公开(公告)号：US20240241086A1

公开(公告)日：2024-07-18

申请号：US18562216

申请日：2022-05-17

Applicant: Agilent Technologies, Inc.

Inventor： Thomas Ortmann ,  Dominik Ruf

IPC: G01N30/22 ,  G01N30/20

CPC classification number: G01N30/22 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/204 ,  G01N2030/207

Abstract: A switching unit is configured for selectively fluidically coupling a sampling volume, a sampling drive, a mobile phase drive, and a separating device. In a sample load configuration, the switching unit is configured for fluidically coupling the sampling volume and the sampling drive, for moving the fluidic sample into the sampling volume. In a decouple configuration, the switching unit is configured for fluidically coupling the sampling volume between the sampling drive and the separating device, while the mobile phase drive is fluidically decoupled from the separating device. In a sample introduction configuration, the switching unit is configured for fluidically coupling the mobile phase drive, the sampling volume, and the separating device for introducing at least an amount of the fluidic sample stored in the sampling volume into the mobile phase for fluid separation by the separating device.

公开(公告)号：US20190120799A1

公开(公告)日：2019-04-25

申请号：US16084456

申请日：2017-03-17

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Sylvain G. CORMIER

IPC: G01N30/20 ,  F16K11/085 ,  G01N30/06 ,  G01N30/22

CPC classification number: G01N30/20 ,  F16K11/085 ,  G01N30/06 ,  G01N30/22 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

Abstract: A rotary injection valve used in chromatography includes a stator having a stator sealing surface and a sample load channel disposed inside the stator body below the stator sealing surface. The valve can have a reduced number of ports thereby allowing faster integration of the valve into a chromatographic system. Flow restriction is reduced compared to valves that use an external sample loop for a similar volume of sample. The lack of stator ports for the sample load channel eliminates the potential for carryover created by external valve couplings. Another advantage is the reduction of surface wear achieved by locating the sample load channel below the stator sealing surface.

公开(公告)号：US20190113484A1

公开(公告)日：2019-04-18

申请号：US16212914

申请日：2018-12-07

Applicant: DIONEX SOFTRON GMBH

Inventor： Hermann HOCHGRAEBER

IPC: G01N30/20 ,  G01N35/10 ,  G01N30/32

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N30/32 ,  G01N35/1097 ,  G01N2030/027 ,  G01N2030/201 ,  G01N2030/207

Abstract: A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column. A sample loop is connected to one of the sample loop ports on one end and to a pump volume of a sample conveying device on the other end. A section of the sample loop can be separated to facilitate receiving a sample fluid in the sample loop. A control unit controls the injection valve and the sample conveying device. The sample injector allows a sample to be loaded into the sample loop and then pressurized to an operating pressure prior to injecting the sample into the chromatography column. The sample loop may also be isolated from the operating pressure for facilitating depressurization of the loop.

公开(公告)号：US20180196018A1

公开(公告)日：2018-07-12

申请号：US15910414

申请日：2018-03-02

Applicant: Agilent Technologies, Inc.

Inventor： Robert William Albrecht, JR.

IPC: G01N30/20 ,  G01N30/34 ,  G01N30/38 ,  B01L3/00 ,  G01N30/02

CPC classification number: G01N30/20 ,  B01L3/502784 ,  G01N30/34 ,  G01N30/38 ,  G01N2030/027 ,  G01N2030/207 ,  G01N2030/347

Abstract: In a liquid chromatography system, a sample is injected into a column by flowing a solvent mixture from a mixer into the column along a solvent mixture flow path; and injecting a sample into the solvent mixture flow path downstream of the mixer. In another liquid chromatography system, a sample is injected into a column by loading an isolator fluid into a sample loop, loading a sample into the sample loop, and flowing the sample into the column as a plug in front of the isolator fluid.

公开(公告)号：US09915634B2

公开(公告)日：2018-03-13

申请号：US14422928

申请日：2012-09-05

Applicant: Akira Aono

Inventor： Akira Aono

IPC: G01N30/16 ,  G01N1/22 ,  G01N30/02

CPC classification number: G01N30/16 ,  G01N1/22 ,  G01N30/24 ,  G01N30/32 ,  G01N2030/009 ,  G01N2030/025 ,  G01N2030/065 ,  G01N2030/202 ,  G01N2030/207

Abstract: A pressurization passage that divides a constant pressure from a pressure source with passage resistances so as to have a predetermined constant pressure is disposed on a downstream side of a sample loop in order to maintain a back pressure of the sample loop constant when a sample gas is collected to the sample loop.

公开(公告)号：US09857339B2

公开(公告)日：2018-01-02

申请号：US14979066

申请日：2015-12-22

Applicant: Waters Technologies Corporation

Inventor： Hillary B Hewitson ,  Sylvain G Cormier ,  Charles H. Phoebe, Jr. ,  Aaron D Phoebe

IPC: G01N30/20 ,  G01N30/06 ,  G01N30/24 ,  G01N35/10 ,  G01N35/00

CPC classification number: G01N30/20 ,  G01N30/06 ,  G01N30/24 ,  G01N35/1097 ,  G01N2030/067 ,  G01N2030/207 ,  G01N2035/00514 ,  G01N2035/1032

Abstract: Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve. The external sampling valve is connected to a priming valve and can be configured to draw sample from a reactor or a reactor stream. The microreactor is connected to a reagent valve and an injection valve. The reagent valve can be configured to draw reagent from a reagent reservoir and discharge reagent to the microreactor to react with sample. The priming valve can be configured to draw wash from a wash reservoir and discharge wash to the external sampling valve to move sample from the external sampling valve to the microreactor. The injection valve is in fluidic communication with a column or detector and discharges the secondary sample into a solvent composition stream.

公开(公告)号：US20170284979A1

公开(公告)日：2017-10-05

申请号：US15622913

申请日：2017-06-14

Applicant: Agilent Technologies, Inc.

Inventor： Bernd Glatz ,  Wolfgang Kretz

IPC: G01N30/20 ,  G01N30/32

CPC classification number: G01N30/20 ,  G01N30/32 ,  G01N30/36 ,  G01N2030/027 ,  G01N2030/207

Abstract: A sample injector for use in a fluid separation system for separating compounds of a fluidic sample in a mobile phase, the sample injector comprising a switchable valve, a sample loop in fluid communication with the valve and configured for receiving the fluidic sample, a metering device in fluid communication with the sample loop and configured for introducing a metered amount of the fluidic sample on the sample loop, and a control unit configured for controlling switching of the valve to transfer the sample loop between a low pressure state and a high pressure state via an intermediate state and for controlling the metering device during the intermediate state to at least partially equilibrate a pressure difference in the sample loop between the low pressure state and the high pressure state.

公开(公告)号：US20170173496A1

公开(公告)日：2017-06-22

申请号：US15400473

申请日：2017-01-06

Applicant: Mark A. Stone

Inventor： Mark A. Stone

IPC: B01D15/14 ,  B01D15/30 ,  B01D15/32 ,  G01N30/16 ,  B01D15/40

CPC classification number: B01D15/14 ,  B01D15/305 ,  B01D15/322 ,  B01D15/40 ,  G01N30/16 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  G01N2030/387

Abstract: Low-retention pre-columns that allow increased injection volumes of solvents chromatographically stronger than the mobile phase and use of solvents with limited solubility in the mobile phase, such as ethyl acetate and MTBE. The system and method also reduces band broadening due to the extra-column effects acting upstream of the analytical column, including band broadening due to the injection process and due to the connecting tubing and fittings between the injection system and the column. A pre-column may also be used as a guard column, thereby minimizing band broadening due to the guard column.

公开(公告)号：US09310342B2

公开(公告)日：2016-04-12

申请号：US13122602

申请日：2009-10-06

Applicant: Toshikatsu Sakai ,  Akira Sezaki ,  Takeshi Takagi ,  Takuya Yotani ,  Makoto Takahara ,  Takayuki Oka

Inventor： Toshikatsu Sakai ,  Akira Sezaki ,  Takeshi Takagi ,  Takuya Yotani ,  Makoto Takahara ,  Takayuki Oka

IPC: G01N30/24 ,  G01N30/26 ,  G01N30/20 ,  G01N30/88 ,  B01D15/16 ,  G01N30/74

CPC classification number: G01N30/24 ,  B01D15/16 ,  G01N30/26 ,  G01N30/34 ,  G01N30/74 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207 ,  G01N2030/8822

Abstract: A liquid chromatography apparatus is provided with a sample preparation unit, a column that separates components of a sample, an eluent supplier that includes a feeder for supplying eluents to the column, a flow path directional valve capable of introducing fixed amounts of the sample and the eluents to the column, an analyzer for analyzing a test solution composed of the sample components separated by the column and one of the eluents, and a controller, wherein the eluent supplier supplies the eluents to the flow path directional valve in an unmixed state. As a result of employing this configuration, analysis time is shortened and eluent consumption is reduced.

Abstract translation: 液相色谱装置具有样品制备单元，分离样品组分的柱，包括用于向柱供给洗脱液的供给器的洗脱液供给器，能够引入固定量的样品的流路切换阀和 用于分析由柱分离的样品组分和洗脱液之一组成的测试溶液的分析器和控制器，其中洗脱剂供体以未混合的状态将洗脱液供应到流路换向阀。 由于采用这种结构，分析时间缩短，洗脱液消耗减少。

公开(公告)号：US20160061788A1

公开(公告)日：2016-03-03

申请号：US14786397

申请日：2014-04-22

Applicant: SEKISUI MEDICAL CO., LTD.

Inventor： Takuya Yotani ,  Hiroaki Taira ,  Takayuki Oka ,  Hideki Muraki

IPC: G01N30/20 ,  G01N33/49

CPC classification number: G01N30/20 ,  G01N33/491 ,  G01N35/1097 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

Abstract: A switching valve includes: (A) a rotor including: (1) a center pipe connection port, (2) a first in-valve flow path in communication with the center pipe connection port, and (3) an arc-like second in-valve flow path; (B) a stator including: (4) a first pipe connection port group which is brought into communication independently with the center pipe connection port via the first in-valve flow path when the rotor is turned, and (5) a second pipe connection port group which is brought into mutual communication via the second in-valve flow path when the rotor is turned; and (C) an arrangement of the rotor and the stator satisfying the following relationship: the state of communication or non-communication among the second pipe connection port group via the second in-valve flow path is switched in accordance with the state of communication between the first pipe connection port group and the center pipe connection port.

Abstract translation: 一种切换阀，包括：（A）转子，包括：（1）中心管连接口，（2）与中心管连接口连通的第一阀门流路，（3）弧形第二 阀门流路; （B）定子，包括：（4）第一管连接端口组，当所述转子转动时，所述第一管连接端口组经由所述第一阀内流路与所述中心管连接口独立连通，以及（5）第二管连接 端子组，当转子旋转时，通过第二入口流路相互连通; 和（C）转子和定子的布置满足以下关系：根据第二管连接端口组之间的通过第二管路连通口组的通信状态或非连通状态根据第 第一个管道连接端口组和中心管道连接端口。