公开(公告)号：US20250067725A1

公开(公告)日：2025-02-27

申请号：US18945444

申请日：2024-11-12

Applicant: 1866402 ONTARIO LIMITED

Inventor： Jeffrey Sutton

IPC: G01N33/50 ,  B01L3/00 ,  C12Q1/44 ,  C12Q1/50 ,  G01N1/38 ,  G01N1/40 ,  G01N15/01 ,  G01N15/06 ,  G01N15/075 ,  G01N33/70

Abstract: There is provided a device and method for separation of blood, including sedimentation of plasma using PVA. The device comprises an inner container enclosed in an outer container, wherein upon alignment of respective openings, allows sample to exit from the inner container into a reaction structure. The reaction structure comprises one or more layers, each with one or more portions each containing concentrations of one or more chemicals.

公开(公告)号：US20240361341A1

公开(公告)日：2024-10-31

申请号：US18627199

申请日：2024-04-04

Applicant: Jana Care, Inc.

Inventor： Daniel B. Lookadoo ,  Ashok A. Kumar ,  Jeremy E. Schonhorn ,  Christopher M. Uherek ,  Michal Depa

IPC: G01N33/70 ,  G01N33/535 ,  G01N33/68 ,  G01N35/00 ,  G16C20/10 ,  H04W84/18

CPC classification number: G01N33/70 ,  G01N33/535 ,  G01N33/6893 ,  G01N35/00069 ,  G16C20/10 ,  H04W84/18

Abstract: Platforms for enzymatic assays for biomarkers, including systems, methods, and measuring devices by which a biomarker, such as creatinine, is measured using a small amount of biological fluid, such as blood, plasma, or serum. The measuring device or biosensor can be a test strip including a layered active component assembly positioned between two outer layers which enables multi-step enzymatic reactions operating in kinetic and/or endpoint (in which the reaction is allowed to near completion), and generally includes multiple layers with primary enzyme(s), coupling enzyme(s), and reagents to produce an optical signal correlated to the concentration of a biomarker in the sample. The test strip can be read using a portable optical reader coupled to a smart phone or tablet.

公开(公告)号：US12117454B2

公开(公告)日：2024-10-15

申请号：US16868644

申请日：2020-05-07

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dirk Block ,  Hans-Peter Brunner ,  Ursula-Henrike Wienhues-Thelen ,  Christian Zaugg ,  Thomas Dieterle ,  Cheryl Mitchell ,  Johan Ubby ,  Sandra Sanders-van Wijk

IPC: G01N33/543 ,  G01N33/62 ,  G01N33/66 ,  G01N33/68 ,  G01N33/70 ,  G01N33/72 ,  G01N33/84

CPC classification number: G01N33/6893 ,  G01N33/62 ,  G01N33/66 ,  G01N33/6869 ,  G01N33/6887 ,  G01N33/70 ,  G01N33/723 ,  G01N33/84 ,  G01N2333/4737 ,  G01N2333/5412 ,  G01N2333/58 ,  G01N2333/78 ,  G01N2333/805 ,  G01N2800/325 ,  G01N2800/347 ,  G01N2800/52

Abstract: Methods for identifying a patient who is eligible for an intensification of heart failure therapy are disclosed. Furthermore, methods for optimizing B-type natriuretic peptide (BNP) and/or N-terminal pro B-type natriuretic peptide (NT-proBNP)-type peptide guided heart failure therapy are disclosed. The methods are based on the measurement of the level of at least one marker in a sample from a patient who has heart failure and who receives B-type natriuretic peptide (BNP) and/or N-terminal pro B-type natriuretic peptide (NT-proBNP)-type peptide guided heart failure therapy. Further described are kits and devices adapted to carry out the described methods.

公开(公告)号：US20240241140A1

公开(公告)日：2024-07-18

申请号：US18557131

申请日：2022-04-26

Applicant: JICHI MEDICAL UNIVERSITY

Inventor： Makoto KUROO

IPC: G01N33/70 ,  G01N33/68

CPC classification number: G01N33/70 ,  G01N33/6893 ,  G01N2800/347 ,  G01N2800/52

Abstract: The present invention includes a method for examining the progression of chronic kidney disease in a subject. The method includes measuring the creatinine concentration in the blood and urine of the subject and the phosphorus concentration in the urine. Next, an estimate for the phosphorous concentration in the primary urine on the basis of Formula (II):







ePTFp
=


Up
Ucr

×
Scr
×
3.33





(
II
)







is calculated, followed by comparing the estimate for the phosphorus concentration in the primary urine with the phosphorus concentration in the primary urine of a normal subject. Another aspect of the invention relates to a method for suppressing the progression of chronic kidney disease in a non-human mammal subject.

公开(公告)号：US20240221958A1

公开(公告)日：2024-07-04

申请号：US18557953

申请日：2022-04-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Felix Gruenewald ,  Martin Klammer ,  Stephen Weber ,  Heike Wegmeyer ,  Ursula-Henrike Wienhues-Thelen ,  Victor Johann Raul Jeger ,  Philipp Schuetz ,  Maria von Holtey

IPC: G16H50/30 ,  G01N33/68 ,  G01N33/70 ,  G01N33/72 ,  G01N33/74

CPC classification number: G16H50/30 ,  G01N33/6893 ,  G01N33/70 ,  G01N33/728 ,  G01N33/74 ,  G01N2333/4703 ,  G01N2333/58 ,  G01N2333/585 ,  G01N2333/805 ,  G01N2333/91188 ,  G01N2800/26 ,  G01N2800/50

Abstract: The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being PCT, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: a cardiac Troponin, Creatinine, a BNP-type peptide, sTREM1, ESM-1, Haptoglobin, Heparin binding protein (HBP) and Aspartate aminotransferase, comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being PCT and a second biomarker selected from the group consisting of: a cardiac Troponin, Creatinine, a BNP-type peptide, sTREM1, ESM-1, Haptoglobin, Heparin binding protein (HBP) and Aspartate aminotransferase, or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection. Moreover, the invention further relates to a computer-implemented method for assessing a subject with suspected infection and a device and a kit for assessing a subject with suspected infection.

公开(公告)号：US12013402B2

公开(公告)日：2024-06-18

申请号：US17433114

申请日：2020-03-27

Applicant: The Regents of the University of California

Inventor： Austin Quach ,  Kym Francis Faull

IPC: G01N33/68 ,  G01N30/34 ,  G01N30/72 ,  G01N30/96 ,  G01N33/50 ,  G01N33/70 ,  G01N33/72 ,  G01N33/92 ,  G16H10/40 ,  G16H50/20

CPC classification number: G01N33/6848 ,  G01N30/34 ,  G01N30/7233 ,  G01N30/96 ,  G01N33/5091 ,  G01N33/6893 ,  G01N33/70 ,  G01N33/728 ,  G01N33/92 ,  G16H10/40 ,  G16H50/20

Abstract: Methods, apparatuses and systems are described that are capable of simultaneously determining the presence, identities or levels of multiple analytes present in a single sample, by carrying out steps including denaturation, normalization, extraction, mixed-mode liquid chromatography and mass spectrometry, whereby the presence, identities or levels of analytes in the single sample are determined.

公开(公告)号：US11867654B2

公开(公告)日：2024-01-09

申请号：US15573686

申请日：2016-01-22

Applicant: INDIAN INSTITUTE OF SCIENCE

Inventor： Vinay Kumar ,  Navakanta Bhat ,  Nikhila Kashyap Dhanvantari Madhuresh

IPC: G01N27/327 ,  G01N33/543 ,  G01N33/493 ,  A61B5/145 ,  A61B5/1468 ,  G01N27/48 ,  G01N33/68 ,  G01N33/70

CPC classification number: G01N27/3277 ,  A61B5/1468 ,  A61B5/14507 ,  A61B5/14546 ,  G01N27/327 ,  G01N27/48 ,  G01N33/493 ,  G01N33/5438 ,  G01N33/68 ,  G01N33/70 ,  G01N2333/76 ,  G01N2333/765

Abstract: An electrochemically active, creatinine-binding device is provided to detect and measure quantitatively, creatinine in biological samples. The device of the present invention is also provided with a device to detect and measure quantitatively creatinine and albumin bioanalytes, simultaneously and to determine albumin to creatinine ratio (ACR). The present invention also provides an electrochemically active, creatinine-binding and albumin-binding device, for collection and retention of biological samples, having creatinine and albumin bioanalytes. In the present invention, a device holder is provided to receive the electrochemically active, creatinine-binding and albumin-binding device. The device, point-of-care biosensor and the method of the present invention, facilitate quantitative measurement of creatinine and albumin bioanalytes in urine and blood samples, and albumin to creatinine ratio (ACR), in urine samples, electrochemically, by determining redox current values.

公开(公告)号：US20230381271A1

公开(公告)日：2023-11-30

申请号：US18361775

申请日：2023-07-28

Applicant: Aurinia Pharmaceuticals Inc.

Inventor： Michael Martin ,  Robert B. Huizinga ,  Neil Solomons

IPC: A61K38/13 ,  A61K31/5377 ,  A61K31/573 ,  A61P37/06 ,  A61P13/12 ,  G01N33/70 ,  G01N33/62 ,  G01N33/68 ,  G01N33/92 ,  G01N33/53

CPC classification number: A61K38/13 ,  A61K31/5377 ,  A61K31/573 ,  A61P37/06 ,  A61P13/12 ,  G01N33/70 ,  G01N33/62 ,  G01N33/6893 ,  G01N33/92 ,  G01N33/5308 ,  G01N2800/52 ,  G01N2800/347

Abstract: Provided herein are methods of employing pharmacodynamics regimens to maximize effectiveness of voclosporin in treatment of proteinuric kidney diseases while minimizing undesirable side effects, such as but not limited to calcineurin inhibitor nephrotoxicity. Also provided are methods of assessments of renal functions and/or conditions, and corresponding protocols to modify, stop, restore and/or re-initiate voclosporin dosing and administrations to maximize effectiveness of voclosporin in treatment of proteinuric kidney diseases while minimizing undesirable side effects.

公开(公告)号：US11761921B2

公开(公告)日：2023-09-19

申请号：US16430057

申请日：2019-06-03

Applicant: Instrumentation Laboratory Company

Inventor： Xiaoxian Xu

IPC: G01N27/327 ,  C12Q1/00 ,  G01N27/333 ,  G01N33/70 ,  G01N33/96 ,  G01N27/30 ,  C12Q1/54 ,  G01N33/53 ,  G16H10/40 ,  G16B25/30 ,  G06F17/18 ,  C12Q1/58 ,  G01N33/543 ,  G06F30/331

CPC classification number: G01N27/3275 ,  C12Q1/002 ,  C12Q1/003 ,  C12Q1/005 ,  C12Q1/54 ,  G01N27/308 ,  G01N27/3272 ,  G01N27/3276 ,  G01N27/3335 ,  G01N33/5308 ,  G01N33/70 ,  G01N33/96 ,  G06F17/18 ,  G16B25/30 ,  G16H10/40 ,  C12Q1/58 ,  G01N27/3274 ,  G01N33/5438 ,  G06F30/331

Abstract: Disclosed herein are compositions for permeable outer diffusion control membranes for creatinine and creatine sensors and methods of making such membranes.

公开(公告)号：US11676705B2

公开(公告)日：2023-06-13

申请号：US17482856

申请日：2021-09-23

Applicant: HEALTHY.IO LTD.

Inventor： Yonatan Adiri ,  Ido Omer ,  Ron Zohar

IPC: G06T7/00 ,  G16H30/40 ,  G16H40/20 ,  G16H10/60 ,  G01N33/70 ,  G01N33/483 ,  G06Q40/08 ,  G01N1/12 ,  G01N21/78 ,  G01N33/487 ,  G01N33/493 ,  G01N33/52 ,  G01N33/68 ,  G16H10/40 ,  G16H30/20 ,  G01N33/50 ,  H04L9/40 ,  H04W4/12 ,  H04W12/06 ,  G06T7/90 ,  G16H70/00 ,  G06F16/583 ,  A61B5/103 ,  A61B5/00 ,  G06Q20/38 ,  G06T7/73 ,  G06T7/11 ,  G16H15/00 ,  G01N1/28

CPC classification number: G16H30/40 ,  A61B5/0013 ,  A61B5/1034 ,  A61B5/445 ,  G01N1/12 ,  G01N21/78 ,  G01N33/4833 ,  G01N33/48778 ,  G01N33/493 ,  G01N33/5094 ,  G01N33/52 ,  G01N33/6803 ,  G01N33/6827 ,  G01N33/70 ,  G06F16/5838 ,  G06Q20/385 ,  G06Q40/08 ,  G06T7/0012 ,  G06T7/0014 ,  G06T7/0016 ,  G06T7/11 ,  G06T7/74 ,  G06T7/90 ,  G16H10/40 ,  G16H10/60 ,  G16H30/20 ,  G16H40/20 ,  G16H70/00 ,  H04L63/126 ,  H04W4/12 ,  H04W12/06 ,  G01N2001/2826 ,  G06T2207/10024 ,  G06T2207/20112 ,  G06T2207/30004 ,  G16H15/00

Abstract: Systems and methods for tracking healing progress of multiple adjacent wounds are provided. In one embodiment, a system may include a processor configured to receive a first image of a plurality of adjacent wounds near a form of colorized surface having colored reference elements, determine colors of the plurality of wounds, correct for local illumination conditions, receive a second image of the plurality of wounds near the form of colorized surface, to determine second colors of the plurality of wounds in the second image, match each of the plurality of wounds in the second image to a wound of the plurality of wounds in the first image, and determine an indicator of the healing progress for each of the plurality of wounds based on changes between the first image and the second image.