公开(公告)号：US12105085B2

公开(公告)日：2024-10-01

申请号：US16617987

申请日：2018-05-18

申请人： National University Corporation Kobe University

发明人： Toshifumi Takeuchi ,  Yukiya Kitayama ,  Hirobumi Sunayama

IPC分类号： G01N33/543

CPC分类号： G01N33/54366

摘要： Provided is a convenient measurement system by which a target to be detected can be quickly recognized with high specificity. This base material for manufacturing a sensor for analyzing a detection target has: a base material; and a polymer film provided on the surface of the base material, wherein the polymer film has a concave that receives the detection target, and the concave has an antibody material bonding group and a signal material bonding group. A sensor for analyzing a detection target has: the base material for manufacturing a sensor for analyzing a detection target; an antibody material specific to the detection target and bonded to the antibody material bonding group; and a signal material that is bonded to the signal material bonding group.

公开(公告)号：US20240207809A1

公开(公告)日：2024-06-27

申请号：US18555668

申请日：2022-08-09

申请人： NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  TIPTON CORP.

发明人： Naoto OHMURA ,  Keigo SHIMIZU ,  Tomoyuki KOBAYASHI ,  Kairi KATO

IPC分类号： B01J19/18 ,  B01F27/272

CPC分类号： B01J19/1806 ,  B01F27/272 ,  B01F2215/0427 ,  B01F2215/0481

摘要： A reaction of a fluid in a reaction chamber is satisfactorily performed.
A fluid control method includes: generating, in a reaction chamber (84) formed between an outer cylinder (61) and an inner cylinder (70) coaxially disposed in the outer cylinder (61), a reaction phase (30) having a ring shape and formed of a reaction target fluid (F1, F2) in which a Taylor vortex (V1) is generated, the reaction phases (30) arranged in an axis (R) direction, and an inhibiting phase (31) having a ring shape that is adjacent to the reaction phase (30) in the axis (R) direction and inhibits the reaction target fluid (F1, F2) in the reaction phase (30) from flowing out to an outside of the reaction phase (30).

公开(公告)号：US20240176616A1

公开(公告)日：2024-05-30

申请号：US18519635

申请日：2023-11-27

申请人： Preferred Networks, Inc. ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

发明人： Kenji TAGATA ,  Harunobu MIYASHITA ,  Junichiro MAKINO

IPC分类号： G06F9/30

CPC分类号： G06F9/3001 ,  G06F9/30032

摘要： A processor includes an arithmetic circuit configured to execute an arithmetic instruction; and a register configured to hold data used by the arithmetic circuit. The processor receives a data movement instruction and the arithmetic instruction corresponding to the data movement instruction, and moves the data from a first memory to the register based on a data movement instruction. The arithmetic circuit executes the arithmetic instruction after a data movement of the data movement instruction is completed.

公开(公告)号：US20240176588A1

公开(公告)日：2024-05-30

申请号：US18519700

申请日：2023-11-27

申请人： Preferred Networks, Inc. ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

发明人： Gentaro WATANABE ,  Junichiro MAKINO

IPC分类号： G06F7/544 ,  G06F5/01 ,  G06F7/485 ,  G06F7/487

CPC分类号： G06F7/5443 ,  G06F5/012 ,  G06F7/485 ,  G06F7/4876

摘要： An operation circuit includes a plurality of multipliers each configured to multiply each of respective first mantissas of a plurality of first data to which a first common exponent is set as a common exponent, by each of respective second mantissas of a plurality of second data to which a second common exponent is set as a common exponent; and a first adder configured to add up a plurality of products calculated by the plurality of multipliers.

公开(公告)号：US20240100093A1

公开(公告)日：2024-03-28

申请号：US18274725

申请日：2022-02-04

申请人： NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

发明人： Takashi AOI ,  Nobuyuki MURAI

IPC分类号： A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/725 ,  C12N5/00 ,  C12N5/0783

CPC分类号： A61K35/17 ,  A61K39/4611 ,  A61K39/4632 ,  A61K39/464411 ,  A61P35/00 ,  C07K14/7051 ,  C12N5/0037 ,  C12N5/0636

摘要： Provided is a γδT cell for securing the purity and number of cells sufficient for treatment. Also provided is a method of generating the γδT cell. More specifically, provided are homogeneous γδT cells excellent in that the γδT cells are not affected by exhaustion of the cells. The foregoing is achieved by γδT cells obtained by subjecting induced pluripotent stem cells (iPS cells) to differentiation induction treatment. Specifically, the foregoing is achieved by γδT cells generated by subjecting iPS cells having a rearranged γδTCR gene (γδTCR-type iPS cells) to differentiation induction treatment. According to the method of generating the γδT cell of the present invention, there can be provided γδT cells and a cell population of γδT cells that have an excellent function of having antigen-specific cytotoxic activity in a MHC-unrestricted manner, and that are more homogeneous and have a higher effect than γδT cells separated from peripheral blood.

公开(公告)号：US20240077463A1

公开(公告)日：2024-03-07

申请号：US18273856

申请日：2022-01-17

申请人： SHIMADZU CORPORATION ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  AJINOMOTO CO., INC.

发明人： Shinnosuke HORIE ,  Yuka FUJITO ,  Tomohisa HASUNUMA ,  Takanobu YOSHIDA ,  Erika URAHATA

IPC分类号： G01N30/72 ,  C12N1/20 ,  G01N30/04 ,  G01N30/26

CPC分类号： G01N30/7233 ,  C12N1/20 ,  G01N30/04 ,  G01N30/26 ,  G01N2030/065

摘要： Provided is a method capable of shortening the time required for analysis and capable of analyzing various substances produced by microorganisms. A method for analyzing a metabolite of a microorganism according to the present invention includes: a step of supplying a mobile phase including carbon dioxide in a liquid state, a subcritical state, or a supercritical state to a container in which a microorganism cultured in a medium is contained together with the medium, to move a component of a metabolite of the microorganism present in the microorganism and the medium to the mobile phase; a step of introducing a mobile phase to which a component of the metabolite has moved into a column; and a step of performing mass spectrometry on a component of the metabolite contained in the mobile phase that has passed through the column.

公开(公告)号：US20230408478A1

公开(公告)日：2023-12-21

申请号：US18036857

申请日：2021-11-12

申请人： National University Corporation Kobe University ,  Bunkoukeiki Co., Ltd.

发明人： Chikahiro MIYAKE ,  Takayuki SOHTOME

IPC分类号： G01N33/00 ,  G01N21/64 ,  G01N21/31 ,  G01N21/84 ,  A01G7/04

CPC分类号： G01N33/0098 ,  G01N21/6486 ,  G01N21/31 ,  G01N21/84 ,  A01G7/045 ,  G01N2021/8466

摘要： The present invention relates to an improved technology for a device that identifies and diagnoses an environmental stress state of plants. A control circuit 20b controls a measurement light source 12 such that a second measurement light ML2 has higher power than a first measurement light ML1 and the first measurement light ML1 and the second measurement light ML2 become opposite-phase rectangular waves, and further controls the measurement light source 12 such that the first measurement light ML1 and the second measurement light ML2 are output in synchronization to form the first measurement light ML1 and the second measurement light ML2 into a quasi-single composite rectangular wave measurement light ML3 of 5 kHz to 30 kHz. A transmitted light detector 18 detects the composite rectangular wave measurement light ML3 transmitted through a plant sample S as a composite rectangular wave transmitted light TL. An analysis circuit 20a calculates a light absorption difference by utilizing the composite rectangular wave transmitted light TL, and calculates Y(ND) which is an oxidized state of P700 as a ROS marker utilizing the light absorption difference, and diagnoses an environmental stress state of plants by utilizing the ROS marker.

公开(公告)号：US11845953B2

公开(公告)日：2023-12-19

申请号：US16496311

申请日：2018-03-20

申请人： NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

发明人： Keiji Nishida ,  Akihiko Kondo ,  Takayuki Arazoe ,  Shin Yoshioka

IPC分类号： C12N15/00 ,  C12N15/01 ,  C12N9/78 ,  C12N9/22 ,  C12N15/90 ,  C12N15/11 ,  C12N15/85

CPC分类号： C12N15/907 ,  C12N9/22 ,  C12N15/11 ,  C12N15/85 ,  C12N2310/20 ,  C12N2800/80

摘要： Provided is a method for altering a targeted site of a DNA in a cell, including a step of stimulating the cell with a factor inducing a DNA modifying enzyme endogenous to the cell, and bringing a complex of a nucleic acid sequence-recognizing module specifically binding to a target nucleotide sequence in a given DNA and a DNA modifying enzyme-binding module bonded to each other into contact with the DNA to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site.

公开(公告)号：US20230348279A1

公开(公告)日：2023-11-02

申请号：US18350092

申请日：2023-07-11

申请人： NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY ,  AGC Inc. ,  MITSUBISHI GAS CHEMICAL COMPANY, INC.

发明人： Akihiko TSUDA ,  Takashi OKAZOE ,  Hidefumi HARADA

IPC分类号： C01B32/80

CPC分类号： C01B32/80

摘要： The objective of the present invention is to provide a method for producing a carbonyl halide efficiently to the used halogenated methane. The method for producing a carbonyl halide according to the present invention is characterized in comprising the steps of preparing a mixed gas comprising oxygen and a halogenated methane having one or more halogeno groups selected from the group consisting of chloro, bromo and iodo, and flowing the mixed gas and irradiating a high energy light to the flowed mixed gas.

公开(公告)号：US20230347297A1

公开(公告)日：2023-11-02

申请号：US18028866

申请日：2021-09-24

申请人： UNITIKA LTD. ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

发明人： Ryota NAKAMURA ,  Kuniko INOUE ,  Kyohei UMAKOSHI ,  Takahiro ONO ,  Hideto MATSUYAMA

IPC分类号： B01D69/02 ,  B01D71/56 ,  B01D69/08 ,  B01D67/00

CPC分类号： B01D69/02 ,  B01D71/56 ,  B01D69/08 ,  B01D67/0016 ,  B01D67/0027 ,  B01D2325/0231 ,  B01D2325/34

摘要： An object of the present invention is to provide a polyamide porous membrane having improved fluid permeation performance. A polyamide porous membrane having a dense layer formed on at least one surface, wherein the polyamide porous membrane has a streak-like recessed portion extending in one direction of a surface of the dense layer, and the streak-like recessed portion has an orientation angle of 0 to 5.0° or 175.0 to 180.0° and an orientation intensity of 1.5 to 2.0 according to predetermined orientation analysis.