公开(公告)号：US20180345174A1

公开(公告)日：2018-12-06

申请号：US16100816

申请日：2018-08-10

申请人： Bio-Rad Laboratories, Inc.

发明人： Larry CUMMINGS

IPC分类号： B01D15/20 ,  G01N30/50 ,  B01J20/281 ,  G01N30/26 ,  C01B25/455 ,  C01B25/32 ,  B01D15/36 ,  B01D15/38 ,  B01J20/04 ,  B01J20/30 ,  B01J20/34

CPC分类号： B01D15/203 ,  B01D15/361 ,  B01D15/3847 ,  B01J20/048 ,  B01J20/282 ,  B01J20/3085 ,  B01J20/34 ,  B01J20/3433 ,  B01J20/3475 ,  C01B25/32 ,  C01B25/327 ,  C01B25/455 ,  G01N30/26 ,  G01N30/48 ,  G01N30/50

摘要： The present invention discloses methods of regenerating apatite surfaces, for example after purification of a target analyte.

公开(公告)号：US20180196019A1

公开(公告)日：2018-07-12

申请号：US15850146

申请日：2017-12-21

申请人： Waters Technologies Corporation

发明人： Michael O. Fogwill ,  Isabelle François

IPC分类号： G01N30/26 ,  G01N30/60

CPC分类号： G01N30/26 ,  G01N30/20 ,  G01N30/34 ,  G01N30/462 ,  G01N30/463 ,  G01N30/465 ,  G01N30/60 ,  B01D15/40

摘要： A method of performing a chromatographic separation includes modulating a portion of a flowstream to a trap column to retain at least one analyte from the flowstream on the trap column. A flow of a modifier is provided through the trap column to generate an elution comprising the at least one analyte. A flow of a compressible fluid-based chromatography (CFC) mobile phase or CFC solvent is merged with the elution from the trap column to generate a diluted elution. Carbon dioxide may be used as the CFC solvent or as a component of the CFC mobile phase. The diluted elution is provided to a CFC column where at least one analyte is focused at a head of the CFC column. Examples of a flowstream that may be used include an eluent from a chromatography column or a fluid flow from an extraction system.

公开(公告)号：US09618487B2

公开(公告)日：2017-04-11

申请号：US14076147

申请日：2013-11-08

申请人： AGILENT TECHNOLOGIES, INC.

发明人： Manuela Senf ,  Daniela Loraing ,  Qi Siegmundt-Pan

IPC分类号： B01D15/10 ,  B01D15/18 ,  B01L3/00 ,  G01N27/26 ,  G01N30/06 ,  G01N30/26 ,  G01N30/60 ,  G01N27/447 ,  G01N30/88

CPC分类号： G01N30/6091 ,  B01D15/10 ,  B01D15/18 ,  B01L3/523 ,  B01L2200/025 ,  B01L2300/044 ,  G01N27/26 ,  G01N27/44704 ,  G01N30/06 ,  G01N30/26 ,  G01N2030/8881

摘要： Prefilled liquid cartridge for fluidically connecting to a sample separation device for separating of components of a fluidic sample by using liquid of the liquid cartridge, wherein the liquid cartridge comprises a liquid container which is prefilled with liquid and a liquid removal access provided at the liquid container, adapted to be fluidically coupled with at least one liquid conduit of the sample separation device by only inserting the liquid cartridge in a corresponding liquid cartridge accommodation of the sample separation device.

公开(公告)号：US09611942B2

公开(公告)日：2017-04-04

申请号：US14002401

申请日：2012-03-01

申请人： Michael Schubert ,  Reinhard Busch ,  Michael Nader

发明人： Michael Schubert ,  Reinhard Busch ,  Michael Nader

IPC分类号： G01N30/20 ,  F16K11/00 ,  F16K11/074 ,  G01N35/10 ,  G01N30/26

CPC分类号： F16K11/00 ,  F16K11/0743 ,  G01N30/20 ,  G01N30/26 ,  G01N35/1097 ,  G01N2030/201 ,  G01N2030/202 ,  Y10T137/86493

摘要： The invention relates to a valve, in particular a sample injection valve, for a device (1) for synthesizing, analyzing, and/or separating, comprising at least three liquid connections (3′, 4′, 5′, 6′, 7′, 7″), a housing (8) as a valve part, and a valve body (9) as another valve part for selectively connecting the liquid connections (3′, 4′, 5′, 6′, 7′, 7″) by means of at least one flow channel (10, 11, 12) bounded at least partially by sealing surfaces (10′, 11′, 12′) between the housing (8) and the valve body (9), wherein the housing (8) and/or the valve body (9) are supported in such a way as to be movable relative to each other. In order to create a one-way valve, at least one valve part (8 or 9) adjacent to the sealing surface (10′, 11′, 12′) and made of a plastic material can be plastically deformed according to a relative position (9′), in particular of the valve body (9), in order to be able to withstand the elevated pressure loads in the flow channel (10, 11, 12) in a liquid-tight manner in the relative position (9′), in particular of the valve body (9).

公开(公告)号：US09457504B2

公开(公告)日：2016-10-04

申请号：US14210319

申请日：2014-03-13

申请人： IDEX Health & Science LLC

发明人： Eric Beemer

IPC分类号： F16L9/14 ,  B29C45/14 ,  B01L3/00 ,  G01N30/60

CPC分类号： B29C45/14819 ,  B01L3/563 ,  B01L2200/0689 ,  B01L2300/0838 ,  B01L2300/163 ,  B29C45/14344 ,  B29C45/14598 ,  B29C2045/1436 ,  F16L31/00 ,  F16L33/24 ,  F16L41/021 ,  G01N30/26 ,  G01N30/6026 ,  G01N30/6039 ,  G01N30/6043

摘要： A connector with a biocompatible fluid passageway to be used as a column filter retainer and the method for manufacturing it is described. The connector has a reinforcement insert and a biocompatible molding covering portions of the reinforcement insert. The reinforcement insert has a first portion, a second portion, and a middle portion between the first portion and the second portion. The first and second portions have threaded sections and each have a plurality of non-threaded sections. For a given portion, the junction of the non-threaded sections forms a lip by which to prevent the molded material from flowing into the threaded sections. In certain embodiments, an interior web is used in the reinforcement insert to provide additional structural support.

摘要翻译： 描述了具有用作柱式过滤器保持器的生物相容性流体通道的连接器及其制造方法。 连接器具有加强插入件和覆盖加强件插入件的部分的生物相容性模制件。 加强插件具有第一部分，第二部分和在第一部分和第二部分之间的中间部分。 第一和第二部分具有螺纹部分，并且每个具有多个非螺纹部分。 对于给定的部分，非螺纹部分的接合处形成唇缘，以防止模制材料流入螺纹部分。 在某些实施例中，在加强件插入件中使用内部纤维网以提供额外的结构支撑。

公开(公告)号：US20150367252A1

公开(公告)日：2015-12-24

申请号：US14747221

申请日：2015-06-23

申请人： Bio-Rad Laboratories, Inc.

发明人： Mark A. Snyder ,  Kimberly C. Brisack

IPC分类号： B01D15/20 ,  B01D15/36

CPC分类号： B01D15/203 ,  B01D15/361 ,  B01D15/3847 ,  B01J20/048 ,  B01J20/282 ,  B01J20/3085 ,  B01J20/34 ,  B01J20/3433 ,  B01J20/3475 ,  C01B25/32 ,  C01B25/327 ,  C01B25/455 ,  G01N30/26 ,  G01N30/48 ,  G01N30/50

摘要： Disclosed herein are methods of regenerating apatite surfaces, for example after purification of a target analyte.

摘要翻译： 本文公开的是再生磷灰石表面的方法，例如在纯化目标分析物之后。

公开(公告)号：US20150336026A1

公开(公告)日：2015-11-26

申请号：US14696572

申请日：2015-04-27

申请人： Waters Technologies Corporation

发明人： Neal B. Almeida ,  Christopher Seith ,  Michael R. Jackson ,  John Angelosanto ,  Joseph A. Jarrell

IPC分类号： B01D15/18 ,  G01N30/26

CPC分类号： B01D15/18 ,  G01N30/26 ,  G01N30/34 ,  Y10T137/0424 ,  Y10T137/4259

摘要： Described is a method for purging a fluid channel is a low pressure gradient formation liquid flow system. Control of the fluid channels for multiple solvents allows for one or more static volumes of solvents not intended for use in an isocratic flow to be purged from their fluid channels to avoid contamination of the isocratic solvent. Advantageously, the method avoids the need to modify equipment or to reconfigure a pumping system so that the inlet is directly coupled to a single solvent source. Thus there is no need to bypass existing valves and liquid coupling components where solvents are combined during conventional gradient operation.

摘要翻译： 描述了一种清洗流体通道的方法是低压梯度形成液体流动系统。 用于多种溶剂的流体通道的控制允许一个或多个静态体积的溶剂不用于从其流体通道中清除等度流，以避免污染等度溶剂。 有利地，该方法避免了修改设备或重新配置泵送系统的需要，使得入口直接耦合到单个溶剂源。 因此，在常规梯度操作期间，不需要绕过现有的阀和液体耦合部件，其中溶剂被组合。

公开(公告)号：US09194848B2

公开(公告)日：2015-11-24

申请号：US14120425

申请日：2014-03-14

申请人： Nicholas DeMarco

发明人： Nicholas DeMarco

IPC分类号： G01N21/00 ,  G01N30/26 ,  G01N30/74 ,  G01N30/64 ,  H05B33/08

CPC分类号： G01N30/74 ,  G01N30/26 ,  G01N30/64 ,  G01N30/78 ,  G01N2030/645 ,  H05B33/0845

摘要： A detector for detecting constituents of a liquid for use in liquid chromatography is disclosed. The detector includes a first optical flow cell body and a second optical flow cell body, each having a channel therethrough that allows passage of a liquid from an inlet port to an outlet port. The first and second optical flow cell bodies are arranged in series such that the liquid exiting the outlet port of the first optical flow cell body enters the inlet port of the second optical flow cell body. An insulator resides between the first optical flow cell body and the second optical flow cell body, which is adapted to electrically insulate the first optical flow cell body from the second optical flow cell body while allowing the liquid to pass from the first optical flow cell body to the second optical flow cell body. The first optical flow cell body is adapted to facilitate measurement of absorption by the liquid of a first wavelength of light, and second optical flow cell body is adapted to facilitate measurement of absorption by the liquid of a second wavelength of light. The first and second optical flow cell bodies are further adapted to perform as electrodes for measuring the conductivity of the liquid.

摘要翻译： 公开了一种用于检测用于液相色谱的液体成分的检测器。 检测器包括第一光流通池体和第二光流通池体，每个具有通道，其允许液体从入口通到出口。 第一和第二光学流通池体串联布置，使得离开第一光学流通池体的出口的液体进入第二光学流通池体的入口。 绝缘体位于第一光流通池体和第二光流通池体之间，其适于使第一光流体单元本体与第二光流体单元本体电绝缘，同时允许液体从第一光流通池体 到第二光流通池体。 第一光流通池本体适于便于测量第一波长的光的液体的吸收，并且第二光流元件主体适于便于测量第二波长的光的液体的吸收。 第一和第二光学流通池体还适于作为用于测量液体的导电性的电极。

公开(公告)号：US20150260693A1

公开(公告)日：2015-09-17

申请号：US14120425

申请日：2014-03-14

申请人： Nicholas DeMarco

发明人： Nicholas DeMarco

IPC分类号： G01N30/26 ,  G01N30/64 ,  H05B33/08 ,  G01N30/74

CPC分类号： G01N30/74 ,  G01N30/26 ,  G01N30/64 ,  G01N30/78 ,  G01N2030/645 ,  H05B33/0845

摘要： A detector for detecting constituents of a liquid for use in liquid chromatography is disclosed. The detector includes a first optical flow cell body and a second optical flow cell body, each having a channel therethrough that allows passage of a liquid from an inlet port to an outlet port. The first and second optical flow cell bodies are arranged in series such that the liquid exiting the outlet port of the first optical flow cell body enters the inlet port of the second optical flow cell body. An insulator resides between the first optical flow cell body and the second optical flow cell body, which is adapted to electrically insulate the first optical flow cell body from the second optical flow cell body while allowing the liquid to pass from the first optical flow cell body to the second optical flow cell body. The first optical flow cell body is adapted to facilitate measurement of absorption by the liquid of a first wavelength of light, and second optical flow cell body is adapted to facilitate measurement of absorption by the liquid of a second wavelength of light. The first and second optical flow cell bodies are further adapted to perform as electrodes for measuring the conductivity of the liquid.

摘要翻译： 公开了一种用于检测用于液相色谱的液体成分的检测器。 检测器包括第一光流通池体和第二光流通池体，每个具有通道，其允许液体从入口通向出口。 第一和第二光学流通池体串联布置，使得离开第一光学流通池体的出口的液体进入第二光学流通池体的入口。 绝缘体位于第一光流通池体和第二光流通池体之间，其适于使第一光流体单元本体与第二光流体单元本体电绝缘，同时允许液体从第一光流通池体 到第二光流通池体。 第一光流通池本体适于便于测量第一波长的光的液体的吸收，并且第二光流元件主体适于便于测量第二波长的光的液体的吸收。 第一和第二光学流通池体还适于作为用于测量液体的导电性的电极。

公开(公告)号：US20150000426A1

公开(公告)日：2015-01-01

申请号：US14308453

申请日：2014-06-18

申请人： Mustang Sampling, LLC

发明人： Claude A. Rolston ,  Kenneth O. Thompson

IPC分类号： G01N30/30 ,  G01N30/32

CPC分类号： G01N33/22 ,  G01N1/14 ,  G01N1/44 ,  G01N30/06 ,  G01N30/26 ,  G01N30/88 ,  G01N33/0016 ,  G01N2030/062

摘要： A system and method for conditioning of very low pressure gas samples extracted from a source, heating the samples, boosting the pressure to a level appropriate for analysis, regulating the gas sample temperature and pressure to prevent dew-point dropout from Joules Thompson condensation, and passing the gas sample to an a remotely located analyzer or analyzer array where the electrical power for the pressurizing pump and heated regulator is provided by heat tracing.

摘要翻译： 一种用于调节从源提取的非常低压气体样品的系统和方法，加热样品，将压力升高到适于分析的水平，调节气体样品温度和压力以防止从焦尔斯汤普森缩合产生露点脱落，以及 将气体样品传送到位于远处的分析仪或分析仪阵列，其中加压泵和加热调节器的电力通过追踪提供。