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    NOVEL MULTIMODAL OSCILLATORY CHROMATOGRAPHIC PURIFICATION SYSTEM
    4.
    发明申请
    NOVEL MULTIMODAL OSCILLATORY CHROMATOGRAPHIC PURIFICATION SYSTEM 审中-公开

    公开(公告)号：US20180001227A1

    公开(公告)日：2018-01-04

    申请号：US15200138

    申请日：2016-07-01

    Applicant: Michael Dale Hilgert

    Inventor： Michael Dale Hilgert

    IPC: B01D15/18 ,  B01D15/32 ,  B01D15/34

    CPC classification number: B01D15/18 ,  B01D15/1814 ,  B01D15/1864 ,  B01D15/1871 ,  B01D15/22 ,  B01D15/325 ,  B01D15/34 ,  G01N30/34 ,  G01N30/6039 ,  G01N30/6069

    Abstract: The present invention comprises a novel multimodal chromatography sequence of short length alternating adsorption and size exclusion media operating with gradient elution. The novel multimodal chromatography in an oscillating series utilizes the alternating solvent exchange media to reposition the active region of separation back in phase with the target solutes.Each solvent exchange column bed length in the sequence is designed to achieve a subtle decrease or increase in the solvent gradient (or salt gradient) concentration associated with the two solutes of interest which results in an extension of the active separation or increasing differences in solute velocity for two solutes of interest.The novel oscillatory chronographic system demonstrates much improved separation capability as shown by a one dimensional model.

    Clamping device for clamping a plurality of columns for sample preparation
    7.
    发明授权
    Clamping device for clamping a plurality of columns for sample preparation 有权
    用于夹紧多个柱的夹紧装置用于样品制备

    公开(公告)号：US09433876B2

    公开(公告)日：2016-09-06

    申请号：US14182036

    申请日：2014-02-17

    Applicant: LCTech GmbH

    Inventor： Maximilian Baumann ,  Martin Brandlhuber ,  Uwe Aulwurm

    IPC: B01D15/22 ,  G01N30/46 ,  G01N30/60 ,  B01D15/10 ,  B01D15/18

    CPC classification number: B01D15/22 ,  B01D15/1864 ,  B01D15/1871 ,  B01D15/1878 ,  G01N30/461 ,  G01N30/465 ,  G01N30/6004 ,  G01N30/6039 ,  G01N30/6047 ,  G01N30/6065

    Abstract: A clamping device for clamping a plurality of columns for sample preparation provides a plurality of clamping blocks and a displacement mechanism for displacing at least one clamping block relative to an opposing clamping block between an open position and a clamping position. At least three clamping blocks are retained in a row one behind the other on a guiding rail so that at least two columns can be clamped in an axial direction one behind the other between the clamping blocks. First and second slidingly displaceable clamping blocks of the least three clamping blocks are retained on the guiding rail and connected to the displacement mechanism by coupling means so that an actuation of the displacement mechanism from the clamping position into the open position brings about a displacement of all the slidingly displaceable clamping blocks and the columns are released.

    Abstract translation: 用于夹紧用于样品制备的多个柱的夹紧装置提供多个夹紧块和用于相对于相对的夹持块在打开位置和夹紧位置之间移动至少一个夹紧块的移动机构。 至少三个夹紧块在导轨上一个接一个地保持在一排中，使得至少两个柱可以在夹紧块之间沿轴向夹紧在另一个之间。 最少三个夹紧块的第一和第二可滑动位移的夹紧块保持在导轨上并通过联接装置连接到位移机构，使得位移机构从夹紧位置致动到打开位置，导致全部位移 滑动位移的夹紧块和柱被释放。

    STERILE CHROMATOGRAPHY AND MANUFACTURING PROCESSES
    9.
    发明申请
    STERILE CHROMATOGRAPHY AND MANUFACTURING PROCESSES 审中-公开
    无菌色谱和制造工艺

    公开(公告)号：US20150203529A1

    公开(公告)日：2015-07-23

    申请号：US14598450

    申请日：2015-01-16

    Applicant: Genzyme Corporation

    Inventor： Rahul Godawat ,  Veena Warikoo ,  Rohan Patil ,  Konstantin Konstantinov ,  Venkat Kishore Ryakala ,  Mahsa Rohani

    IPC: C07K1/16

    CPC classification number: C07K1/16 ,  A61L2/081 ,  B01D15/1807 ,  B01D15/1864 ,  B01D15/20 ,  B01D15/363 ,  B01D15/3809 ,  B01D15/426 ,  C07K1/165 ,  C07K1/22 ,  C12N9/2465 ,  C12Y302/01022

    Abstract: Provided herein are methods of performing chromatography with gamma-irradiated chromatography resin that include providing a chromatography column including a gamma-irradiated chromatography resin; performing a first cycle of chromatography through the column, where the cycle includes exposing the chromatography resin to a denaturing buffer; and performing at least one additional cycle of chromatography through the column. Also provided are integrated, closed or substantially closed, and continuous processes for manufacturing of a recombinant protein that include the use of at least one chromatography column including gamma-irradiated chromatography resin, where the gamma-irradiated chromatography resin is exposed to denaturing buffer during each cycle in the process, and reduced bioburden buffer is used in the process.

    Abstract translation: 本文提供了使用γ-辐射色谱树脂进行色谱法的方法，其包括提供包含γ-辐射色谱树脂的色谱柱; 通过色谱柱进行第一次色谱循环，其中循环包括将色谱树脂暴露于变性缓冲液; 并通过柱进行至少一个附加的色谱循环。 还提供了整合的，封闭的或基本上封闭的，连续的制备重组蛋白质的方法，其包括使用至少一个色谱柱，包括γ-照射的色谱树脂，其中在每个过程中将γ-辐照色谱树脂暴露于变性缓冲液 在该过程中循环，并且在该过程中使用减少的生物负载缓冲液。

    METHOD AND APPARATUS FOR CHARACTERIZING IMPURITY PROFILE OF ORGANIC MATERIALS
    10.
    发明申请
    METHOD AND APPARATUS FOR CHARACTERIZING IMPURITY PROFILE OF ORGANIC MATERIALS 审中-公开
    用于表征有机材料的有害化学特性的方法和装置

    公开(公告)号：US20150177199A1

    公开(公告)日：2015-06-25

    申请号：US14576319

    申请日：2014-12-19

    Applicant: János Borbély ,  Krisztián Gábor Torma ,  Erika Fazekas

    Inventor： János Borbély ,  Krisztián Gábor Torma ,  Erika Fazekas

    IPC: G01N30/06 ,  G01N30/74

    CPC classification number: B01D15/34 ,  B01D15/1864 ,  B01D15/1878 ,  G01N30/463 ,  G01N30/468 ,  G01N30/74 ,  G01N2030/884 ,  G01N30/02

    Abstract: Method and apparatus for characterizing drug-modified polymers, macromolecules, proteins, antigens, antibodies or nanoparticles and quantitative determination of their impurity profile by two-dimensional liquid chromatography analysis. The first dimension is preferably size exclusion chromatography (SEC)—which is also known as gel permeation chromatography in case of non-aqueous samples (GPC)—for complete molecular weight analysis of nanoscale particles. It is not just included the application of separating small molecules from big molecules, but it is also the separation of different sorts of oligomers (e.g. monomers, dimers, trimers, tetramers). The second dimension is adapted for separating and characterizing small molecules which can be impurities or non-reacted modifiers with high-performance liquid chromatography (HPLC). Between the dimensions it is feasible to use solid phase extraction column(s) to collect small molecules, wash off or change solvent, or minimize broadening of their peaks.

    Abstract translation: 用于表征药物改性聚合物，大分子，蛋白质，抗原，抗体或纳米颗粒的方法和装置，并通过二维液相色谱分析定量测定其杂质分布。 第一维度优选是尺寸排阻色谱法（SEC） - 其在非水样品（GPC）的情况下也称为凝胶渗透色谱法 - 用于纳米级颗粒的完全分子量分析。 不仅仅包括从大分子中分离小分子的应用，而且也是不同种类的低聚物（例如单体，二聚体，三聚体，四聚体）的分离。 第二个维度适用于分离和表征可以使用高效液相色谱（HPLC）的杂质或非反应改性剂的小分子。 在尺寸之间，使用固相萃取塔收集小分子是可行的，洗涤或改变溶剂，或最小化它们峰的扩展。

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