公开(公告)号：US12121504B1

公开(公告)日：2024-10-22

申请号：US18611026

申请日：2024-03-20

申请人： KING SAUD UNIVERSITY

发明人： Jamal Mohammed Ali Khaled ,  Naiyf Sultan Helial Alaloi Alharbi ,  Ramzi Ahmed Abdullah Mothana ,  Shine Moosa Kadaikunnan ,  Ahmed Saad Alobaidi

IPC分类号： A61K31/231 ,  A61P31/10 ,  B01D15/42 ,  C11B1/10 ,  C12P7/6427

CPC分类号： A61K31/231 ,  A61P31/10 ,  B01D15/426 ,  C11B1/10 ,  C12P7/6427 ,  A61K2236/35

摘要： A method of using a truffle-derived biomass for producing 1,3-diolein includes obtaining a mycelial biomass from truffles, preparing an extract from the mycelial biomass, and isolating the 1,3-diolein from the extract. In an embodiment, isolating the 1,3-diolein from the extract can include using column chromatography for eluting a portion of a first extract with a mixture including chloroform and methanol into a plurality of fractions, and using column chromatography for eluting at least one of the fractions with methanol to provide 1,3-diolein.

公开(公告)号：US20240318283A1

公开(公告)日：2024-09-26

申请号：US18269411

申请日：2021-12-21

申请人： KOREA ATOMIC ENERGY RESEARCH INSTITUTE

发明人： Kang Hyuk CHOI ,  Ul Jae PARK ,  Jun Sing LEE ,  A Ran KIM

IPC分类号： C22B59/00 ,  B01D15/18 ,  B01D15/36 ,  B01D15/42 ,  C22B3/24 ,  C22B3/42 ,  G21G1/00

CPC分类号： C22B59/00 ,  B01D15/1871 ,  B01D15/362 ,  B01D15/426 ,  C22B3/24 ,  C22B3/42 ,  G21G1/001 ,  G21G2001/0094

摘要： The present invention relates to a method of producing and refining carrier-free lutetium-177 using chromatography, and more specifically to a method of producing and refining carrier-free lutetium 1-77 using chromatography having excellent resolution of lutetium and ytterbium without a concentration gradient of an eluent.

公开(公告)号：US20240269581A1

公开(公告)日：2024-08-15

申请号：US18167979

申请日：2023-02-13

申请人： DIONEX CORPORATION

发明人： Yongjing Chen ,  Yan Liu

IPC分类号： B01D15/42 ,  B01D61/44 ,  B01D61/46

CPC分类号： B01D15/426 ,  B01D61/445 ,  B01D61/46 ,  B01D15/361 ,  B01D2313/13 ,  B01D2313/50 ,  B01D2317/025

摘要： An electrolytic eluent generator system includes a flow-through eluent generating zone, a first reservoir comprising configured to hold a first ion source; a second reservoir configured to hold a second ion source; a first ion exchange connector disposed between the first reservoir and the eluent generating zone, wherein the connector substantially prevents liquid flow through the ion exchange connector and transports ions only of the same charge as said first ions; and a second ion exchange connector disposed between the second reservoir and the eluent generation zone, wherein the connector substantially prevents liquid flow through the ion exchange connector and transports ions only of the same charge as said second ions. The second ion exchange connector is of opposite charge to the first ion exchange connector.

公开(公告)号：US11987853B2

公开(公告)日：2024-05-21

申请号：US17047672

申请日：2019-04-22

申请人： NOVASEP PROCESS SOLUTIONS

发明人： Eric Valery ,  Cédric Prieur

IPC分类号： C13K11/00 ,  B01D15/18 ,  B01D15/42 ,  C13K1/00

CPC分类号： C13K11/00 ,  B01D15/185 ,  B01D15/1871 ,  B01D15/426 ,  C13K1/00

摘要： The invention relates to a method for purifying a mixture to be separated, in a multicolumn chromatography system, the method comprising successively and cyclically:



a step of collecting a raffinate, a step of injecting the mixture to be separated, a step of collecting an extract and an eluent injection step, at an operating temperature;
wherein the mixture to be separated has a viscosity at 20° C. greater than or equal to 3 mPa·s; and wherein the dry matter mass concentration of the mixture to be separated is equal, within 5%, to a threshold concentration, said threshold concentration is such that:
the viscosity of the mixture to be treated at a dry matter mass concentration equal to the threshold concentration and at the operating temperature, is equal to twice the viscosity of the mixture to be treated, at a dry matter mass concentration equal to 85% of the threshold concentration and at the operating temperature.

公开(公告)号：US11931391B2

公开(公告)日：2024-03-19

申请号：US17660848

申请日：2022-04-27

申请人： CARGILL, INCORPORATED

发明人： Skye Doering ,  Dan S. Gaspard ,  Kristopher T. Mortenson ,  Adam T. Zarth

IPC分类号： A61K36/28 ,  A23L2/52 ,  A23L33/105 ,  A61K31/216 ,  A61K36/185 ,  B01D15/12 ,  B01D15/16 ,  B01D15/36 ,  B01D15/42

CPC分类号： A61K36/28 ,  A23L2/52 ,  A23L33/105 ,  A61K31/216 ,  A61K36/185 ,  B01D15/125 ,  B01D15/161 ,  B01D15/363 ,  B01D15/426 ,  A23V2002/00 ,  A61K2236/31 ,  A61K2236/331 ,  A61K2236/333 ,  A61K2236/37 ,  A61K2236/39 ,  A61K2236/55

摘要： A method for making a caffeoylquinic composition from a botanical source is disclosed. The method may include chromatographing an extract of biomass on an ion exchange stationary phase and obtaining an eluent comprising a caffeoylquinic composition. The biomass may be stevia or yerba mate, for example. The caffeoylquinic composition includes one or more of monocaffeoylquinic acid, dicaffeoylquinic acid, and salts of the foregoing.

公开(公告)号：US11912739B2

公开(公告)日：2024-02-27

申请号：US16993654

申请日：2020-08-14

申请人： Genzyme Corporation

发明人： Rahul Godawat ,  Veena Warikoo ,  Rohan Patil ,  Konstantin Konstantinov ,  Venkat Kishore Ryakala ,  Mahsa Rohani

IPC分类号： C07K1/16 ,  A61L2/08 ,  B01D15/18 ,  B01D15/20 ,  B01D15/36 ,  B01D15/38 ,  B01D15/42 ,  C07K1/22 ,  C12N9/40

CPC分类号： C07K1/16 ,  A61L2/081 ,  B01D15/1864 ,  B01D15/20 ,  B01D15/363 ,  B01D15/3809 ,  B01D15/426 ,  C07K1/165 ,  C07K1/22 ,  C12N9/2465 ,  B01D15/1807 ,  C12Y302/01022

摘要： Provided herein are methods of performing chromatography with gamma-irradiated chromatography resin that include providing a chromatography column including a gamma-irradiated chromatography resin; performing a first cycle of chromatography through the column, where the cycle includes exposing the chromatography resin to a denaturing buffer; and performing at least one additional cycle of chromatography through the column. Also provided are integrated, closed or substantially closed, and continuous processes for manufacturing of a recombinant protein that include the use of at least one chromatography column including gamma-irradiated chromatography resin, where the gamma-irradiated chromatography resin is exposed to denaturing buffer during each cycle in the process, and reduced bioburden buffer is used in the process.

公开(公告)号：US11840582B2

公开(公告)日：2023-12-12

申请号：US17373369

申请日：2021-07-12

申请人： Peking University Shenzhen Graduate School

发明人： Zhen Yang ,  Qingzhou Zhang ,  Fengxia Li ,  Chongguo Jiang ,  Jianxian Gong ,  Jun Huang ,  Weibin Zhang

IPC分类号： C07K7/64 ,  B01D11/04 ,  B01D15/42 ,  C07K1/107 ,  C07K1/14 ,  C07K1/16 ,  G01N30/14 ,  G01N30/02

CPC分类号： C07K7/645 ,  B01D11/0492 ,  B01D15/426 ,  C07K1/1077 ,  C07K1/145 ,  C07K1/16 ,  G01N30/14 ,  G01N2030/027

摘要： The present disclosure relates to a method of synthesizing cyclosporine derivatives. The method includes: providing a precursor fluid of the cyclosporine derivative, an alkaline fluid and a ClCH2OCOCl solution; premixing the precursor fluid and the alkaline fluid to obtain a premixed solution; feeding the premixed solution into a first reaction chamber, reacting to prepare a first reaction liquid; feeding the first reaction liquid into a second reaction chamber, reacting the first reaction liquid with a CO2 fluid to prepare a second reaction liquid; and reacting the second reaction liquid with the ClCH2OCOCl solution.

公开(公告)号：US20230357650A1

公开(公告)日：2023-11-09

申请号：US17755331

申请日：2020-07-22

申请人： ExxonMobil Technology and Engineering Company

发明人： Changyub Paek ,  Joseph M. Falkowski ,  Randall D. Partridge ,  Yogesh V. Joshi ,  Carmen C. Lasso

IPC分类号： C10G25/00 ,  B01J20/22 ,  B01J20/34 ,  C10G25/12 ,  B01D15/42

CPC分类号： C10G25/003 ,  B01J20/226 ,  B01J20/3475 ,  B01J20/3425 ,  C10G25/12 ,  B01D15/426

摘要： A process for separating one or more one-ring cycloparaffins and one or more multi-ring cycloparaffins from a hydrocarbon mixture is disclosed. The process comprises the steps of providing the hydrocarbon mixture; and contacting the hydrocarbon mixture with an adsorbent material comprising a metal organic framework to separate the one or more one-ring cycloparaffins and the one or more multi-ring cycloparaffins from the hydrocarbon mixture. The process is conducted in a liquid phase.

公开(公告)号：US20230338568A1

公开(公告)日：2023-10-26

申请号：US18001764

申请日：2020-12-23

申请人： GENEQUANTUM HEALTHCARE (SUZHOU) CO., LTD.

发明人： Gang QIN ,  Chong LIU ,  Lehua HU

IPC分类号： B01D15/18 ,  B01D15/42 ,  A61K47/68 ,  B01D15/32

CPC分类号： A61K47/6855 ,  A61K47/6803 ,  A61K47/6889 ,  B01D15/1871 ,  B01D15/325 ,  B01D15/426

摘要： It relates to the medicinal chemistry field, particularly to a process for separating the isomeric compounds comprising a ring-opened thiosuccinimide group and a chiral moiety.

公开(公告)号：US20230234848A1

公开(公告)日：2023-07-27

申请号：US17918978

申请日：2021-04-16

申请人： RECION TECHNOLOGIES, INC.

发明人： Salman SAFARIMOHSENABAD ,  Daniel S. ALESSI

IPC分类号： C01B25/30 ,  C01D15/02 ,  C01D15/08 ,  B01J39/02 ,  B01J39/10 ,  B01J49/53 ,  C22B26/12 ,  C22B3/42 ,  B01D15/36 ,  B01D15/20 ,  B01D15/42 ,  C25B1/14 ,  C25B1/16

CPC分类号： C01B25/306 ,  C01B25/303 ,  C01D15/02 ,  C01D15/08 ,  B01J39/02 ,  B01J39/10 ,  B01J49/53 ,  C22B26/12 ,  C22B3/42 ,  B01D15/362 ,  B01D15/203 ,  B01D15/426 ,  C25B1/14 ,  C25B1/16 ,  C01P2006/80

摘要： A method of producing lithium phosphate from a lithium source includes the step of (a) concentrating the lithium to produce a lithium concentrate, with an ion exchange sorbent, and (b) reacting the lithium concentrate with phosphate anions to produce lithium phosphate. The lithium phosphate may then be converted to lithium hydroxide or lithium 5 carbonate by reaction with calcium hydroxide or by electrolysis.