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    Differential viscometer with solvent compressibility correction
    3.
    发明申请
    Differential viscometer with solvent compressibility correction 审中-公开

    公开(公告)号：US20180188146A1

    公开(公告)日：2018-07-05

    申请号：US15736291

    申请日：2016-07-08

    申请人： Wyatt Technology Corporation

    发明人： Steven P. Trainoff

    IPC分类号： G01N11/08 ,  G01N30/64 ,  G01N30/32

    CPC分类号： G01N11/08 ,  G01N30/32 ,  G01N30/62 ,  G01N30/64 ,  G01N2030/625 ,  G01N2030/626

    摘要： An improved version of the capillary bridge viscometer that compensates for the effect of solvent compressibility is disclosed. A novel, yet simple and inexpensive modification to a conventional capillary bridge viscometer design can improve its ability to reject pump pulses by more than order of magnitude. This improves the data quality and allows for the use of less expensive pumps. A pulse compensation volume is added such that it transmits pressure to the differential pressure transducer without sample flowing there through. The pressure compensation volume enables the cancelation of the confounding effects of pump pulses in a capillary bridge viscometer.

    Gaseous Mercury Detection Systems, Calibration Systems, and Related Methods
    4.
    发明申请
    Gaseous Mercury Detection Systems, Calibration Systems, and Related Methods 有权
    气体汞检测系统，校准系统和相关方法

    公开(公告)号：US20160033456A1

    公开(公告)日：2016-02-04

    申请号：US14811317

    申请日：2015-07-28

    申请人： Seth N. Lyman

    发明人： Seth N. Lyman

    IPC分类号： G01N30/72 ,  H01J49/04

    CPC分类号： G01N30/7206 ,  G01N30/08 ,  G01N33/0045 ,  G01N2030/025 ,  G01N2030/085 ,  G01N2030/121 ,  G01N2030/143 ,  G01N2030/626 ,  H01J49/0422

    摘要： Embodiments disclosed herein are directed to gaseous mercury detection systems, calibration systems, and related methods. The gaseous mercury detection systems are configured to detect gas-phase mercury-compounds present in ambient air. For example, the gaseous mercury detection systems collect gas-phase mercury-compounds from ambient air and release the gas-phase mercury-compounds at concentrations capable of being measured by a gas-chromatography mass spectrometer without heating the gas-phase mercury-compounds above a decomposition temperature of at least one gaseous mercury compound that may present in the mercury-containing gas. The calibration systems are configured to determine an accuracy of or calibrate a gaseous mercury detection system. The disclosed calibration systems may be integrated with or distinct from the gaseous mercury detection systems disclosed herein.

    摘要翻译： 本文公开的实施例涉及气态汞检测系统，校准系统和相关方法。 气态汞检测系统配置成检测环境空气中存在的气相汞化合物。 例如，气态汞检测系统从环境空气中收集气相汞化合物，并以能够通过气相色谱质谱仪测量的浓度释放气相汞化合物，而不加热上述气相汞化合物 可能存在于含汞气体中的至少一种气态汞化合物的分解温度。 校准系统被配置为确定气态汞检测系统的精度或校准。 所公开的校准系统可以与本文公开的气态汞检测系统集成或不同。

    Method for fractionating various components contained in a sample solution by liquid chromatograph mass spectrometer
    5.
    发明授权
    Method for fractionating various components contained in a sample solution by liquid chromatograph mass spectrometer 有权
    通过液相色谱质谱仪对样品溶液中所含的各种组分进行分级的方法

    公开(公告)号：US07901628B2

    公开(公告)日：2011-03-08

    申请号：US12078220

    申请日：2008-03-28

    申请人： Yoshitake Yamamoto

    发明人： Yoshitake Yamamoto

    IPC分类号： G01N30/02 ,  H01J49/00 ,  B01D59/44 ,  G01N15/06

    CPC分类号： G01N30/8624 ,  G01N30/7233 ,  G01N30/7293 ,  G01N30/8631 ,  G01N30/8641 ,  G01N2030/027 ,  G01N2030/626 ,  H01J49/04 ,  Y10T436/24

    摘要： A method for fractionating a sample solution includes the steps of setting a first mass spectrometry condition and mass range information; setting a second mass spectrometry condition and mass range information; executing a mass scan by the mass spectrum acquisition portion under the first mass spectrometry condition and obtaining first mass spectrum data; extracting first chromatogram data from the first mass spectrum data based on the first mass range information; executing a mass scan by the mass spectrum acquisition portion under the second mass spectrometry condition to obtain second mass spectrum data; extracting second chromatogram data from the second mass spectrum data based on the second mass range information; switching the first and second spectrometry conditions and repeating the mass scan cyclically; adding the first and second chromatograph data to obtain a chromatogram data; and operating the fraction collector based on the chromatogram data.

    摘要翻译： 分离样品溶液的方法包括设定第一质谱条件和质量范围信息的步骤; 设置第二个质谱条件和质量范围信息; 在第一质谱条件下由质谱获取部分进行质量扫描，获得第一质谱数据; 基于第一质量范围信息从第一质谱数据中提取第一色谱图数据; 在第二质谱条件下通过质谱采集部分进行质量扫描以获得第二质谱数据; 基于第二质量范围信息从第二质谱数据中提取第二色谱图数据; 切换第一和第二光谱测定条件并循环重复质谱; 加入第一和第二色谱数据以获得色谱数据; 并基于色谱图数据操作馏分收集器。

    Signal to noise ratio in chromatography
    8.
    发明申请
    Signal to noise ratio in chromatography 审中-公开
    色谱中的信噪比

    公开(公告)号：US20040205422A1

    公开(公告)日：2004-10-14

    申请号：US10728182

    申请日：2003-12-04

    发明人： Robert W. Allington

    IPC分类号： G06F011/00

    CPC分类号： G01N30/78 ,  G01N30/8603 ,  G01N2030/626 ,  G01N2030/324

    摘要： Signals obtained in capillary High Performance Liquid Chromatography (HPLC) are notoriously noisy. The signal can be improved by increasing the path length of the light passing through the sample stream, but increased path length decreases resolution (resolving N closely spaced peaks in the actual separation into N peaks of almost equal separation on the chromatogram. A novel approach is to operate on segments of the chromatogram signal, averaging, integrating, or correlating the data within the segment. This approach may be utilized with analog or digital signals. The important information, contained in the integrated, summed or correlated signal, will increase the chromatographic signal relative to the noise information.

    摘要翻译： 在毛细管高效液相色谱（HPLC）中获得的信号是臭名昭着的噪音。 可以通过增加通过样品流的光的路径长度来改善信号，但是增加的路径长度降低了分辨率（将实际分离中的N个紧密间隔的峰分解成在色谱图上几乎相等的分离的N个峰。 对色谱图信号的段进行操作，对段内的数据进行平均，积分或相关，这种方法可以用于模拟或数字信号，包含在积分，相加或相关信号中的重要信息将增加色谱 信号相对于噪声信息。

    Method and apparatus to enhance the signal to noise ratio in chromatography
    9.
    发明申请
    Method and apparatus to enhance the signal to noise ratio in chromatography 审中-公开
    提高色谱信噪比的方法和装置

    公开(公告)号：US20040204866A1

    公开(公告)日：2004-10-14

    申请号：US10801409

    申请日：2004-03-16

    发明人： Robert W. Allington

    IPC分类号： G01N001/00

    CPC分类号： G01N30/8603 ,  G01N27/44717 ,  G01N27/44721 ,  G01N30/78 ,  G01N2030/626 ,  Y10T436/25 ,  G01N2030/324

    摘要： Signals obtained in capillary High Performance Liquid Chromatography (HPLC) are notoriously noisy. The signal can be improved by increasing the path length of the light passing through the sample stream, but increased path length decreases resolution (resolving N closely spaced peaks in the actual separation into N peaks of almost equal separation on the chromatogram. A novel approach is to utilize a number of photocell sensors lined up along a capillary through which the solution passes. In one embodiment of this invention, the flow of the solution is stopped with the solvent spike oriented with a particular photocell sensor. Then a single, continuous scan or multiple scans of a section of the quiescent solution may be taken and integrated, summed, or statistically correlated. In another embodiment, a solvent spike is detected and tracked. A set of photocell sensors is chosen at increments of time such that the leading photocell is at the solvent spike. The set of photocells is scanned repeatedly. The important information, contained in the integrated, summed or correlated signal, will increase the chromatographic signal relative to the noise information. In this way, the effective path length is increased without including any moving parts or significant loss of resolution.

    摘要翻译： 在毛细管高效液相色谱（HPLC）中获得的信号是臭名昭着的噪音。 可以通过增加通过样品流的光的路径长度来改善信号，但是增加的路径长度降低了分辨率（将实际分离中的N个紧密间隔的峰分解成在色谱图上几乎相等的分离的N个峰。 在本发明的一个实施方案中，溶液的流动在用特定的光电池传感器定向的溶剂尖峰的情况下停止，然后单次连续扫描或 可以对静态溶液的一部分进行多次扫描并进行积分，相加或统计相关。在另一个实施例中，检测和跟踪溶剂尖峰。以增量选择一组光电池传感器，使得前导光电管 在溶剂尖峰处，重复扫描光电池组，包含在积分，相加或相关信号中的重要信息， 将相对于噪声信息增加色谱信号。 以这种方式，增加有效路径长度，而不包括任何移动部件或显着的分辨率损失。

    Liquid chromatograph mass spectrometer
    10.
    发明申请
    Liquid chromatograph mass spectrometer 审中-公开
    液相色谱质谱仪

    公开(公告)号：US20030113936A1

    公开(公告)日：2003-06-19

    申请号：US10015668

    申请日：2001-12-17

    申请人： SHIMADZU CORPORATION

    发明人： Yoshitake Yamamoto

    IPC分类号： G01N030/02 ,  G01N024/00

    CPC分类号： G01N30/8624 ,  G01N30/7233 ,  G01N30/7293 ,  G01N30/8631 ,  G01N30/8641 ,  G01N2030/027 ,  G01N2030/626 ,  H01J49/04 ,  Y10T436/24

    摘要： In a liquid chromatograph mass spectrometer, chromatogram data is obtained by carrying out alternately a mass scanning in a positive ion detection mode and a mass scanning in a negative ion detection mode, obtaining the chromatogram data in every positive and negative polarities through summing up the mass spectrum data obtained at the respective mass scannings, and adding the data of both polarities. Since the chromatograms in both polarities are averaged, even if there is a level difference therebetween, a chromatogram in a normal form can be obtained.

    摘要翻译： 在液相色谱质谱仪中，通过以正离子检测模式和负离子检测模式的质量扫描交替进行质谱扫描，通过将质量的总和获得每个正极性和负极性的色谱图数据来获得色谱图数据 在各个质量扫描中获得的光谱数据，并且添加两个极性的数据。 由于两极性的色谱图是平均的，所以即使在它们之间存在水平差，也可以获得正常形式的色谱图。