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公开(公告)号：US12106951B2
公开(公告)日：2024-10-01
申请号：US17599231
申请日：2020-03-12
CPC分类号： H01J49/0036 , G01N27/62 , H01J49/0009 , H01J49/10
摘要： Provided is a technique for accurately determining a performance of a single detector that detects ions having passed through a mass analysis unit. A mass analysis system according to the present disclosure includes, in a mass analysis device, a first converter configured to calculate a first measured value based on an intensity and an area of a pulse in an electric signal output from the detector configured to detect the ions having passed through the mass analysis unit, a second converter configured to obtain a second measured value by counting the number of pulses of the electric signal, a calculation unit configured to calculate an A/P ratio indicating a ratio of the first measured value to the second measured value, a determination unit configured to determine a performance of the detector based on a value of the A/P ratio, and a control unit configured to control at least an output of a determination result obtained by the determination unit.
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公开(公告)号：US20240192180A1
公开(公告)日：2024-06-13
申请号：US18554237
申请日：2022-02-04
CPC分类号： G01N30/32 , G01N30/468 , G01N2030/027 , G01N2030/324 , G01N2030/328 , G01N2030/385 , G01N2030/8804
摘要： An automatic analyzer includes a liquid feed unit including a liquid feed unit and a liquid feed flow passage and feeding a mobile phase, a sample introduction unit introducing a sample to the mobile phase, a separation column separating the sample into plural components, a detector detecting the component, and a control unit. A pressure sensor detecting pressure of the liquid feed flow passage is provided, and the control unit calculates a pressure rise rate of the time immediately after starting liquid feeding of the mobile phase based on the pressure detected by the pressure sensor and a compression pressure variation amount and a pressure average after continuing liquid feeding of the mobile phase for a certain time, and determines completion of equilibration of the separation column.
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公开(公告)号：US11635413B2
公开(公告)日：2023-04-25
申请号：US17424526
申请日：2020-02-04
发明人： Yuka Sumigama , Yuichiro Hashimoto
摘要： The invention provides a liquid chromatograph mass spectrometer which prevents contamination of a pump and a column and can perform mass calibration without adding a complicated mechanism. This liquid chromatograph mass spectrometer includes a liquid chromatograph including a liquid feed pump configured to feed a mobile phase solvent, a mass spectrometer configured to analyze a mass of a sample, and a standard sample container configured to be connected in series with the liquid chromatograph and the mass spectrometer in a flow path that connects the liquid chromatograph and the mass spectrometer and configured to house a standard sample for mass calibration.
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公开(公告)号：US20220270868A1
公开(公告)日：2022-08-25
申请号：US17628388
申请日：2020-07-22
摘要： There is provided a mass spectrometer that can appropriately maintain the atmospheric pressure of a vacuum chamber, and a method of controlling the same. An example of a mass spectrometer according to the present invention includes first vacuum chambers, first vacuum pumps, an atmospheric pressure relating value acquiring unit, and an adjustment unit configured to adjust the effective exhaust velocity of the first vacuum pumps, and controllers. The controllers control the adjustment unit corresponding to an atmospheric pressure relating value.
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公开(公告)号：US11955327B2
公开(公告)日：2024-04-09
申请号：US17433133
申请日：2020-01-22
IPC分类号： H01J49/42 , G01N27/623 , G01T1/20 , G01T1/28
CPC分类号： H01J49/42 , G01N27/623 , G01T1/2018 , G01T1/28
摘要： The present invention implements an ion detector with which it is possible to avoid direct collisions of negative ions with a scintillator, prevent degradation of the scintillator, prolong life of the scintillator, reduce the need for maintenance, and perform highly sensitive detection of both positive and negative ions. With respect to a reference line 65 connecting a central point 63 of a positive ion CD 52 and a central point 64 of a counter electrode 54, a central point 66 of a negative ion CD 53 is provided in a region of a side opposite to a region of a side of a central point 67 of a scintillator 56. Positive ions entering from an ion entrance 62 receive a deflection force and collide with the positive ion CD 52 to generate secondary electrons. The generated secondary electrons collide with the scintillator 56 to generate light. The generated light passes through a light guide 59 and is detected by a photomultiplier tube 58. A negative potential barrier is generated along the reference line 65. Negative ions entering form the ion entrance 62 are attracted to and collide with the negative ion CD 53 to generate positive ions. The generated positive ions collide with the positive ion CD 52 to generate secondary electrons. The generated secondary electrons collide with the scintillator 56 and are detected by the photomultiplier tube 58.
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公开(公告)号：US20240060942A1
公开(公告)日：2024-02-22
申请号：US18261299
申请日：2021-12-07
CPC分类号： G01N30/6091 , G01N30/54 , B01D15/161 , G01N2030/027
摘要： Provided is an analyzer column cartridge that can control the temperature of an analysis column while saving resources and costs. An analyzer column cartridge 1 includes: metal blocks 7, 8 that accommodate an analysis column 10 used in a liquid chromatography; and housings 2, 3 that accommodate the metal blocks 7, 8. A plurality of holes 11A, 11B, 11C, 11D, and 11E that communicate with an accommodation space of the analysis column 10 are formed in the metal block 8. The housing has a plurality of windows 6A, 6B, 6C, 6D, and 6E formed at positions facing the plurality of holes 11A, 11B, 11C, 11D, and 11E formed in the metal block 8.
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公开(公告)号：US20230408459A1
公开(公告)日：2023-12-21
申请号：US18253987
申请日：2021-12-08
发明人： Daisuke Kanai , Yuichiro Hashimoto
CPC分类号： G01N30/24 , G01N35/02 , G01N2030/027
摘要： Provided is an autosampler of a liquid chromatograph that can manage a sample container even in a case where the throughput of a pretreatment unit exceeds the throughput of the autosampler.
An autosampler of a liquid chromatograph includes a plurality of sample aspiration nozzles that aspirates a sample from sample containers installed at respective sample aspiration points; a sample transfer means that transfers the sample containers to the respective sample aspiration points; and a retraction point where one of the sample containers is put into the autosampler and one of the sample containers collected from the sample aspiration points can be held.-
公开(公告)号：US11749517B2
公开(公告)日：2023-09-05
申请号：US17286054
申请日：2019-10-10
CPC分类号： H01J49/167 , G01N30/7266 , H01J49/0445 , H01J49/0477
摘要： An object of the present invention is to improve the safety and stability of an ion source by making a temperature distribution of a heated gas uniform while ensuring heat insulating properties. The ion source according to the present invention includes a gas introduction port inside a probe holder that holds an ion probe. A heater that increases the temperature of a heated gas and the gas introduction port are connected by a plurality of pipes which extend along an extending direction of the ion probe and are independent of each other (see FIG. 4).
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公开(公告)号：US20220283193A1
公开(公告)日：2022-09-08
申请号：US17628367
申请日：2020-07-17
摘要： There is provided a specimen analyzer that can measure carry-over without degrading a specimen processing capability. A specimen analyzer according to the present invention measures a first sample including a first specimen and a first internal reference material, subsequently measures a second sample including a second specimen and a second internal reference material, and calculates an amount of the second specimen included in the second sample using an amount of the first internal reference material measured when the first sample has been measured and an amount of the second internal reference material measured when the second sample has been measured.
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公开(公告)号：US11251030B2
公开(公告)日：2022-02-15
申请号：US17266367
申请日：2019-07-24
发明人： Yuichiro Hashimoto
摘要： An object of the invention is to provide a mass spectrometry apparatus capable of obtaining a highly accurate quantitative result and being low-cost. A small section measurement instruction unit 101 instructs a detector 9 to perform measurement on a plurality of small sections 5 in a channel 4, the signals detected by the detector 9 are stored in a data storage unit 102, the signals are integrated by a small section signal amount integration unit 103, and variance of the integrated signals is calculated by a signal variance calculation unit 104. A signal variance evaluation unit 105 evaluates the signal variance of signals of each small section 5 in the same channel 4. When the signal variance is evaluated to be stable, an operation control unit 106 controls operations of the ion source 6 to continue measurement without warning. When the signal variance is evaluated to be unstable, the warning is performed during the measurement or after the measurement.
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