公开(公告)号：US20240353401A1

公开(公告)日：2024-10-24

申请号：US18042138

申请日：2021-08-18

Applicant: Regenacellx.SL

Inventor： Michael EDEL

IPC: G01N33/543 ,  B82Y5/00 ,  C12N15/115 ,  G01N33/569 ,  G01N33/68

CPC classification number: G01N33/54388 ,  C12N15/115 ,  G01N33/56983 ,  G01N33/6893 ,  B82Y5/00 ,  C12N2310/16 ,  G01N2333/165 ,  G01N2800/26

Abstract: The present disclosure relates to compositions and methods for detecting SARS-CoV-2 spike protein and diagnosing SARS-CoV-2 infection. The present disclosure also relates to kits and devices for detecting SARS-CoV-2 spike protein and diagnosing SARS-CoV-2 infection.

公开(公告)号：US12084489B2

公开(公告)日：2024-09-10

申请号：US17052470

申请日：2019-05-02

Applicant: The U.S.A., as represented by the Secretary, Department of Health and Human Services ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

Inventor： Masaru Kanekiyo ,  Michael Gordon Joyce ,  Wei Bu ,  Jeffrey I. Cohen ,  Yaroslav Tsybovsky

IPC: C07K16/08 ,  A61K47/68 ,  C12Q1/70 ,  G01N33/569

CPC classification number: C07K16/085 ,  A61K47/6803 ,  A61K47/6839 ,  C12Q1/705 ,  G01N33/56994 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C12Q2600/158 ,  G01N2333/05 ,  G01N2800/26

Abstract: Anti-EBV gH antibodies, anti-EBV gL antibodies, anti-EBV gH/gL antibodies, and compositions of matter useful for the detection, diagnosis, prevention, and treatment of Epstein Barr Virus infection in humans, and methods of using those compositions of matter for the same.

公开(公告)号：US20240272178A1

公开(公告)日：2024-08-15

申请号：US18568334

申请日：2022-06-17

Applicant: SphingoTec GmbH

Inventor： Andreas BERGMANN

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2800/26

Abstract: Subject matter of the present invention is a method for predicting sepsis, severe sepsis or septic shock in a patient comprising determining the level of Pro-Tachykinin A or fragments thereof of at least 5 amino acids in a bodily fluid obtained from said subject, and correlating the determined level of Pro-Tachykinin A or fragments thereof of at least 5 amino acids with sepsis or septic shock, wherein an elevated level above a certain threshold is predictive of sepsis, severe sepsis or septic shock.

公开(公告)号：US12055545B2

公开(公告)日：2024-08-06

申请号：US17717200

申请日：2022-04-11

Applicant: MeMed Diagnostics Ltd.

Inventor： Eran Eden ,  Kfir Oved ,  Assaf Cohen-Dotan ,  Roy Navon ,  Olga Boico ,  Meital Paz

IPC: A61P31/04 ,  A61P31/12 ,  G01N33/50 ,  G01N33/535 ,  G01N33/547 ,  G01N33/569 ,  G01N33/68 ,  C07K14/52 ,  C07K14/525 ,  C07K14/54

CPC classification number: G01N33/56944 ,  A61P31/04 ,  A61P31/12 ,  G01N33/50 ,  G01N33/5005 ,  G01N33/535 ,  G01N33/547 ,  G01N33/56911 ,  G01N33/56983 ,  G01N33/6863 ,  G01N33/6869 ,  G01N33/6893 ,  G01N2333/521 ,  G01N2333/525 ,  G01N2333/5412 ,  G01N2333/5753 ,  G01N2333/70578 ,  G01N2333/70596 ,  G01N2333/715 ,  G01N2333/7151 ,  G01N2333/7155 ,  G01N2800/26 ,  G01N2800/60

Abstract: Methods of determining infection type are disclosed. In one embodiment, the method comprises measuring the amount of TRAIL and/or IP10 no more than two days from symptom onset.

公开(公告)号：US20240255525A1

公开(公告)日：2024-08-01

申请号：US18286064

申请日：2022-04-12

Applicant: Universitätsklinikum Jena

Inventor： Hortense SLEVOGT ,  Mario MÜLLER

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2333/70503 ,  G01N2800/26

Abstract: The present invention relates to the field of in vitro diagnosis of a systemic inflammation or prognosis of a risk of mortality of a subject with a systemic inflammation. In another aspect, the invention relates to the field of monitoring a systemic inflammation. The invention further relates to the use of a biomarker for in vitro diagnosing a systemic inflammation in a subject or prognosing a risk of mortality of a subject with a systemic inflammation. In particular, the biomarker is soluble V-set and immunoglobulin domain-containing protein 4 (sVSIG4). Preferably, the systemic inflammation is caused by an infectious agent, more preferably is a sepsis.

公开(公告)号：US12044681B2

公开(公告)日：2024-07-23

申请号：US17372575

申请日：2021-07-12

Applicant: MeMed Diagnostics Ltd.

Inventor： Eran Eden ,  Kfir Oved ,  Assaf Cohen-Dotan ,  Roy Navon ,  Olga Boico ,  Gali Kronenfeld ,  Meital Paz ,  Ellen Bamberger

IPC: C07K16/18 ,  C07K14/525 ,  C07K14/54 ,  C07K14/555 ,  C07K14/575 ,  C07K16/12 ,  C07K16/24 ,  C07K16/26 ,  C07K16/28 ,  G01N33/50 ,  G01N33/52 ,  G01N33/53 ,  G01N33/535 ,  G01N33/543 ,  G01N33/547 ,  G01N33/569 ,  G01N33/577 ,  G01N33/58 ,  G01N33/60 ,  G01N33/68 ,  G16B40/20 ,  G16B40/30 ,  G16B20/00 ,  G16B40/00

CPC classification number: G01N33/56911 ,  C07K14/525 ,  C07K14/5412 ,  C07K14/555 ,  C07K14/57527 ,  C07K16/12 ,  C07K16/18 ,  C07K16/241 ,  C07K16/248 ,  C07K16/249 ,  C07K16/26 ,  C07K16/2818 ,  C07K16/2875 ,  G01N33/5091 ,  G01N33/52 ,  G01N33/53 ,  G01N33/535 ,  G01N33/54306 ,  G01N33/547 ,  G01N33/577 ,  G01N33/581 ,  G01N33/582 ,  G01N33/60 ,  G01N33/6863 ,  G01N33/6869 ,  G01N33/6893 ,  G16B40/20 ,  G16B40/30 ,  G01N2333/525 ,  G01N2333/5412 ,  G01N2333/555 ,  G01N2333/5753 ,  G01N2333/585 ,  G01N2333/70578 ,  G01N2333/70596 ,  G01N2333/7155 ,  G01N2333/902 ,  G01N2333/916 ,  G01N2469/00 ,  G01N2800/122 ,  G01N2800/26 ,  G16B20/00 ,  G16B40/00

Abstract: Methods of diagnosing infections are disclosed. In one embodiment, the method comprises measuring the amount of each of the polypeptides TRAIL, CRP, IP10 and at least one additional polypeptide selected from the group consisting of IL-6 and PCT.

公开(公告)号：US20240230676A1

公开(公告)日：2024-07-11

申请号：US18558150

申请日：2022-04-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Felix Gruenewald ,  Victor Johann Raul Jeger ,  Martin Klammer ,  Philipp Schuetz ,  Maria von Holtey ,  Stephen Weber ,  Heike Wegmeyer ,  Ursula-Henrike Wienhues-Thelen

IPC: G01N33/68 ,  C12Q1/37 ,  C12Q1/52 ,  G01N33/72 ,  G16H50/20

CPC classification number: G01N33/6893 ,  C12Q1/37 ,  C12Q1/52 ,  G01N33/728 ,  G16H50/20 ,  G01N2333/4722 ,  G01N2333/8139 ,  G01N2333/91188 ,  G01N2800/26 ,  G01N2800/50

Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being ESM-1, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is Creatinine or a Cystatin C, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being ESM-1 and a second biomarker being Creatinine or a Cystatin C or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection. Moreover, the invention further relates to a computer-implemented method for assessing a subject with suspected infection and a device and a kit for assessing a subject with suspected infection.

公开(公告)号：US20240230672A1

公开(公告)日：2024-07-11

申请号：US18557890

申请日：2022-04-29

Applicant: Roche Diagnostics GmbH ,  Mochida Pharmaceutical Co., Ltd.

Inventor： Felix Gruenewald ,  Victor Johann Raul Jeger ,  Martin Klammer ,  Philipp Schuetz ,  Maria von Holtey ,  Stephen Weber ,  Heike Wegmeyer ,  Ursula-Henrike Wienhues-Thelen

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N2333/65 ,  G01N2333/70596 ,  G01N2333/8139 ,  G01N2333/91188 ,  G01N2800/26

Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being Presepsin, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: GDF-15, Creatinine, sFlt1, IGFBP7, sTREM1, Cystatin C and PSP (Pancreatic Stone Protein), comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being Presepsin and a second biomarker selected from the group consisting of: GDF-15, Creatinine, sFlt1, IGFBP7, sTREM1, Cystatin C and PSP (Pancreatic Stone Protein), or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection. Moreover, the invention further relates to a computer-implemented method for assessing a subject with suspected infection and a device and a kit for assessing a subject with suspected infection.

公开(公告)号：US12031174B2

公开(公告)日：2024-07-09

申请号：US16362478

申请日：2019-03-22

Applicant: IDEXX LABORATORIES, INC.

Inventor： Giosi Farace ,  Jon Braff ,  Murthy V S N Yerramilli

IPC: C12Q1/06 ,  C12Q1/22 ,  C12Q1/24 ,  G01N15/02 ,  G01N15/0227 ,  G01N33/493 ,  G01N33/52

CPC classification number: C12Q1/06 ,  C12Q1/22 ,  C12Q1/24 ,  G01N15/0227 ,  G01N33/493 ,  G01N33/52 ,  G01N2015/0294 ,  G01N2800/26

Abstract: The disclosure relates generally to methods for measuring bacteria in biological samples. More particularly, the disclosure relates to methods for measuring bacteria using an aqueous clearance solution.

公开(公告)号：US20240219405A1

公开(公告)日：2024-07-04

申请号：US18558133

申请日：2022-04-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Felix Gruenewald ,  Victor Johann Raul Jeger ,  Martin Klammer ,  Philipp Schuetz ,  Maria von Holtey ,  Stephen Weber ,  Heike Wegmeyer ,  Ursula-Henrike Wienhues-Thelen

IPC: G01N33/68 ,  G01N33/70

CPC classification number: G01N33/6893 ,  G01N33/6869 ,  G01N33/6887 ,  G01N33/70 ,  G01N2333/5412 ,  G01N2333/91188 ,  G01N2800/26 ,  G01N2800/50

Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being IL-6, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is Creatinine or a cardiac Troponin, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being IL-6 and a second biomarker being a cardiac Troponin or Creatinine or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection. Moreover, the invention further relates to a computer-implemented method for assessing a subject with suspected infection and a device and a kit for assessing a subject with suspected infection.