公开(公告)号：US12123868B2

公开(公告)日：2024-10-22

申请号：US18167557

申请日：2023-02-10

申请人： Alentic Microscience Inc.

发明人： Alan Marc Fine

IPC分类号： G01N33/53 ,  G01N21/77 ,  G01N33/50 ,  G01N33/536 ,  G01N33/543 ,  G01N33/58

CPC分类号： G01N33/5302 ,  G01N21/77 ,  G01N33/5094 ,  G01N33/536 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/582 ,  G01N33/585

摘要： An indicator of a first type and an indicator of a second type are attached to a unit of a chemical component in a sample to form a first multi-indicator complex. The first multi-indicator complex includes the unit of the chemical component, the indicator of the first type, and the indicator of the second type. The indicator of the first type and the indicator of the second type have different discernible characteristics. An image of the sample, including the first multi-indicator complex corresponding to the unit of the chemical component, is captured by an image sensor. Based on a first image of the sample, a count is generated of multi-indicator complexes that include an indicator of the first type and an indicator of the second type, including the first multi-indicator complex. Based on the count, a presence or a level of the chemical component in the sample is identified.

公开(公告)号：US20240183844A1

公开(公告)日：2024-06-06

申请号：US18406279

申请日：2024-01-08

申请人： The Regents of the University of California ,  Brigham Young University

发明人： Holger Schmidt ,  Aaron Roe Hawkins ,  David W. Deamer

IPC分类号： G01N33/53 ,  B01L3/00 ,  C12Q1/6825 ,  C12Q1/70 ,  G01N33/487 ,  G01N33/543 ,  G01N35/00

CPC分类号： G01N33/5302 ,  B01L3/50273 ,  C12Q1/6825 ,  C12Q1/70 ,  G01N33/48721 ,  G01N33/54333 ,  G01N35/00 ,  B01L2200/0668 ,  G01N2035/00247

摘要： A disclosed system uses modulations of ionic current across a nanopore in a membrane to detect target molecules passing through the nanopore. This principle has been applied mainly to nucleic acid sequencing, but can also be used to detect other molecular targets such as proteins and small molecules. In addition, the system delivers target molecules to a nanopore to provide label-free single molecule analysis using a chip-based system. Target molecules are concentrated on microscale carrier beads, and the beads are delivered and optically trapped in an area within the capture radius of the nanopore. The target molecules are released from the beads and detected using nanopore current modulation. In addition, the disclosed system combines sample preparation (e.g. purification, extraction, and pre-concentration) with nanopore-based readout on a microfluidic chip. Finally, target molecules can be specifically bound to carrier beads and particles are positioned within the capture volume of a nanopore using a chip-based microfluidic platform proven to handle specific detection of molecular targets from milliliters of raw sample.

公开(公告)号：US11935657B2

公开(公告)日：2024-03-19

申请号：US17408698

申请日：2021-08-23

申请人： Reliant Immune Diagnostics, Inc.

发明人： Jovan Hutton Pulitzer ,  Henry Joseph Legere, III

IPC分类号： G06K9/00 ,  G01N33/53 ,  G01N33/543 ,  G06Q30/0251 ,  G06T7/00 ,  G16H10/65 ,  G16H50/30 ,  H04N23/60 ,  G06F3/0482

CPC分类号： G16H50/30 ,  G01N33/5302 ,  G01N33/54388 ,  G01N33/54389 ,  G01N33/54391 ,  G06Q30/0267 ,  G06Q30/0269 ,  G06T7/0014 ,  G16H10/65 ,  H04N23/64 ,  G01N2333/59 ,  G01N2333/9513 ,  G06F3/0482 ,  G06F2218/00

摘要： A system and method are provided for collection and testing of a biologic sample. The system and method comprise collecting by a user of a testing device a biologic sample for use with the testing device, assigning correlative values as test results, and receiving the test results at a server disposed on a network. Some aspects further include presenting advertisements and other messages to users through a mobile application operating on a mobile device. These aspects take into account the results of the self-diagnostic test and present different advertisements to the user based on the results of the test.

公开(公告)号：US20240011975A1

公开(公告)日：2024-01-11

申请号：US18021611

申请日：2021-09-08

申请人： 3M INNOVATIVE PROPERTIES COMPANY

发明人： Joshua M. Fishman ,  Paul B. Armstrong ,  Caleb T. Nelson ,  Kayla C. Niccum ,  Henrik B. van Lengerich ,  Tonya D. Bonilla ,  Karl K. Stensvad

IPC分类号： G01N33/53 ,  G01N33/552 ,  G01N33/487

CPC分类号： G01N33/5302 ,  G01N33/552 ,  G01N33/487

摘要： An article includes a flexible carrier film with a first major surface having an array of structures, at least a portion of which include an inorganic layer and an analyte binding layer. The analyte binding is bonded to the inorganic layer via a network of hydrocarbon linking groups, and the analyte binding layer includes at least one functional group selected to bind with a biochemical analyte. Recessed features interspersed with the structures are free of the inorganic layer and the analyte binding layer.

公开(公告)号：US20230365663A1

公开(公告)日：2023-11-16

申请号：US18309590

申请日：2023-04-28

申请人： Albert Einstein College of Medicine

发明人： Jacqueline M. Achkar ,  Jonathan Lai ,  Elise Ishida ,  Daniel Hofmann ,  Tingting Chen

IPC分类号： C07K16/12 ,  G01N33/569 ,  G01N33/53 ,  G01N33/543

CPC分类号： C07K16/1289 ,  G01N33/5302 ,  G01N33/54388 ,  G01N33/5695 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565

摘要： Provided are high affinity Mycobacterium tuberculosis capsule-specific antibodies and fragments thereof, as well as methods of use and devices employing such antibodies and/or fragments.

公开(公告)号：US20230316022A1

公开(公告)日：2023-10-05

申请号：US18312605

申请日：2023-05-05

申请人： John P. Peeters

发明人： John P. Peeters

IPC分类号： G06K7/14 ,  G06Q20/40 ,  G06K7/10 ,  A61B5/00 ,  G01N33/53 ,  A61B5/01 ,  A61B5/103 ,  A61B5/145 ,  A61B5/1455 ,  H04L9/00 ,  H04N1/00

CPC分类号： G06K7/1413 ,  A61B5/0002 ,  A61B5/01 ,  A61B5/1032 ,  A61B5/14514 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/442 ,  A61B5/4833 ,  A61B5/6833 ,  G01N33/5302 ,  G06K7/10297 ,  G06K7/1417 ,  G06Q20/401 ,  H04L9/50 ,  H04N1/00342 ,  A61B2562/0247 ,  A61B2562/0261 ,  A61B2562/0271 ,  A61B2562/08

摘要： A system is described to create customized unique identification (UID) codes combined with customized printable optical or NFC sensors and to combine these unique sensors and unique IDs with unique environmental events, traceability, unique data from cell phones (including geolocation) and person-specific unique indicators such as biomarkers to create completely unique, low cost and proprietary printable genomic and environmental blockchain sensor networks for the Internet of Things (IoT), counterfeit identification, healthcare, pharmaceutical applications and small payment transactions worldwide.

公开(公告)号：US11703506B2

公开(公告)日：2023-07-18

申请号：US17000322

申请日：2020-08-23

申请人： ACCELLIX LTD.

发明人： Harvey Lee Kasdan ,  Julien Meissonnier ,  Yoav Zuta ,  Micha Rosen ,  Yael Himmel ,  Yehoshua Broder ,  Bruce Davis ,  Bruce Goldman ,  Boaz Giron ,  Zion Botesazan ,  Eliezer Blasberg ,  Ilan Semmel ,  Jacques Aschkenasy

IPC分类号： B01L3/00 ,  G01N33/569 ,  G01N21/75 ,  G01N21/64 ,  G01N21/03 ,  G01N15/14 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/58 ,  G01N33/68 ,  G01N15/10 ,  G01N35/00

CPC分类号： G01N33/56972 ,  B01L3/502 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502715 ,  B01L3/502761 ,  G01N15/1459 ,  G01N15/1484 ,  G01N21/03 ,  G01N21/6428 ,  G01N21/75 ,  G01N33/5091 ,  G01N33/5302 ,  G01N33/54386 ,  G01N33/569 ,  G01N33/582 ,  G01N33/68 ,  G01N33/6872 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2300/041 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/123 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0487 ,  G01N2015/1006 ,  G01N2021/0328 ,  G01N2021/6439 ,  G01N2021/6482 ,  G01N2035/00158 ,  G01N2333/70535 ,  G01N2333/70596 ,  G01N2800/26

摘要： The present invention provides self-contained systems for performing an assay for determining a chemical state, the system including a stationary cartridge for performing the assay therein, at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with said sample to report a result of the assay, wherein the at least one reagent, the sample and the at least one reporter functionality are contained within the cartridge.

公开(公告)号：US11693008B2

公开(公告)日：2023-07-04

申请号：US16774078

申请日：2020-01-28

申请人： Institute of Apicultural Research, Chinese Academy of Agricultural Sciences

发明人： Han Hu ,  Qiaohong Wei ,  Si Chen ,  Mao Feng ,  Lifeng Meng ,  Bin Han ,  Yu Fang ,  Chuan Ma ,  Jianke Li

IPC分类号： G01N33/577 ,  C07K16/18 ,  G01N33/53 ,  G01N33/535

CPC分类号： G01N33/577 ,  C07K16/18 ,  G01N33/5302 ,  G01N33/535

摘要： Match-paired monoclonal antibodies against major royal jelly protein 4 (MRJP4) are secreted by hybridoma cell lines having microbial deposit numbers of CGMCC No. 17294 and CGMCC No. 17295, which are used in an ELISA kit and a colloidal gold immunoassay strip for detecting the MRJP4. The positive and MRJP4-specific cell lines are obtained by cell fusion using an antigen of MRJP4 recombinant protein and a cross-reaction with other major royal jelly proteins. The MRJP4 recombinant protein is used as an antigen to obtain several positive cell lines by cell fusion and two MRJP4-specific fusion cell lines are obtained by a cross-reaction with other major royal jelly proteins. Primary screening of a matched antibody pair is performed according to antibody pairing for recognizing different epitopes.

公开(公告)号：US20230184778A1

公开(公告)日：2023-06-15

申请号：US18167557

申请日：2023-02-10

申请人： Alentic Microscience Inc.

发明人： Alan Marc Fine

IPC分类号： G01N33/58 ,  G01N33/543 ,  G01N33/50 ,  G01N21/77 ,  G01N33/53 ,  G01N33/536

CPC分类号： G01N33/582 ,  G01N33/54313 ,  G01N33/5094 ,  G01N21/77 ,  G01N33/5302 ,  G01N33/543 ,  G01N33/585 ,  G01N33/536

摘要： An indicator of a first type and an indicator of a second type are attached to a unit of a chemical component in a sample to form a first multi-indicator complex. The first multi-indicator complex includes the unit of the chemical component, the indicator of the first type, and the indicator of the second type. The indicator of the first type and the indicator of the second type have different discernible characteristics. An image of the sample, including the first multi-indicator complex corresponding to the unit of the chemical component, is captured by an image sensor. Based on a first image of the sample, a count is generated of multi-indicator complexes that include an indicator of the first type and an indicator of the second type, including the first multi-indicator complex. Based on the count, a presence or a level of the chemical component in the sample is identified.

公开(公告)号：US20230142304A1

公开(公告)日：2023-05-11

申请号：US17987486

申请日：2022-11-15

申请人： Compassionate Analytics Inc.

发明人： Philippe Lucas ,  Caleb Eades

IPC分类号： G01N33/94 ,  G01N33/53 ,  G01N33/52 ,  G01N21/78

CPC分类号： G01N33/948 ,  G01N33/5302 ,  G01N33/52 ,  G01N21/78 ,  G01N33/523

摘要： A method for quantification of the concentration of one or more cannabinoid compounds in a liquid sample is provided. The method involves contacting the liquid sample with at least one cannabinoid-sensitive visualization reagent, allowing the at least one cannabinoid-sensitive visualization reagent to develop for a defined amount of time; and comparing the resulting color change of the at least one cannabinoid-sensitive visualization reagent to a calibrated quantification reference chart.