公开(公告)号：US20240345075A1

公开(公告)日：2024-10-17

申请号：US18606510

申请日：2024-03-15

Applicant: Rutgers, The State University of New Jersey

Inventor： Maria L. Gennaro ,  Jeisac Guzmán Rivera ,  Dirk Foster Moore

IPC: G01N33/543 ,  G01N33/577 ,  G01N33/68

CPC classification number: G01N33/54366 ,  G01N33/577 ,  G01N33/6893 ,  G01N2800/24

Abstract: Embodiments disclosed here are directed to novel methods for diagnosing MIS-C or severe acute COVID-19, by detecting a biomarker in a blood sample from a subject suspected of or suffering from MIS-C or severe acute COVID-19, where the methods are for early detection or diagnosis of MIS-C or severe acute COVID-19. Also, disclosed are embodiments directed to apparatuses for use with the novel methods described here. Methods of detecting at least one biomarker and/or diagnosing MIS-C or severe acute COVID-19 disease in a pediatric subject suspected from suffering MIS-C or severe acute COVID-19 that can be used in combination with methods of treating a subject suspected of or suffering from MIS-C or severe acute COVID-19, accelerates the diagnosis and treatment, and improves prognosis.

公开(公告)号：US12105085B2

公开(公告)日：2024-10-01

申请号：US16617987

申请日：2018-05-18

Applicant: National University Corporation Kobe University

Inventor： Toshifumi Takeuchi ,  Yukiya Kitayama ,  Hirobumi Sunayama

IPC: G01N33/543

CPC classification number: G01N33/54366

Abstract: Provided is a convenient measurement system by which a target to be detected can be quickly recognized with high specificity. This base material for manufacturing a sensor for analyzing a detection target has: a base material; and a polymer film provided on the surface of the base material, wherein the polymer film has a concave that receives the detection target, and the concave has an antibody material bonding group and a signal material bonding group. A sensor for analyzing a detection target has: the base material for manufacturing a sensor for analyzing a detection target; an antibody material specific to the detection target and bonded to the antibody material bonding group; and a signal material that is bonded to the signal material bonding group.

公开(公告)号：US12054549B2

公开(公告)日：2024-08-06

申请号：US18050817

申请日：2022-10-28

Applicant: Merck Patent GmbH

Inventor： Ilhan Celik ,  Eike Staub ,  Miriam Urban ,  Sabine Raab-Westphal ,  Eileen Samy ,  Andrew Bender ,  Georgianna Varrone ,  Yin Wu ,  Daigen Xu

IPC: A61K39/00 ,  A61K39/395 ,  A61P11/00 ,  A61P17/02 ,  C07K16/28 ,  C12Q3/00 ,  G01N33/543

CPC classification number: C07K16/2848 ,  A61K39/395 ,  A61P11/00 ,  A61P17/02 ,  C07K16/2839 ,  C12Q3/00 ,  G01N33/54366 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/76

Abstract: A method can treat a patient suffering from at least one of fibrosis and a fibrotic disorder. The method includes administering a therapeutically effective amount of an anti-αv integrin antibody DI17E6, or a biologically active variant or modification thereof, to the patient.

公开(公告)号：US12013396B2

公开(公告)日：2024-06-18

申请号：US16941933

申请日：2020-07-29

Applicant: TEXAS TECH UNIVERSITY SYSTEM

Inventor： Dimitri Pappas

IPC: G01N33/569 ,  B01L3/00 ,  G01N33/543 ,  C12Q1/00 ,  G01N33/00

CPC classification number: G01N33/56972 ,  B01L3/50273 ,  G01N33/54366 ,  G01N33/569 ,  C12Q1/00 ,  G01N33/00

Abstract: Disclosed is a system and method for a microdevice to separate blood cells based on differences in antigen expression. Specifically, cells of the same phenotype are separated based on whether or not they are activated during infection or resting. The device of the present disclosure takes a small sample of blood and provides differential cell counts that can be used to test for infection and inflammatory response. The device can be used to identify sepsis and other infections rapidly. By measuring differences in activated white cell counts such as neutrophils, the device of the present disclosure measures physiological response to infection in hospitalized patients recovering from burns, surgeries, etc.

公开(公告)号：US20240192220A1

公开(公告)日：2024-06-13

申请号：US18583498

申请日：2024-02-21

Applicant: Universiti Brunei Darussalam

Inventor： Nura Fazira NOOR AZAM ,  Minhaz Uddin AHMED ,  Noor Faizah MOHD-NAIM

IPC: G01N33/58 ,  B82Y5/00 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  C01G55/00 ,  G01N27/30 ,  G01N27/327 ,  G01N33/12 ,  G01N33/543 ,  G01N33/547 ,  G01N33/68 ,  H01F1/06

CPC classification number: G01N33/587 ,  C01G55/004 ,  G01N27/308 ,  G01N27/3278 ,  G01N33/12 ,  G01N33/54366 ,  G01N33/547 ,  G01N33/582 ,  G01N33/68 ,  H01F1/068 ,  B82Y5/00 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  C01P2004/64 ,  C01P2006/42

Abstract: The present application discloses an electrochemiluminescence immunosensor. The immunosensor includes an electrode functionalized by a nanocomposite film. The film further includes carbon nanohorns dispersed in Nafion® perfluorinated resin solution. The polymeric solution is further stabilized by magnetic nanoparticles. The immunosensor is a Point of care (POC)-based. The immunosensor is configured to work in the range from 100 ng/mL to 1 fg/mL, and has tendency to detect even traces of the tropomyosin. The immunosensor is capable to detect traces even less than 1 fg/mL, hence having high specificity for Tro-Ag detection in food products with distinguished repeatability.

公开(公告)号：US20240192219A1

公开(公告)日：2024-06-13

申请号：US18583424

申请日：2024-02-21

Applicant: Universiti Brunei Darussalam

Inventor： Nura Fazira NOOR AZAM ,  Minhaz Uddin AHMED ,  Noor Faizah MOHD-NAIM

IPC: G01N33/58 ,  B82Y5/00 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  C01G55/00 ,  G01N27/30 ,  G01N27/327 ,  G01N33/12 ,  G01N33/543 ,  G01N33/547 ,  G01N33/68 ,  H01F1/06

CPC classification number: G01N33/587 ,  C01G55/004 ,  G01N27/308 ,  G01N27/3278 ,  G01N33/12 ,  G01N33/54366 ,  G01N33/547 ,  G01N33/582 ,  G01N33/68 ,  H01F1/068 ,  B82Y5/00 ,  B82Y25/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  C01P2004/64 ,  C01P2006/42

Abstract: The present application discloses an electrochemiluminescence immunosensor. The immunosensor includes an electrode functionalized by a nanocomposite film. The film further includes carbon nanohorns dispersed in Nafion® perfluorinated resin solution. The polymeric solution is further stabilized by magnetic nanoparticles. The immunosensor is a Point of care (POC)-based. The immunosensor is configured to work in the range from 100 ng/mL to 1 fg/mL, and has tendency to detect even traces of the tropomyosin. The immunosensor is capable to detect traces even less than 1 fg/mL, hence having high specificity for Tro-Ag detection in food products with distinguished repeatability.

公开(公告)号：US20240159782A1

公开(公告)日：2024-05-16

申请号：US18418565

申请日：2024-01-22

Applicant: Access Medical Systems, LTD.

Inventor： Hong Tan ,  Ming Xia ,  Yushan Tan ,  Jun Chen ,  Erhua Cao ,  Genqian Li ,  Robert F. Zuk

IPC: G01N35/00 ,  B01L3/00 ,  G01N33/543

CPC classification number: G01N35/00 ,  B01L3/527 ,  G01N33/54353 ,  G01N33/54366 ,  B01L3/502 ,  B01L2200/16 ,  B01L2300/042 ,  G01N35/026

Abstract: This invention relates to an apparatus for conducting immunoassay test. The apparatus includes a groove unit having a groove along a vertical direction configured to hold a rod-shaped portion of a probe along the vertical direction, and a push pin configured to move along a horizontal direction, the push pin being capable of residing at a first position and a second position. A tip of the push pin is capable of pressing the rod-shaped portion of the probe against the groove when the push pin resides at the first position. The distance between the tip of the push pin and the groove is larger than a diameter of the rod-shaped portion of the probe when the push pin resides at the second position.

公开(公告)号：US20240142443A1

公开(公告)日：2024-05-02

申请号：US18408845

申请日：2024-01-10

Applicant: Yantai AusBio Laboratories Co., Ltd.

Inventor： Zhaoqiang Wang ,  Wolfgang Mann ,  Wolfgang Heimberg

IPC: G01N33/543 ,  B01L9/00 ,  B03C1/00 ,  B03C1/01 ,  B03C1/28 ,  B03C1/30 ,  B04B5/04 ,  B04B7/04 ,  B04B15/02 ,  B08B3/02 ,  B08B3/04 ,  B08B3/06 ,  B08B3/10 ,  B08B9/00 ,  G01N35/02

CPC classification number: G01N33/54326 ,  B01L9/523 ,  B01L13/02 ,  B03C1/002 ,  B03C1/01 ,  B03C1/288 ,  B03C1/30 ,  B04B5/0407 ,  B04B5/0414 ,  B04B7/04 ,  B04B15/02 ,  B08B3/02 ,  B08B3/04 ,  B08B3/06 ,  B08B3/10 ,  B08B9/00 ,  G01N33/54366 ,  G01N35/028 ,  B01L2300/0829 ,  B01L2400/0409 ,  B04B2011/046

Abstract: A centrifuge for cleaning a reaction vessel unit, having a rotor for holding at least one reaction vessel unit with its opening(s) directed outwardly, a motor for rotating the rotor around a rotation axis, a housing having a substantially cylindrical inner surface, wherein a drain is provided for discharging fluid expelled from the reaction vessel unit, wherein a gap is provided between the inner surface and the rotor so that by rotating the rotor a wind is generated which drives the expelled fluid on the inner surface to the drain wherein an aspiration pump is connected to the drain for discharging fluid.

公开(公告)号：US11971413B2

公开(公告)日：2024-04-30

申请号：US16753970

申请日：2019-10-10

Applicant: BEIJING BOE TECHNOLOGY DEVELOPMENT CO., LTD. ,  BOE TECHNOLOGY GROUP CO., LTD.

Inventor： Zijian Zhao

IPC: C07K7/06 ,  A61K38/00 ,  C07K1/06 ,  G01N33/543 ,  G01N33/574 ,  G01N33/58

CPC classification number: G01N33/57492 ,  C07K1/061 ,  C07K7/06 ,  G01N33/54366 ,  G01N33/582 ,  A61K38/00

Abstract: The embodiments disclosed herein provide a peptoid, which is a compound of Formula I or a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof. N—R4, N—R3, N—R2, and N—R1 in Formula I are




respectively. The peptoid has a strong binding ability with an EpCAM protein. It can be used as molecular probes for diseases associated with an EpCAM protein, to achieve targeted therapy, in vivo imaging diagnosis and prognosis monitoring of the diseases associated with the EpCAM protein at low cost, high accuracy and high efficiency.

公开(公告)号：US11971409B2

公开(公告)日：2024-04-30

申请号：US16892642

申请日：2020-06-04

Applicant: Berkeley Lights, Inc.

Inventor： Kevin T. Chapman ,  Mark P. White ,  Xiaohua Wang ,  Minha Park ,  Guido K. Stadler ,  Randall D. Lowe, Jr. ,  Xiao Guan Radstrom ,  Jason M. McEwen ,  Gang F. Wang ,  George L. Fox ,  Peggy A. Radel

IPC: B01L3/00 ,  C07K16/00 ,  C07K16/28 ,  C07K16/30 ,  C12Q1/6886 ,  G01N33/50 ,  G01N33/543 ,  G01N33/569 ,  G01N33/574

CPC classification number: G01N33/574 ,  B01L3/502761 ,  C07K16/00 ,  C07K16/2887 ,  C07K16/30 ,  C12Q1/6886 ,  G01N33/5047 ,  G01N33/505 ,  G01N33/5052 ,  G01N33/54366 ,  G01N33/56972 ,  B01L2200/0647 ,  G01N2800/7028

Abstract: A method of preparing an antibody therapeutic is provided comprising: (a) providing a dissociated cell sample from at least one solid tumor sample obtained from a patient; (b) loading the dissociated cell sample into a microfluidic device having a flow region and at least one isolation region fluidically connected to the flow region; (c) moving at least one B cell from the dissociated cell sample into at least one isolation region in the microfluidic device, thereby obtaining at least one isolated B cell; and (d) using the microfluidic device to identify at least one B cell that produces antibodies capable of binding to cancer cells. The cancer cells can be the patient's own cancer cells. Also provided are methods of treating patients, methods of labeling or detecting cancer, engineered T or NK cells comprising antibodies or fragments thereof, and engineered antibody constructs.