公开(公告)号：US12123857B2

公开(公告)日：2024-10-22

申请号：US16996225

申请日：2020-08-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Marc Kaminski ,  Stefan Quint ,  Benjamin Tiemann

IPC: G01N30/72 ,  G01N30/20 ,  G01N30/88 ,  G06F16/28 ,  G01N30/02

CPC classification number: G01N30/88 ,  G01N30/20 ,  G06F16/285 ,  G01N2030/027 ,  G01N2030/202 ,  G01N2030/8804

Abstract: A method of monitoring a state of a liquid chromatography (LC) stream of an automated analyzer is provided including automatically monitoring a system pressure of an injection assembly of the liquid chromatography stream to generate a time series of system pressures, classifying the time series in one of two or more predetermined classes indicating different states of the LC stream and triggering a response based on the classification result.

公开(公告)号：US20240329016A1

公开(公告)日：2024-10-03

申请号：US18738234

申请日：2024-06-10

Applicant: SHIMADZU CORPORATION

Inventor： Yukihiko KUDO

IPC: G01N30/72 ,  G01N30/02 ,  G01N30/04 ,  G01N30/62 ,  G01N30/86 ,  G01N30/88

CPC classification number: G01N30/7206 ,  G01N30/8634 ,  G01N30/8668 ,  G01N30/8679 ,  G01N30/88 ,  G01N2030/025 ,  G01N2030/047 ,  G01N2030/626 ,  G01N2030/8804 ,  G01N2030/8845

Abstract: In a quantitative determination device 100 for brominated flame-retardant compounds, a storage section 41 holds a relative response factor 411 representing a relationship of a measured intensity of a compared compound to that of a reference compound selected from target compounds. A standard-sample measurer 43 acquires the intensity of the reference compound by measuring a standard sample, using an analyzer 10, 20. A target-sample measurer 45 acquires the intensities of the reference and compared compounds by measuring a target sample, using the analyzer. A reference-compound quantity determiner 46 determines a quantitative value of the reference compound in the target sample. A compared-compound quantity determiner 47 determines a quantitative value of the compared compound based on the quantity of the reference compound in the standard sample, intensity of the reference compound acquired by the standard-sample measurer, intensity of the compared compound acquired by the target-sample measurer, and relative response factor of the compared compound.

公开(公告)号：US12025618B2

公开(公告)日：2024-07-02

申请号：US16635938

申请日：2018-08-01

Applicant: AMGEN INC.

Inventor： Chao-Hsiang Wu

IPC: G01N33/68 ,  C12N9/42 ,  G01N30/88

CPC classification number: G01N33/68 ,  C12N9/2437 ,  G01N30/88 ,  G01N2030/8804 ,  G01N2030/8836

Abstract: Systems and methods that facilitate the automatic (or substantially automatic) preparation of a sample of a product containing polypeptides for glycan analysis and automatic (or substantially automatic) performance of a glycan assay of that sample. Thus, the preparation and analysis can be performed substantially in-real time, or, in other words, much more quickly than presently allowed by conventional systems and methods.

公开(公告)号：US11994502B2

公开(公告)日：2024-05-28

申请号：US17340264

申请日：2021-06-07

Applicant: Snapdragon Chemistry, Inc.

Inventor： Adrian G. Amador ,  Yuanqing Fang ,  David D. Ford ,  Mikhail V. Goncharuk ,  Grace Russell

IPC: G01N30/30 ,  G01N30/02 ,  G01N30/32 ,  G01N30/84 ,  G01N30/88

CPC classification number: G01N30/88 ,  G01N30/30 ,  G01N30/32 ,  G01N30/84 ,  G01N2030/027 ,  G01N2030/324 ,  G01N2030/8435 ,  G01N2030/8804 ,  G01N2030/8809

Abstract: The present disclosure relates to a computer-implemented method for analyzing a product stream of a chemical reaction. The method includes withdrawing a portion of the product stream of the chemical reaction from a reactor, the portion of the product stream having a volume of less than about 200 μL. The method further includes mixing the portion of the product stream with a diluent to produce a sample and then transferring the sample to a liquid chromatography device. A measured chemical profile is then developed, via the liquid chromatography device, which can be used for process monitoring or real time decision making. In some embodiments, the method can include adjusting a reaction condition in the reactor based on differences between the measured chemical profile and a desired chemical profile.

公开(公告)号：US11959892B2

公开(公告)日：2024-04-16

申请号：US17436102

申请日：2019-03-06

Applicant: SHIMADZU CORPORATION

Inventor： Hiroshi Ohashi ,  Takayuki Kihara ,  Hiroshi Miura

IPC: G01N30/00 ,  G01N30/32 ,  G01N30/88 ,  G01N30/02

CPC classification number: G01N30/32 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/8804

Abstract: A liquid chromatograph is presented which enables automatic resolution of a liquid sending failure when the liquid sending failure caused by a liquid sending pump occurs, and execution of a new analysis with good reproducibility after the liquid sending failure is resolved. The liquid sending failure can be automatically resolved by a purging operation. A sample remaining in the analysis flow path is washed away by a non-injection analysis after the liquid sending failure is resolved, and a new analysis can be executed with good reproducibility.

公开(公告)号：US11899000B2

公开(公告)日：2024-02-13

申请号：US16011761

申请日：2018-06-19

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Peyton C. Beals ,  Richard W. Andrews ,  Barry Sunray ,  Steven M. Binney

IPC: G01N30/64 ,  G01N30/86 ,  G01N30/34 ,  G01N30/88 ,  G01N21/53

CPC classification number: G01N30/64 ,  G01N30/34 ,  G01N30/8624 ,  G01N30/8658 ,  G01N30/8662 ,  G01N30/8675 ,  G01N30/88 ,  G01N21/53 ,  G01N2030/8804

Abstract: A method of performing experiments on samples may include receiving criteria defining a starting state for performing an experiment in a system including a scientific instrument; determining whether the starting state is established in the system; and, responsive to the starting state being established, allowing the experiment, that analyzes a sample using the scientific instrument, to proceed. Determining whether the starting state is established may include automated monitoring of at least one parameter for at least one data channel, and determining whether all such parameters simultaneously meet associated conditions of the criteria for specified time periods. The method may include automatically monitoring the system and re-establishing the starting state prior to performing each of one or more subsequent experiments. The method may include automatically monitoring and establishing a second starting state prior to performing each of one or more additional experiments.

公开(公告)号：US20240003784A1

公开(公告)日：2024-01-04

申请号：US17856713

申请日：2022-07-01

Applicant: Chemtech Services, Inc.

Inventor： John F. Hart

IPC: G01N1/22 ,  G01N30/72 ,  G01N30/88

CPC classification number: G01N1/22 ,  G01N30/7206 ,  G01N30/88 ,  G01N2001/2261 ,  G01N2030/8804 ,  G01N2030/025

Abstract: A method of extracting a vapor from chemical processing equipment which may be operated under pressure or vacuum conditions and adjusting the density, temperature, dilution, pressure and flow conditions for subsequently compositional analysis by chemical analysis equipment interfaced with computer controls which subsequently control the process variable related to operating chemical process equipment.

公开(公告)号：US20230408464A1

公开(公告)日：2023-12-21

申请号：US18197077

申请日：2023-05-14

Applicant: SHIMADZU CORPORATION

Inventor： Shinichi FUJISAKI ,  Tomohiro KAWASE

IPC: G01N30/74 ,  G01N30/86

CPC classification number: G01N30/74 ,  G01N30/8634 ,  G01N2030/8804 ,  G01N30/8679 ,  G01N30/8662

Abstract: An analysis assistance device includes an estimator that estimates a distribution of measurement quality indicator data by performing a regression analysis with use of a plurality of analysis condition data pieces supplied to an analysis device and a plurality of measurement data pieces obtained by the analysis device based on the plurality of analysis condition data pieces, and an analysis assistance information outputter that outputs a distribution of the measurement quality indicator data to a display device. The analysis condition data pieces include a first factor. The estimator estimates respective distributions of the measurement quality indicator data in a case in which the first factor is a first value and a case in which the first factor is a second value. The analysis assistance information outputter outputs the respective distributions to the display device.

公开(公告)号：US20230358771A1

公开(公告)日：2023-11-09

申请号：US17928527

申请日：2021-01-18

Applicant: SHIMADZU CORPORATION

Inventor： Tomohiro KAWASE ,  Yugo HASE ,  Takayuki NAKATANI

IPC: G01N35/00 ,  G01N30/34

CPC classification number: G01N35/00732 ,  G01N30/34 ,  G01N2030/8804

Abstract: Identification information for identifying each analysis appliance and consumable information representing a usage state of a consumable included in each analysis appliance are acquired by an information acquirer from a control device. The identification information and the consumable information acquired by the information acquirer are held by an information holder. A display controller causes a display device to display a list screen of identification information held by the information holder. Further, the display controller causes a usage state of a consumable for each analysis appliance to be displayed on the list screen based on consumable information held by the information holder.

公开(公告)号：US11656208B2

公开(公告)日：2023-05-23

申请号：US17206994

申请日：2021-03-19

Applicant: Waters Technologies Corporation

Inventor： Sylvain Cormier ,  Richard W. Andrews ,  Peyton C. Beals

IPC: G01N30/32 ,  G01N30/34 ,  G01N30/20 ,  G01N30/24 ,  G01N30/22 ,  G01N30/86 ,  G01N30/88 ,  G01N30/02

CPC classification number: G01N30/32 ,  G01N30/20 ,  G01N30/22 ,  G01N30/24 ,  G01N30/34 ,  G01N30/8665 ,  G01N30/88 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/328 ,  G01N2030/347 ,  G01N2030/8804 ,  G01N2030/889 ,  G01N2030/8881

Abstract: A chromatography system includes a gradient delay volume defined as an overall fluid volume between where gradient is proportioned until an inlet of a chromatography column, a pump pumping a flow of gradient; and at least one valve located downstream from the pump, the at least one valve having a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the at least one valve, the at least one valve having at least two positions. A first position of the at least two positions of the at least one valve increases the gradient delay volume of the chromatography system relative to when the at least one valve is in a second position.