公开(公告)号：US11874233B2

公开(公告)日：2024-01-16

申请号：US18089109

申请日：2022-12-27

Applicant: AMGEN INC.

Inventor： Thomas Clark Pearson ,  Graham F. Milne ,  Dmitry Fradkin ,  Erwin Freund

IPC: G01N21/90 ,  G06T7/00 ,  H04N23/74 ,  H04N23/84 ,  H04N23/90

CPC classification number: G01N21/9027 ,  G06T7/0004 ,  H04N23/74 ,  H04N23/84 ,  H04N23/90 ,  G01N2201/06113 ,  G06T2207/10024 ,  G06T2207/10152

Abstract: In a method for imaging a container holding a sample, the container is illuminated with a laser sheet of a first color, and one or more images of the container are capturing by a first imager configured to filter out colors other than the first color. Simultaneously with illuminating the container with the laser sheet of the first color, the container is illuminated with light of a second color different than the first color, wherein the light of the second color illuminates at least a majority of an entire volume of the container. One or more additional imagers of the container are captured by a second imager configured to filter out colors other than the second color. The one or more images and the one or more additional images are analyzed to detect particles within, and/or on an exterior surface of, the container.

公开(公告)号：US11501458B2

公开(公告)日：2022-11-15

申请号：US17063310

申请日：2020-10-05

Applicant: AMGEN INC.

Inventor： Graham F. Milne ,  Erwin Freund ,  Ryan L. Smith

IPC: G01N21/88 ,  G06T7/60 ,  G06T7/246 ,  G01N21/90 ,  G01N15/14 ,  G01N21/31 ,  G01N21/51 ,  G06T7/00 ,  G01N15/10

Abstract: The apparati, methods, and computer program products disclosed herein can be used to nondestructively detect undissolved particles, such as glass flakes and/or protein aggregates, in a fluid in a vessel, such as, but not limited to, a fluid that contains a drug.

公开(公告)号：US20220057336A1

公开(公告)日：2022-02-24

申请号：US17414544

申请日：2019-12-16

Applicant: AMGEN INC.

Inventor： Thomas Clark Pearson ,  Graham F. Milne ,  Dmitry Fradkin ,  Erwin Freund

IPC: G01N21/90 ,  G06T7/00 ,  H04N5/235 ,  H04N5/247 ,  H04N9/04

Abstract: In a method for imaging a container holding a sample, the container is illuminated with a laser sheet that impinges upon the container in a first direction corresponding to a first axis. A plane of the laser sheet is defined by the first axis and a second axis orthogonal to the first axis. The method also includes capturing, by a camera having an imaging axis that is substantially orthogonal to at least the first axis, an image of the container. The method further includes analyzing, by one or more processors, the image of the container to detect particles within, and/or on an exterior surface of, the container.

公开(公告)号：US10832433B2

公开(公告)日：2020-11-10

申请号：US15881163

申请日：2018-01-26

Applicant: AMGEN INC.

Inventor： Graham F. Milne ,  Erwin Freund ,  Ryan L. Smith

IPC: G01N15/14 ,  G06T7/60 ,  G06T7/246 ,  G01N21/90 ,  G01N21/31 ,  G01N21/51 ,  G06T7/00 ,  G01N21/88 ,  G01N15/10

Abstract: The apparati, methods, and computer program products disclosed herein can be used to nondestructively detect undissolved particles, such as glass flakes and/or protein aggregates, in a fluid in a vessel, such as, but not limited to, a fluid that contains a drug.

公开(公告)号：US12214383B2

公开(公告)日：2025-02-04

申请号：US18235419

申请日：2023-08-18

Applicant: AMGEN INC.

Inventor： Dmitry Fradkin ,  Thomas Clark Pearson ,  Neelima Chavali ,  Erwin Freund

IPC: G06N20/00 ,  B07C5/342 ,  G01N21/90 ,  G01N35/00 ,  G06T7/00

Abstract: A robotic inspection platform comprises a robotic arm, an imager, and a controller. The controller causes the robotic arm to retrieve, using its end effector, a container, and to manipulate the container such that the container is sequentially placed in a plurality of orientations while in view of the imager. The controller also causes the imager to capture images, with each of the images being captured while the container is in a respective one of the orientations. The controller also determines one or more attributes of the container, and/or a sample within the container, by analyzing the images using a pattern recognition model and, based on the attribute(s), determines whether the container and/or sample satisfies one or more criteria. If the container and/or sample fails to satisfy the criteria, the controller causes the robotic arm to place the container in an area (e.g., bin) reserved for rejected containers and/or samples.

公开(公告)号：US20230139131A1

公开(公告)日：2023-05-04

申请号：US18089109

申请日：2022-12-27

Applicant: AMGEN INC.

Inventor： Thomas Clark Pearson ,  Graham F. Milne ,  Dmitry Fradkin ,  Erwin Freund

IPC: G01N21/90 ,  G06T7/00 ,  H04N23/74 ,  H04N23/84 ,  H04N23/90

Abstract: In a method for imaging a container holding a sample, the container is illuminated with a laser sheet of a first color, and one or more images of the container are capturing by a first imager configured to filter out colors other than the first color. Simultaneously with illuminating the container with the laser sheet of the first color, the container is illuminated with light of a second color different than the first color, wherein the light of the second color illuminates at least a majority of an entire volume of the container. One or more additional imagers of the container are captured by a second imager configured to filter out colors other than the second color. The one or more images and the one or more additional images are analyzed to detect particles within, and/or on an exterior surface of, the container.

公开(公告)号：US11499922B2

公开(公告)日：2022-11-15

申请号：US16977025

申请日：2019-02-12

Applicant: AMGEN INC.

Inventor： Thomas C. Pearson ,  Neelima Chavali ,  Dmitry Fradkin ,  Graham F. Milne ,  Erwin Freund

IPC: G01N21/90

Abstract: An inspection system for a drug container is provided to identify foreign matter, such as particles or fibers, within the drug container prior to filling with a drug. The system includes a camera device aligned with an axis of the drug container and captures a series of images of an interior surface of a sidewall of the drug container while the robot causes relative movement between the drug container and the camera device along a linear path. Atypical lighting, which improves contrast between particles and the background in images is employed to aid detection. A control circuit then processes the series of images to identify foreign matter within the drug container.

公开(公告)号：US20210010946A1

公开(公告)日：2021-01-14

申请号：US16977025

申请日：2019-02-12

Applicant: AMGEN INC.

Inventor： Thomas C. Pearson ,  Neelima Chavali ,  Dmitry Fradkin ,  Graham F. Milne ,  Erwin Freund

IPC: G01N21/90

Abstract: An inspection system for a drug container is provided to identify foreign matter, such as particles or fibers, within the drug container prior to filling with a drug. The system includes a camera device aligned with an axis of the drug container and captures a series of images of an interior surface of a sidewall of the drug container while the robot causes relative movement between the drug container and the camera device along a linear path. Atypical lighting, which improves contrast between particles and the background in images is employed to aid detection. A control circuit then processes the series of images to identify foreign matter within the drug container.

公开(公告)号：US11803983B2

公开(公告)日：2023-10-31

申请号：US17964669

申请日：2022-10-12

Applicant: AMGEN INC.

Inventor： Graham F. Milne ,  Erwin Freund ,  Ryan L. Smith

IPC: G06T7/60 ,  G06T7/246 ,  G01N21/90 ,  G01N15/14 ,  G01N21/31 ,  G01N21/51 ,  G06T7/00 ,  G01N21/88 ,  G01N15/10

CPC classification number: G06T7/60 ,  G01N15/1429 ,  G01N15/1475 ,  G01N21/31 ,  G01N21/51 ,  G01N21/8851 ,  G01N21/9027 ,  G06T7/0012 ,  G06T7/246 ,  G01N15/1427 ,  G01N2015/1075 ,  G01N2015/1087 ,  G01N2015/144 ,  G01N2015/1445 ,  G01N2015/1452 ,  G01N2015/1472 ,  G01N2015/1477 ,  G01N2015/1493 ,  G01N2015/1497 ,  G06T2207/10004 ,  G06T2207/10016 ,  G06T2207/30004 ,  G06T2207/30241 ,  G06T2207/30242

Abstract: An apparatus for nondestructive detection of transparent or reflective objects in a vessel includes an imager configured to acquire data that represent light reflected from spatial locations in the vessel as a function of time, a memory operably coupled to the imager and configured to store the data, and a processor operably coupled to the memory and configured to detect the objects based on the data by (i) identifying a respective maximum amount of reflected light, over time, for each location in the spatial locations based on the data representing light reflected from the spatial locations as a function of time, and (ii) determining a presence or absence of the objects in the vessel based on the number of spatial locations whose respective maximum amount of reflected light, over time, exceeds a predetermined value.

公开(公告)号：US20210213486A1

公开(公告)日：2021-07-15

申请号：US17058933

申请日：2019-06-12

Applicant: AMGEN INC.

Inventor： Dmitry Fradkin ,  Thomas C. Pearson ,  Neelima Chavali ,  Erwin Freund

IPC: B07C5/342 ,  G06T7/00 ,  G01N21/90 ,  G01N35/00 ,  G06N20/00

Abstract: A robotic inspection platform comprises a robotic arm, an imager, and a controller. The controller causes the robotic arm to retrieve, using its end effector, a container, and to manipulate the container such that the container is sequentially placed in a plurality of orientations while in view of the imager. The controller also causes the imager to capture images, with each of the images being captured while the container is in a respective one of the orientations. The controller also determines one or more attributes of the container, and/or a sample within the container, by analyzing the images using a pattern recognition model and, based on the attribute(s), determines whether the container and/or sample satisfies one or more criteria. If the container and/or sample fails to satisfy the criteria, the controller causes the robotic arm to place the container in an area (e.g., bin) reserved for rejected containers and/or samples.