公开(公告)号：US12205680B2

公开(公告)日：2025-01-21

申请号：US16290713

申请日：2019-03-01

Applicant: Genzyme Corporation

Inventor： Dhanuka Pulasthi Wasalathanthri ,  Jagdish C. Tewari ,  Xuezhen Kang ,  Marina Hincapie ,  Shawn L. Barrett ,  Julie Susanne Pollock

IPC: G16C20/10 ,  C07K1/16 ,  C12M1/00 ,  C12M1/12 ,  C12M1/36 ,  G01N21/3577 ,  G01N21/552 ,  G01N30/46 ,  G01N30/78 ,  G01N30/86 ,  B01D15/18 ,  G01N21/35 ,  G01N21/84 ,  G01N30/88

Abstract: The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.

公开(公告)号：US20220101953A1

公开(公告)日：2022-03-31

申请号：US17643128

申请日：2021-12-07

Applicant: Genzyme Corporation

Inventor： Dhanuka Pulasthi Wasalathanthri ,  Jagdish C. Tewari ,  Xuezhen Kang ,  Marina Hincapie ,  Shawn L. Barrett ,  Julie Susanne Pollock

IPC: G16C20/10 ,  C12M1/00 ,  C07K1/16 ,  C12M1/12 ,  C12M1/36 ,  G01N30/86 ,  G01N30/46 ,  G01N30/78 ,  G01N21/552 ,  G01N21/3577

Abstract: The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.

公开(公告)号：US20210115385A1

公开(公告)日：2021-04-22

申请号：US17076064

申请日：2020-10-21

Applicant: Genzyme Corporation

Inventor： Robert Snow ,  Joseph P. Kutzko ,  Xuezhen Kang

IPC: C12M1/36 ,  C12M1/34

Abstract: Methods for controlling a biological manufacturing system include directing a light beam to pass through a wall of a vessel containing a first fluid generated by the biological manufacturing system, measuring an angle of refraction of the light beam in the first fluid, the angle of refraction corresponding to an angle between a propagation direction of the light beam in the first fluid and a normal to an interface between the vessel wall and the first fluid, determining information about the first fluid based on the measured angle of refraction, and adjusting a parameter of the biological manufacturing system based on the information about the first fluid.

公开(公告)号：US12073924B2

公开(公告)日：2024-08-27

申请号：US17643128

申请日：2021-12-07

Applicant: Genzyme Corporation

Inventor： Dhanuka Pulasthi Wasalathanthri ,  Jagdish C. Tewari ,  Xuezhen Kang ,  Marina Hincapie ,  Shawn L. Barrett ,  Julie Susanne Pollock

IPC: C12M3/00 ,  B01L3/00 ,  C07K1/16 ,  C12M1/00 ,  C12M1/12 ,  C12M1/36 ,  G01N21/3577 ,  G01N21/552 ,  G01N30/46 ,  G01N30/78 ,  G01N30/86 ,  G16C20/10 ,  B01D15/18 ,  G01N21/35 ,  G01N21/84 ,  G01N30/88

CPC classification number: G16C20/10 ,  C07K1/16 ,  C12M21/14 ,  C12M37/00 ,  C12M41/48 ,  C12M47/12 ,  G01N21/3577 ,  G01N21/552 ,  G01N30/46 ,  G01N30/78 ,  G01N30/86 ,  B01D15/1814 ,  B01D15/1871 ,  G01N2021/3595 ,  G01N2021/8416 ,  G01N2030/8813 ,  G01N2030/8886 ,  G01N2201/129

Abstract: The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.

公开(公告)号：US20190272894A1

公开(公告)日：2019-09-05

申请号：US16290713

申请日：2019-03-01

Applicant: Genzyme Corporation

Inventor： Dhanuka Pulasthi Wasalathanthri ,  Jagdish C. Tewari ,  Xuezhen Kang ,  Marina Hincapie ,  Shawn L. Barrett ,  Julie Susanne Pollock ,  Lin Huang

IPC: G16C20/10 ,  C12M1/00 ,  C12M1/36 ,  C12M1/12 ,  C07K1/16

Abstract: The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.