公开(公告)号：US20160041072A1

公开(公告)日：2016-02-11

申请号：US14781200

申请日：2014-03-27

申请人： SEKISUI MEDICAL CO., LTD.

发明人： Takuya Yotani ,  Takayuki Oka ,  Hideki Muraki

IPC分类号： G01N1/14 ,  G01N33/49 ,  G01N15/14

CPC分类号： G01N1/14 ,  G01N15/1429 ,  G01N30/16 ,  G01N30/18 ,  G01N33/491 ,  G01N33/4915 ,  G01N35/1016 ,  G01N35/1095 ,  G01N2015/1486 ,  G01N2030/8822

摘要： Provided is a sample injection device for flow-type analysis including a cylindrical needle (27) which penetrates through an upper wall and a lower wall of a sample injection portion (22) of a carrier-liquid channel through ring-like sealing members (25, 26). The needle (27) includes an inner hole (41) which is closed on a side of a lower end of the needle (27) and open on an outer peripheral surface as a horizontal hole (42). The needle moving unit (44) induces the needle (27) to move downward so that the horizontal hole (42) faces an inside of a sample vessel (40) to draw the sample to the inside of the needle (27). Then the moving unit (44) induces the needle (27) to move upward so that the horizontal hole (42) faces an inside of the sample injection portion (22) to inject the sample in the inside of the needle (27). At an intermediate position, washing liquid is discharged from the horizontal hole (42) of the needle (27), and the washing liquid is recovered via a discharge path (15).

摘要翻译： 本发明提供一种用于流动型分析的样品注射装置，其包括圆柱形针（27），其穿过环状密封构件（25）穿过载液通道的样品注入部分（22）的上壁和下壁 ，26）。 针（27）包括在针（27）的下端侧封闭并且在作为水平孔（42）的外周面上开口的内孔（41）。 针移动单元（44）引导针（27）向下移动，使得水平孔（42）面向样品容器（40）的内部，以将样品抽吸到针（27）的内部。 然后，移动单元（44）引导针（27）向上移动，使得水平孔（42）面向样品注射部分（22）的内部，以将样品注射到针（27）的内部。 在中间位置，洗涤液从针（27）的水平孔（42）排出，洗涤液通过排出路径（15）回收。

公开(公告)号：USD734484S1

公开(公告)日：2015-07-14

申请号：US29480095

申请日：2014-01-23

申请人： SEKISUI MEDICAL CO., LTD.

设计人： Masato Nishikawa ,  Takayuki Oka ,  Takuya Yotani

公开(公告)号：US09778232B2

公开(公告)日：2017-10-03

申请号：US14775402

申请日：2014-03-11

申请人： Sekisui Medical Co., Ltd.

发明人： Takuya Yotani ,  Takayuki Oka ,  Hideki Muraki

IPC分类号： G01N30/60 ,  G01N30/16 ,  G01N30/88

CPC分类号： G01N30/6026 ,  G01N30/16 ,  G01N30/6004 ,  G01N30/603 ,  G01N30/6047 ,  G01N30/6052 ,  G01N30/606 ,  G01N2030/8822

摘要： A cylindrical column body (101) holds a filler. A pair of end caps (105, 106) covers both ends of the column body (101) and has a flow hole for a carrier liquid (111, 112) arranged in the center thereof. An end surface on the side of a large diameter portion (113a, 114a) of a pair of columnar joint members (113, 114) contacts an end surface of the pair of end caps (105, 106) and also has a communication hole (115, 116) arranged in the center thereof. A sealing member (117, 118) is arranged on a contact surface between the end cap (105, 106) and the joint member (113, 114). A bottomed cylindrical case (121) accommodates the pair of end caps (105, 106) and a large diameter portion of the pair of joint members (113, 114) in an engaged state. A cover member (124) is detachably installed on a side of an opening of the case (121).

公开(公告)号：US09304139B2

公开(公告)日：2016-04-05

申请号：US14508143

申请日：2014-10-07

申请人： SEKISUI MEDICAL CO., LTD.

发明人： Hiroaki Taira ,  Takayuki Oka

IPC分类号： G01N33/72 ,  G01N33/48 ,  G01N30/06 ,  G01N30/34 ,  G01N30/88 ,  B01D15/36 ,  G01N30/96

CPC分类号： G01N33/721 ,  B01D15/362 ,  G01N30/06 ,  G01N30/34 ,  G01N30/96 ,  G01N2030/067 ,  G01N2030/8822 ,  G01N2030/8831 ,  G01N2440/00

摘要： An object of the present invention is to provide a method for analyzing hemoglobins which can accurately separate hemoglobins in a short time by liquid chromatography. The method for analyzing hemoglobins by liquid chromatography includes pretreating a sample with an oxidant and a binder for trivalent heme iron.

摘要翻译： 本发明的目的是提供一种分析血红蛋白的方法，其可以通过液相色谱在短时间内精确分离血红蛋白。 通过液相色谱分析血红蛋白的方法包括用氧化剂和三价血红素铁的粘合剂预处理样品。

公开(公告)号：USD719671S1

公开(公告)日：2014-12-16

申请号：US29480094

申请日：2014-01-23

申请人： Sekisui Medical Co., Ltd.

设计人： Masato Nishikawa ,  Takayuki Oka ,  Takuya Yotani

公开(公告)号：US09841406B2

公开(公告)日：2017-12-12

申请号：US14786397

申请日：2014-04-22

申请人： Sekisui Medical Co., Ltd.

发明人： Takuya Yotani ,  Hiroaki Taira ,  Takayuki Oka ,  Hideki Muraki

IPC分类号： G01N30/20 ,  G01N35/10 ,  G01N33/49

CPC分类号： G01N30/20 ,  G01N33/491 ,  G01N35/1097 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/207

摘要： A switching valve includes: (A) a rotor including: (1) a center pipe connection port, (2) a first in-valve flow path in communication with the center pipe connection port, and (3) an arc-like second in-valve flow path; (B) a stator including: (4) a first pipe connection port group which is brought into communication independently with the center pipe connection port via the first in-valve flow path when the rotor is turned, and (5) a second pipe connection port group which is brought into mutual communication via the second in-valve flow path when the rotor is turned; and (C) an arrangement of the rotor and the stator satisfying the following relationship: the state of communication or non-communication among the second pipe connection port group via the second in-valve flow path is switched in accordance with the state of communication between the first pipe connection port group and the center pipe connection port.

公开(公告)号：US09810604B2

公开(公告)日：2017-11-07

申请号：US14781200

申请日：2014-03-27

申请人： Sekisui Medical Co., Ltd.

发明人： Takuya Yotani ,  Takayuki Oka ,  Hideki Muraki

IPC分类号： G01N35/10 ,  G01N1/14 ,  G01N30/16 ,  G01N15/14 ,  G01N33/49 ,  G01N30/18 ,  G01N30/88

CPC分类号： G01N1/14 ,  G01N15/1429 ,  G01N30/16 ,  G01N30/18 ,  G01N33/491 ,  G01N33/4915 ,  G01N35/1016 ,  G01N35/1095 ,  G01N2015/1486 ,  G01N2030/8822

摘要： Provided is a sample injection device for flow-type analysis including a cylindrical needle (27) which penetrates through an upper wall and a lower wall of a sample injection portion (22) of a carrier-liquid channel through ring-like sealing members (25, 26). The needle (27) includes an inner hole (41) which is closed on a side of a lower end of the needle (27) and open on an outer peripheral surface as a horizontal hole (42). The needle moving unit (44) induces the needle (27) to move downward so that the horizontal hole (42) faces an inside of a sample vessel (40) to draw the sample to the inside of the needle (27). Then the moving unit (44) induces the needle (27) to move upward so that the horizontal hole (42) faces an inside of the sample injection portion (22) to inject the sample in the inside of the needle (27). At an intermediate position, washing liquid is discharged from the horizontal hole (42) of the needle (27), and the washing liquid is recovered via a discharge path (15).

公开(公告)号：US20160153942A1

公开(公告)日：2016-06-02

申请号：US14905472

申请日：2014-07-17

申请人： SEKISUI MEDICAL CO., LTD.

发明人： Takuya Yotani ,  Hiroaki Taira ,  Takayuki Oka ,  Hideki Muraki

IPC分类号： G01N30/34 ,  G01N33/49 ,  G01N30/16

CPC分类号： G01N30/34 ,  G01N30/16 ,  G01N30/88 ,  G01N33/491 ,  G01N2030/027 ,  G01N2030/347 ,  G01N2030/8822

摘要： A gradient liquid feed device allows reduction in size of a high performance liquid chromatography type sample analyzer. The gradient liquid feed device includes a plurality of carrier liquid reservoir tanks configured to store carrier liquids of mutually different compositions, a plurality of single plunger pumps capable of drawing and discharging the carrier liquid from the plurality of carrier liquid reservoir tanks, a mixer configured to mix the carrier liquids discharged from the plurality of liquid feed pumps and feed the mixed carrier liquid, and a pulse damper in communication with the mixer and configured to absorb pulsation that may occur during liquid feeding. The single plunger pumps have a function for variably setting a length of stroke for drawing and discharging the carrier liquid and a function for variably setting a ratio between the carrier liquid drawing time and the carrier liquid discharge time.

摘要翻译： 梯度液体供给装置允许降低高效液相色谱型样品分析仪的尺寸。 梯度液体供给装置包括：多个载液储存箱，其配置成储存相互不同组成的载液;多个单柱塞泵，能够从多个载液储罐中抽吸和排出载液;混合器， 混合从多个液体供给泵排出的载液，并输送混合载液，以及与混合器连通的脉冲阻尼器，并配置成吸收在液体供给期间可能发生的脉动。 单柱塞泵具有用于可变地设定用于抽吸和排出载液的行程长度的功能，以及用于可变地设定载液时间与载液排出时间之间的比率的功能。

公开(公告)号：US20160103103A1

公开(公告)日：2016-04-14

申请号：US14775402

申请日：2014-03-11

申请人： SEKISUI MEDICAL CO., LTD.

发明人： Takuya Yotani ,  Takayuki Oka ,  Hideki Muraki

IPC分类号： G01N30/60 ,  G01N30/16

CPC分类号： G01N30/6026 ,  G01N30/16 ,  G01N30/6004 ,  G01N30/603 ,  G01N30/6047 ,  G01N30/6052 ,  G01N30/606 ,  G01N2030/8822

摘要： A cylindrical column body (101) holds a filler. A pair of end caps (105, 106) covers both ends of the column body (101) and has a flow hole for a carrier liquid (111, 112) arranged in the center thereof. An end surface on the side of a large diameter portion (113a, 114a) of a pair of columnar joint members (113, 114) contacts an end surface of the pair of end caps (105, 106) and also has a communication hole (115, 116) arranged in the center thereof. A sealing member (117, 118) is arranged on a contact surface between the end cap (105, 106) and the joint member (113, 114). A bottomed cylindrical case (121) accommodates the pair of end caps (105, 106) and a large diameter portion of the pair of joint members (113, 114) in an engaged state. A cover member (124) is detachably installed on a side of an opening of the case (121).

摘要翻译： 圆柱形柱体（101）保持填料。 一对端盖（105,106）覆盖柱体（101）的两端，并具有用于布置在其中心的载液（111,112）的流动孔。 一对柱状接头构件（113,114）的大径部（113a，114a）侧的端面与一对端盖（105,106）的端面接触，并且还具有连通孔 115,116）。 密封构件（117,118）布置在端盖（105,106）和接头构件（113,114）之间的接触表面上。 有底的圆筒形壳体（121）在一对接合状态下容纳一对端盖（105,106）和一对接头构件（113,114）的大直径部分。 盖构件（124）可拆卸地安装在壳体（121）的开口的一侧。

公开(公告)号：US20140287453A1

公开(公告)日：2014-09-25

申请号：US14357274

申请日：2012-11-09

申请人： Sekisui Medical Co., Ltd.

发明人： Takayuki Oka ,  Takuya Yotani ,  Hideki Muraki

IPC分类号： G01N1/14

CPC分类号： G01N1/14 ,  G01N30/18 ,  G01N30/20 ,  G01N2030/8822

摘要： When injecting a sample into carrier-liquid channels (3A and 3B), injection shock is prevented. Septa 13 and 14 constitute the upper wall and the lower wall of a sample injection part (11) of the carrier-liquid channels (3A and 3B). A needle (27) can vertically penetrate the septum (13) on the upper wall side and also penetrate the septum (14) on the lower wall side. A needle moving unit (28) induces the needle (27) to penetrate the septum (14) on the lower wall side and induces the tip of the needle to face the inside of a sample vessel (26). A measurement pump (29) is operated for drawing and as a result a sample is drawn into the needle (27). Next, the needle (27) is extracted from the septum (14) on the lower wall side, the tip of the needle is induced to face the inside of the sample injection part (11), the measurement pump (29) is caused to discharge and as a result the sample within the needle (27) is injected.

摘要翻译： 当将样品注入载液通道（3A和3B）时，可防止注射冲击。 隔垫13和14构成载液通道（3A和3B）的样品注入部分（11）的上壁和下壁。 针（27）可以垂直地穿透上壁侧的隔膜（13）并且还穿过下壁侧的隔膜（14）。 针移动单元（28）引导针（27）穿过下壁侧的隔膜（14），并且引导针的尖端面对样品容器（26）的内部。 操作测量泵（29）进行拉伸，结果将样品吸入针（27）。 接下来，从下壁侧的隔膜（14）取出针（27），引导针尖朝向试样注入部（11）的内部，使测定用泵（29） 放电，结果注射针（27）内的样品。