公开(公告)号：US12013929B2

公开(公告)日：2024-06-18

申请号：US18158621

申请日：2023-01-24

申请人： Open Text Inc.

发明人： Andrew Sandoval

IPC分类号： G06F21/52 ,  B01D15/18 ,  G01N30/20 ,  G01N30/22 ,  G01N30/46 ,  G01N30/60 ,  G06F11/36

CPC分类号： G06F21/52 ,  B01D15/1885 ,  G01N30/20 ,  G01N30/22 ,  G01N30/466 ,  G01N30/6043 ,  G06F11/3688 ,  G01N2030/202 ,  G01N2030/207 ,  G06F2221/033

摘要： Examples of the present disclosure describe systems and methods for detecting and mitigating stack pivoting exploits. In aspects, various “checkpoints” may be identified in software code. At each checkpoint, the current stack pointer, stack base, and stack limit for each mode of execution may be obtained. The current stack pointer for each mode of execution may be evaluated to determine whether the stack pointer falls within a stack range between the stack base and the stack limit of the respective mode of execution. When the stack pointer is determined to be outside of the expected stack range, a stack pivot exploit is detected and one or more remedial actions may be automatically performed.

公开(公告)号：US20240192181A1

公开(公告)日：2024-06-13

申请号：US18286590

申请日：2022-02-02

申请人： HITACHI HIGH-TECH CORPORATION

发明人： Yusuke SHIMIZU ,  Yu IIJIMA ,  Taichiro YAMASHITA ,  Ai MASUDA ,  Daichi FURUKAWA

IPC分类号： G01N30/46 ,  G01N30/60

CPC分类号： G01N30/46 ,  G01N30/6043 ,  G01N30/6091

摘要： A chromatograph allows easy replacement of a separation column while preventing an operator from contacting with a configuration related to the separation column. A column cartridge accommodates the separation column and is detachably provided in a predetermined column installation position. An upstream pipe is detachably provided on the column cartridge in a state of being installed at the column installation position, and supplies a mobile phase to the separation column of the column cartridge. A downstream pipe is detachably provided on the column cartridge in a state of being installed at the column installation position, and delivers the mobile phase that has passed through the separation column of the column cartridge. A cover integrally covers the column installation position, the upstream pipe, and the downstream pipe and has an insertion hole that allows the column cartridge to be installed from the outer side of the cover.

公开(公告)号：US20180346957A1

公开(公告)日：2018-12-06

申请号：US16053906

申请日：2018-08-03

申请人： Rodolfo Cesar BELLINZONI ,  Nicolás MAGI ,  Emmanuel Gérard Etienne RÉGULIER ,  Ana ROMO ,  Marcelo Arnolfo SPITTELER

发明人： Rodolfo Cesar BELLINZONI ,  Nicolás MAGI ,  Emmanuel Gérard Etienne RÉGULIER ,  Ana ROMO ,  Marcelo Arnolfo SPITTELER

IPC分类号： C12Q1/06 ,  G01N30/74 ,  B01D15/18 ,  B01D15/34 ,  C12Q1/04 ,  G01N15/02 ,  G01N30/46 ,  G01N30/84 ,  G01N30/60 ,  G01N30/78 ,  G01N15/00 ,  G01N30/02

CPC分类号： C12Q1/06 ,  B01D15/1864 ,  B01D15/1885 ,  B01D15/34 ,  C12Q1/04 ,  G01N15/0205 ,  G01N30/468 ,  G01N30/6043 ,  G01N30/74 ,  G01N30/78 ,  G01N30/84 ,  G01N2015/0065 ,  G01N2030/027 ,  G01N2030/8429 ,  G01N2030/8435 ,  G01N2333/005

摘要： The present invention provides a high throughput method to quantify and characterize the size and integrity of viruses and viral molecules. In one embodiment, the present invention provides a method to quantify and characterize size and integrity of Foot and Mouth Disease virus (FMDV) using chromatographic system and in-line Dynamic Light Scattering (DLS) technique. In one embodiment, the present invention further comprises a column-switching system for running multiple analyses simultaneously. The present invention also provides a method to develop and evaluate FMDV containing products for preventing Foot and Mouth Disease (FMD). In one embodiment, the methods described herein assess the stability of FMDV. In another embodiment, the methods described herein serve as in-process quality control for a manufacturing process of FMD vaccine.

公开(公告)号：US20180043284A1

公开(公告)日：2018-02-15

申请号：US15793923

申请日：2017-10-25

申请人： GE Healthcare BioProcess R&D AB

发明人： KLAUS GEBAUER

IPC分类号： B01D15/14 ,  G01N30/60 ,  B01D15/22 ,  G01N30/46 ,  B01D15/18 ,  G01N30/88

CPC分类号： B01D15/14 ,  B01D15/1864 ,  B01D15/1885 ,  B01D15/22 ,  G01N30/466 ,  G01N30/6039 ,  G01N30/6043 ,  G01N30/6091 ,  G01N2030/8881 ,  Y10T29/49826

摘要： A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

公开(公告)号：US09457504B2

公开(公告)日：2016-10-04

申请号：US14210319

申请日：2014-03-13

申请人： IDEX Health & Science LLC

发明人： Eric Beemer

IPC分类号： F16L9/14 ,  B29C45/14 ,  B01L3/00 ,  G01N30/60

CPC分类号： B29C45/14819 ,  B01L3/563 ,  B01L2200/0689 ,  B01L2300/0838 ,  B01L2300/163 ,  B29C45/14344 ,  B29C45/14598 ,  B29C2045/1436 ,  F16L31/00 ,  F16L33/24 ,  F16L41/021 ,  G01N30/26 ,  G01N30/6026 ,  G01N30/6039 ,  G01N30/6043

摘要： A connector with a biocompatible fluid passageway to be used as a column filter retainer and the method for manufacturing it is described. The connector has a reinforcement insert and a biocompatible molding covering portions of the reinforcement insert. The reinforcement insert has a first portion, a second portion, and a middle portion between the first portion and the second portion. The first and second portions have threaded sections and each have a plurality of non-threaded sections. For a given portion, the junction of the non-threaded sections forms a lip by which to prevent the molded material from flowing into the threaded sections. In certain embodiments, an interior web is used in the reinforcement insert to provide additional structural support.

摘要翻译： 描述了具有用作柱式过滤器保持器的生物相容性流体通道的连接器及其制造方法。 连接器具有加强插入件和覆盖加强件插入件的部分的生物相容性模制件。 加强插件具有第一部分，第二部分和在第一部分和第二部分之间的中间部分。 第一和第二部分具有螺纹部分，并且每个具有多个非螺纹部分。 对于给定的部分，非螺纹部分的接合处形成唇缘，以防止模制材料流入螺纹部分。 在某些实施例中，在加强件插入件中使用内部纤维网以提供额外的结构支撑。

公开(公告)号：US08980093B2

公开(公告)日：2015-03-17

申请号：US13015400

申请日：2011-01-27

申请人： Yuri P. Belov ,  Carlo G. Pentano ,  Ksenia Lvova

发明人： Yuri P. Belov ,  Carlo G. Pentano ,  Ksenia Lvova

IPC分类号： G01N30/56 ,  G01N30/60

CPC分类号： G01N30/56 ,  G01N30/6043 ,  G01N30/6078 ,  G01N2030/567

摘要： A multicapillary sample preparation device, especially useful for handling biological samples, comprising a plurality of uniform capillary tubes coated with a stationary phase, and arranged in a monolithic element. The multicapillary device is suitable for attachment to a pipette, micropipette, syringe, or other analytical or sample preparation instrument.

摘要翻译： 一种特别可用于处理生物样品的多毛细管样品制备装置，包括多个均匀的毛细管，涂覆有固定相，并且布置在整体元件中。 多毛细管装置适用于连接移液管，微量吸管，注射器或其他分析或样品制备仪器。

公开(公告)号：US08883089B2

公开(公告)日：2014-11-11

申请号：US12116041

申请日：2008-05-06

申请人： Robert Lee Grenz ,  William Christopher Hudson

发明人： Robert Lee Grenz ,  William Christopher Hudson

IPC分类号： G01N33/00 ,  B01D15/00 ,  B01L3/00 ,  G01N1/40 ,  B01D15/22 ,  B01D15/18 ,  G01N30/00 ,  G01N30/60

CPC分类号： G01N30/6091 ,  B01D15/1885 ,  B01D15/22 ,  B01L3/50255 ,  B01L2200/0631 ,  B01L2200/142 ,  B01L2300/0681 ,  B01L2300/0829 ,  G01N1/40 ,  G01N30/6043 ,  G01N2030/009

摘要： Polyamide sample preparation tubes with a hollow polyamide tube and an extraction medium contained within the tube are utilized in the sample preparation devices. The sample preparation tubes are substantially inert and show little tendency to dissolve or leach contaminants into nonaqueous liquids. The polyamide tubes may be used in preparing samples for analytical procedures such as GC, GC/MS, LC or LC/MS.

摘要翻译： 在样品制备装置中使用具有中空聚酰胺管和包含在管内的萃取介质的聚酰胺样品制备管。 样品制备管基本上是惰性的，并且几乎没有将污染物溶解或浸出到非水液体中的倾向。 聚酰胺管可用于制备用于GC，GC / MS，LC或LC / MS等分析程序的样品。

公开(公告)号：US20140261838A1

公开(公告)日：2014-09-18

申请号：US14210319

申请日：2014-03-13

申请人： Eric Beemer

发明人： Eric Beemer

IPC分类号： F16L9/14 ,  B29C45/14

CPC分类号： B29C45/14819 ,  B01L3/563 ,  B01L2200/0689 ,  B01L2300/0838 ,  B01L2300/163 ,  B29C45/14344 ,  B29C45/14598 ,  B29C2045/1436 ,  F16L31/00 ,  F16L33/24 ,  F16L41/021 ,  G01N30/26 ,  G01N30/6026 ,  G01N30/6039 ,  G01N30/6043

摘要： A connector with a biocompatible fluid passageway to be used as a column filter retainer and the method for manufacturing it is described. The connector has a reinforcement insert and a biocompatible molding covering portions of the reinforcement insert. The reinforcement insert has a first portion, a second portion, and a middle portion between the first portion and the second portion. The first and second portions have threaded sections and each have a plurality of non-threaded sections. For a given portion, the junction of the non-threaded sections forms a lip by which to prevent the molded material from flowing into the threaded sections. In certain embodiments, an interior web is used in the reinforcement insert to provide additional structural support.

摘要翻译： 描述了具有用作柱式过滤器保持器的生物相容性流体通道的连接器及其制造方法。 连接器具有加强插入件和覆盖加强件插入件的部分的生物相容性模制件。 加强插件具有第一部分，第二部分和在第一部分和第二部分之间的中间部分。 第一和第二部分具有螺纹部分，并且每个具有多个非螺纹部分。 对于给定的部分，非螺纹部分的接合处形成唇缘，以防止模制材料流入螺纹部分。 在某些实施例中，在加强件插入件中使用内部纤维网以提供额外的结构支撑。

公开(公告)号：US20130180405A1

公开(公告)日：2013-07-18

申请号：US13350442

申请日：2012-01-13

申请人： Ron W. Currie ,  David Christiansen

发明人： Ron W. Currie ,  David Christiansen

IPC分类号： B01D53/02 ,  B01D53/30

CPC分类号： B01D53/025 ,  B01J20/28097 ,  B01J20/286 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/3272 ,  B01J2220/606 ,  B01J2220/84 ,  B01J2220/86 ,  G01N30/30 ,  G01N30/54 ,  G01N30/6043 ,  G01N2030/025 ,  G01N2030/3069

摘要： A multicapillary bundle for use in a gas chromatograph. Each of the capillaries in the bundle is formed using a coating solution containing a stationary phase and a solvent. The capillaries are coated with stationary phase by reducing pressure at a vacuum end of the capillary and creating a moving interface between the coating solution and a film of stationary phase deposited on each of the capillaries. The reducing pressure at the vacuum end of the capillary and the temperature of the capillary are controlled to maintain motion of the moving interface away from the vacuum end of the capillary. Maintained movement of the interface prevents recoating of the stationary phase. A heating wire and capillaries are embedded in a thermally conductive polymer to create a highly responsive method of heating the multicapillary column. An electronic control device controls the feedback temperature of the multicapillary column using the heating wire.

摘要翻译： 用于气相色谱仪的多毛细管束。 束中的每个毛细管是使用含有固定相和溶剂的涂布溶液形成的。 通过在毛细管的真空端降低压力并在涂层溶液和沉积在每个毛细管上的固定相的膜之间产生移动界面，毛细管被固定相涂覆。 控制毛细管真空端的减压和毛细管的温度，以保持移动界面的运动远离毛细管的真空端。 维护接口的运动可防止固定相重新涂覆。 将加热丝和毛细管嵌入导热聚合物中以产生加热多毛细管柱的高反应性方法。 电子控制装置使用加热丝来控制多毛柱的反馈温度。

公开(公告)号：US08336403B2

公开(公告)日：2012-12-25

申请号：US12448689

申请日：2008-01-21

申请人： Hideji Tajima

发明人： Hideji Tajima

IPC分类号： B01L3/02

CPC分类号： B01L3/0275 ,  B01D15/3804 ,  B01J2220/64 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/042 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/069 ,  G01N30/6043 ,  G01N2035/1053

摘要： The present invention relates to a pipette tip having a support and a fluid enclosed therein, an apparatus for treating the pipette tip having a support and a fluid enclosed therein, and a method of treating the pipette tip having a support and a fluid enclosed therein. The present invention aims at providing separation and purification that may be performed more efficiently and rapidly than the treatments using a conventional treatment using liquid chromatograph or a filter, and constituted to have a function for sustainedly activating the support by comprising a pipette tip comprising an attachment opening that is to be attached to a nozzle for sucking and discharging a gas or to a connecting tube attachable to the nozzle and may be communicated with the nozzle, and an opening that allows flow-in and flow-out of a liquid in response to the suction and discharging of the gas; a support enclosed in the pipette tip, which may adsorb or capture a biological material in the liquid or react with or bond to the biological material; and a fluid for sustainedly activating the support, which comprises a predetermined liquid or a predetermined gas that is enclosed in the pipette tip in a breakable state and comes into contact with the support.

摘要翻译： 本发明涉及具有支撑体和封闭在其中的流体的移液管尖端，用于处理具有支撑件和封闭在其中的流体的移液管尖端的装置，以及处理具有支撑件的移液管尖端和封闭在其中的流体的方法。 本发明旨在提供可以比使用液相色谱仪或过滤器的常规处理的处理更有效和快速地进行的分离和纯化，并且构成为具有通过包括附着物的移液管尖端来持续活化载体的功能 要连接到用于吸入和排出气体的喷嘴的开口或连接到喷嘴的连接管，并且可以与喷嘴连通，以及允许响应于流体流动而流入和流出液体的开口 气体的吸入和排出; 包封在移液管尖端的支架，其可以吸附或捕获液体中的生物材料或与生物材料反应或结合到生物材料上; 以及用于持续地启动支撑件的流体，其包括预定液体或预定的气体，所述预定液体或预定气体以可破坏的状态包封在吸头中并与支撑体接触。