-
公开(公告)号：US20240127540A1
公开(公告)日：2024-04-18
申请号：US18397218
申请日：2023-12-27
Applicant: AMGEN INC.
Inventor： Graham F. Milne , Dmitry Fradkin , Thomas Clark Pearson
IPC: G06T17/20 , G01N15/0227 , G01N15/06 , G06T7/20 , G06T15/06 , G06V10/762 , H04N5/06
CPC classification number: G06T17/20 , G01N15/0227 , G01N15/06 , G06T7/20 , G06T15/06 , G06V10/763 , H04N5/06 , G01N15/075 , G06T2200/08 , G06T2207/30242
Abstract: A method of aligning images for 3D imaging of a sample includes, for each of multiple cameras located around a vessel, activating a respective light source that provides backlighting for the vessel, and capturing a respective 2D calibration image of the vessel. The method also includes, for each 2D calibration image, measuring a respective vertical position, horizontal position, and rotation of the image, in part by detecting edges of the vessel as depicted in the image. The method also includes generating calibration data based on the measured vertical positions, horizontal positions, and rotations for the respective 2D calibration images, capturing, by each camera, a respective set of 2D images of the sample in the vessel, and digitally resampling, using the calibration data, at least one of the respective sets of 2D images to correct for vertical offset, horizontal offset, and rotational offset of the set(s) of 2D images.
-
公开(公告)号：US11874233B2
公开(公告)日：2024-01-16
申请号：US18089109
申请日：2022-12-27
Applicant: AMGEN INC.
Inventor： Thomas Clark Pearson , Graham F. Milne , Dmitry Fradkin , Erwin Freund
CPC classification number: G01N21/9027 , G06T7/0004 , H04N23/74 , H04N23/84 , H04N23/90 , G01N2201/06113 , G06T2207/10024 , G06T2207/10152
Abstract: In a method for imaging a container holding a sample, the container is illuminated with a laser sheet of a first color, and one or more images of the container are capturing by a first imager configured to filter out colors other than the first color. Simultaneously with illuminating the container with the laser sheet of the first color, the container is illuminated with light of a second color different than the first color, wherein the light of the second color illuminates at least a majority of an entire volume of the container. One or more additional imagers of the container are captured by a second imager configured to filter out colors other than the second color. The one or more images and the one or more additional images are analyzed to detect particles within, and/or on an exterior surface of, the container.
-
公开(公告)号：US11501458B2
公开(公告)日：2022-11-15
申请号：US17063310
申请日：2020-10-05
Applicant: AMGEN INC.
Inventor： Graham F. Milne , Erwin Freund , Ryan L. Smith
IPC: G01N21/88 , G06T7/60 , G06T7/246 , G01N21/90 , G01N15/14 , G01N21/31 , G01N21/51 , G06T7/00 , G01N15/10
Abstract: The apparati, methods, and computer program products disclosed herein can be used to nondestructively detect undissolved particles, such as glass flakes and/or protein aggregates, in a fluid in a vessel, such as, but not limited to, a fluid that contains a drug.
-
公开(公告)号：US20220057336A1
公开(公告)日：2022-02-24
申请号：US17414544
申请日：2019-12-16
Applicant: AMGEN INC.
Inventor： Thomas Clark Pearson , Graham F. Milne , Dmitry Fradkin , Erwin Freund
Abstract: In a method for imaging a container holding a sample, the container is illuminated with a laser sheet that impinges upon the container in a first direction corresponding to a first axis. A plane of the laser sheet is defined by the first axis and a second axis orthogonal to the first axis. The method also includes capturing, by a camera having an imaging axis that is substantially orthogonal to at least the first axis, an image of the container. The method further includes analyzing, by one or more processors, the image of the container to detect particles within, and/or on an exterior surface of, the container.
-
公开(公告)号：US10832433B2
公开(公告)日：2020-11-10
申请号：US15881163
申请日：2018-01-26
Applicant: AMGEN INC.
Inventor： Graham F. Milne , Erwin Freund , Ryan L. Smith
IPC: G01N15/14 , G06T7/60 , G06T7/246 , G01N21/90 , G01N21/31 , G01N21/51 , G06T7/00 , G01N21/88 , G01N15/10
Abstract: The apparati, methods, and computer program products disclosed herein can be used to nondestructively detect undissolved particles, such as glass flakes and/or protein aggregates, in a fluid in a vessel, such as, but not limited to, a fluid that contains a drug.
-
Patent Agency Ranking
公开(公告)号：US20190011688A1
公开(公告)日：2019-01-10
申请号：US16113489
申请日：2018-08-27
Applicant: AMGEN INC.
Inventor： Dmitry Fradkin , Graham F. Milne , Thomas Clark Pearson
Abstract: A system is described to facilitate the characterization of particles within a fluid contained in a vessel using an illumination system that directs source light through each vessel. One or more optical elements may be implemented to refract the source light and to illuminate the entire volume of the vessel. As the refracted source light passes through the vessel and interacts with particles suspended in the fluid, scattered light is produced and directed to an imager, while the refracted source light is diverted away from the imager to prevent the source light from drowning out the scattered light. The system can therefore advantageously utilize an imager with a large depth of field to accurately image the entire volume of fluid at the same time, facilitating the determination of the number and size of particles suspended in the fluid.
-
公开(公告)号：US12169177B2
公开(公告)日：2024-12-17
申请号：US17786742
申请日：2020-12-17
Applicant: AMGEN INC.
Inventor： Graham F. Milne , Dmitry Fradkin
Abstract: Assemblies (10), devices, and methods are described herein that allow an examiner to inspect a container (12) of liquid product (14) through a bottom wall (18) of the container using a line-of-sight diversion member (28, e.g. beam splitter, mirror or prism). In some forms, the assemblies described herein can be provided with mounts and connecting arms to couple the devices to inspection booths.
-
公开(公告)号：US20240344920A1
公开(公告)日：2024-10-17
申请号：US18685086
申请日：2022-08-22
Applicant: AMGEN INC.
Inventor： Al Patrick Goodwin , Joseph Peter Bermacki , Thomas Clark Pearson , Graham F. Milne , Jonathan Parsons , Corey Bishop , Barry Donohoe , Osvaldo Perez-Varela
CPC classification number: G01M3/38 , G01B11/2522 , G01N21/909 , G01N2201/0612
Abstract: An apparatus, system, or method for vial seal inspection may be based on three-dimensional data that is representative of at least a portion of a vial seal. More particularly, apparatuses, systems, and methods for vial seal inspection may include at least one laser triangulation sensor.
-
公开(公告)号：US20230139131A1
公开(公告)日：2023-05-04
申请号：US18089109
申请日：2022-12-27
Applicant: AMGEN INC.
Inventor： Thomas Clark Pearson , Graham F. Milne , Dmitry Fradkin , Erwin Freund
Abstract: In a method for imaging a container holding a sample, the container is illuminated with a laser sheet of a first color, and one or more images of the container are capturing by a first imager configured to filter out colors other than the first color. Simultaneously with illuminating the container with the laser sheet of the first color, the container is illuminated with light of a second color different than the first color, wherein the light of the second color illuminates at least a majority of an entire volume of the container. One or more additional imagers of the container are captured by a second imager configured to filter out colors other than the second color. The one or more images and the one or more additional images are analyzed to detect particles within, and/or on an exterior surface of, the container.
-
公开(公告)号：US11499922B2
公开(公告)日：2022-11-15
申请号：US16977025
申请日：2019-02-12
Applicant: AMGEN INC.
Inventor： Thomas C. Pearson , Neelima Chavali , Dmitry Fradkin , Graham F. Milne , Erwin Freund
IPC: G01N21/90
Abstract: An inspection system for a drug container is provided to identify foreign matter, such as particles or fibers, within the drug container prior to filling with a drug. The system includes a camera device aligned with an axis of the drug container and captures a series of images of an interior surface of a sidewall of the drug container while the robot causes relative movement between the drug container and the camera device along a linear path. Atypical lighting, which improves contrast between particles and the background in images is employed to aid detection. A control circuit then processes the series of images to identify foreign matter within the drug container.
-
-
-
-
-
-
-
-
-
Search Results
36
records
(took 0.021 seconds)
