公开(公告)号：US12061180B2

公开(公告)日：2024-08-13

申请号：US18063128

申请日：2022-12-08

申请人： Alexander Bozic

发明人： Alexander Bozic

IPC分类号： G01N30/84 ,  B01D15/40 ,  B01D45/08 ,  G01N30/06 ,  G01N30/80

CPC分类号： G01N30/84 ,  B01D15/40 ,  B01D45/08 ,  G01N30/06 ,  G01N2030/065 ,  G01N30/80

摘要： The present invention relates to a gas-liquid separator for a chromatography system, comprising:



(a) a separating region having an inlet nozzle, a baffle unit and a gas distribution unit;
(b) a dividing region having a liquid outlet; and
(c) a gas discharge region having a gas outlet;
wherein the separating region is connected to the dividing region by a separating opening and the distance of the inlet nozzle from the baffle unit is greater than the smallest longitudinal extension of the separating opening and the inlet nozzle is configured such that a gas-liquid stream directed through the inlet nozzle can act on the baffle unit.




The present invention further relates to a chromatography system comprising a separator according to the invention and to a chromatography method wherein the separator is used.

公开(公告)号：US11988649B2

公开(公告)日：2024-05-21

申请号：US17063873

申请日：2020-10-06

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Purnendu K. Dasgupta ,  Bikash Chouhan ,  Joseph Ray

IPC分类号： G01N30/38 ,  B01D15/36 ,  G01N30/84

CPC分类号： G01N30/38 ,  B01D15/361 ,  G01N2030/8458

摘要： A device for ion chromatography comprises a tube with an inlet opening and an outlet opening and an inner diameter from about 40 microns to about 10 microns. There is an aperture through one side of the tube into a lumen of the tube. At least a portion of the inner surface of the tube has a first charge. An ion exchange barrier covers the aperture on an outside surface of the tube. The inner surface of the tube, from the inlet opening to the aperture, is coated with ion exchange particles having a diameter ranging from about 30 nm to about 200 nm. The ion exchange particles have a second charge opposite the first charge. The inner surface of the tube, from the outlet opening to the aperture, is not coated with ion exchange particles.

公开(公告)号：US20240096612A1

公开(公告)日：2024-03-21

申请号：US18271386

申请日：2021-09-22

申请人： SHIMADZU CORPORATION

发明人： Keisuke SHIMA ,  Yuko FUKUYAMA

IPC分类号： H01J49/04 ,  G01N30/84

CPC分类号： H01J49/0431 ,  G01N30/84 ,  G01N2030/8452

摘要： The present invention provides a method for mass spectrometry of a negatively charged organic synthetic compound, and a matrix that can be used in said method. A method for mass spectrometry of a negatively charged organic synthetic compound, the method comprising using, as a liquid matrix, an ionic liquid comprising an amine ion and an acidic group-containing organic substance ion. For example, the amine is 3-aminoquinoline (3-AQ), and the acidic group-containing organic substance is p-coumaric acid (p-CA). The negatively charged organic synthetic compound to be analyzed is, for example, an organic synthetic polymer compound or a complex compound.

公开(公告)号：US11680929B2

公开(公告)日：2023-06-20

申请号：US16850238

申请日：2020-04-16

申请人： Bruker BioSpin GmbH

发明人： Ernst Ulrich Braumann ,  Martin Hofmann

IPC分类号： G01N30/84 ,  B01D15/10 ,  B01L3/02

CPC分类号： G01N30/84 ,  B01D15/10 ,  B01L3/0241 ,  B01L2300/0838 ,  B01L2300/0867

摘要： An apparatus for collecting liquid fractions from a separation/reaction apparatus (1). A capillary (2) guides an extracted liquid fraction to a branching unit (3), a collection arrangement (4) carries a plurality of target vessels (5) receiving the liquid fraction from the capillary and a fluid line (6) is flow-connected to a fluid pump (7) and opens into the branching unit. The capillary and the fluid line each have outlet openings in the direct vicinity of one another at their end facing a target vessel such that liquid emerging from the outlet opening (2′) of the capillary transitions into the outlet opening (6′) of the fluid line. This precludes back mixing with earlier/later liquid fractions, precludes uncontrolled dripping of sample substance at the transfer point, speeds displacement of the target vessels in the collection arrangement, facilitates automation of the fraction processing procedure, and results in a more compact fraction collection apparatus.

公开(公告)号：US11428675B2

公开(公告)日：2022-08-30

申请号：US16524269

申请日：2019-07-29

申请人： Activated Research Company, LLC

发明人： Andrew Jones ,  Tommy Saunders ,  Mike Hofflander

IPC分类号： G01N30/64 ,  G01N30/38 ,  G01N30/34 ,  G01N30/02 ,  G01N30/84

摘要： In the present system and method, a conduit from a LC device continuously transports solvent, buffers, and analytes to the inlet of a solvent removal and analyte conversion device which evaporates the solvents, leaving non-volatile analytes for detection. The device comprises a rotating disk. The liquid chromatograph device can be any device using liquid chromatography to separate molecules. The solvents in the LC effluent can include, but are not limited to, water, methanol, acetonitrile, tetrahydrofuran, and acetone. After removal of the volatile components, the non-volatile analytes are converted with a concentrated energy source so that they may be detectable.

公开(公告)号：US20220268745A1

公开(公告)日：2022-08-25

申请号：US17737163

申请日：2022-05-05

申请人： Puridify Ltd.

发明人： Michael Williams ,  Iwan Roberts ,  Oliver Hardick ,  Matthew Townsend ,  Christopher Morris ,  Shameer Subratty

IPC分类号： G01N30/38 ,  G01N30/60 ,  G01N30/84

摘要： A chromatography system for at least one of tangential flow chromatography and lateral flow chromatography comprising: an inlet; a functionalised adsorbent chromatography medium downstream of the inlet; an outlet downstream of the adsorbent chromatography medium; and a flow guide downstream of the inlet and upstream of the adsorbent chromatography medium and configured to distribute a flow of a liquid from the inlet across a width of the adsorbent chromatography medium; wherein the flow guide comprises a pattern of channels providing flow paths from the inlet to different parts of the adsorbent chromatography medium along the width of the adsorbent chromatography medium, wherein the pattern of channels is provided so as to reduce a difference in arrival time and/or flow velocity of liquid reaching the adsorbent chromatography medium across the width of the adsorbent chromatography medium.

公开(公告)号：US20220146470A1

公开(公告)日：2022-05-12

申请号：US17441551

申请日：2020-03-10

申请人： LABORATORIOS ERN, S.A. ,  Nabriva Therapeutics Ireland DAC

发明人： Robert DIVASTO ,  Marta MARIÑO

IPC分类号： G01N30/84 ,  G01N30/34 ,  G01N30/64

摘要： The present invention relates to a method for the detection and quantification of fosfomycin and impurities and/or degradation products thereof in samples of fosfomycin or a pharmaceutically acceptable salt thereof or in pharmaceutical compositions comprising fosfomycin or a pharmaceutically acceptable salt thereof. The present invention further relates to a process for manufacturing fosfomycin, or a pharmaceutically acceptable salt thereof having a specified purity degree, as well as to the fosfomycin or a pharmaceutically acceptable salt thereof as obtained. The present invention further relates to a process for manufacturing a pharmaceutical composition comprising fosfomycin or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient having a specified purity degree, as well as to the pharmaceutical composition as obtained.

公开(公告)号：US11092003B2

公开(公告)日：2021-08-17

申请号：US16409204

申请日：2019-05-10

申请人： Saudi Arabian Oil Company

发明人： Jason R. Cox

IPC分类号： E21B49/00 ,  E21B47/11 ,  C09K8/035 ,  C09K8/588 ,  B01D53/02 ,  C08F112/08 ,  C08F112/14 ,  G01N30/72 ,  G01N30/84 ,  G01N30/88

摘要： Tracing subterranean fluid flow includes providing a first polymeric tracer to a first injector, collecting a first aqueous sample from a first producer, and assessing the presence of the first polymeric tracer in the first aqueous sample. The first polymeric tracer includes a first polymer formed from at least a first monomer. The presence of the first polymeric tracer in the first aqueous sample is assessed by removing water from the first aqueous sample to yield a first dehydrated sample. pyrolyzing the first dehydrated sample to yield a first gaseous sample, and assessing the presence of a pyrolization product of the first polymer in the first gaseous sample. The presence of the pyrolization product of the first polymer in the first gaseous sample is indicative of the presence of a first subterranean flow pathway between the first injector location and the first producer location.

公开(公告)号：US20210239718A1

公开(公告)日：2021-08-05

申请号：US17234616

申请日：2021-04-19

申请人： Quest Diagnostics Investments Incorporated

发明人： Qibo Jiang ,  Richard E. Reitz ,  Sum Chan

IPC分类号： G01N33/82 ,  G01N30/72 ,  G01N30/84 ,  H01J49/26 ,  H01J49/00 ,  G01N33/487 ,  B01D15/08 ,  G01N30/88

摘要： Provided are methods for determining the amount of vitamin C in a sample using mass spectrometry. The methods generally involve ionizing vitamin C in a sample and detecting and quantifying the amount of the ion to determine the amount of vitamin C in the sample.

公开(公告)号：US11031225B2

公开(公告)日：2021-06-08

申请号：US16335077

申请日：2017-09-13

申请人： DH Technologies Development Pte. Ltd.

发明人： Thomas R. Covey ,  Yves LeBlanc ,  Bradley B. Schneider

IPC分类号： H01J49/06 ,  G01N30/72 ,  G01N30/84

摘要： Because most ion optics of mass spectrometry systems are subject to ion deposition and may exhibit significantly different behavior following substantial contamination (e.g., loss of sensitivity), fouled surfaces must be regularly cleaned to maintain sensitivity. While the surfaces of front-end components (e.g., curtain plates, orifice plates, Qjet, Q0, IQ0) may be relatively easy to clean, the fouling of components contained within the downstream high-vacuum chambers (e.g., Q1, IQ1) can incur substantial delays and expense as the high-vacuum chambers must be vented and substantially disassembled prior to cleaning. Methods and systems for controlling contamination of components of mass spectrometer systems are provided herein. By reducing the transmission of contaminating ions during non-data acquisition periods, the present teachings can increase throughput, improve robustness, and/or decrease the downtime typically required to vent/disassemble/clean the fouled components.