公开(公告)号：US12049671B2

公开(公告)日：2024-07-30

申请号：US17409132

申请日：2021-08-23

申请人： EXACT SCIENCES CORPORATION ,  Mayo Foundation for Medical Education and Research

发明人： Hatim T. Allawi ,  Michael W. Kaiser ,  Graham P. Lidgard ,  William R. Taylor ,  Tamara J. Sander ,  Abram M. Vaccaro

IPC分类号： C12Q1/6883 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6853 ,  C12Q1/6886 ,  G01N33/533 ,  G01N33/574 ,  G16Z99/00

CPC分类号： C12Q1/6883 ,  C12Q1/6809 ,  C12Q1/6827 ,  C12Q1/6853 ,  C12Q1/6886 ,  G01N33/533 ,  G01N33/57419 ,  G16Z99/00 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/16

摘要： Provided herein is technology for neoplasia screening, and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of cancer, in particular, colorectal cancer.

公开(公告)号：US20240248041A1

公开(公告)日：2024-07-25

申请号：US18624533

申请日：2024-04-02

申请人： OUTSENSE DIAGNOSTICS LTD.

发明人： Ishay Attar ,  Yaara Kapp-Barnea

IPC分类号： G01N21/64 ,  A61B10/00 ,  E03D11/13 ,  G01J3/10 ,  G01J3/28 ,  G01J3/42 ,  G01J5/0806 ,  G01J5/0808 ,  G01J5/10 ,  G01N21/31 ,  G01N33/493 ,  G01N33/574

CPC分类号： G01N21/6486 ,  A61B10/0038 ,  A61B10/007 ,  G01J3/10 ,  G01J3/2803 ,  G01J5/0806 ,  G01J5/0808 ,  G01J5/10 ,  G01N21/31 ,  G01N21/645 ,  G01N33/493 ,  A61B2010/0006 ,  E03D11/13 ,  G01J2003/104 ,  G01J3/42 ,  G01N2021/6421 ,  G01N33/57419

摘要： Apparatus and methods are described for use with a bodily emission of a subject that is disposed within a toilet bowl. One or more light sensors are configured to receive light from the toilet bowl, while the bodily emission is disposed within the toilet bowl. A computer processor detects a set of three or more spectral components that have a characteristic relationship with each other in a light spectrum of a microorganism, by analyzing the received light, and determines that there is a presence of the microorganism within the bodily emission in response thereto. Other applications are also described.

公开(公告)号：US12043871B2

公开(公告)日：2024-07-23

申请号：US18062419

申请日：2022-12-06

申请人： Mayo Foundation for Medical Education and Research

发明人： William R. Taylor ,  Jonathan J. Harrington ,  Patrick S. Quint ,  Hongzhi Zou ,  Harold R. Bergen, III ,  David I. Smith ,  David A. Ahlquist

IPC分类号： C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q1/37 ,  C12Q1/40 ,  C12Y302/01001 ,  C12Y304/2107 ,  G01N33/57407 ,  G01N33/57419 ,  G01N33/57438 ,  C12Q2600/154 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2333/928 ,  G01N2333/966 ,  G01N2560/00

摘要： This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

公开(公告)号：US11981959B2

公开(公告)日：2024-05-14

申请号：US17748522

申请日：2022-05-19

申请人： MORGAN AND MENDEL GENOMICS, INC. ,  ALBERT EINSTEIN COLLEGE OF MEDICINE

发明人： Harry Ostrer ,  Johnny C. Loke ,  Ishraq Alim

IPC分类号： G01N31/00 ,  C12Q1/6804 ,  C12Q1/6827 ,  G01N15/14 ,  G01N33/50 ,  G01N33/53 ,  G01N33/574 ,  G01N15/10

CPC分类号： C12Q1/6827 ,  C12Q1/6804 ,  G01N15/14 ,  G01N33/5023 ,  G01N33/5035 ,  G01N33/5041 ,  G01N33/57419 ,  G01N33/57484 ,  G01N2015/1006

摘要： Heritable pathogenic variants in the mismatch repair (MMR) pathway, also known as Lynch Syndrome (LS), can lead to the development of colon cancer and other cancers. Following mismatch, a complex of proteins consisting of MLH1, MSH2, MSH6 and PMS2 translocate into the nucleus to signal recruitment of repair mechanisms. Flow cytometry-based, functional variant assays (FVAs), were developed to determine whether variants in these MMR repair genes and/or other related genes would augment the nuclear translocation of MLH1 and MSH2 and downstream nuclear phosphorylation of ATM and ATR in response to DNA mismatches. Each assay distinguished pathogenic variants in MMR repair genes (MLH1, MSH2, PMS2 and MSH6) from benign controls. The combination of multiple assays provided robust separation between heterozygous pathogenic variant carriers and benign controls. The ability to produce distinct molecular phenotypes by these assays suggest FVA assays of MMR pathways could be used to identify LS and associated risk of colon and other cancers and could act as an adjunct to MMR gene sequencing panels in categorizing variants.

公开(公告)号：US20240148893A1

公开(公告)日：2024-05-09

申请号：US18178854

申请日：2023-03-06

申请人： NATIONAL CANCER CENTER JAPAN ,  RIN INSTITUTE INC.

发明人： Yasuhiro MATSUMURA ,  Masahiro Yasunaga ,  Shinji Saijou ,  Shingo Hanaoka ,  Takahiro Anzai ,  Shino Manabe

IPC分类号： A61K47/68 ,  A61K39/395 ,  A61K49/00 ,  A61P35/00 ,  C07K16/30 ,  C12N5/10 ,  C12N15/09 ,  C12N15/62 ,  G01N33/574

CPC分类号： A61K47/6851 ,  A61K39/395 ,  A61K49/00 ,  A61P35/00 ,  C07K16/30 ,  C12N5/10 ,  C12N15/09 ,  C12N15/62 ,  G01N33/574 ,  G01N33/57419

摘要： An object of the present invention is to provide an anticancer drug capable of treating cancer by finding a target molecule specifically expressed in cancer cells and by specifically acting on the target molecule, and to provide a cancer testing method including a step of measuring the target molecule in a sample. The present invention provides an anticancer drug containing, as an active ingredient thereof, an anti-transmembrane protein 180 (TMEM-180) antibody or an antigen-binding fragment thereof. In addition, the present invention provides a cancer testing method including a step of measuring the amount of TMEM-180 in a sample collected from a subject.

公开(公告)号：US11970744B2

公开(公告)日：2024-04-30

申请号：US17304068

申请日：2021-06-14

申请人： Siemens Healthcare Diagnostics Inc.

发明人： Michael Stürzl ,  Roland S. Croner ,  Andreas Konrad

IPC分类号： C12Q1/68 ,  C12Q1/6886 ,  G01N33/574 ,  G16H50/30

CPC分类号： C12Q1/6886 ,  G01N33/57419 ,  G16H50/30 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N2333/78 ,  G01N2333/96494 ,  G01N2800/50 ,  Y02A90/10

摘要： The present invention relates to the methods and products for detection of colorectal cancer. Additionally, the present invention relates to methods and products for determining the probability, risk or incidence of colorectal cancer and of colorectal cancer metastasis. The products and methods of the present invention include detecting the level of expression of COL10A1 or MMP11, in combination, from samples, including tissue samples, from humans who currently have been diagnosed with cancer or who were previously diagnosed with cancer and those who are thought to have cancer and are undergoing diagnosis.

公开(公告)号：US11952429B2

公开(公告)日：2024-04-09

申请号：US17848694

申请日：2022-06-24

申请人： PRECISION BIOLOGICS, INC.

发明人： J. Andrew Bristol ,  Judith A. Kantor

IPC分类号： A61K45/06 ,  A61K39/395 ,  A61K47/68 ,  C07K16/18 ,  C07K16/30 ,  G01N33/574 ,  G01N33/577 ,  A61K39/00

CPC分类号： C07K16/3046 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6859 ,  A61K47/6863 ,  C07K16/18 ,  C07K16/303 ,  G01N33/57419 ,  G01N33/57438 ,  G01N33/577 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/732

摘要： The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to the nucleic acids, and uses for these antibodies, nucleic acids and amino acids.

公开(公告)号：US20230399699A1

公开(公告)日：2023-12-14

申请号：US18034571

申请日：2021-11-02

申请人： SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUEE SOCPRA SANTE ET HUMAINES, S.E.C.

发明人： Jean-francois BEAULIEU ,  Elizabeth Herring ,  Eric Tremblay

IPC分类号： C12Q1/6886 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  G01N33/57419 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/154 ,  C12Q2600/156

摘要： The present disclosure concerns a method for stratifying the risk of a subject of having an advanced colorectal adenoma or a colorectal cancer based on determining the presence of overexpressed mRNA transcripts in the subject's stool. The method can be used to screen for subjects suitable for a colonoscopy. The method can also be used to tailor the stratified subject's treatment regimen.

公开(公告)号：US11802874B2

公开(公告)日：2023-10-31

申请号：US15556568

申请日：2016-03-10

申请人： FUNDACIÓ INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE (IDIBELL) ,  INSTITUT CATALÀ D'ONCOLOGIA (ICO)

发明人： Oriol Casanovas Casanovas ,  Gabriela Jiménez Valerio ,  María Ochoa De Olza ,  Valentí Navarro Pérez ,  Nicklas Bassani ,  Helena Verdaguer

IPC分类号： G01N33/574

CPC分类号： G01N33/57415 ,  G01N33/57419 ,  G01N33/57438 ,  G01N2333/475 ,  G01N2800/52

摘要： The present invention corresponds to the field of cancer and is related to predicting cancer detection, diagnosis, monitoring and prediction of response to treatment, in particular platelet derived-endothelial cell growth factor (PD-ECGF) levels for their use as a potential value in monitoring disease evolution and predicting response to anti-angiogenic treatment.

公开(公告)号：US11773169B2

公开(公告)日：2023-10-03

申请号：US16964236

申请日：2019-01-25

申请人： YMMUNOBIO AG

发明人： Mitsuro Kanda

IPC分类号： C07K16/28 ,  A61P35/04 ,  C12N15/113 ,  G01N33/574 ,  A61K39/00

CPC分类号： C07K16/286 ,  A61P35/04 ,  C12N15/1138 ,  G01N33/57407 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57423 ,  G01N33/57438 ,  G01N33/57446 ,  G01N33/57492 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/76 ,  C12N2310/141

摘要： From gene expression analysis with a long-term recurrence-free group and a recurrence metastasis group of stomach cancer, CHRNB2 and NPTXR were identified as drug discovery targets. Tumor growth was successfully inhibited by an antibody medicine or a nucleic acid medicine targeting CHRNB2 or NPTXR. Furthermore, a polyclonal antibody and a monoclonal antibody linking to CHRNB2 or NPTXR are provided. Since these receptor molecules are novel molecular targets, treatment of cases which the existing therapeutic drugs have no effect on is made possible.