公开(公告)号：US12106953B2

公开(公告)日：2024-10-01

申请号：US18274597

申请日：2022-03-15

Applicant: INFICON, Inc.

Inventor： Norbert Mueller ,  Daniel Vanoni ,  Jochen Wagner

IPC: H01J49/14 ,  G01N27/64 ,  G01N30/72 ,  H01J49/00

CPC classification number: H01J49/147 ,  G01N27/64 ,  G01N30/7206 ,  H01J49/0031 ,  H01J49/145

Abstract: A wide-range ion source for a mass spectrometer comprises a first portion and a second portion that is positioned downstream of the first portion. The first portion includes an anode and a first filament that is positioned proximate the anode and secured in place relative to the anode. The first filament is exposed to a pressure of a process chamber. A first electron repeller has at least a partially circular shape. The second portion includes a tubular anode, a second filament surrounding the tubular anode, an extraction lens defining an opening and a focus lens to conduct ions into a volume.

公开(公告)号：US20190157056A1

公开(公告)日：2019-05-23

申请号：US16259769

申请日：2019-01-28

Applicant: LECO Corporation

Inventor： Anatoly N. Verenchikov ,  Alexander Kolosov

IPC: H01J49/00 ,  H01J49/14 ,  H01J49/10 ,  H01J49/04

CPC classification number: H01J49/0031 ,  G01N2030/8482 ,  H01J49/0036 ,  H01J49/0418 ,  H01J49/102 ,  H01J49/145

Abstract: One aspect of the disclosure provides a method of mass spectrometric analysis that includes producing either glow discharge within a noble gas between 3-100 mBar pressure, sampling and conditioning glow discharge products within a gas flow through a conductive channel, removing charged particles while transferring excited Ridberg atoms, and mixing conditioned discharge products with analyte flow within an enclosed chamber at elevated temperatures above 150° Celsius for producing a Penning reaction between analyte molecules and Ridberg atoms. The method further includes sampling, by a gas flow, said analyte ions for mass spectrometric analysis, and at least one of the following steps: (i) removing charge within said conditioning channel; (ii) coaxially mixing of analyte flow with the flow of conditioned plasma; and (iii) cooling of the mixed flow within a sonic or supersonic jet for reducing the region of Penning ionization to cold jet.

公开(公告)号：US20180277349A1

公开(公告)日：2018-09-27

申请号：US15922377

申请日：2018-03-15

Applicant: Smiths Detection-Watford Limited

Inventor： Stephen Taylor ,  Jonathan Atkinson

IPC: H01J49/14 ,  H01J49/00 ,  G01N27/62

CPC classification number: H01J49/145 ,  G01N27/622 ,  H01J49/0009 ,  H01J49/0031 ,  H01J49/0072 ,  H01J49/10

Abstract: An ionising apparatus for ionising a sample of gaseous fluid. The ionising apparatus comprises an ioniser configured to provide reactant ions; an ion modifier configured to modify the reactant ions, and a reaction region arranged to receive the modified reactant ions and a sample and to combine the sample with the modified reactant ions to ionise the sample for analysis by a detector configured to identify a substance of interest in the sample.

公开(公告)号：US10012623B2

公开(公告)日：2018-07-03

申请号：US15529309

申请日：2015-11-20

Applicant: Marco Cisterni

Inventor： Marco Cisterni

IPC: H01J49/00 ,  G01N30/72 ,  G01N30/14 ,  H01J49/14

CPC classification number: G01N30/7206 ,  G01N30/14 ,  G01N2030/143 ,  H01J49/0031 ,  H01J49/10 ,  H01J49/145 ,  H01J49/147

Abstract: Gas chromatograph-mass spectrometer comprising an ion source, the walls of which are realized or covered with at least one layer of graphene. Thus realized, the gas chromato graph-mass spectrometer proves to be particularly suited to the analysis samples containing hydrogen in addition to the substances to be analyzed. This situation generally occurs when the mass spectrometer is coupled to a gas chromatograph that utilizes hydrogen as the carrier gas.

公开(公告)号：US09929000B2

公开(公告)日：2018-03-27

申请号：US14523350

申请日：2014-10-24

Applicant: Waters Technologies Corporation

Inventor： Michael J. Tomany ,  Marc V. Gorenstein ,  Joseph A. Jarrell

IPC: H01J49/00 ,  H01J49/10 ,  H01J49/14 ,  G01N30/72 ,  G01N33/68 ,  H01J49/04

CPC classification number: H01J49/10 ,  G01N30/72 ,  G01N30/7266 ,  G01N33/6848 ,  H01J49/0445 ,  H01J49/145 ,  Y10T436/25875

Abstract: A method of ionizing a sample includes providing an aqueous liquid and directing a jet comprising carbon dioxide to interact with the provided aqueous liquid. One or both of the aqueous liquid and the jet comprise the sample. At least a portion of the sample is ionized due to the interaction.

公开(公告)号：US09679755B2

公开(公告)日：2017-06-13

申请号：US15049366

申请日：2016-02-22

Applicant: SHIMADZU CORPORATION

Inventor： Yusuke Tateishi ,  Kazuteru Takahashi ,  Hideki Sato

IPC: H01J49/10 ,  H01J49/14

CPC classification number: H01J49/147 ,  H01J27/024 ,  H01J27/205 ,  H01J49/067 ,  H01J49/145

Abstract: In an ion source 3 in which a repeller electrode 32 for forming a repelling electric field that repels ions toward an ion emission port 311 is provided inside of an ionization chamber 31, ion focusing electrodes 36 and 37 are respectively arranged between an electron introduction port 312 and a filament 34 and between an electron discharge port 313 and a counter filament 35. An electric field formed by applying a predetermined voltage to each of the ion focusing electrodes 36 and 37 intrudes into the ionization chamber 31 through the electron introduction port 312 and the electron discharge port 313, and becomes a focusing electric field that pushes the ions in an ion optical axis C direction. Ions at positions off a central part of the ionization chamber 31 receive the combined force of the force of the repelling electric field and the force of the focusing electric field, and move toward the ion emission port 311 while approaching the ion optical axis C. Accordingly, the amount of ions sent out from the ion emission port increases. Further, even if a charge-up phenomenon occurs, the ion trajectories less easily change, and the stability of the sensitivity can be enhanced.

公开(公告)号：US20170115314A1

公开(公告)日：2017-04-27

申请号：US15194009

申请日：2016-06-27

Applicant: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED

Inventor： Brett HOLMQUIST ,  Nigel CLARKE

IPC: G01N33/82 ,  H01J49/00 ,  H01J49/14 ,  G01N30/72

CPC classification number: G01N33/82 ,  G01N30/7233 ,  G01N2030/009 ,  G01N2030/027 ,  G01N2030/8813 ,  H01J49/004 ,  H01J49/145

Abstract: The invention relates to the detection of vitamin D. In a particular aspect, the invention relates to methods for detecting derivatized vitamin D by mass spectrometry.

公开(公告)号：US20170103878A1

公开(公告)日：2017-04-13

申请号：US15386790

申请日：2016-12-21

Applicant: BIOCHROMATO, INC.

Inventor： Kazumasa Kinoshita ,  Yuki Kudo ,  Takao Nishiguchi

IPC: H01J49/04 ,  H01J49/00

CPC classification number: H01J49/0422 ,  H01J49/0027 ,  H01J49/145

Abstract: An object of the present invention is to provide a technology that enables highly sensitive atmospheric-pressure real-time mass spectrometry of a volatile substance. The present invention provides a coupling device for a mass spectrometry apparatus that is an interface member to be connected to an atmospheric-pressure real-time mass spectrometry apparatus, the coupling device including (A) an excitation gas introducing port, a sample gas introducing port, and an ionized sample gas discharging port, and (B) a channel through which the excitation gas introducing port and the ionized sample gas discharging port are in communication, and (C) a space for mixing excitation gas and sample gas being formed in a region of a portion of the channel recited in (B), by the coupling device having a structure in which the sample gas introducing port and the channel recited in (B) are in communication.

公开(公告)号：US20170082435A1

公开(公告)日：2017-03-23

申请号：US15267677

申请日：2016-09-16

Applicant: Micromass UK Limited

Inventor： Mark Towers ,  Paul Murray

IPC: G01C15/00 ,  H01J49/16 ,  H01J49/14 ,  H01J49/02 ,  H01J49/00 ,  H01J49/04

CPC classification number: G01C15/004 ,  H01J49/0031 ,  H01J49/025 ,  H01J49/0404 ,  H01J49/0409 ,  H01J49/145 ,  H01J49/165

Abstract: An ion analysis instrument is disclosed comprising an indicator device for providing an indication of a relative positioning of an ion source, a sample, and/or a sampling orifice or capillary of an ion analysis instrument such as a mass or ion mobility spectrometer in order to facilitate re-alignment of one or more of these components following a change. The indicator device comprises a source of electromagnetic radiation such as a pair of lasers or image projection devices.

公开(公告)号：US09564302B2

公开(公告)日：2017-02-07

申请号：US14894494

申请日：2014-06-20

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Thomas R. Covey ,  Bradley B. Schneider

IPC: H01J37/00 ,  B01D15/34 ,  G01N27/62 ,  H01J49/00 ,  H01J49/14 ,  H01J49/16

CPC classification number: G01N27/624 ,  H01J49/0031 ,  H01J49/004 ,  H01J49/0422 ,  H01J49/145 ,  H01J49/165

Abstract: Methods and systems for performing mass spectrometry are provided herein. In accordance with various aspects of the applicants' teachings, the methods and systems can utilize an ion mobility spectrometer operating at atmospheric or low-vacuum pressure to remove the major contributors to the contamination and degradation of critical downstream components of a mass spectrometer located within a high-vacuum system (e.g., ion optics, mass filters, detectors), with limited signal loss.

Abstract translation: 本文提供了用于进行质谱分析的方法和系统。 根据申请人的教导的各个方面，所述方法和系统可以利用在大气压或低真空压力下操作的离子迁移谱仪来除去主要贡献者对位于一个或多个内部的质谱仪的关键下游组分的污染和降解 高真空系统（例如离子光学，质量过滤器，检测器），信号损失有限。