公开(公告)号：US12072274B2

公开(公告)日：2024-08-27

申请号：US17276717

申请日：2019-09-16

申请人： University of Southampton ,  The University of Western Australia

发明人： Hywel Morgan ,  Daniel Spencer ,  Timothy John Jay Inglis ,  Teagan Paton ,  Kieran Mulroney

IPC分类号： G01N15/12 ,  C12Q1/18 ,  G01N15/02 ,  G01N15/0227 ,  G01N15/10 ,  G01N15/1031

CPC分类号： G01N15/12 ,  C12Q1/18 ,  G01N15/0227 ,  G01N15/1023 ,  G01N15/1031 ,  G01N2015/0294 ,  G01N2015/1006 ,  G01N2015/1029 ,  G01N2015/103

摘要： A method of antimicrobial susceptibility testing comprises: preparing samples of microorganisms suspended in an electrolyte, comprising a first sample of the microorganisms unexposed to antimicrobial agents and a second sample of the microorganisms exposed to an antimicrobial agent; passing the first sample through an impedance flow cytometer to obtain a first impedance signal representing one or more components of impedance values of the unexposed microorganisms; passing the second sample through the impedance flow cytometer to obtain a second impedance signal representing one or more components of the impedance values of the exposed microorganisms; comparing the first impedance signal and the second impedance signal; and determining a susceptibility of the microorganisms to the antimicrobial agent based on any differences between the first impedance signal and second impedance signal.

公开(公告)号：US20240278553A1

公开(公告)日：2024-08-22

申请号：US18402731

申请日：2024-01-03

申请人： SEMES CO., LTD.

发明人： Sang Uk SON

IPC分类号： B41J2/045 ,  G01N15/0227

CPC分类号： B41J2/04535 ,  B41J2/04508 ,  G01N15/0227

摘要： A droplet inspection method using a 2-dimensional (2D) image of a droplet includes ejecting ink onto a substrate based on a preset inspection pattern using an inkjet head, acquiring a 2D image of the droplet of ink ejected to a plurality of positions on the substrate using a measurement camera located on a side surface or above the substrate, and calculating a diameter of the droplet from the 2D image and calculating a volume of the droplet using the calculated diameter of the droplet and a pre-measured contact angle of the substrate for inspection.

公开(公告)号：US20240210297A1

公开(公告)日：2024-06-27

申请号：US18564650

申请日：2022-05-16

申请人： Beckman Coulter, Inc.

发明人： Jozef SOFKA

IPC分类号： G01N15/0227 ,  G01N15/01 ,  G01N15/14 ,  G01N15/1434

CPC分类号： G01N15/0227 ,  G01N15/01 ,  G01N15/1434 ,  G01N15/147 ,  G01N2015/1445

摘要： Techniques for oblique illumination of samples in microscopy imaging are presented. The sample may be obliquely illuminated by directing light from a light emitter toward a sample at an oblique angle, rather than directly along the optical axis of an imaging device. The oblique angle may be created using an aperture mask with an aperture that is not coaxial with the optical axis of the imaging device. The oblique angle may also be created using a light emitter and collector lens that are not coaxial with the optical axis of the imaging device, such that the condenser lens directs the light toward the sample. Images obtained using the oblique illumination provide improved contrast of translucent particles and may have an embossed, three-dimensional appearance.

公开(公告)号：US20240201063A1

公开(公告)日：2024-06-20

申请号：US18592400

申请日：2024-02-29

申请人： Ventana Medical Systems, Inc.

发明人： Joerg Bredno ,  Auranuch Lorsakul

IPC分类号： G01N15/0227 ,  G01N15/14 ,  G01N15/1433 ,  G06F18/232 ,  G06K1/00 ,  G06V10/25 ,  G06V10/762 ,  G06V20/69 ,  G16H10/40 ,  G16H30/40 ,  G16H50/70

CPC分类号： G01N15/0227 ,  G01N15/1433 ,  G06F18/232 ,  G06K1/00 ,  G06V10/25 ,  G06V10/763 ,  G06V20/695 ,  G16H10/40 ,  G16H30/40 ,  G16H50/70 ,  G01N2015/1497 ,  G06V2201/03

摘要： The present disclosure is directed, among other things, to automated systems and methods for analyzing, storing, and/or retrieving information associated with biological objects having irregular shapes. In some embodiments, the systems and methods partition an input image into a plurality of sub-regions based on localized colors, textures, and/or intensities in the input image, wherein each sub-region represents biologically meaningful data.

公开(公告)号：US20240175795A1

公开(公告)日：2024-05-30

申请号：US18552529

申请日：2022-04-07

申请人： PLANKTON ANALYTICS LIMITED

发明人： Philip Frederick Culverhouse ,  Julian Bernard Tilbury

IPC分类号： G01N15/0227 ,  G01N15/14 ,  G01N15/1433

CPC分类号： G01N15/0227 ,  G01N15/1433 ,  G01N2015/1479

摘要： A flow cell for the analysis of objects in a liquid stream is provided, the flow cell comprising: a flow cell body having a chamber therein defined by an inner surface of the flow cell body, the flow cell body having an inlet end and an outlet end; the inlet end of the flow cell body being provided with a first fluid coupling member having a flow passage therethrough; the outlet end of the flow cell body being provided with a second fluid coupling member having a flow passage therethrough; the flow cell body comprising a first transparent portion, through which light may enter the chamber to illuminate objects within the chamber, and a second transparent portion through which objects within the chamber may be imaged; wherein the chamber comprises a first transition portion adjacent the inlet end of the flow cell body, the first transition portion comprising a smooth transition between the flow passage of the first fluid coupling member and the inner surface of the flow cell body defining the chamber; and wherein the chamber comprises a second transition portion adjacent the outlet end of the flow cell body, the second transition portion comprising a smooth transition between the flow passage of the second fluid coupling member and the inner surface of the flow cell body defining the chamber. An imaging apparatus comprising the flow cell is also provided. The flow cell and imaging apparatus find use in imaging such objects as plankton, detritus and bubbles in liquid streams.

公开(公告)号：US20240125676A1

公开(公告)日：2024-04-18

申请号：US18399419

申请日：2023-12-28

申请人： Honeywell International Inc.

发明人： Andy Walker Brown ,  Adam D. McBrady ,  Ryadh Abdullah Zakaria ,  Stephan Michael Bork

IPC分类号： G01N1/22 ,  G01N15/0227 ,  G06T7/62

CPC分类号： G01N1/2273 ,  G01N15/0227 ,  G06T7/62 ,  G01N15/01 ,  G01N2015/0233

摘要： A flow device, method, and system are provided for determining the fluid particle composition. An example flow device includes a fluid sensor configured to monitor at least one particle characteristic of fluid flowing through the fluid sensor. The example flow device also includes at least one processor configured to, upon determining the at least one particle characteristic satisfies a particle criteria, generate a control signal for an external device. The example flow device also includes a fluid composition sensor configured to be powered based on the control signal and further configured to capture data relating to the fluid particle composition. The example flow device is also configured to generate one or more particle profiles of at least one component of the fluid based on the data captured by the fluid composition sensor.

公开(公告)号：US20240102907A1

公开(公告)日：2024-03-28

申请号：US17754831

申请日：2020-10-06

申请人： HORIBA, Ltd.

发明人： Yasuhiro TATEWAKI ,  Shingo FUJIWARA

IPC分类号： G01N15/0227 ,  G01N15/0205

CPC分类号： G01N15/0227 ,  G01N15/0211 ,  G01N2015/0053

摘要： A particle group characteristic measurement device includes an image acquisition portion that acquires images of a particle group, a particle information extraction portion that processes acquisition images acquired by the image acquisition portion, and then extracts particle information which is information about particles appearing in the acquisition images, and a particle group characteristic calculation portion that calculates a particle group characteristic at a plurality of time points in a time series based on the particle information extracted from a plurality of the acquisition images acquired prior to respective time points. The particle group characteristic calculation portion calculates the particle group characteristic at each time point based on the plurality of acquisition images used to calculate the particle group characteristic at time points previous to that time point, and on the particle information extracted from the plurality of acquisition images whose image acquisition time periods partially overlap each other.

公开(公告)号：US11927520B2

公开(公告)日：2024-03-12

申请号：US17415130

申请日：2019-05-30

申请人： Hewlett-Packard Development Company, L.P.

发明人： Viktor Shkolnikov ,  Daixi Xin ,  Yang Lei

IPC分类号： G01N15/10 ,  G01N15/00

CPC分类号： G01N15/1031 ,  G01N15/0227 ,  G01N2015/0053

摘要： A particle monitoring system may include a flow passage, a particle imager to image a targeted particle within the flow passage, electrodes supported proximate the flow passage, a power source connected to the electrodes and a controller to cause the power source to charge to electrodes so as to (1) apply an electric field balanced with respect to gravity so as to hold, levitate and rotate a targeted particle within the flow passage during imaging and (2) release the targeted particle following the imaging.

公开(公告)号：US20240077400A1

公开(公告)日：2024-03-07

申请号：US18261404

申请日：2021-12-13

申请人： UNISERS LTD

发明人： Fabian Walter ,  Ali Özhan Altun ,  Timo Stefan Schneider

IPC分类号： G01N15/02

CPC分类号： G01N15/0227

摘要： Method including providing a substrate having a non-metallic surface with particles on the surface; depositing a layer of metal on the surface and the particles, so that each particle and an area of the surface without particles has a layer of metal, wherein, each particle has a gap between metal on that particle and metal on the surface; illuminating metal with electromagnetic rays, so that rays are scattered by metal on particles to produce scattered rays; or rays are absorbed by metal on particles and another portion of rays are reflected by metal on the surface to produce reflected rays; receiving scattered or reflected rays at an array of photodiodes; forming an image as pixels corresponding to photodiodes, wherein the colour of each pixel corresponds to the intensity and/or frequency of the rays received at that pixel; processing the image to determine the size of the particles.

公开(公告)号：US11900540B2

公开(公告)日：2024-02-13

申请号：US17616548

申请日：2020-06-02

申请人： AMGEN INC.

发明人： Graham F. Milne ,  Dmitry Fradkin ,  Thomas Clark Pearson

IPC分类号： G06T17/20 ,  G06V10/762 ,  G01N15/02 ,  G01N15/06 ,  G06T7/20 ,  G06T15/06 ,  H04N5/06

CPC分类号： G06T17/20 ,  G01N15/0227 ,  G01N15/06 ,  G06T7/20 ,  G06T15/06 ,  G06V10/763 ,  H04N5/06 ,  G01N2015/0693 ,  G06T2200/08 ,  G06T2207/30242

摘要： A method for 3D imaging of a sample, in a vessel having a longitudinal axis orthogonal to a horizontal plane, includes capturing, by at least three cameras located at different positions around the vessel, respective 2D images of the sample. Each image comprises pixels having associated pixel values. The optical axis of a first camera is inclined or declined at a first angle relative to the horizontal plane, with the first angle being greater than or equal to zero degrees. The optical axis of a second camera is inclined or declined at a second, larger angle relative to the horizontal plane. The method also includes generating a 3D image of the sample based on the pixel values associated with the 2D image pixels, and one or more look-up tables that collectively indicate, for pixels in each image, expected paths for light traversing the vessel and the sample.