公开(公告)号：US20240192181A1

公开(公告)日：2024-06-13

申请号：US18286590

申请日：2022-02-02

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Yusuke SHIMIZU ,  Yu IIJIMA ,  Taichiro YAMASHITA ,  Ai MASUDA ,  Daichi FURUKAWA

IPC: G01N30/46 ,  G01N30/60

CPC classification number: G01N30/46 ,  G01N30/6043 ,  G01N30/6091

Abstract: A chromatograph allows easy replacement of a separation column while preventing an operator from contacting with a configuration related to the separation column. A column cartridge accommodates the separation column and is detachably provided in a predetermined column installation position. An upstream pipe is detachably provided on the column cartridge in a state of being installed at the column installation position, and supplies a mobile phase to the separation column of the column cartridge. A downstream pipe is detachably provided on the column cartridge in a state of being installed at the column installation position, and delivers the mobile phase that has passed through the separation column of the column cartridge. A cover integrally covers the column installation position, the upstream pipe, and the downstream pipe and has an insertion hole that allows the column cartridge to be installed from the outer side of the cover.

公开(公告)号：US11860142B2

公开(公告)日：2024-01-02

申请号：US17296317

申请日：2019-10-25

Applicant: Hitachi High-Tech Corporation

Inventor： Masuyuki Sugiyama ,  Yuichiro Hashimoto ,  Hideki Hasegawa

IPC: G01N30/72 ,  G01N30/32 ,  G01N30/46 ,  G01N30/02 ,  G01N27/623

CPC classification number: G01N30/7266 ,  G01N27/623 ,  G01N30/32 ,  G01N30/46 ,  G01N2030/027

Abstract: A liquid chromatograph mass spectrometer specifying a location where a flow path is clogged and recovering in a short time. The liquid chromatograph mass spectrometer includes a first flow path passing through a separation column, a second flow path not passing through the separation column, a mass spectrometry unit on the downstream side of the first and second flow paths that analyzes a sample that has passed through the first flow path, a first valve for connecting any one of the first and second flow paths to the mass spectrometry unit, and a controller for controlling driving of the first valve connecting the first flow path to the mass spectrometric unit, comparing the measured value of the mass spectrometric unit with a predetermined threshold value, and connecting the second flow path to the mass spectrometry unit when it is determined to be abnormal.

公开(公告)号：US09772306B2

公开(公告)日：2017-09-26

申请号：US15115217

申请日：2015-12-24

Applicant: NUCTECH COMPANY LIMITED

Inventor： Qingjun Zhang ,  Yuanjing Li ,  Zhiqiang Chen ,  Ziran Zhao ,  Yinong Liu ,  Yaohong Liu ,  Qiufeng Ma ,  Huishao He ,  Weiping Zhu ,  Xiang Zou ,  Jianping Chang ,  Song Liang

IPC: G01N27/00 ,  G01N27/62 ,  G01N27/64 ,  G01N30/30 ,  G01N30/46

CPC classification number: G01N27/622 ,  G01N27/64 ,  G01N30/30 ,  G01N30/46 ,  G01N30/466 ,  G01N2030/3038

Abstract: The present invention discloses a gas analyzing apparatus and a sampling device. The gas analyzing apparatus includes a sampling device and an ion mobility spectrum analysis device. The sampling device includes a multi-capillary column and a temperature control system. The ion mobility spectrum analysis device is adapted for analyzing a gas leaded-in by the sampling device and includes a reaction cavity for reaction between sample molecules and reaction ions, the cavity having a sampling opening for leading-in of the gas. An outlet end of the multi-capillary column is inserted directly into the cavity of the ion mobility spectrum analysis device through the sampling opening of the ion mobility spectrum analysis device.

公开(公告)号：US09341604B2

公开(公告)日：2016-05-17

申请号：US14357157

申请日：2012-11-08

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： Xudong Fan ,  Yogesh B. Gianchandani ,  Jing Liu

IPC: G01N30/46 ,  G01N30/60 ,  G01N30/72

CPC classification number: G01N30/461 ,  G01N30/46 ,  G01N30/463 ,  G01N30/465 ,  G01N30/466 ,  G01N30/468 ,  G01N30/6095 ,  G01N30/72

Abstract: The present disclosure provides adaptive methods for gas chromatography analysis of a gas sample comprising one or more target analytes (such as a micro-gas chromatography) and adaptive gas chromatography devices for carrying out such analytical methods. Broadly, the system can regulate flow into a downstream chromatographic column by detecting one or more upstream conditions. For example, one adaptive chromatography device comprises a first column, a modulator component, and a second column. A first detector or sensor detects the presence of target analytes upstream from the second column, while a second detector detects the presence of target analytes eluted from the second column. The modulator component assembly is responsive to an output generated by the first detector and adaptively regulates fluid flow into the second column. Such adaptive chromatography (micro-GC) systems have higher separation speed, better analyte identification capability, and far greater energy savings.

Abstract translation: 本公开提供了用于气体样品的气相色谱分析的自适应方法，所述气体样品包含一种或多种靶分析物（例如微气相色谱）和用于进行这种分析方法的适应性气相色谱装置。 通常，系统可以通过检测一个或多个上游条件来调节流入下游色谱柱的流量。 例如，一个自适应色谱装置包括第一列，调制器组件和第二列。 第一检测器或传感器检测来自第二列上游的目标分析物的存在，而第二检测器检测从第二列洗脱的目标分析物的存在。 调制器部件组件响应于由第一检测器产生的输出并且自适应地调节流入第二列的流体流。 这种自适应色谱（micro-GC）系统具有更高的分离速度，更好的分析物识别能力和更大的能量节省。

公开(公告)号：USRE37194E1

公开(公告)日：2001-05-29

申请号：US09567618

申请日：2000-05-09

Applicant: Gregory L. Kirk ,  Robert H. Grubbs

Inventor： Gregory L. Kirk ,  Robert H. Grubbs

IPC: C25B1502

CPC classification number: G01N30/466 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00308 ,  B01J2219/00315 ,  B01J2219/00355 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00463 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00511 ,  B01J2219/0052 ,  B01J2219/00547 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00711 ,  B82Y30/00 ,  C07K1/045 ,  C40B60/14 ,  C40B70/00 ,  G01N30/46 ,  G01N30/60 ,  G01N30/6043 ,  G01N2030/524 ,  Y10T436/113332 ,  Y10T436/114165 ,  Y10T436/114998 ,  Y10T436/117497 ,  Y10T436/12

Abstract: A high throughput chemical synthesis system utilizing cylindrical reaction vessels is disclosed. Reaction vessels are utilized which include a tubular member adapted for placement of electronically readable identifying indicia thereon. The identifying indicia are representative of reaction conditions within the tubular member and of one or more reagents utilized in a reaction within the tubular members. A method of performing chemical synthesis on solid phase reactive material within a plurality of reaction vessels using a plurality of reaction stages resulting in final products and employing identifying indicia representing the reaction stages is also disclosed. The method includes reading the identifying indicia located on the reaction vessels, reacting one or more reagents within the reaction vessels under particular reaction conditions which may be determined by reading the identifying indicia, thereby synthesizing chemical compounds within the reaction vessels. The method allows chemical synthesis to occur according to a predetermined set of reactions and also allows for combinatorial chemistry to be performed utilizing random mix and split techniques. The final synthesized products may be tested for chemical or biological activity. The chemical structures of desired end products may be obtained by reading recorded information wherein the reaction conditions and reagents of reaction steps have been recorded, preferably in conjunction with the identifying indicia.

Abstract translation: 公开了一种利用圆柱形反应容器的高通量化学合成系统。 使用反应容器，其包括适于在其上放置电子可读识别标记的管状构件。 识别标记是管状构件内的反应条件以及在管状构件内的反应中使用的一种或多种试剂的代表。 还公开了使用多个反应阶段在多个反应容器内对固相反应性材料进行化学合成的方法，所述反应阶段产生最终产物并采用代表反应级的识别标记。 该方法包括读取位于反应容器上的识别标记，在特定反应条件下在反应容器内反应一种或多种试剂，该反应条件可通过读取识别标记确定，由此合成反应容器内的化合物。 该方法允许根据预定的一组反应进行化学合成，并且还允许使用随机混合和分离技术进行组合化学。 最终的合成产物可以测试化学或生物活性。 期望的最终产物的化学结构可以通过阅读记录的信息来获得，其中已经记录了反应步骤的反应条件和试剂，优选结合识别标记。

公开(公告)号：US12073924B2

公开(公告)日：2024-08-27

申请号：US17643128

申请日：2021-12-07

Applicant: Genzyme Corporation

Inventor： Dhanuka Pulasthi Wasalathanthri ,  Jagdish C. Tewari ,  Xuezhen Kang ,  Marina Hincapie ,  Shawn L. Barrett ,  Julie Susanne Pollock

IPC: C12M3/00 ,  B01L3/00 ,  C07K1/16 ,  C12M1/00 ,  C12M1/12 ,  C12M1/36 ,  G01N21/3577 ,  G01N21/552 ,  G01N30/46 ,  G01N30/78 ,  G01N30/86 ,  G16C20/10 ,  B01D15/18 ,  G01N21/35 ,  G01N21/84 ,  G01N30/88

CPC classification number: G16C20/10 ,  C07K1/16 ,  C12M21/14 ,  C12M37/00 ,  C12M41/48 ,  C12M47/12 ,  G01N21/3577 ,  G01N21/552 ,  G01N30/46 ,  G01N30/78 ,  G01N30/86 ,  B01D15/1814 ,  B01D15/1871 ,  G01N2021/3595 ,  G01N2021/8416 ,  G01N2030/8813 ,  G01N2030/8886 ,  G01N2201/129

Abstract: The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.

公开(公告)号：US20230219063A1

公开(公告)日：2023-07-13

申请号：US18147894

申请日：2022-12-29

Applicant: JCR Pharmaceuticals Co., Ltd.

Inventor： Tomoki FUKATSU ,  Chika MOROOKA

IPC: B01J20/283 ,  G01N30/46 ,  G01N30/06 ,  B01J41/07 ,  B01J20/286 ,  G01N30/88 ,  B01J20/285 ,  B01D15/30 ,  G01N30/74 ,  B01D15/18 ,  B01J41/14 ,  B01J41/20 ,  B01J41/05 ,  G01N30/34 ,  B01D15/36 ,  B01J20/32 ,  C07K16/00

CPC classification number: B01J20/283 ,  G01N30/461 ,  G01N30/06 ,  B01J41/07 ,  B01J20/286 ,  G01N30/88 ,  B01J20/285 ,  B01D15/305 ,  G01N30/74 ,  B01D15/1871 ,  B01J41/14 ,  B01J41/20 ,  B01J41/05 ,  G01N30/46 ,  G01N30/34 ,  B01D15/363 ,  B01J20/3219 ,  B01J20/3248 ,  G01N2030/8836 ,  C07K16/00 ,  G01N2030/067

Abstract: A chromatography column for the use of separation of acidic sugar chains, wherein the column comprises a first column and a second column, the second column connected by a flow path downstream of an outlet of the first column, and selected from the following (1) or (2): (1) the carrier of the first column is hydrophobically modified silica having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine; (2) the carrier of the first column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is hydrophobically modified silica having a group containing a primary amine, a secondary amine, or/and a tertiary amine.

公开(公告)号：US20170234839A1

公开(公告)日：2017-08-17

申请号：US15502222

申请日：2015-08-07

Applicant: Shimadzu Corporation

Inventor： Hidetoshi TERADA ,  Yuji KATSUYAMA ,  Katsuhiko MIWA ,  Chie KUSHIBE

IPC: G01N30/14 ,  G01N30/86 ,  G01N30/80 ,  G01N30/24 ,  G01N30/46

CPC classification number: G01N30/14 ,  B01D15/1885 ,  G01N30/24 ,  G01N30/46 ,  G01N30/466 ,  G01N30/80 ,  G01N30/82 ,  G01N30/86 ,  G01N30/8658

Abstract: Provided is a preparative separation liquid chromatograph system and preparative separation condition searching method which allows for an easy setting of the preparative separation condition. A sample temporally separated into components by a separation column is introduced into a detector and a fraction collector, with each component fractionated and collected by the fraction collector based on the result of a detection by the detector. A controlling and processing unit holds the following data for each sample or compound in the form of a database: chromatogram data obtained when a liquid chromatograph analysis in a preparative separation condition searching mode is performed for various standard samples under a search condition; and chromatogram data obtained when a liquid chromatograph analysis in a preparative separation mode is performed under one or more sets of preparative separation conditions for the various standard samples, along with the preparative separation condition used in this analysis.

公开(公告)号：US20160146764A1

公开(公告)日：2016-05-26

申请号：US14548432

申请日：2014-11-20

Applicant: Saudi Arabian Oil Company

Inventor： Naim Akmal ,  Saeed Hasan Al-Shahrani ,  Anwar H. Al-Khawajah ,  Milind M. Vaidya ,  Jean-Pierre R. Ballaguet ,  Sebastien A. Duval

IPC: G01N30/04

CPC classification number: G01N30/04 ,  B01D53/002 ,  B01D53/225 ,  B01D53/30 ,  B01D2257/102 ,  B01D2257/304 ,  B01D2257/504 ,  B01D2257/702 ,  B01D2257/80 ,  C10G5/06 ,  C10L3/10 ,  G01N30/46 ,  G01N2030/025 ,  G01N2030/8854 ,  Y02C10/10

Abstract: A gas chromatographic method for analyzing natural gas and a natural gas upgrading system using the gas chromatographic method for analyzing natural gas. The method includes transporting the natural gas through a chiller, transporting the natural gas from the chiller to at least two gas upgrading membranes, and operating a gas chromatographic system having at least one upstream gas chromatograph and at least two downstream gas chromatographs. The at least one upstream gas chromatograph, the first downstream gas chromatograph, and the second downstream gas chromatograph all operate simultaneously and utilize the same heating oven to heat samples of natural gas.

Abstract translation: 使用气相色谱法分析天然气的气相色谱法和天然气改质系统。 该方法包括运送天然气通过冷却器，将天然气从冷却器输送至至少两个气体升级膜，并运行具有至少一个上游气相色谱仪和至少两个下游气相色谱仪的气相色谱系统。 所述至少一个上游气相色谱仪，第一下游气相色谱仪和第二下游气相色谱仪均同时运行，并利用相同的加热炉来加热天然气样品。

公开(公告)号：US20140283593A1

公开(公告)日：2014-09-25

申请号：US14296863

申请日：2014-06-05

Applicant: SCHLUMBERGER TECHNOLOGY CORPORATION

Inventor： NEIL WILLIAM BOSTROM ,  ROBERT LEONARD KLEINBERG ,  KRISTOFER GUNNAR PASO ,  BHAVANI RAGHURAMAN ,  GORDON R. LAMBERTUS

IPC: G01N30/62 ,  G01N30/28 ,  G01V9/00

CPC classification number: G01N30/62 ,  E21B49/08 ,  E21B2049/085 ,  G01N30/28 ,  G01N30/46 ,  G01N30/88 ,  G01N2030/8854 ,  G01V9/00

Abstract: Advanced remote self-contained chromatographic systems and techniques for analyzing a mixture comprising components having a wide range of boiling points. The chromatographic systems and techniques can utilize components and techniques that allow staged, simultaneous, and/or sequential vaporization of an analyte to facilitate rapid analysis. The chromatographic systems and techniques can also utilize components and techniques that focus eluents from a first separation stage prior to reduce characterization time in subsequent stages.

Abstract translation: 高级远程独立色谱系统和用于分析包含沸点范围广的组分的混合物的技术。 色谱系统和技术可以利用允许分析物的分期，同时和/或顺序蒸发以促进快速分析的组分和技术。 色谱系统和技术还可以利用在第一分离阶段聚焦洗脱剂的组分和技术，然后减少后续阶段的表征时间。