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    SAMPLE IONISATION USING A PULSED LASER SOURCE
    1.
    发明申请
    SAMPLE IONISATION USING A PULSED LASER SOURCE 审中-公开

    公开(公告)号：US20190252170A1

    公开(公告)日：2019-08-15

    申请号：US16272693

    申请日：2019-02-11

    申请人： Micromass UK Limited

    发明人： Paul Murray ,  Mark William Towers ,  Matthew Havard

    IPC分类号： H01J49/04 ,  H01J49/16 ,  G01N27/62

    摘要： A mass and/or ion mobility spectrometer 100 comprises a sample plate 102 that supports a target sample 104. The spectrometer 100 further comprises a laser source 110 that generates a series of laser pulses 112 and a control system 118 that moves a focal point of the laser source 110 substantially continuously across the sample plate 102 such that respective packets of ions are generated by respective laser pulses 112 impinging upon respective locations on the target sample 104. The control system 118 performs plural cycles of ion analysis that each produce a set of spectral data corresponding to one or more of the packets of ions. The spectrometer 100 can provide mass and/or ion mobility spectrometry having increased speed and efficiency.

    Ion source alignment
    2.
    发明授权
    Ion source alignment 有权

    公开(公告)号：US10161750B2

    公开(公告)日：2018-12-25

    申请号：US15267677

    申请日：2016-09-16

    申请人： Micromass UK Limited

    发明人： Mark Towers ,  Paul Murray

    IPC分类号： G01C15/00 ,  H01J49/00 ,  H01J49/02 ,  H01J49/14 ,  H01J49/16 ,  H01J49/04

    摘要： An ion analysis instrument is disclosed comprising an indicator device for providing an indication of a relative positioning of an ion source, a sample, and/or a sampling orifice or capillary of an ion analysis instrument such as a mass or ion mobility spectrometer in order to facilitate re-alignment of one or more of these components following a change. The indicator device comprises a source of electromagnetic radiation such as a pair of lasers or image projection devices.

    Method of Transmitting Ions Through an Aperture
    3.
    发明申请
    Method of Transmitting Ions Through an Aperture 审中-公开

    公开(公告)号：US20180308677A1

    公开(公告)日：2018-10-25

    申请号：US15953913

    申请日：2018-04-16

    申请人： MICROMASS UK LIMITED

    发明人： Jeffery Mark Brown ,  Paul Murray

    IPC分类号： H01J49/06 ,  H01J49/40 ,  H01J49/16 ,  H01J49/00 ,  H01J49/04

    CPC分类号： H01J49/061 ,  H01J49/0027 ,  H01J49/0495 ,  H01J49/06 ,  H01J49/164 ,  H01J49/40

    摘要： A mass spectrometer includes: an ion source; an aperture; a flight region arranged between the ion source and aperture for separating ions according to their mass to charge ratio; and ion optics arranged and configured for causing ions to be reflected or deflected whilst they separate according to mass to charge ratio in the flight region and such that the ions are focussed to a geometrical focal point at the aperture so that the ions are transmitted through the aperture. The multi-reflecting or multi-deflecting ion optics provides a relatively long flight path for the ions, whilst naturally converging the ion beam to a focus. As this focus is arranged at the aperture, it enables the aperture to be made relatively small whilst still maintaining high ion transmission efficiency.

    Method of transmitting ions through an aperture
    7.
    发明授权
    Method of transmitting ions through an aperture 有权

    公开(公告)号：US10388503B2

    公开(公告)日：2019-08-20

    申请号：US15953913

    申请日：2018-04-16

    申请人： MICROMASS UK LIMITED

    发明人： Jeffery Mark Brown ,  Paul Murray

    IPC分类号： H01J49/40 ,  H01J49/06 ,  H01J49/00 ,  H01J49/04 ,  H01J49/16

    摘要： Methods and apparatuses for transmitting ions through an aperture are described. In one embodiment, a mass spectrometer may include an ion source; an aperture; a flight region arranged between the ion source and aperture for separating ions according to their mass to charge ratio; and ion optics arranged and configured for causing ions to be reflected or deflected while they separate according to mass to charge ratio in the flight region and such that the ions are focused to a geometrical focal point at the aperture so that the ions are transmitted through the aperture. The multi-reflecting or multi-deflecting ion optics provides a relatively long flight path for the ions, while naturally converging the ion beam to a focus. As this focus is arranged at the aperture, it enables the aperture to be made relatively small while still maintaining high ion transmission efficiency.

    Data Directed Storage of Imaging Mass Spectra
    10.
    发明申请
    Data Directed Storage of Imaging Mass Spectra 有权
    数据定向存储成像质谱

    公开(公告)号：US20160027626A1

    公开(公告)日：2016-01-28

    申请号：US14776036

    申请日：2014-03-14

    申请人： MICROMASS UK LIMITED

    发明人： Richard Chapman ,  Jeffery Mark Brown ,  Paul Murray ,  Keith Richardson ,  Emmy Maria Hoyes

    IPC分类号： H01J49/00

    CPC分类号： H01J49/0004 ,  H01J49/0031 ,  H01J49/0036

    摘要： A method of ion imaging is disclosed comprising scanning a sample and acquiring first mass spectral data related to a first pixel location at a first spatial resolution and determining whether or not the first mass spectral data satisfies a condition. If it is determined that the first mass spectral data does satisfy the condition then the first mass spectral data is stored, recorded or prioritized. If it is determined that the first mass spectral data does not satisfy the condition then the first mass spectral data is discarded or downgraded. Scanning of the sample then continues at the first spatial resolution and further mass spectral data related to further pixel locations is acquired.

    摘要翻译： 公开了一种离子成像方法，包括扫描样本并以第一空间分辨率获取与第一像素位置相关的第一质谱数据，并确定第一质谱数据是否满足条件。 如果确定第一质谱数据确实满足条件，则存储，记录或优先化第一质谱数据。 如果确定第一质谱数据不满足条件，则第一质谱数据被丢弃或降级。 样本的扫描然后以第一空间分辨率继续进行，并且获取与另外的像素位置相关的进一步的质谱数据。