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    PRESEPSIN MARKER PANELS FOR EARLY DETECTION OF SEPSIS
    2.
    发明公开
    PRESEPSIN MARKER PANELS FOR EARLY DETECTION OF SEPSIS 审中-公开

    公开(公告)号：US20240230672A1

    公开(公告)日：2024-07-11

    申请号：US18557890

    申请日：2022-04-29

    申请人： Roche Diagnostics GmbH ,  Mochida Pharmaceutical Co., Ltd.

    发明人： Felix Gruenewald ,  Victor Johann Raul Jeger ,  Martin Klammer ,  Philipp Schuetz ,  Maria von Holtey ,  Stephen Weber ,  Heike Wegmeyer ,  Ursula-Henrike Wienhues-Thelen

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6893 ,  G01N2333/65 ,  G01N2333/70596 ,  G01N2333/8139 ,  G01N2333/91188 ,  G01N2800/26

    摘要： The present invention concerns the field of diagnostics. Specifically, it relates to a method for assessing a subject with suspected infection comprising the steps of determining the amount of a first biomarker in a sample of the subject, said first biomarker being Presepsin, determining the amount of a second biomarker in a sample of the subject, wherein said second biomarker is selected from the group consisting of: GDF-15, Creatinine, sFlt1, IGFBP7, sTREM1, Cystatin C and PSP (Pancreatic Stone Protein), comparing the amounts of the biomarkers to references for said biomarkers and/or calculating a score for assessing the subject with suspected infection based on the amounts of the biomarkers, and assessing said subject based on the comparison and/or the calculation. The invention also relates to the use of a first biomarker being Presepsin and a second biomarker selected from the group consisting of: GDF-15, Creatinine, sFlt1, IGFBP7, sTREM1, Cystatin C and PSP (Pancreatic Stone Protein), or a detection agent specifically binding to said first biomarker and a detection agent specifically binding to said second biomarker for assessing a subject with suspected infection. Moreover, the invention further relates to a computer-implemented method for assessing a subject with suspected infection and a device and a kit for assessing a subject with suspected infection.

    MICROFLUIDIC PLATFORM FOR DETECTION OF LIVER INJURY
    3.
    发明公开
    MICROFLUIDIC PLATFORM FOR DETECTION OF LIVER INJURY 审中-公开

    公开(公告)号：US20240228927A1

    公开(公告)日：2024-07-11

    申请号：US18405741

    申请日：2024-01-05

    申请人： Javelin Biotech, Inc.

    发明人： Murat Cirit

    IPC分类号： C12M3/06 ,  C12M1/00 ,  C12M1/34 ,  G01N33/50

    CPC分类号： C12M23/16 ,  C12M23/22 ,  C12M29/14 ,  C12M29/24 ,  C12M41/32 ,  C12M41/34 ,  G01N33/5067 ,  G01N2333/765 ,  G01N2333/9108 ,  G01N2333/91188 ,  G01N2333/916

    摘要： A microfluidic chip is configured to determine DILI parameters. The microfluidic chip includes a cell chamber hosting a tissue culture comprising liver tissue; a reoxygenation chamber configured to add oxygen to a fluid media; a fluid loop configured to recirculate the fluid media through the cell chamber and the reoxygenation chamber and supply oxygenated fluid media to the tissue culture; and an oxygen sensor configured to measure an oxygen concentration within the fluid media. The microfluidic chip includes a controller configured to perform operations including recirculating the fluid media in the fluid loop, the fluid media comprising a drug dose; obtaining measurements of the oxygen concentration at a sequence of time points during recirculating; and determining, based on the measured oxygen concentration, at least one physiologic parameter value of the tissue culture that describes a clinical test metric describing a damage level to the tissue culture.

    COMPOSITION FOR DIAGNOSING PANCREATIC CANCER AND METHOD FOR DIAGNOSING PANCREATIC CANCER USING SAME
    8.
    发明申请
    COMPOSITION FOR DIAGNOSING PANCREATIC CANCER AND METHOD FOR DIAGNOSING PANCREATIC CANCER USING SAME 审中-公开
    用于诊断胰腺癌的组合物和使用其诊断胰腺癌的方法

    公开(公告)号：US20160252512A1

    公开(公告)日：2016-09-01

    申请号：US14901157

    申请日：2014-10-31

    申请人： SK TELECOM CO., LTD. ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION

    发明人： Sangjo HAN ,  Yonghwan CHOI ,  Sung Gon YI ,  Taegyun YUN ,  Junghyun NAMKUNG ,  Youngsoo KIM ,  Taesung PARK ,  Jin-Young JANG

    IPC分类号： G01N33/574 ,  C12Q1/68

    CPC分类号： G01N33/57438 ,  C12Q1/6886 ,  C12Q2600/158 ,  G01N2333/705 ,  G01N2333/91188 ,  G01N2333/924

    摘要： A composition, for diagnosing the possibility of onset of pancreatic cancer including an agent measuring the expression level of marker protein of diagnosing the possibility of onset of pancreatic cancer, or mRNA expression level of a gene encoding the protein, a kit including the composition, and a method of diagnosing pancreatic cancer using the maker are provided. The diagnostic markers of pancreatic cancer in accordance with the present disclosure are useful for predicting or diagnosing the onset, the possibility of onset, and the severity of pancreatic cancer in an early stage, and are also applied to a study on the tumorigenesis of pancreatic cancer. In addition, the diagnosis method of the present invention allows for the convenient detection of pancreatic cancer in a non-invasive manner in a sample such as blood.

    摘要翻译： 一种用于诊断胰腺癌发作的可能性的组合物，包括测定诊断胰腺癌发病的可能性的标志物蛋白的表达水平的试剂，或编码该蛋白质的基因的mRNA表达水平，包含该组合物的试剂盒，以及 提供了使用制造商诊断胰腺癌的方法。 根据本公开的胰腺癌的诊断标志物可用于预测或诊断早期胰腺癌的发病，发病的可能性和严重程度，并且还应用于胰腺癌的肿瘤发生研究 。 此外，本发明的诊断方法允许在诸如血液的样品中以非侵入性方式方便地检测胰腺癌。