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    MASS SPECTROMETRY DEVICE AND MASS SPECTROMETRY METHOD
    1.
    发明公开
    MASS SPECTROMETRY DEVICE AND MASS SPECTROMETRY METHOD 审中-公开

    公开(公告)号：US20240234119A9

    公开(公告)日：2024-07-11

    申请号：US18277643

    申请日：2021-12-06

    申请人： HAMAMATSU PHOTONICS K.K.

    发明人： Tsuyoshi HIRAO ,  Yasuhide NAITO ,  Norimasa KOSUGI

    IPC分类号： H01J49/04 ,  H01J49/00

    CPC分类号： H01J49/0463 ,  H01J49/0004 ,  H01J49/0031

    摘要： The mass spectrometer includes a sample stage, an irradiation unit that irradiates the sample with an energy beam and ionizes a component of the sample, an extraction electrode that extracts the ionized sample from the surface of the sample by a potential difference from the sample stage, an MCP that emits electrons in accordance with the ionized sample, an imaging part that acquires an image based on the electrons emitted by the MCP, and a control unit that controls operations of the irradiation unit, the extraction electrode, and the imaging part. The control unit changes the potential of the extraction electrode at a timing in accordance with the detection target component after the irradiation of the energy beam by the irradiation unit, and causes the imaging part to acquire an image as an analysis target in a period in accordance with the detection target component.

    MASS SPECTROMETRY DEVICE AND MASS SPECTROMETRY METHOD
    2.
    发明公开
    MASS SPECTROMETRY DEVICE AND MASS SPECTROMETRY METHOD 审中-公开

    公开(公告)号：US20240136170A1

    公开(公告)日：2024-04-25

    申请号：US18277643

    申请日：2021-12-06

    申请人： HAMAMATSU PHOTONICS K.K.

    发明人： Tsuyoshi HIRAO ,  Yasuhide NAITO ,  Norimasa KOSUGI

    IPC分类号： H01J49/04 ,  H01J49/00

    CPC分类号： H01J49/0463 ,  H01J49/0004 ,  H01J49/0031

    摘要： The mass spectrometer includes a sample stage, an irradiation unit that irradiates the sample with an energy beam and ionizes a component of the sample, an extraction electrode that extracts the ionized sample from the surface of the sample by a potential difference from the sample stage, an MCP that emits electrons in accordance with the ionized sample, an imaging part that acquires an image based on the electrons emitted by the MCP, and a control unit that controls operations of the irradiation unit, the extraction electrode, and the imaging part. The control unit changes the potential of the extraction electrode at a timing in accordance with the detection target component after the irradiation of the energy beam by the irradiation unit, and causes the imaging part to acquire an image as an analysis target in a period in accordance with the detection target component.

    Laser ablation sampling system and method
    4.
    发明授权
    Laser ablation sampling system and method 有权

    公开(公告)号：US11841297B2

    公开(公告)日：2023-12-12

    申请号：US17514304

    申请日：2021-10-29

    申请人： UT-Battelle, LLC

    发明人： Vilmos Kertesz ,  Bernadeta R. Srijanto ,  Charles P. Collier ,  John F. Cahill

    IPC分类号： G01N1/04 ,  G01N1/38 ,  H01J49/16 ,  H01J49/04

    CPC分类号： G01N1/04 ,  G01N1/38 ,  H01J49/0463 ,  H01J49/164 ,  G01N2001/045 ,  G01N2001/383

    摘要： A method and system for sampling a solid sample material can include the step of mounting the sample material on a support. A sample surface is coated with a surface treatment composition in a dry deposition process. A solvent supply conduit for supplying solvent to the sample surface and a solvent exhaust conduit for withdrawing solvent from the sample surface can be provided. Solvent is flowed from the solvent supply conduit to the surface treatment composition and the sample surface such that the solvent contacts the surface treatment composition. A laser beam is directed from a laser source to the sample and the surface treatment composition. The laser beam will ablate the sample and the surface treatment composition in portions intersected by the laser beam. Ablated sample material enters the solvent liquid and will be transported with the solvent away from the sample surface through the solvent exhaust conduit.

    LASER ABLATION CELL
    8.
    发明申请
    LASER ABLATION CELL 有权
    激光消融细胞

    公开(公告)号：US20160049283A1

    公开(公告)日：2016-02-18

    申请号：US14779133

    申请日：2014-03-24

    申请人： ETH ZURICH ,  PAUL SCHERRER INSTITUT

    发明人： Detlef GUNTHER ,  Daniel GROLIMUND ,  Hao WANG

    IPC分类号： H01J49/10 ,  H01J49/04

    CPC分类号： H01J49/105 ,  G01N33/57415 ,  G01N33/60 ,  G01N33/6848 ,  H01J49/0004 ,  H01J49/0031 ,  H01J49/04 ,  H01J49/0409 ,  H01J49/0459 ,  H01J49/0463 ,  H01J49/40

    摘要： A laser ablation cell (1) comprises a flow channel (11) having an essentially constant cross-sectional area so as to ensure a strictly laminar flow in the flow channel. A sample chamber (21) is provided adjacent to a lateral opening (14) of the flow channel. A laser beam (41) enters the sample chamber (21) through a lateral window (16) and impinges on a surface (24) of a sample (23) to ablate material from the sample. The sample may be positioned in such a distance from the flow channel that the laser-generated aerosol mass distribution has its center within the flow channel. This leads to short aerosol washout times. The laser ablation as cell is particularly well suited for aerosol generation in inductively coupled plasma mass spectrometry (ICPMS), including imaging applications.

    摘要翻译： 激光消融电池（1）包括具有基本上恒定的横截面积的流动通道（11），以确保流动通道中严格的层流。 样品室（21）邻近流动通道的侧向开口（14）设置。 激光束（41）通过侧窗（16）进入样品室（21）并撞击样品（23）的表面（24）以从样品中烧蚀材料。 样品可以定位在与流动通道相距的距离处，使得激光产生的气溶胶质量分布在流动通道内具有其中心。 这导致短气溶胶冲洗时间。 激光消融作为细胞特别适用于电感耦合等离子体质谱（ICPMS）中的气溶胶生成，包括成像应用。

    LASER ABLATION ATMOSPHERIC PRESSURE IONIZATION MASS SPECTROMETRY
    10.
    发明申请
    LASER ABLATION ATMOSPHERIC PRESSURE IONIZATION MASS SPECTROMETRY 审中-公开
    激光吸收大气压力离子质谱法

    公开(公告)号：US20150357173A1

    公开(公告)日：2015-12-10

    申请号：US14763522

    申请日：2014-01-28

    申请人： WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER

    发明人： CHRISTINA KOEPPEN ,  OLGA REIFSCHNEIDER ,  CHRISTOPH ALEXANDER WEHE ,  MICHAEL SPERLING ,  UWE KARST

    IPC分类号： H01J49/04 ,  H01J49/00

    CPC分类号： H01J49/0463 ,  H01J49/0031

    摘要： In an embodiment, the present invention provides an apparatus for mass spectrometry which includes a laser ablation sampler comprising a laser ablation chamber and a laser. The laser ablation chamber is configured so that the laser can irradiate and ablate a material from a sample to generate an ablated sample material. An atmospheric pressure ionization source generates an ion population. The atmospheric pressure ionization source is operatively connected to the laser ablation chamber via a transfer line so that an ablated sample material is transportable thereto. A mass spectrometer is operatively connected to the laser ablation chamber and to the atmospheric pressure ionization source. The ablated sample material interacts with the atmospheric pressure ionization source to generate an ion population having a mass-to-charge ratio distribution. The ion population is transmitted to the mass spectrometer, which provides information on a mass-to-charge ratio distribution of the ion population.

    摘要翻译： 在一个实施方案中，本发明提供了一种用于质谱的装置，其包括激光烧蚀取样器，其包括激光烧蚀室和激光器。 激光烧蚀室被配置为使得激光器能够从样品照射和消融材料以产生消融的样品材料。 大气压电离源产生离子群。 大气压电离源通过传输线可操作地连接到激光烧蚀室，使得烧蚀的样品材料可以运送到其上。 质谱仪可操作地连接到激光消融室和大气压电离源。 烧蚀的样品材料与大气压电离源相互作用以产生具有质荷比分布的离子群。 离子群体被传递到质谱仪，其提供关于离子群体的质荷比分布的信息。