Compositions and methods for controlling cellular function

    公开(公告)号:US10907219B2

    公开(公告)日:2021-02-02

    申请号:US15119506

    申请日:2015-02-18

    发明人: Fu-Sen Liang Wei Wang

    IPC分类号: C12Q1/68 C12Q1/6897

    摘要: This disclosure describes compositions and methods that involve a first modular component and a second modular component. The first modular component includes a first target molecule coupled to a first dimerizing moiety. The second modular component includes a second target molecule coupled to a second dimerizing moiety. The first dimerizing moiety dimerizes with the second dimerizing moiety when the first dimerizing moiety binds a chemical induced proximity (CIP) inducer.

    SYSTEMS AND METHODS FOR ANALYZING STABILITY USING METAL RESISTANCE VARIATIONS

    公开(公告)号:US20200293288A1

    公开(公告)日:2020-09-17

    申请号:US16856887

    申请日:2020-04-23

    申请人: STC.UNM

    发明人: James Plusquellic

    摘要: This disclosure describes techniques for analyzing statistical quality of bitstrings produced by a physical unclonable function (PUF). The PUF leverages resistance variations in the power grid wires of an integrated circuit. Temperature and voltage stability of the bitstrings are analyzed. The disclosure also describes converting a voltage drop into a digital code, wherein the conversion is resilient to simple and differential side-channel attacks.

    Method of diagnosing and/or monitoring therapy of atherosclerosis

    公开(公告)号:US10744214B2

    公开(公告)日:2020-08-18

    申请号:US16065393

    申请日:2016-12-28

    申请人: STC.UNM

    IPC分类号: A61K51/04 A61K49/10 A61K47/22

    摘要: The present invention is directed to novel non-invasive diagnostic took to dispose numerous disease states and/or conditions. The presets invention, represents a clear advance in the art which presently relies on tissue biopsy for diagnoses of these disease states. The novel imaging probe is capable of detecting infected cells, as well tissue. The methods described herein are able to diagnose, treat and/or monitor the therapy of numerous diseases and conditions including atherosclerosis, atherothrombosis, cerebral vascular disease, cerebral ischemia, cerebral infarct and meningitis as well as pneumonitis, pericarditis, multiple sclerosis, lupus erythematosus and pancreatitis, among others.

    Systems and methods for measuring absorption coefficients of doped optical fibers

    公开(公告)号:US10739229B2

    公开(公告)日:2020-08-11

    申请号:US16522449

    申请日:2019-07-25

    申请人: STC.UNM

    IPC分类号: G01M11/00

    摘要: A system for measuring an absorption coefficient of a doped optical fiber may include: a laser source configured to transmit laser light at a selectable wavelength; a single-mode optical fiber including an end configured to splice to the doped optical fiber; two or more multimode fibers at a side of the doped optical fiber, spaced apart along the side of the doped optical fiber, configured to collect spontaneous emissions from the side of the doped optical fiber; and/or a photodiode or power meter connected to the two or more multimode fibers. A method for measuring an absorption coefficient of a doped optical fiber may include: collecting, from a side of the doped optical fiber, an emission spectrum using two or more multimode fibers; and/or calculating the absorption coefficient form using the emission spectrum and McCumber theory.