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公开(公告)号：US20160202149A1
公开(公告)日：2016-07-14
申请号：US14778293
申请日：2014-03-10
IPC分类号： G01N1/04
摘要： A trace analyte collection swab having a collection surface at least partially coated with a microscopically tacky substance to enhance pick-up efficiency is described. In embodiments, the trace analyte collection swab comprises a substrate including a surface having a trace analyte collection area and a coating disposed on the surface of the substrate in the trace analyte collection area. The coating is configured to be microscopically adhesive to collect particles of the trace analyte from a surface when the trace analyte collection area is placed against the surface. In one embodiment, the coating comprises Polyisobutylene.
摘要翻译： 描述了具有至少部分涂覆有微观粘性物质以提高拾取效率的收集表面的痕量分析物收集拭子。 在实施方案中，痕量分析物收集拭子包括包含具有痕量分析物收集区域的表面的底物和在痕量分析物收集区域中设置在基底表面上的涂层。 当将痕量分析物收集区域放置在表面上时，该涂层被配置为具有显微粘合性以从表面收集痕量分析物的颗粒。 在一个实施方案中，涂层包含聚异丁烯。
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公开(公告)号：US10345264B2
公开(公告)日：2019-07-09
申请号：US15569822
申请日：2016-04-28
发明人： Jan Hendrikse , Vladimir Romanov , Udo Verkerk , Alan Hopkinson
摘要： The present disclosure relates to an ion exchange process, as well as a process and system for detecting nitrates, which employ a class of dopants comprising at least two functional groups capable of simultaneous convergent hydrogen bonding with a nitrate ion. In an aspect, the present disclosure provides an ion exchange process for forming a negatively charged nitrate-dopant ion analyte for analysis by a spectrometry analysis instrument, comprising: providing a gas comprising a dopant in both neutral and ionized forms; contacting a nitrate-containing sample with the gas comprising the dopant and thereby desorbing a nitrate ion from the sample to form a negatively charged nitrate-dopant ion analyte and replacing the desorbed nitrate ion with a negatively charged ionized dopant molecule; wherein the dopant is an organic compound comprising two or more carbon atoms and two or more functional groups capable of simultaneous convergent hydrogen bonding with a nitrate ion; or the dopant is an organic compound comprising at least two carbon atoms and only a single functional group capable of hydrogen bonding with a nitrate ion, which group is a —COOH functional group, and where the carbon atom of the —COOH functional group is bonded directly to another carbonyl group; and with the proviso that the dopant is not lactic acid, a lactic acid salt or a compound that forms lactate ions upon ionization.
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3.发明申请公开(公告)号：US20180275018A1
公开(公告)日：2018-09-27
申请号：US15989502
申请日：2018-05-25
摘要： An ion mobility spectrometer analytical instrument, including an ion mobility spectrometer, a swab interface, and a desorber assembly. The desorber assembly includes a heat transfer device configured to heat a desorber, as well as a supply configured to direct gas through the desorber. The instrument further includes a drift tube, high voltage device arrayed, at least in part, proximate to the drift tube, wherein the high voltage device is configured to change a polarity of a voltage applied to the drift tube and have an absolute voltage of about 500 to 1500 volts. The instrument further includes a reactant supply unit adapted to supply reactant during a sample substance analysis, and a control unit.
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公开(公告)号：US20210389275A1
公开(公告)日：2021-12-16
申请号：US17412997
申请日：2021-08-26
发明人： Qunzhou Bian , John J. Carroll
IPC分类号： G01N27/622 , H01J49/00 , B08B6/00 , G06K9/00 , H01J49/02 , H01J49/06 , G01N23/00 , H01J49/04
摘要： Method and systems for managing clear-down are provided. The method can include generating a clear-down trigger associated with an ion mobility spectrometer and operating the ion mobility spectrometer in fast clear-down mode in response to the clear-down trigger. Methods and systems can further provide that where the ion mobility spectrometer operates in fast-switching mode, the ion mobility spectrometer alternating a plurality of times between operation according to a positive ion mode and operation according to a negative ion mode, and further operating according to the positive ion mode for less than about 1 second before switching to the operation according to the negative ion mode, and operating according to the negative ion mode for less than about 1 second before switching to the operation according to the positive ion mode.
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公开(公告)号：US10139366B2
公开(公告)日：2018-11-27
申请号：US14218109
申请日：2014-03-18
发明人： Bohdan Atamanchuk , Volodimir Bondarenko , Vlad Sergeyev , Henryk Zaleski , Daniel Levin , Mark Piniarski , Igor Kubelik , Qunzhou Bian , Simon Feldberg , Douglas J. Green , Brian Boso , Atin J. Patel
摘要： An ion detection assembly is described that includes a drift chamber, an inlet assembly, and a collector assembly. The drift chamber is formed of substantially non-conductive material and/or semi-conductive material. A patterned resistive trace is deposited on one or more of an interior surface or an exterior surface of the drift chamber. The patterned resistive trace is configured to connect to a source of electrical energy. The inlet assembly and the collector assembly are in fluid communication with the drift chamber. The inlet assembly includes an inlet for receiving a sample, a reaction region for ionizing the sample, and a gate for controlling entrance of the ionized sample to the drift chamber. The collector assembly includes a collector plate for collecting the ionized sample after the ionized sample passes through the drift chamber.
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公开(公告)号：US20160155623A1
公开(公告)日：2016-06-02
申请号：US14900539
申请日：2014-06-19
发明人： Henryk Zaleski
CPC分类号： H01J49/168 , G01N27/622 , H01J27/26
摘要： A corona ionization source assembly and fabrication methods are described that include a fine wire including a wire core including a first material, and a wire coating including a second material, where the wire coating surrounds a portion of the wire core, and the diameter of the wire coating is greater than the diameter of the wire core. Additionally, the fine wire may be coupled to a mounting post. In an implementation, a process for fabricating the corona ionization source assembly that employs the techniques of the present disclosure includes forming a wire core, forming a wire coating that surrounds the wire core, forming a mask layer on at least a portion of the wire coating, etching the wire coating, and removing the mask layer from the wire coating.
摘要翻译： 描述了电晕电离源组件和制造方法，其包括细线，其包括包括第一材料的线芯和包括第二材料的线涂层，其中线涂层围绕线芯的一部分，以及线芯的直径 电线涂层大于电线芯的直径。 此外，细线可以联接到安装柱。 在一个实施方案中，采用本公开技术的制造电晕电离源组件的方法包括形成线芯，形成围绕线芯的线涂层，在电线涂层的至少一部分上形成掩模层 ，蚀刻电线涂层，以及从电线涂层去除掩模层。
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7.发明授权公开(公告)号：US09048077B2
公开(公告)日：2015-06-02
申请号：US14362555
申请日：2012-12-05
发明人： Jan Hendrikse
CPC分类号： H01J49/04 , G01N27/624 , H01J49/0031 , H01J49/0036 , H01J49/0081
摘要： A mass spectrometry system for screening a sample for one or more analytes includes a pre-mass spectrometry screening apparatus configured to pre-screen an ionized sample to generate output correlated to the composition of the sample, and a mass spectrometer. A sample gate is opened to allow flow of at least a portion of the ionized sample to the mass spectrometer and closed to prevent flow of the ionized sample to the mass spectrometer. A processing system compares results of the pre-mass spectrometry screening to an analyte database, wherein correlation of the results to an analyte within the analyte database comprises a preliminary positive identification. When the processing system determines that a preliminary positive identification is made, it causes the gate to open for a period of time. However, when the processing system determines that a preliminary positive identification is not made, it causes the gate to remain closed.
摘要翻译： 用于筛选一种或多种分析物的样品的质谱系统包括预质谱筛选装置，其被配置为预先筛选电离样品以产生与样品的组成相关的输出和质谱仪。 打开样品门以允许至少一部分离子化样品流到质谱仪并关闭以防止离子化样品流向质谱仪。 处理系统将预质谱筛选的结果与分析物数据库进行比较，其中结果与分析物数据库内的分析物的相关性包括初步阳性鉴定。 当处理系统确定进行初步的肯定识别时，会使门打开一段时间。 然而，当处理系统确定没有进行初步肯定识别时，它使门保持关闭。
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8.发明申请公开(公告)号：US20140339417A1
公开(公告)日：2014-11-20
申请号：US14362555
申请日：2012-12-05
发明人： Jan Hendrikse
CPC分类号： H01J49/04 , G01N27/624 , H01J49/0031 , H01J49/0036 , H01J49/0081
摘要： A mass spectrometry system for screening a sample for one or more analytes includes a pre-mass spectrometry screening apparatus configured to pre-screen an ionized sample to generate output correlated to the composition of the sample, and a mass spectrometer. A sample gate is opened to allow flow of at least a portion of the ionized sample to the mass spectrometer and closed to prevent flow of the ionized sample to the mass spectrometer. A processing system compares results of the pre-mass spectrometry screening to an analyte database, wherein correlation of the results to an analyte within the analyte database comprises a preliminary positive identification. When the processing system determines that a preliminary positive identification is made, it causes the gate to open for a period of time. However, when the processing system determines that a preliminary positive identification is not made, it causes the gate to remain closed.
摘要翻译： 用于筛选一种或多种分析物的样品的质谱系统包括预质谱筛选装置，其被配置为预先筛选电离样品以产生与样品的组成相关的输出和质谱仪。 打开样品门以允许至少一部分离子化样品流到质谱仪并关闭以防止离子化样品流向质谱仪。 处理系统将预质谱筛选的结果与分析物数据库进行比较，其中结果与分析物数据库内的分析物的相关性包括初步阳性鉴定。 当处理系统确定进行初步的肯定识别时，会使门打开一段时间。 然而，当处理系统确定没有进行初步肯定识别时，它使门保持关闭。
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公开(公告)号：US20200033233A1
公开(公告)日：2020-01-30
申请号：US16536994
申请日：2019-08-09
摘要： A trace analyte collection swab having a collection surface at least partially coated with a microscopically tacky substance to enhance pick-up efficiency is described. In embodiments, the truce analyte collection swab comprises a substrate including a surface having a trace analyte collection area and a coating disposed on the surface of the substrate in the trace analyte collection area. The coating is configured to be microscopically adhesive to collect particles of the trace analyte from a surface when the trace analyte collection area is placed against the surface. In one embodiment, the coating comprises Polyisobutylene.
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公开(公告)号：US20190178843A1
公开(公告)日：2019-06-13
申请号：US16280822
申请日：2019-02-20
发明人： Qunzhou Bian , John J. Carroll
摘要： Method and systems for managing clear-down are provided. The method can include generating a clear-down trigger associated with an ion mobility spectrometer and operating the ion mobility spectrometer in fast clear-down mode in response to the clear-down trigger. Methods and systems can further provide that where the ion mobility spectrometer operates in fast-switching mode, the ion mobility spectrometer alternating a plurality of times between operation according to a positive ion mode and operation according to a negative ion mode, and further operating according to the positive ion mode for less than about 1 second before switching to the operation according to the negative ion mode, and operating according to the negative ion mode for less than about 1 second before switching to the operation according to the positive ion mode.
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