公开(公告)号：US12106954B2

公开(公告)日：2024-10-01

申请号：US17277999

申请日：2019-10-17

申请人： SHIMADZU CORPORATION

发明人： Yiming Lin ,  Wenjian Sun

IPC分类号： H01J49/16 ,  H01J49/04 ,  H01J49/26

CPC分类号： H01J49/16 ,  H01J49/04 ,  H01J49/26

摘要： The present invention provides dielectric barrier discharge ionization, including a dielectric barrier discharge tube and an electrode pair consisting of a first electrode and a second electrode. At least a portion of the dielectric barrier discharge tube is provided between the first electrode and the second electrode. The electrode pair can ionize the sample after the power is turned on. The dielectric barrier discharge tube is in communication with a vacuum portion. The pressure range in the dielectric barrier discharge tube is 0.01 to 100 Pa. The dielectric barrier discharge ionization provided by the invention remedies the defects of existing low-pressure ion sources in the pressure range, and provides the low-pressure ion source with high ionization ability, high versatility and simple devices.

公开(公告)号：US20240207969A1

公开(公告)日：2024-06-27

申请号：US18525021

申请日：2023-11-30

申请人： Elemental Scientific Lasers, LLC

发明人： Ciaran J. O'Connor ,  Erik B. Larsen ,  Leif C. Summerfield

IPC分类号： B23K26/03 ,  B23K26/0622 ,  B23K26/08 ,  B23K26/082 ,  B23K26/12 ,  B23K26/361 ,  B23K26/362 ,  B23K26/402 ,  B23K103/00 ,  G01N1/44 ,  G01N21/71 ,  G01N21/88 ,  G02B21/00 ,  G02B26/10 ,  G06T7/00 ,  H01J49/04

CPC分类号： B23K26/032 ,  B23K26/0622 ,  B23K26/082 ,  B23K26/0861 ,  B23K26/0876 ,  B23K26/123 ,  B23K26/127 ,  B23K26/361 ,  B23K26/362 ,  G01N1/44 ,  G01N21/718 ,  G01N21/8806 ,  G06T7/0004 ,  B23K26/402 ,  B23K2103/30 ,  B23K2103/50 ,  G02B21/0016 ,  G02B26/105 ,  G06T2207/10056 ,  G06T2207/20021 ,  G06T2207/20104 ,  H01J49/04

摘要： A laser ablation system, and method, facilitates the execution of user-defined scans (i.e., in which a laser beam is scanned across a sample along a beam trajectory to ablate or dissociate a portion of the sample) and enables the user define additional scans while a scan is being executed.

公开(公告)号：US20240055248A1

公开(公告)日：2024-02-15

申请号：US18384075

申请日：2023-10-26

申请人： PerkinElmer Scientific Canada ULC

发明人： Hamid Badiei ,  Brian Chan

IPC分类号： H01J49/06 ,  H01J49/10 ,  H01J49/04

CPC分类号： H01J49/068 ,  H01J49/105 ,  H01J49/04 ,  H01J49/067

摘要： Certain configurations of a sampler cone and its use with a metal gasket to seal the sampler cone to a mass spectrometer interface are described. The sampler cone, interface or both may comprise one or more surface features. Coupling of the sampler cone to the interface can compress or crush the metal gasket to provide a seal between the sampler cone and the interface. For example, a crushing force provided by surface features of the sampler cone and interface can crush the gasket and provide a substantially fluid tight seal between the sampler cone and the interface.

公开(公告)号：US20230420236A1

公开(公告)日：2023-12-28

申请号：US18209074

申请日：2023-06-13

申请人： Purdue Research Foundation

发明人： Robert Graham Cooks ,  Guangtao Li ,  Guangming Huang ,  Jason Duncan ,  Xin Li ,  Ewa Sokol ,  Xin Yan

IPC分类号： H01J49/04 ,  H01J49/00 ,  G01N27/62 ,  H01J49/42

CPC分类号： H01J49/04 ,  H01J49/0445 ,  H01J49/0018 ,  H01J49/045 ,  G01N27/62 ,  H01J49/0031 ,  H01J49/4205 ,  Y10T436/24

摘要： The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

公开(公告)号：US20230335387A1

公开(公告)日：2023-10-19

申请号：US18084978

申请日：2022-12-20

申请人： IAS Inc.

发明人： Katsuhiko Kawabata ,  Tatsuya Ichinose ,  Kohei Nishiguchi

IPC分类号： H01J49/10 ,  G01N27/623 ,  H01J49/00 ,  H01J49/04

CPC分类号： H01J49/105 ,  G01N27/623 ,  H01J49/0009 ,  H01J49/04

摘要： A method for analyzing a sample containing metal fine particles with an inductively coupled plasma mass spectrometer. The method enables analysis of the sample without the need of standard metal fine particles. Specifically, the present invention relates to a method for analyzing metal fine particles in liquid by use of an inductively coupled plasma mass spectrometer. In the method, the analysis apparatus is provided with a standard solution introduction apparatus including a standard solution storage unit for storing a standard solution containing a specific element in a known concentration, a syringe pump for suctioning and discharging the standard solution, and a solution introduction unit having a standard solution nebulizer and a standard solution spray chamber that are supplied with the standard solution, the standard solution is directly supplied to the standard solution nebulizer at a flow rate of 3 μL/min or less.

公开(公告)号：US11788987B2

公开(公告)日：2023-10-17

申请号：US17412997

申请日：2021-08-26

申请人： SMITHS DETECTION MONTREAL INC.

发明人： Qunzhou Bian ,  John J. Carroll

IPC分类号： G01N27/622 ,  H01J49/00 ,  B08B6/00 ,  H01J49/02 ,  H01J49/06 ,  G01N23/00 ,  H01J49/04

CPC分类号： G01N27/622 ,  B08B6/00 ,  G01N23/00 ,  H01J49/0031 ,  H01J49/025 ,  H01J49/04 ,  H01J49/06 ,  H01J49/061 ,  G06F2218/10

摘要： Method and systems for managing clear-down are provided. The method can include generating a clear-down trigger associated with an ion mobility spectrometer and operating the ion mobility spectrometer in fast clear-down mode in response to the clear-down trigger. Methods and systems can further provide that where the ion mobility spectrometer operates in fast-switching mode, the ion mobility spectrometer alternating a plurality of times between operation according to a positive ion mode and operation according to a negative ion mode, and further operating according to the positive ion mode for less than about 1 second before switching to the operation according to the negative ion mode, and operating according to the negative ion mode for less than about 1 second before switching to the operation according to the positive ion mode.

公开(公告)号：US11728146B2

公开(公告)日：2023-08-15

申请号：US17575135

申请日：2022-01-13

申请人： Wisconsin Alumni Research Foundation

发明人： Michael Scott Westphall ,  Joshua Jacques Coon

IPC分类号： G01N1/42 ,  H01J49/04 ,  H01J49/00 ,  H01J49/06

CPC分类号： H01J49/0004 ,  G01N1/42 ,  H01J49/04 ,  H01J49/0468 ,  H01J49/0486 ,  H01J49/0495 ,  H01J49/062

摘要： Imaging by cryo-electron microscopy (cryo-EM) requires that a sample be encased in an amorphous solid, such as amorphous ice. In current cryo-EM preparation systems, once the sample has been deposited on an EM grid and coated in the amorphous solid, the EM grid must be removed from vacuum and then transferred into the vacuum of the cryo-EM system. As a result, samples deposited on the grid are exposed to damage and contamination. The present invention provides improved EM grid handling systems and devices compatible with advanced cryo-EM sample preparation techniques and which reduce or eliminate exposure of the sample on the grid to atmosphere and elevated temperatures. These methods and devices will also significantly reduce handling time and complexities associated with cryo-EM sample preparation.

公开(公告)号：US20230178350A1

公开(公告)日：2023-06-08

申请号：US18063975

申请日：2022-12-09

申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION ,  THERMO FINNIGAN LLC

发明人： Donald F. HUNT ,  Ann M. ENGLISH ,  Scott A. UGRIN ,  Dina L. BAI ,  Jeffrey SHABANOWITZ ,  John Edward Philip SYKA

IPC分类号： H01J49/00 ,  G01N33/68 ,  H01J49/04 ,  H01J49/42

CPC分类号： H01J49/0072 ,  G01N33/6848 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/4295 ,  G01N2560/00

摘要： The present disclosure relates to novel and improved methods of analyzing proteins, peptides and polypeptides by mass spectrometry using ion-ion reactions. More specifically the disclosure relates to improved methods for implementing the m/z selective arresting of ion-ion reactions within the ion-ion reaction cell of a mass spectrometer system during a period where ion-ion reactions are performed.

公开(公告)号：US20190250167A1

公开(公告)日：2019-08-15

申请号：US15893259

申请日：2018-02-09

申请人： Francisco FERNANDEZ LIMA ,  Kevin Jeanne DIT FOUQUE

发明人： Francisco FERNANDEZ LIMA ,  Kevin Jeanne DIT FOUQUE

IPC分类号： G01N33/68 ,  H01J49/00 ,  H01J49/04

CPC分类号： G01N33/6848 ,  G01N2560/00 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/40

摘要： The invention pertains to materials and methods for identifying and/or isolating isomers, particularly, of biomolecules, such as polypeptides and proteins. The methods of identifying and/or isolating isomers of a molecule according to the invention comprise subjecting a sample to ionization prior to IMS followed by MS. In some embodiments, the sample is subjected to metallization during the ionization step.

公开(公告)号：US10304667B1

公开(公告)日：2019-05-28

申请号：US15842729

申请日：2017-12-14

申请人： Thermo Finnigan LLC

发明人： Steven L. Reeber ,  Cornelia L. Boeser

IPC分类号： H01J49/04 ,  H01J37/32 ,  H01J49/26 ,  H01J49/10

CPC分类号： H01J37/32862 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/0404 ,  H01J49/107 ,  H01J49/24 ,  H01J49/26

摘要： A method of removing sample residue from a surface of a mass spectrometer inlet, with the surface being adjacent to an ion passageway, is provided. A pendent droplet of a cleaning solvent is formed at a tip of a capillary, with the tip being spaced apart from the surface. The pendent droplet detaches from the tip and contacts the surface. The surface is heated to a temperature T at least 50° C. above the boiling point of the least volatile component of the cleaning solvent.