公开(公告)号：US20230187198A1

公开(公告)日：2023-06-15

申请号：US18066099

申请日：2022-12-14

Applicant: Waters Technologies Corporation

Inventor： Joseph A. Jarrell ,  Patrick Brophy ,  Kevin Giles

IPC: H01J49/42 ,  H01J49/00

CPC classification number: H01J49/429 ,  H01J49/4245 ,  H01J49/0036

Abstract: There is provided a method of operating a charge detection mass spectrometer (CDMS), the CDMS comprising an electrostatic ion trap, the electrostatic ion trap comprising a plurality of electrodes, the method comprising: a) introducing a first ion into the electrostatic ion trap at a first ion energy, b) setting the voltage of the plurality of electrodes to a first voltage map, c) obtaining first CDMS data indicative of a first ion oscillation frequency, d) obtaining an acceptable range or ranges of ion oscillation frequencies, e) changing the first ion energy to a second ion energy and/or changing the first voltage map to a second voltage map, and f) obtaining second CDMS data indicative of a second ion oscillation frequency.

公开(公告)号：US20180252684A1

公开(公告)日：2018-09-06

申请号：US15909264

申请日：2018-03-01

Applicant: Waters Technologies Corporation

Inventor： Michael O. Fogwill ,  Joseph A. Jarrell ,  Joseph D. Michienzi ,  Thomas S. McDonald

IPC: G01N30/32 ,  G01N30/34 ,  G01N30/72

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01D15/40 ,  G01N30/34 ,  G01N30/36 ,  G01N30/62 ,  G01N30/7233 ,  G01N2030/326 ,  G01N2030/347 ,  G01N2030/623

Abstract: The present disclosure relates to methodologies, systems and apparatus for controlling pressure in a CO2-based chromatography system. A first CO2 pump operates in constant flow mode and delivers CO2 to a chromatography column, and liquid modifier is introduced to the chromatography column according to a gradient. A second CO2 pump is disposed downstream of the column and operates in constant pressure mode to introduce CO2 into a flow stream at an output of the column. Liquid modifier is also introduced into the flow stream at the output of the column according to a reverse gradient compared to the gradient entering the chromatography column.

公开(公告)号：US09362098B2

公开(公告)日：2016-06-07

申请号：US14579038

申请日：2014-12-22

Applicant: Waters Technologies Corporation

Inventor： Joseph A. Jarrell

IPC: H01J49/40 ,  H01J49/26 ,  H01J49/00 ,  H01J27/00 ,  H01J49/06

CPC classification number: H01J49/06 ,  H01J49/405

Abstract: An ion optical element that may be used as an ion guide in a mass spectrometer, as a reflectron in a time-of-flight mass spectrometer, as an ion mobility drift tube in an ion mobility spectrometer, or as a collision cell or reaction cell in a mass spectrometer. The ion optical element has an inner tube made of a first ceramic material within an outer ceramic tube made of a second ceramic material. The electrical resistivity of the second ceramic material is two orders of magnitude or more higher than the electrical resistivity of the first ceramic material. In certain embodiments, the thermal conductivity of the second ceramic material is at least about an order of magnitude higher than the thermal conductivity of the first ceramic material.

Abstract translation: 可以在质谱仪中用作离子导向器的离子光学元件，作为飞行时间质谱仪中的反射器，作为离子迁移谱仪中的离子迁移率漂移管，或者作为碰撞池或反应池 在质谱仪中。 离子光学元件具有由第二陶瓷材料制成的外陶瓷管内的由第一陶瓷材料制成的内管。 第二陶瓷材料的电阻率比第一陶瓷材料的电阻率高两个数量级。 在某些实施例中，第二陶瓷材料的热导率比第一陶瓷材料的热导率高至少约一个数量级。

公开(公告)号：US20150179421A1

公开(公告)日：2015-06-25

申请号：US14579038

申请日：2014-12-22

Applicant: Waters Technologies Corporation

Inventor： Joseph A. Jarrell

IPC: H01J49/06 ,  H01J49/40

CPC classification number: H01J49/06 ,  H01J49/405

Abstract: An ion optical element that may be used as an ion guide in a mass spectrometer, as a reflectron in a time-of-flight mass spectrometer, as an ion mobility drift tube in an ion mobility spectrometer, or as a collision cell or reaction cell in a mass spectrometer. The ion optical element has an inner tube made of a first ceramic material within an outer ceramic tube made of a second ceramic material. The electrical resistivity of the second ceramic material is two orders of magnitude or more higher than the electrical resistivity of the first ceramic material. In certain embodiments, the thermal conductivity of the second ceramic material is at least about an order of magnitude higher than the thermal conductivity of the first ceramic material.

Abstract translation: 可以在质谱仪中用作离子导向器的离子光学元件，作为飞行时间质谱仪中的反射器，作为离子迁移谱仪中的离子迁移率漂移管，或者作为碰撞池或反应池 在质谱仪中。 离子光学元件具有由第二陶瓷材料制成的外陶瓷管内的由第一陶瓷材料制成的内管。 第二陶瓷材料的电阻率比第一陶瓷材料的电阻率高两个数量级。 在某些实施例中，第二陶瓷材料的热导率比第一陶瓷材料的热导率高至少约一个数量级。

公开(公告)号：US20150118762A1

公开(公告)日：2015-04-30

申请号：US14523350

申请日：2014-10-24

Applicant: Waters Technologies Corporation

Inventor： Michael J. Tomany ,  Marc V. Gorenstein ,  Joseph A. Jarrell

IPC: G01N33/00

CPC classification number: H01J49/10 ,  G01N30/72 ,  G01N30/7266 ,  G01N33/6848 ,  H01J49/0445 ,  H01J49/145 ,  Y10T436/25875

Abstract: A method of ionizing a sample includes providing an aqueous liquid and directing a jet comprising carbon dioxide to interact with the provided aqueous liquid. One or both of the aqueous liquid and the jet comprise the sample. At least a portion of the sample is ionized due to the interaction.

Abstract translation: 电离样品的方法包括提供水性液体并引导包含二氧化碳的射流以与所提供的水性液体相互作用。 含水液体和射流中的一种或两种包含样品。 由于相互作用，至少一部分样品被电离。

公开(公告)号：US20150048255A1

公开(公告)日：2015-02-19

申请号：US14458311

申请日：2014-08-13

Applicant: Waters Technologies Corporation (a Delaware corp)

Inventor： Joseph A. Jarrell

IPC: H01J49/10 ,  H01J49/04 ,  H01J49/26

CPC classification number: H01J49/16 ,  H01J49/0454

Abstract: An ion source for a mass spectrometer and a method of ionizing a sample are disclosed. A droplet generator is configured to emit a stream of analyte droplets, which are ionized upon impact with a target, thus forming an ion stream. Preferably, the droplets have a diameter that is greater than a preset value to increase the kinetic energy of the droplets. Additionally, the droplet generator can be configured to create a gas flow that increases the kinetic energy of the droplets. In one embodiment, the target is positioned upstream of an inlet of a mass spectrometer so that the ion stream enters the inlet. In another preferred embodiment, the target is positioned downstream of the inlet so that the stream of droplets passes through the inlet of the mass spectrometer, and the inlet is provided with a pressure drop that increases the kinetic energy of the droplets.

Abstract translation: 公开了用于质谱仪的离子源和离子化样品的方法。 液滴发生器被配置为发射分析物液滴流，其在与靶碰撞时被离子化，从而形成离子流。 优选地，液滴具有大于预设值的直径以增加液滴的动能。 另外，液滴发生器可以被配置成产生增加液滴动能的气流。 在一个实施方案中，靶位于质谱仪的入口的上游，使得离子流进入入口。 在另一个优选实施例中，靶位于入口的下游，使得液滴流通过质谱仪的入口，并且入口设置有增加液滴的动能的压降。

公开(公告)号：US11273390B2

公开(公告)日：2022-03-15

申请号：US16570534

申请日：2019-09-13

Applicant: Waters Technologies Corporation

Inventor： Edouard S. P. Bouvier ,  Pamela C. Iraneta ,  Joseph A. Luongo ,  Joseph A. Jarrell

IPC: B01D15/22 ,  B01D15/16 ,  B01D15/20 ,  G01N30/30 ,  G01N30/54 ,  G01N30/88 ,  G01N30/02

Abstract: An apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column wherein the insulating member is formed from a vacuum chamber surrounding the chromatography column. Another apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column, wherein the insulating member includes aerogel. Also described is a method of insulating a chromatography column comprising forming a jacket surrounding the chromatography column, and creating a vacuum chamber in an area between the jacket and the chromatography column.

公开(公告)号：US11185795B2

公开(公告)日：2021-11-30

申请号：US15487599

申请日：2017-04-14

Applicant: Waters Technologies Corporation

Inventor： Edouard S. P. Bouvier ,  Joseph A. Jarrell ,  Wade P. Leveille ,  Fabrice Gilles Ernest Gritti ,  Theodore A. Dourdeville ,  Michael O. Fogwill

IPC: B01D15/16 ,  B01D15/20 ,  B01D15/22 ,  G01N30/30 ,  G01N30/60 ,  G01N30/02 ,  G01N30/32

Abstract: Apparatus and methods for performing chromatography may include a chromatography column and a vacuum insulated jacket having an inner wall and an outer wall. A vacuum area may be formed between the inner wall and the outer wall. The inner wall of the vacuum insulated jacket may surround the chromatography column. A gap may be formed between an outer wall of the chromatography column and the inner wall of the vacuum insulated jacket. The vacuum insulated jacket may extend beyond one or more end frits of the column. The gap may be filled with one or more materials so as to form an insulating or thermal barrier.

公开(公告)号：US10413846B2

公开(公告)日：2019-09-17

申请号：US14406279

申请日：2013-06-26

Applicant: Waters Technologies Corporation

Inventor： Edouard S.P. Bouvier ,  Pamela C. Iraneta ,  Joseph A. Luongo ,  Joseph A. Jarrell

IPC: B01D15/16 ,  B01D15/20 ,  B01D15/22 ,  G01N30/30 ,  G01N30/54 ,  G01N30/88 ,  G01N30/02

Abstract: An apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column wherein the insulating member is formed from a vacuum chamber surrounding the chromatography column. Another apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column, wherein the insulating member includes aerogel. Also described is a method of insulating a chromatography column comprising forming a jacket surrounding the chromatography column, and creating a vacuum chamber in an area between the jacket and the chromatography column.

公开(公告)号：US20170282096A1

公开(公告)日：2017-10-05

申请号：US15487599

申请日：2017-04-14

Applicant: Waters Technologies Corporation

Inventor： Edouard S.P. Bouvier ,  Joseph A. Jarrell ,  Wade P. Leveille ,  Fabrice Gilles Ernest Gritti ,  Theodore A. Dourdeville ,  Michael O. Fogwill

IPC: B01D15/16 ,  G01N30/60 ,  G01N30/30 ,  G01N30/32 ,  B01D15/22 ,  B01D15/20

CPC classification number: B01D15/161 ,  B01D15/20 ,  B01D15/22 ,  G01N30/30 ,  G01N30/32 ,  G01N30/6052 ,  G01N2030/027 ,  G01N2030/3007

Abstract: Apparatus and methods for performing chromatography may include a chromatography column and a vacuum insulated jacket having an inner wall and an outer wall. A vacuum area may be formed between the inner wall and the outer wall. The inner wall of the vacuum insulated jacket may surround the chromatography column. A gap may be formed between an outer wall of the chromatography column and the inner wall of the vacuum insulated jacket. The vacuum insulated jacket may extend beyond one or more end frits of the column. The gap may be filled with one or more materials so as to form an insulating or thermal barrier.