公开(公告)号：US20240255521A1

公开(公告)日：2024-08-01

申请号：US18561185

申请日：2022-05-20

Applicant: The Medical College of Wisconsin, Inc. ,  Duke University

Inventor： Ramani Ramchandran ,  Kevin Rarick ,  Rahima Zennadi

IPC: G01N33/68 ,  G01N33/543 ,  G01N33/58 ,  G01N33/80

CPC classification number: G01N33/6854 ,  G01N33/543 ,  G01N33/58 ,  G01N33/80 ,  G01N2333/914 ,  G01N2800/22 ,  G01N2800/2871 ,  G01N2800/321 ,  G01N2800/347 ,  G01N2800/50

Abstract: The present invention provides methods and kits for detecting cilium markers in samples and uses thereof for detecting and treating endothelial damage or dysfunction or vascular injury in the subject. In one aspect, the disclosure provides a method of detecting endothelial damage or dysfunction or vascular injury in a subject in need thereof, the method comprising: detecting one or more markers of cilium in a biological sample from the subject, wherein a higher level of cilium detected in the biological sample compared to control indicates endothelial damage or dysfunction or vascular injury.

公开(公告)号：US20190242897A1

公开(公告)日：2019-08-08

申请号：US16270306

申请日：2019-02-07

Applicant: STC.UNM

Inventor： Tione Buranda ,  Jacob Ongudi Agola ,  Soumik BasuRay ,  Scarlett Swanson ,  Angela Wandinger-Ness ,  Peter C. Simons ,  Virginie Bondu

IPC: G01N33/573 ,  G01N33/86

CPC classification number: G01N33/573 ,  G01N33/86 ,  G01N2333/914 ,  G01N2800/224 ,  G01N2800/26

Abstract: In one embodiment, the invention provides a method of diagnosing sepsis or a virus-related infection (often a viral hemorrhagic fever infection) in a subject by detecting and measuring the level of a set of sepsis and virus infection-associated-GTPase biomarkers in a sample obtained from the subject using multiplexed flow cytometry. Related kits are also provided. In a preferred embodiment, the invention provides point of care diagnostic methods for determining an early stage sepsis or the severity of a virus infection, especially in a hospital or other setting.

公开(公告)号：US20180258491A1

公开(公告)日：2018-09-13

申请号：US15853699

申请日：2017-12-22

Applicant: Zainab JAGANI ,  Gregory HOFFMAN ,  Frank Peter STEGMEIER ,  Craig Stephen MICKANIN

Inventor： Zainab JAGANI ,  Gregory HOFFMAN ,  Frank Peter STEGMEIER ,  Craig Stephen MICKANIN

IPC: C12Q1/6886 ,  C12N15/113 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/30 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/57496 ,  G01N2333/914

Abstract: The invention provides methods of detecting cancer biomarkers, such as one or more SWI/SNF complex mutations, in order to determine a cancer subject's amenability to therapeutic treatment with a BRM inhibitor. Kits, methods of screening for candidate FIRM inhibitors, and associated methods of treatment are also provided.

公开(公告)号：US20180177749A1

公开(公告)日：2018-06-28

申请号：US15831018

申请日：2017-12-04

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： David Potter ,  Zhijun Guo

IPC: A61K31/155 ,  A61P35/00 ,  A61K31/4409 ,  A61K31/426 ,  A61K31/417 ,  G01N33/574

CPC classification number: A61K31/155 ,  A61K31/417 ,  A61K31/426 ,  A61K31/4409 ,  A61P35/00 ,  C12Y114/14001 ,  C12Y303/02009 ,  G01N33/574 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57423 ,  G01N33/57442 ,  G01N33/57449 ,  G01N33/6893 ,  G01N2333/90245 ,  G01N2333/914 ,  G01N2800/52

Abstract: Certain embodiments of the invention provide a method for identifying a cancer cell that is sensitive to a biguanide compound or other CYP epoxygenase inhibitor, comprising detecting increased expression of at least one cytochrome P450 (CYP) and/or decreased expression of soluble epoxide hydrolase (EPHX2) in the cancer cell, wherein increased CYP expression and/or decreased expression of EPHX2 in the cancer cell correlates with increased sensitivity of the cancer cell to the biguanide compound or other CYP epoxygenase inhibitor.

公开(公告)号：US09873918B2

公开(公告)日：2018-01-23

申请号：US14236118

申请日：2012-08-09

Applicant: Ulrich G. Steidl ,  Laura Barreyro De Pujato ,  Britta Will ,  Amit Verma

Inventor： Ulrich G. Steidl ,  Laura Barreyro De Pujato ,  Britta Will ,  Amit Verma

IPC: A61K39/00 ,  C07K14/54 ,  C07K16/24 ,  C12Q1/68 ,  A61K39/395 ,  A61K31/7088 ,  A61K35/15 ,  A61K47/48 ,  A61K51/10 ,  G01N33/68

CPC classification number: C12Q1/6886 ,  A61K31/7088 ,  A61K35/15 ,  A61K39/395 ,  A61K47/6843 ,  A61K47/6845 ,  A61K47/6849 ,  A61K51/1018 ,  A61K51/1021 ,  A61K51/1027 ,  A61K51/1033 ,  A61K2039/505 ,  C07K14/5421 ,  C07K16/244 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/6869 ,  G01N2333/7155 ,  G01N2333/914 ,  G01N2500/10

Abstract: Methods are disclosed for diagnosis, prognosis and therapy of acute myeloid leukemia and myelodysplastic syndromes using interleukin 1 receptor accessory protein and other targets.

公开(公告)号：US20170312332A1

公开(公告)日：2017-11-02

申请号：US15647154

申请日：2017-07-11

Applicant: The Board of Trustees of the Leland Stanford Junior University

Inventor： Daria Mochly-Rosen ,  Xin Qi ,  Nir Qvit

IPC: A61K38/08 ,  C12Q1/34 ,  C07K7/06 ,  C07K7/08 ,  C07K14/705 ,  C07K14/47 ,  C12N9/14 ,  G01N33/573 ,  C07K14/00 ,  A61K38/16 ,  A61K38/00 ,  A61K51/08

CPC classification number: A61K38/08 ,  A61K38/00 ,  A61K38/16 ,  A61K51/08 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/47 ,  C07K14/4722 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/14 ,  C12Q1/34 ,  G01N33/573 ,  G01N2333/4703 ,  G01N2333/914 ,  G01N2500/02 ,  G01N2500/10 ,  G01N2500/20

Abstract: The present disclosure provides peptides and constructs that inhibit mitochondrial fission, and compositions comprising the peptides or constructs. The present disclosure provides methods of reducing abnormal mitochondrial fission in a cell. Also provided are methods for designing and validating mitochondrial fission inhibitor constructs and peptides, including but not limited to, evaluating the effects of the constructs and peptides on binding of dynamin-1-related protein (Drp1) GTPase activity, Drp1 to mitochondrial fission 1 protein (Fis1), reduction of mitochondrial damage, reduction in cell death, inhibition of mitochondrial fragmentation in a cell under pathological conditions, and reduced loss of neurites in primary dopaminergic neurons in a Parkinsonism cell culture.

公开(公告)号：US09791446B2

公开(公告)日：2017-10-17

申请号：US15015309

申请日：2016-02-04

Applicant: MeMed Diagnostics Ltd.

Inventor： Eran Eden ,  Kfir Oved

IPC: G01N33/569 ,  A61K45/06

CPC classification number: G01N33/56983 ,  A61K45/06 ,  G01N33/569 ,  G01N33/56911 ,  G01N2333/4737 ,  G01N2333/914

Abstract: The present invention provides methods of detecting infection using biomarkers. The methods disclosed herein include measuring the expression level of one or more polypeptide determinants in which the alteration of the expression level indicates infection of the patient. The methods provided herein are for distinguishing between bacterial infection, mixed infection, and/or viral infection. The methods disclosed herein may also further comprise measuring one or more non-polypeptide determinants. The present disclosure also provides methods for selection of a treatment regimen for the subject based on whether the subject is identified as having a bacterial or mixed infection, or a viral infection.

公开(公告)号：US09709565B2

公开(公告)日：2017-07-18

申请号：US13090893

申请日：2011-04-20

Applicant: Eran Eden ,  Kfir Oved

Inventor： Eran Eden ,  Kfir Oved

IPC: C40B40/10 ,  G01N33/569 ,  A61K45/06 ,  C12Q1/02

CPC classification number: G01N33/56983 ,  A61K45/06 ,  G01N33/569 ,  G01N33/56911 ,  G01N2333/4737 ,  G01N2333/914

Abstract: The present invention provides methods of detecting infection using biomarkers. The methods disclosed herein include measuring the expression level of one of more polypeptide determinant in which the alteration of the expression level indicates infection of the patient in a sample of the subject and determining a clinically significant alteration in the level of the one or more polypeptides in the sample, wherein the alteration indicates an infection in the subject. The methods provided herein are for distinguishing between bacterial infection, mixed infection and/or viral infection.

公开(公告)号：US20170198353A1

公开(公告)日：2017-07-13

申请号：US15188489

申请日：2016-06-21

Applicant: Memorial Sloan- Kettering Cancer Institute

Inventor： Alberto Bardelli ,  Federica Di Nicolantonio ,  Salvatore Siena ,  David B. Solit

IPC: C12Q1/68 ,  G01N33/574 ,  A61K39/395 ,  A61K31/4184 ,  C07K16/28

CPC classification number: C12Q1/6886 ,  A61K31/21 ,  A61K31/4184 ,  A61K31/4427 ,  A61K31/519 ,  A61K39/3955 ,  C07K16/2863 ,  C07K2317/24 ,  C07K2317/76 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/57419 ,  G01N33/5748 ,  G01N2333/82 ,  G01N2333/914 ,  G01N2800/52

Abstract: The disclosure provides compositions and methods for detecting and predicting acquired resistance to anti-EGFR treatment in colorectal cancers. Also provided are compositions and methods of preventing, reversing or delaying the acquired resistance. The present disclosure also provides kits for use in the methods described herein.

公开(公告)号：US20170107299A1

公开(公告)日：2017-04-20

申请号：US15395114

申请日：2016-12-30

Applicant: OvaScience, Inc.

Inventor： David T. WEAVER ,  Bo ZHANG

IPC: C07K16/40

CPC classification number: C07K16/40 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  C12Y306/04013 ,  G01N33/566 ,  G01N33/56966 ,  G01N33/573 ,  G01N2333/914

Abstract: Anti-VASA antibodies (mAbs), particularly humanized mAbs that specifically bind to VASA with high affinity, are disclosed. The amino acid sequences of the CDRs of the light chains and the heavy chains, as well as consensus sequences for these CDRs, of these anti-VASA mAbs are provided. The disclosure also provides nucleic acid molecules encoding the anti-VASA mAbs, expression vectors, host cells, methods for making the anti-VASA mAbs, and methods for expressing the anti-VASA mAbs. Finally, methods of using the anti-VASA mAbs to isolate and/or purify cells expressing VASA are disclosed.