公开(公告)号：US20240361311A1

公开(公告)日：2024-10-31

申请号：US18560223

申请日：2022-05-12

Applicant: Hitachi HIgh-Tech Corporation

Inventor： Taira SASAKI ,  Masashi MARUYAMA ,  HIrotaka SAKUMA ,  Toshinari SAKURAI ,  Shigeki MATSUBARA

IPC: G01N33/552 ,  G01N1/30 ,  G01N33/52

CPC classification number: G01N33/552 ,  G01N1/30 ,  G01N33/52

Abstract: An object of the present disclosure is to provide a control glass slide containing a control substance in a form in which the control glass slide is capable of preventing outflow of a dye generated by staining of the control substance for the purpose of accuracy control in a pathological examination. One aspect of the present embodiment is a control glass slide for a pathological examination, including a control spot on a glass slide, the control spot containing a control substance in the pathological examination and a dye trapping material.

公开(公告)号：US12078646B2

公开(公告)日：2024-09-03

申请号：US17978793

申请日：2022-11-01

Applicant: Wisconsin Alumni Research Foundation

Inventor： Ying Ge ,  Song Jin ,  Kyle Brown ,  Kevin Buck

IPC: G01N33/92 ,  C11D1/14 ,  G01N21/33 ,  G01N33/52

CPC classification number: G01N33/92 ,  C11D1/143 ,  G01N21/33 ,  G01N33/52

Abstract: Exosomes are a small type of extracellular vesicles containing nucleic acids, lipids, and proteins that are implicated in tumorigenesis, metastasis, and cardiac regeneration, and therefore serve as potentially useful biomarkers from fluids or as vehicles for drug delivery. Global bottom-up mass spectrometry-based proteomics has been previously used to profile exosome cargo for diagnostic purposes. However, the current protocols for MS analysis of extracellular vesicles and exosome proteomics are challenging due to labor-intensive sample preparation, including lengthy digestion times and removal of MS incompatible reagents, and the need for high sensitivity. To address these challenges, the present invention provides a novel, high-throughput strategy for extracellular vesicle analysis and exosome proteomics using a photo-cleavable, anionic surfactant, preferably 4-hexylphenylazosulfonate (Azo). These photo-cleavable, anionic surfactants are able to facilitate high-throughput digestion with minimal sample cleanup for quantitative and highly reproducible analysis.

公开(公告)号：US20240272182A1

公开(公告)日：2024-08-15

申请号：US18568467

申请日：2022-06-09

Applicant: Veriteque USA, Inc.

Inventor： Christian Loane

IPC: G01N33/94 ,  G01N33/52

CPC classification number: G01N33/948 ,  G01N33/52 ,  G01N33/946

Abstract: Detection kits for identifying the presence of a drug are provided. In one exemplary implementation, the kit includes a dry colorimetric reagent and a delivery device containing a solvent or solvent mixture including the solvent. The delivery device is configured to deliver a portion of the solvent or solvent mixture to a target residue to form a sample residue. When at least a portion of the sample residue is brought into contact with the mixture, the mixture undergoes a chemical reaction when the sample residue contains a drug, in which the chemical reaction produces a visible color change that is indicative of the presence of the drug within the sample residue. Methods of manufacturing a detection kit are also provided.

公开(公告)号：US20240272083A1

公开(公告)日：2024-08-15

申请号：US18634961

申请日：2024-04-14

Applicant: Roche Diabetes Care, Inc.

Inventor： Lukas Alperowitz ,  Max Berg ,  Florian Bodelée ,  Fredrik Hailer ,  Bernd Limburg

IPC: G01N21/78 ,  G01N21/77 ,  G01N33/52 ,  G01S17/88

CPC classification number: G01N21/78 ,  G01N33/52 ,  G01S17/88 ,  G01N2021/7759

Abstract: A method for determining analyte concentration in a body fluid using a mobile device having a camera and a lidar sensor that have an overlapping field of view. In the method, an object is selected and the user is prompted to apply a body fluid sample to a reagent test region. The user is prompted to provide the object within the overlapping field of view of the camera and the lidar sensor. The processor of the mobile device generates a lidar measurement data set representing the object, which is compared to a pre-generated data set. When there is a degree of congruence from the comparison that is above a pre-determined minimum, the camera captures an image of the reagent test region having the body fluid sample applied thereto and concentration of analyte in the sample is determined. When the congruence is below a pre-determined minimum, image capturing is not allowed.

公开(公告)号：US12061201B2

公开(公告)日：2024-08-13

申请号：US17027513

申请日：2020-09-21

Applicant: Rutgers, The State University of New Jersey

Inventor： Daniel S. Pilch ,  Edgar Ferrer-González ,  Edmond J. LaVoie

IPC: C07F5/02 ,  G01N33/52 ,  G01N33/569 ,  G01N33/58

CPC classification number: G01N33/582 ,  C07F5/022 ,  G01N33/52 ,  G01N33/56911

Abstract: The invention provides a compound of formula I:




or a salt thereof, wherein Y, Z, L, and W have any of the values described in the specification, as well as compositions comprising a compound of formula I or a salt thereof. The compounds are useful as tools for visualizing FtsZ and monitoring cell division in a broad range of Gram-positive and Gram-negative bacterial pathogens of acute clinical importance and for identifying new FtsZ inhibitors.

公开(公告)号：US20240192136A1

公开(公告)日：2024-06-13

申请号：US18078153

申请日：2022-12-09

Applicant: Hach Company

Inventor： Daniel Gustav Mieritz ,  Darren Kent MacFarland

IPC: G01N21/64 ,  G01N33/52

CPC classification number: G01N21/6428 ,  G01N33/52 ,  G01N2021/6439

Abstract: An embodiment provides a method for measuring an analyte component of an aqueous sample, including: introducing an indicator solution to the aqueous sample, wherein the indicator solution comprises a plurality of micelles, wherein an indicator is within the micelles and the plurality of micelles is assembled from a cationic surfactant to form an indicator solution; and measuring an analyte component concentration of the aqueous sample, wherein the measuring comprises measuring a change in fluorescence in the aqueous sample, wherein the change in fluorescence is responsive to the analyte component interacting with the indicator. Other aspects are described and claimed.

公开(公告)号：US20240175864A1

公开(公告)日：2024-05-30

申请号：US18431691

申请日：2024-02-02

Applicant: WESTLAKE UNIVERSITY

Inventor： Liang GAO ,  Ruili FENG ,  Yanlu CHEN

IPC: G01N33/52 ,  G01N1/30

CPC classification number: G01N33/52 ,  G01N1/30

Abstract: A biological tissue sample imaging method, comprising: (1) put a magnetic material plate, a gel precursor solution and a biological tissue sample in an embedding container, and then forming a gel to obtain a gel body, in which the biological tissue sample, and a porous plate having ferromagnetism are embedded; and (2) mount the gel body on the sample holder magnetic base of an imaging microscope, and image.

公开(公告)号：US20240175862A1

公开(公告)日：2024-05-30

申请号：US18446153

申请日：2023-08-08

Applicant: Lankenau Institute for Medical Research

Inventor： Margaretha Wallon

IPC: G01N33/49 ,  A61K33/243 ,  A61P1/08 ,  A61P39/06 ,  G01N33/52 ,  G01N33/53 ,  G01N33/80

CPC classification number: G01N33/49 ,  A61K33/243 ,  A61P1/08 ,  A61P39/06 ,  G01N33/52 ,  G01N33/5306 ,  G01N33/80

Abstract: A method for assessing susceptibility to nausea of a patient comprises assessing the GSH recycling dependent antioxidant activity of the patient's blood cells prior to receiving an emetogenic agent. e.g., a cytostatic agent or a surgical anesthetic.

公开(公告)号：US20240166658A1

公开(公告)日：2024-05-23

申请号：US18278694

申请日：2022-02-25

Applicant: University of Tasmania

Inventor： Nathan L. KILAH ,  Chloe M. TAYLOR ,  Michael C. BREADMORE

IPC: C07D487/22 ,  C09K11/06 ,  G01N31/22 ,  G01N33/18 ,  G01N33/24 ,  G01N33/52

CPC classification number: C07D487/22 ,  C09K11/06 ,  G01N31/22 ,  G01N33/1826 ,  G01N33/24 ,  G01N33/52 ,  C09K2211/1074

Abstract: The present invention relates generally to porphyrin derivatives and their use in detecting poly- and perfluoroalkyl substances (PFAS). In particular, the present invention is directed to porphyrin derivatives having at least one receptor arm comprising an anion binding group substituted with a poly- or perfluorinated aliphatic group and their use as sensors for the detection of PFAS.

公开(公告)号：US20240141413A1

公开(公告)日：2024-05-02

申请号：US18498488

申请日：2023-10-31

Applicant: The Hong Kong University of Science and Technology

Inventor： I-Ming HSING ,  Yumeng CAO

IPC: C12Q1/6823 ,  C12N9/22 ,  C12Q1/44 ,  C12Q1/6844 ,  C12Q1/6888 ,  G01N33/52 ,  G01N33/543

CPC classification number: C12Q1/6823 ,  C12N9/22 ,  C12Q1/44 ,  C12Q1/6844 ,  C12Q1/6888 ,  G01N33/52 ,  G01N33/54326 ,  C12N2310/10

Abstract: The subject invention relates to a contamination-free method that utilizes CRISPR/Cas enzyme specific sequence recognition towards the loop region in the LAMP amplicons to accomplish one-pot detection for rapid visual readout diagnostics of the presence or absence of target nucleic acid sequences.