公开(公告)号：US20240329016A1

公开(公告)日：2024-10-03

申请号：US18738234

申请日：2024-06-10

申请人： SHIMADZU CORPORATION

发明人： Yukihiko KUDO

IPC分类号： G01N30/72 ,  G01N30/02 ,  G01N30/04 ,  G01N30/62 ,  G01N30/86 ,  G01N30/88

CPC分类号： G01N30/7206 ,  G01N30/8634 ,  G01N30/8668 ,  G01N30/8679 ,  G01N30/88 ,  G01N2030/025 ,  G01N2030/047 ,  G01N2030/626 ,  G01N2030/8804 ,  G01N2030/8845

摘要： In a quantitative determination device 100 for brominated flame-retardant compounds, a storage section 41 holds a relative response factor 411 representing a relationship of a measured intensity of a compared compound to that of a reference compound selected from target compounds. A standard-sample measurer 43 acquires the intensity of the reference compound by measuring a standard sample, using an analyzer 10, 20. A target-sample measurer 45 acquires the intensities of the reference and compared compounds by measuring a target sample, using the analyzer. A reference-compound quantity determiner 46 determines a quantitative value of the reference compound in the target sample. A compared-compound quantity determiner 47 determines a quantitative value of the compared compound based on the quantity of the reference compound in the standard sample, intensity of the reference compound acquired by the standard-sample measurer, intensity of the compared compound acquired by the target-sample measurer, and relative response factor of the compared compound.

公开(公告)号：US11879898B2

公开(公告)日：2024-01-23

申请号：US17417572

申请日：2019-12-23

申请人： DH Technologies Development Pte. Ltd.

发明人： Subhakar N Dey ,  Michal Weinstock

IPC分类号： G01N33/00 ,  G01N33/74 ,  G01N1/34 ,  G01N1/40 ,  G01N30/04 ,  G01N30/72 ,  G01N30/02 ,  G01N30/06

CPC分类号： G01N33/743 ,  G01N1/34 ,  G01N1/4077 ,  G01N30/04 ,  G01N30/72 ,  G01N2001/4083 ,  G01N2001/4088 ,  G01N2030/027 ,  G01N2030/045 ,  G01N2030/067 ,  G01N2560/00

摘要： The teachings herein provide for a method of analyzing testosterone using mass spectrometry. The method entails combining in a vial or well, a tagging reagent that is reactive with testosterone, an aqueous precipitation agent that precipitate proteins from solution, and an internal standard solution, the internal standard solution containing a known concentration of an isotopically enriched testosterone and then adding to the vial or well, a sample containing or suspected to contain testosterone. The vial can then be mixed to cause simultaneous precipitation of proteins and reaction of any testosterone present with the tagging reagent to form a mixture of a precipitate and a liquid solution. The liquid solution can then be separated from any precipitate and then analyzed for testosterone using liquid chromatography tandem mass spectrometry.

公开(公告)号：US11774413B2

公开(公告)日：2023-10-03

申请号：US17366467

申请日：2021-07-02

申请人： Shimadzu Corporation

发明人： Tomoyuki Yamazaki

IPC分类号： B01D15/20 ,  B01D15/22 ,  G01N30/04 ,  G01N30/80 ,  G01N30/84 ,  G01N30/26 ,  G01N30/82 ,  G01N30/06

CPC分类号： G01N30/04 ,  B01D15/20 ,  B01D15/22 ,  G01N30/06 ,  G01N30/26 ,  G01N30/80 ,  G01N30/82 ,  G01N30/84

摘要： A preparative liquid chromatograph includes a liquid chromatograph section, a trap section, an eluent supply section, a collector, and a flow path switching section. The flow path switching section is configured to be selectively switched to a component trap mode that connects the liquid chromatograph section and the trap section in such a way that a sample component separated in a separation column is trapped by a trap column of the trap section; and a collection mode that connects the eluent supply section and the trap section and connects the trap section and the collector in such a way that the components trapped in the trap column are eluted by an eluent from the eluent supply section and are guided to the collector.

公开(公告)号：US11747310B2

公开(公告)日：2023-09-05

申请号：US16664403

申请日：2019-10-25

申请人： WATERS TECHNOLOGIES CORPORATION

发明人： Michael F. Morris ,  Matthew A. Lauber ,  Darryl W. Brousmiche

IPC分类号： G01N30/00 ,  G01N30/02 ,  B01D15/30 ,  C07D215/48 ,  G01N30/04 ,  C07H15/26 ,  G01N30/88 ,  G01N33/68 ,  G01N30/62

CPC分类号： G01N30/02 ,  B01D15/305 ,  C07D215/48 ,  C07H15/26 ,  G01N30/04 ,  G01N30/88 ,  G01N33/6842 ,  G01N2030/027 ,  G01N2030/047 ,  G01N2030/626 ,  G01N2030/8836 ,  G01N2400/00 ,  G01N2440/38

摘要： Methods are provided for making rapid labeled dextran ladders and other calibrants useful in liquid chromatography. The methodologies include a two-step process comprising a reductive amination step of providing a reducing glycan and reacting it with a compound having a primary amine to produce an intermediate compound. The intermediate compound is then rapidly tagged with a rapid tagging reagent to produce the rapid labeled dextran ladder.

公开(公告)号：US11692983B2

公开(公告)日：2023-07-04

申请号：US17159923

申请日：2021-01-27

申请人： Promega Corporation

发明人： Joshua Jacques Coon ,  Michael M. Rosenblatt ,  Marjeta Urh

IPC分类号： G01N30/86 ,  G01N30/02 ,  H01J49/00 ,  G01N30/04 ,  G01N30/88

CPC分类号： G01N30/8665 ,  G01N2030/027 ,  G01N2030/047 ,  G01N2030/8831 ,  H01J49/0009

摘要： The present invention provides reagents for instrumentation quality control and methods of use thereof. In particular, sets of peptides or other molecules are provided for evaluating the performance of instruments with mass spectrometry (MS) and/or liquid chromatography (LC) functionalities.

公开(公告)号：US11680894B2

公开(公告)日：2023-06-20

申请号：US17555803

申请日：2021-12-20

申请人： MLS ACQ, Inc.

发明人： Eddie Dean Wyatt ,  Martin L. Spartz

IPC分类号： G01N21/3504 ,  G01N30/02 ,  G01N30/86 ,  G01N33/00 ,  G01N21/35 ,  G01N30/04 ,  G01N30/72

CPC分类号： G01N21/3504 ,  G01N30/02 ,  G01N30/8668 ,  G01N30/8672 ,  G01N30/7206 ,  G01N33/0047 ,  G01N2021/3595 ,  G01N2030/025 ,  G01N2030/042

摘要： A process for identifying an unknown compound in a sample includes matching a peak in a primary Fourier Transform Infrared spectral region of the sample spectrum with reference spectra in the same spectral region to generate an initial list of potential candidates, based, for example on goodness of fit criteria. The initial list can be reduced by retention time information and/or global peak matching techniques that analyze the sample spectrum in regions outside the primary region.

公开(公告)号：US11585790B1

公开(公告)日：2023-02-21

申请号：US17387975

申请日：2021-07-28

申请人： Pace Analytical Services, LLC

发明人： Johnny Alan Mitchell ,  Nic Rasnake ,  Leora Loftis

IPC分类号： G01N30/14 ,  G01N33/18 ,  G01N30/72 ,  G01N33/24 ,  G01N30/02 ,  G01N30/04

摘要： A sample may be prepared and then analyzed using a liquid chromatography with tandem mass spectrometry system to determine presence and concentration of herbicide(s) present in the sample. In some examples, the method involves providing a sample containing one or more herbicides and adding a base to the sample. The base may increase the pH of the sample to ≥12, thereby hydrolyzing esters of the one or more herbicides. The method may further involve, subsequent to hydrolyzing the esters of the one or more herbicides, adding an acid to the sample so as to lower the pH of the sample to ≤3. Once prepared, the sample can be injected into a liquid chromatography instrument to separate the herbicide molecules from other molecules present in the sample before being ionized and characterized by mass-to-charge ratio and relative abundance using one or more mass spectrometers.

公开(公告)号：US11536726B2

公开(公告)日：2022-12-27

申请号：US17043165

申请日：2019-04-01

申请人： Metabolon, Inc.

发明人： Lisa Ford ,  Kirk L. Pappan ,  Tiffany A. Freed ,  Kelsey M. Eason

IPC分类号： G01N33/68 ,  G01N30/72 ,  G01N33/49 ,  H01J49/00 ,  H01J49/04 ,  G01N33/483 ,  G01N33/52 ,  G01N30/02 ,  G01N30/04

摘要： A method for determining in a sample, by mass spectrometry, the amount of one or more analytes selected from the group consisting of 12,13-DiHOME, 3-hydroxybutyrate (BHBA), 3-hydroxyoctanoate, 3-methylglutarylcarnitine, 3-ureidopropionate, 7-alpha-hydroxy-4-cholesten-3-one (7-Hoca), citrate, fucose, fumarate, gamma-tocopherol, glutamate, glutarate, glycerol, glycochenodeoxycholate, glycocholate, hypoxanthine, maleate, malonate, mannose, orotate, 2,3-pyrdinedicarboxylate, ribose, serine, taurine, taurochenodeoxycholate, taurocholate, palmitoleate, linolenate, xanthine, xylitol, and combinations thereof is described. The method comprises subjecting the sample to an ionization source under conditions suitable to produce one or more ions detectable by mass spectrometry from each of the one or more analytes; measuring, by mass spectrometry, the amount of the one or more ions from each of the one or more analytes; and using the measured amount to determine the amount of each of the one or more analytes in the sample.

公开(公告)号：US11371968B2

公开(公告)日：2022-06-28

申请号：US16917908

申请日：2020-07-01

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Daniel Thielsch ,  Dominik Ruf

IPC分类号： G01N30/20 ,  B01D15/14 ,  G01N30/04 ,  G01N30/10 ,  G01N30/36 ,  G01N30/32

摘要： A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured for adjusting a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

公开(公告)号：US11280767B2

公开(公告)日：2022-03-22

申请号：US16084402

申请日：2017-10-20

申请人： LG Chem, Ltd.

发明人： Yeu Young Youn ,  Byoung Hyoun Kim ,  Young Hee Lim ,  Hye Sung Cho ,  Su Youn Han ,  Mi Ra Hong ,  Yeon Hwa Lee

IPC分类号： G01N30/00 ,  G01N30/14 ,  G01N30/72 ,  B01J20/285 ,  G01N1/40 ,  G01N30/06 ,  G01N30/66 ,  G01N30/88 ,  B01J20/26 ,  B01J20/281 ,  G01N30/04

摘要： A pretreatment method for analyzing dioxin compounds and an analytical method using the same, in which a column packed with polymer beads that are capable of selectively adsorbing dioxin compounds is used in a purification step during pretreatment, thereby remarkably reducing a time required for pretreatment and improving a recovery rate of an internal standard for purification, are provided.