公开(公告)号：US20240295517A1

公开(公告)日：2024-09-05

申请号：US18572702

申请日：2022-06-23

申请人： ROYAL MELBOURNE INSTITUTE OF TECHNOLOGY

发明人： Sharath SRIRAM ,  Ganganath PERERA ,  Madhu BHASKARAN

IPC分类号： G01N27/12 ,  G01N33/543 ,  G01N33/551

CPC分类号： G01N27/125 ,  G01N33/5438 ,  G01N33/551 ,  G01N2333/4737 ,  G01N2333/5412

摘要： The invention provides a sensor for detecting a bioanalyte, comprising: a substrate; a pair of terminal electrodes disposed on the substrate in mutually spaced apart and opposing relation; and a sensing element, between and in electrical contact with the pair of terminal electrodes, wherein the sensing element comprises: (i) a semiconducting portion of the substrate, wherein the semiconducting portion comprises a high-resistivity non-oxide semiconductor and wherein a conduction path between the terminal electrodes passes through the semiconducting portion; and (ii) a bioanalyte binding site on a surface of the semiconducting portion, wherein binding of a bioanalyte to the bioanalyte binding site causes a change in electrical resistance of the sensor.

公开(公告)号：US11994517B2

公开(公告)日：2024-05-28

申请号：US18000944

申请日：2021-06-16

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Aaron Kauffmann ,  Jon Stradinger

IPC分类号： G01N33/543 ,  B01L3/00 ,  G01N33/68

CPC分类号： G01N33/54326 ,  B01L3/502761 ,  G01N33/54386 ,  G01N33/6872 ,  B01L2200/04 ,  B01L2200/0668 ,  B01L2200/16 ,  B01L2400/043 ,  G01N2333/4737

摘要： Analytical assay reaction cartridges, kits containing same, and methods of production and use thereof are disclosed. These cartridges include a magnetic assembly that surrounds at least a portion of a sample read window on the cartridge. The cartridge also includes an analytical reagent positioned therewithin, wherein the analytical reagent comprises magnetic beads coated with at least one anti-red blood cell antibody.

公开(公告)号：US20180306809A1

公开(公告)日：2018-10-25

申请号：US16029373

申请日：2018-07-06

申请人： VETICA LABS, INC.

发明人： Juan Estruch ,  Genevieve Hansen

IPC分类号： G01N33/68 ,  C07K16/28 ,  A23K50/40 ,  G01N33/564 ,  G01N33/50 ,  C07K16/18 ,  C07K16/12 ,  G01N33/569

CPC分类号： G01N33/6893 ,  A23K50/40 ,  C07K16/12 ,  C07K16/18 ,  C07K16/28 ,  C07K16/2839 ,  G01N33/5005 ,  G01N33/564 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/195 ,  G01N2333/4727 ,  G01N2333/4737 ,  G01N2333/70546 ,  G01N2333/79 ,  G01N2800/06 ,  G01N2800/24

摘要： The present invention provides methods and systems to accurately detect and measure levels of endogenous antibodies, for examples endogenous IgA, to particular antigens in a biological sample from a companion animal, which is useful to diagnose inflammatory conditions, including bowel disease (IBD), gastrointestinal infections, and food sensitivities in companion animals, e.g., dogs or cats, and to distinguish among such gastrointestinal disorders. Such methods and systems identify whether a sample from the patient is associated with an inflammatory condition, infection, and/or food sensitivity condition, by using non-invasive means, thus conveniently providing information useful for guiding treatment decisions.

公开(公告)号：US20180231536A1

公开(公告)日：2018-08-16

申请号：US15952958

申请日：2018-04-13

申请人： Theranos IP Company, LLC

发明人： Tammy BURD ,  Ian GIBBONS ,  Elizabeth A. HOLMES ,  Gary FRENZEL ,  Anthony Joseph NUGENT

IPC分类号： G01N33/53 ,  G01N35/10 ,  A61B5/15 ,  G01N35/02 ,  G01N35/00 ,  G01N33/94 ,  G01N33/68 ,  G01N33/574 ,  G01N33/569 ,  G01N33/543 ,  G01N1/38 ,  B01L9/00 ,  B01L7/00 ,  B01L3/00 ,  B01L3/02 ,  B01J19/00 ,  A61B5/151 ,  A61B10/00 ,  A61B10/02

CPC分类号： G01N33/5304 ,  A61B5/15 ,  A61B5/150755 ,  A61B5/151 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/007 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/543 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/0097 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/91205 ,  G01N2333/9129 ,  G01N2800/26 ,  G01N2800/60 ,  G16H10/40 ,  Y10T29/49826 ,  Y10T436/25375

摘要： The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US20180209993A1

公开(公告)日：2018-07-26

申请号：US15928066

申请日：2018-03-21

申请人： Robert L. WOLFERT ,  Yu Ping MAGUIRE ,  Yu Ping LI ,  Mark Joseph SARNO

发明人： Robert L. WOLFERT ,  Yu Ping MAGUIRE ,  Yu Ping LI ,  Mark Joseph SARNO

IPC分类号： G01N33/68 ,  A61K31/4418 ,  A61K31/404 ,  A61K31/40 ,  A61K31/366 ,  A61K31/22 ,  C12Q1/44 ,  G01N33/92

CPC分类号： G01N33/6893 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K31/4418 ,  C12Q1/44 ,  G01N33/92 ,  G01N2333/4737 ,  G01N2333/918 ,  G01N2800/32 ,  G01N2800/324

摘要： This invention relates to a method for assessing risk of Coronary Vascular Disease (CVD). Specifically, it relates to utilizing risk assessment from both Lipoprotein Associated Phospholipase A2 (Lp-PLA2) and C-reactive protein (CRP) in combination. In addition the invention relates to a method for assessing risk of Coronary Vascular Disease (CVD) in a patient with low to normal Low Density Lipoprotein Cholesterol (LDL) levels utilizing both LDL and Lipoprotein Associated Phospholipase A2 (Lp-PLA2). Moreover, the invention relates to the use of risk associated with Lp-PLA2, CRP and LDL in combination and specific ranges thereof to predict Coronary Vascular Disease.

公开(公告)号：US20180141041A1

公开(公告)日：2018-05-24

申请号：US15820719

申请日：2017-11-22

申请人： KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS

发明人： Se-Hwan PAEK

IPC分类号： B01L3/00 ,  G01N33/543 ,  G01N33/558 ,  G01N33/68 ,  G01N33/74 ,  C12Q1/26 ,  H04N9/07 ,  H04N5/225

CPC分类号： B01L3/5023 ,  B01L2300/0654 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0825 ,  B01L2300/0887 ,  B01L2400/0406 ,  C12Q1/26 ,  C12Y113/12004 ,  G01N33/54366 ,  G01N33/558 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/4737 ,  G01N2333/585 ,  G01N2333/90241 ,  G01N2333/908 ,  G01N2800/26 ,  H04N5/2254 ,  H04N5/2256 ,  H04N9/07

摘要： Disclosed is a biochemical-immunological hybrid biosensor. The biochemical-immunological hybrid biosensor includes a reaction strip in the form of a porous membrane through which a sample moves by capillary action. The reaction strip can simultaneously measure heterogeneous multiple biomarkers through both a biochemical analysis and an immunoassay in an independent manner based on membrane chromatography to diagnose a particular disease.

公开(公告)号：US20180128826A1

公开(公告)日：2018-05-10

申请号：US15802075

申请日：2017-11-02

申请人： ACCESS MEDICAL SYSTEMS, LTD.

发明人： Robert F. Zuk ,  Qing Xia

IPC分类号： G01N33/543

CPC分类号： G01N33/54393 ,  G01N33/536 ,  G01N33/54386 ,  G01N2333/4737

摘要： The present invention is directed an immunoassay method, which re-uses an antibody-immobilized test probe and reagents for quantitating an analyte in different samples, anywhere from about 3 to 20 times, while maintaining acceptable clinical assay performance. The method regenerates the test probe by dipping the test probe in an acidic solution having pH about 1-4, after the completion of each cycle of reaction. The present invention is also directed to a unitized cartridge (a strip) for an immunoassay test. Each unitized cartridge contains all necessary reagents can be used for 3-20 cycles to measure 3-20 different samples.

公开(公告)号：US20180074057A1

公开(公告)日：2018-03-15

申请号：US15713722

申请日：2017-09-25

申请人： MeMed Diagnostics Ltd.

发明人： Eran EDEN ,  Kfir OVED

IPC分类号： G01N33/569 ,  A61K45/06

CPC分类号： G01N33/56983 ,  A61K45/06 ,  G01N33/569 ,  G01N33/56911 ,  G01N2333/4737 ,  G01N2333/914

摘要： The present invention provides methods of detecting infection using biomarkers. The methods disclosed herein include measuring the expression level of one or more polypeptide determinants in which the alteration of the expression level indicates infection of the patient. The methods provided herein are for distinguishing between bacterial infection, mixed infection, and/or viral infection. The methods disclosed herein may also further comprise measuring one or more non-polypeptide determinants. The present disclosure also provides methods for selection of a treatment regimen for the subject based on whether the subject is identified as having a bacterial or mixed infection, or a viral infection.

公开(公告)号：US20170370867A1

公开(公告)日：2017-12-28

申请号：US15643208

申请日：2017-07-06

申请人： OXFORD UNIVERSITY INNOVATION LIMITED ,  UNIVERSIDADE ESTADUAL PAULISTA “JÚLIO DE MESQUITA FILHO” - UNESP

发明人： Jason Davis ,  Paulo Roberto Bueno

IPC分类号： G01N27/22 ,  H01L29/16 ,  G01N27/27 ,  G01N33/68 ,  G01N27/02 ,  G01N33/543 ,  H01L31/115 ,  G01R27/26

CPC分类号： G01N27/221 ,  G01N27/026 ,  G01N27/227 ,  G01N27/27 ,  G01N33/5438 ,  G01N33/68 ,  G01N2333/4737 ,  G01R27/2605 ,  H01L29/1606 ,  H01L31/115

摘要： The present application relates to a sensing method that is carried out using an electrode that comprises an electrode substrate functionalised with sensing elements. The method involves conducting electrochemical impedance spectroscopy at a plurality of applied voltages and then integrating measurement data as a function of voltage. Also provided is an apparatus for carrying out the sensing method. The method and apparatus are suitable for a broad range of sensing applications, including the detection of diagnostic biomarkers, drug screening, development of glycoarray systems and the sensing of environmental parameters such as light intensity, temperature and humidity.

公开(公告)号：US20170343557A1

公开(公告)日：2017-11-30

申请号：US15513122

申请日：2015-09-22

申请人： Kenneth Kun-Yu WU ,  NATIONAL HEALTH RESEARCH INSTITUTES

发明人： Cheng-Chin Kuo ,  Kenneth Kun-Yu WU

IPC分类号： G01N33/68 ,  G01N33/564

CPC分类号： G01N33/6812 ,  G01N33/564 ,  G01N33/577 ,  G01N33/6893 ,  G01N2333/4737 ,  G01N2800/104 ,  G01N2800/26

摘要： A diagnostic method for inflammatory diseases, and the diagnostic kit used in the method. The diagnostic method includes the use of a novel tryptophan metabolite, 5-methoxytryptophan (5-MTP), as a diagnostic biomarker of inflammation. Specifically, a highly specific competitive ELISA is provided to measure 5-MTP level in human serum for gauging occurrence and severity of inflammatory diseases, including sepsis and systemic lupus.