(公告)号:US20240248034A1
公开(公告)日:2024-07-25
申请号:US18518036
申请日:2023-11-22
发明人: Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Paul E. Glenn , Lawrence C. West , Benjamin Cipriany , Keith G. Fife
IPC分类号: G01N21/64 , C12Q1/6874
CPC分类号: G01N21/6408 , C12Q1/6874 , G01N21/6428 , G01N21/6452 , G01N21/648 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2201/0446 , G01N2201/062
摘要: Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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公开(公告)号:US11977257B2
公开(公告)日:2024-05-07
申请号:US17893101
申请日:2022-08-22
发明人: Ali Kabiri , Bing Shen , Gerard Schmid , James Beach , Kyle Preston , Sharath Hosali
CPC分类号: G02B6/122 , G02B6/136 , G02B2006/12109 , G02B2006/12138
摘要: Apparatus and methods for improving optical signal collection in an integrated device are described. A microdisk can be formed in an integrated device and increase collection and/or concentration of radiation incident on the microdisk and re-radiated by the microdisk. An example integrated device that can include a microdisk may be used for analyte detection and/or analysis. Such an integrated device may include a plurality of pixels, each having a reaction chamber for receiving a sample to be analyzed, an optical microdisk, and an optical sensor configured to detect optical emission from the reaction chamber. The microdisk can comprise a dielectric material having a first index of refraction that is embedded in one or more surrounding materials having one or more different refractive index values.
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公开(公告)号:US11971963B2
公开(公告)日:2024-04-30
申请号:US16407033
申请日:2019-05-08
发明人: Umut Eser , Michael Meyer
IPC分类号: G06F18/25 , G06F18/2135 , G06F18/214 , G06F18/22
CPC分类号: G06F18/256 , G06F18/21355 , G06F18/214 , G06F18/22
摘要: Methods and apparatus for predicting an association between input data in a first modality and data in a second modality using a statistical model trained to represent interactions between data having a plurality of modalities including the first modality and the second modality, the statistical model comprising a plurality of encoders and decoders, each of which is trained to process data for one of the plurality of modalities, and a joint-modality representation coupling the plurality of encoders and decoders. The method comprises selecting, based on the first modality and the second modality, an encoder/decoder pair or a pair of encoders, from among the plurality of encoders and decoders, and processing the input data with the joint-modality representation and the selected encoder/decoder pair or pair of encoders to predict the association between the input data and the data in the second modality.
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公开(公告)号:US11967436B2
公开(公告)日:2024-04-23
申请号:US16406993
申请日:2019-05-08
发明人: Marylens Hernandez , Umut Eser , Michael Meyer , Henri Lichenstein , Tian Xu , Jonathan M. Rothberg
摘要: Methods and apparatus for predicting an association between input data in a first modality and data in a second modality using a statistical model trained to represent interactions between data having a plurality of modalities including the first modality and the second modality, the statistical model comprising a plurality of encoders and decoders, each of which is trained to process data for one of the plurality of modalities, and a joint-modality representation coupling the plurality of encoders and decoders. The method comprises selecting, based on the first modality and the second modality, an encoder/decoder pair or a pair of encoders, from among the plurality of encoders and decoders, and processing the input data with the joint-modality representation and the selected encoder/decoder pair or pair of encoders to predict the association between the input data and the data in the second modality.
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公开(公告)号:US20240118280A1
公开(公告)日:2024-04-11
申请号:US18335963
申请日:2023-06-15
发明人: Omer Ad , Robert E. Boer
IPC分类号: G01N33/573 , G01N33/543
CPC分类号: G01N33/573 , G01N33/54366 , G01N2333/912 , G01N2333/96436
摘要: Aspects of the disclosure relate to methods and compositions for identifying, isolating, and/or sequencing a target protein or peptide from a sample of proteins or peptides.
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公开(公告)号:US20240110871A1
公开(公告)日:2024-04-04
申请号:US18465965
申请日:2023-09-12
发明人: Jonathan C. Schultz
IPC分类号: G01N21/64
CPC分类号: G01N21/6428 , G01N21/6402 , G01N21/645 , G01N2021/6439 , G01N2201/06113 , G01N2201/0636
摘要: Disclosed herein are embodiments of a sensor chip package that comprises a cap that engages the sensor chip and serving as a helmet that covers some or all of a top surface of the sensor chip. Aspects of the present disclosure provide a cap design that has an optical component to deflect an excitation light signal towards the top surface of sensor chip to excite samples within the sample wells. In some embodiments, the optical component may be a mirror or prism that provides a right angle coupling of excitation light signal to the sensor chip. Some embodiments are directed to a cap design in which a mirror is supported by multiple support surfaces of the cap body such that a mirror of a different length will provide a different tilt angle when supported by the same support surfaces.
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