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公开(公告)号：US20240133904A1
公开(公告)日：2024-04-25
申请号：US18057333
申请日：2022-11-21
IPC分类号： G01N33/86 , C07K16/18 , C07K16/26 , C07K16/36 , G01N33/543
CPC分类号： G01N33/86 , C07K16/18 , C07K16/26 , C07K16/36 , G01N33/54388 , C07K2317/32 , C07K2317/92 , G01N33/5302 , G01N2333/75 , G01N2800/224 , G01N2800/226
摘要： Disclosed are an immunochemical assay device and a method of using the immunochemical assay device for detecting one or more targets or markers such as Cardiac Troponin I, NT-pro-BNP, D-dimer and/or cross-linked fibrin in a fluid sample.
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公开(公告)号：US11884979B2
公开(公告)日：2024-01-30
申请号：US16333177
申请日：2017-09-15
IPC分类号： C12Q1/68 , C12Q1/6883 , C12Q1/6876 , G01N33/50 , C12Q1/6813 , C12Q1/6851 , C12Q1/686
CPC分类号： C12Q1/6883 , C12Q1/686 , C12Q1/6813 , C12Q1/6851 , C12Q1/6876 , G01N33/502 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N2800/224
摘要： Provided herein are methods and kits for analyzing a biological sample obtained from a subject having, suspected of having, or being at risk for a disease associated with the contact activation system.
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公开(公告)号：US20240027477A1
公开(公告)日：2024-01-25
申请号：US18212002
申请日：2023-06-20
申请人： C A Casyso GmbH
CPC分类号： G01N33/86 , G01N33/4905 , G01N11/14 , B01L3/52 , B01L3/502 , G01N11/00 , B01L2200/10 , B01L2300/0636 , B01L2300/0861 , B01L2300/0627 , B01L2300/087 , B01L2400/0475 , G01N2011/0046 , G01N2333/96458 , G01N2800/224
摘要： The present invention is directed to a cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, in particular a blood sample, comprising a cartridge body having at least one measurement cavity formed therein and having at least one probe element arranged in said at least one measurement cavity for performing a test on said sample liquid; and a cover being attachable on said cartridge body; wherein said cover covers at least partially said at least one measurement cavity and forms a retaining element for retaining said probe element in a predetermined position within said at least one measurement cavity. The invention is directed to a measurement system and a method for measuring viscoelastic characteristics of a sample liquid.
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公开(公告)号：US09970948B2
公开(公告)日：2018-05-15
申请号：US15025586
申请日：2014-10-22
CPC分类号： G01N33/86 , G01N21/11 , G01N33/491 , G01N35/1002 , G01N35/1011 , G01N35/1016 , G01N35/1083 , G01N2021/825 , G01N2035/00346 , G01N2035/0453 , G01N2035/1058 , G01N2800/224
摘要： If an air bubble is entrained when a reagent is added to a sample, disturbance caused by this air bubble may prevent accurate optical measurement, thereby reducing accuracy for measuring blood clotting ability. The position to dispense the reagent depends on accuracy of stopping a reagent dispensing mechanism and dimensional errors of individual detectors, and thus conventional reagent discharging method may entrain an air bubble because a distance between a nozzle for dispensing the reagent and an inner wall of a reaction vessel is not constant and conditions for dispensing the reagent to the sample vary. In the present invention, an automatic analyzer with a nozzle for sucking and discharging the reagent for blood clotting reaction is provided with a dispensing mechanism that keeps a constant position for the nozzle to discharge the reagent by pressing the nozzle against the inner wall of the reaction vessel within the elastic range.
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公开(公告)号：US09897616B2
公开(公告)日：2018-02-20
申请号：US14581500
申请日：2014-12-23
发明人： Hyun-Ju Doh , Doo-Sik Kim , Kwang-Hoe Chung
CPC分类号： G01N33/86 , C07K16/18 , C07K16/36 , C07K2317/92 , G01N2333/75 , G01N2800/224
摘要： Disclosed are a monoclonal antibody against human D-dimer produced in a mouse and high molecular weight cross-linked fibrin including a corresponding epitope, a cell line secreting the monoclonal antibody, and methods for producing the same. The anti-D-dimer monoclonal antibody of the present invention may be effectively used as a diagnosis agent for screening and detecting in-vivo D-dimer, and high molecular weight cross-linked fibrin and its derivatives containing the D-dimer since the monoclonal antibody specifically reacts with D-dimer, and cross-linked fibrin and its derivatives containing the D-dimer, which do not bind to human fibrinogen or fibrin.
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6.发明申请公开(公告)号：US20180031539A1
公开(公告)日：2018-02-01
申请号：US15661313
申请日：2017-07-27
发明人： Midori SHIMA , Keiji NOGAMI , Tomoko MATSUMOTO , Yuka TABUCHI , Nobuo ARAI
CPC分类号： G01N33/4905 , G01N21/77 , G01N21/82 , G01N33/86 , G01N35/00584 , G01N2021/7783 , G01N2035/0097 , G01N2333/7454 , G01N2333/755 , G01N2800/224 , G01N2800/56 , G01N2800/7033
摘要： Disclosed is a method for determining the severity of hemophilia, the method including the steps of: coagulating a blood specimen to acquire a coagulation waveform; acquiring an average change rate of a coagulation rate from the coagulation waveform; and determining the severity of hemophilia in the blood specimen based on the average change rate of the coagulation rate.
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公开(公告)号：US20170246632A1
公开(公告)日：2017-08-31
申请号：US15507616
申请日：2015-08-28
申请人： Alberto C. Redaelli , Marco Rasponi , THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA , THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
CPC分类号： B01L3/502746 , A61B5/14546 , B01L2400/086 , G01N15/1056 , G01N33/5091 , G01N33/56966 , G01N33/56972 , G01N2015/1006 , G01N2800/224 , G01N2800/226
摘要： Provided herein is technology relating to microfluidic devices and particularly, but not exclusively, to devices, methods, systems, and kits for imparting stresses on a fluid flowing through a microfluidic device that is designed to mimic a stress profile of a macrofluidic device or pathology.
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公开(公告)号：US09739733B2
公开(公告)日：2017-08-22
申请号：US14648124
申请日：2013-12-05
申请人： T2 Biosystems, Inc.
CPC分类号： G01N24/088 , C12Q1/56 , G01N33/4905 , G01N2333/75 , G01N2800/224 , G01R33/448 , G01R33/465 , G06F19/00 , G16H50/20 , Y02A90/26
摘要： The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed.
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公开(公告)号：US20170189903A1
公开(公告)日：2017-07-06
申请号：US15465490
申请日：2017-03-21
IPC分类号： B01L3/00 , G01N29/036 , G01N33/49 , G01N11/16
CPC分类号： B01L3/50273 , B01L3/502 , B01L3/502753 , B01L2300/0663 , B01L2300/0816 , B01L2300/0877 , B01L2300/165 , B01L2400/0433 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , G01N11/16 , G01N29/032 , G01N29/036 , G01N29/2418 , G01N33/4905 , G01N2291/02466 , G01N2291/0251 , G01N2291/02818 , G01N2291/02827 , G01N2291/0427 , G01N2800/224
摘要： A sample testing cartridge is usable to perform a variety of tests on a viscoelastic sample, such hemostasis testing on a whole blood or blood component sample. The cartridge includes a sample processing portion that is in fluid communication with a sample retention structure. A suspension, such as a beam, arm, cantilever or similar structure supports or suspends the sample retention portion relative to the sample processing portion in a unitary structure. In this manner, the sample retention portion may be placed into dynamic excitation responsive to excitation of the cartridge and correspondingly dynamic, resonant excitation of the sample contained within the sample retention portion, while the sample processing portion remains fixed. Observation of the excited sample yields data indicative of hemostasis. The data may correspond to hemostasis parameters such as time to initial clot formation, rate of clot formation, maximum clot strength and degree of clot lysis.
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公开(公告)号：US20170153255A1
公开(公告)日：2017-06-01
申请号：US15345070
申请日：2016-11-07
申请人： BAXALTA INCORPORATED , BAXALTA GMBH
发明人： Katalin VARADI , Hanspeter ROTTENSTEINER , Peter TURECEK , Hans-Peter SCHWARZ , Jutta SCHREINER
IPC分类号： G01N33/86 , G01N33/573
CPC分类号： G01N33/86 , C12Q1/37 , C12Q1/56 , G01N33/573 , G01N2333/755 , G01N2333/96486 , G01N2800/224 , G01N2800/52
摘要： The invention generally relates to methods of measuring cleaved von Willebrand factor (VWF) fragments. More specifically, the invention relates to methods of measuring the ability of a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13) to cleave VWF in vivo. The invention also relates to methods of using various animal models which demonstrate ADAMTS13 activity similar to that of a human. The invention further relates to methods of measuring the cleavage products of rVWF in mammals, particularly in humans and in human plasma.
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