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公开(公告)号：US12078588B2
公开(公告)日：2024-09-03
申请号：US18303073
申请日：2023-04-19
CPC分类号： G01N21/03 , B01L3/5027 , B01L3/502723 , G01N21/11 , G01N21/253 , B01L2200/143 , B01L2200/146 , B01L2300/0851 , B01L2300/0858 , B01L2300/0877 , B01L2400/0622 , G01N2021/0346 , G01N2021/0357
摘要： Reusable network of spatially-multiplexed microfluidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid. System and method for photometric measurements of multiple fluid samples employing such network of channels.
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公开(公告)号：US20240248025A1
公开(公告)日：2024-07-25
申请号：US18156692
申请日：2023-01-19
发明人： Vince Siu , Bing Dang , Bo Wen , Kuan Yu Hsieh
CPC分类号： G01N21/11 , G01N1/38 , G01N21/03 , G01N21/251 , G01N2021/0325
摘要： A liquid metering and mixing system for preparing a plurality of samples for analysis. The system includes: a liquid metering apparatus disposed in fluid communication with a sample holder and a plurality of reaction chambers and configured to meter a volume of a liquid into each of the plurality of reaction chambers, wherein each of the plurality of reaction chambers includes a reagent; and a mixing apparatus comprising a plurality of mixing elements, wherein each of the plurality of mixing elements is disposed in a corresponding reaction chamber of the plurality of reaction chambers and is adapted to mix the volume of the liquid with the reagent in preparation for analysis
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公开(公告)号：US12000849B2
公开(公告)日：2024-06-04
申请号：US17530623
申请日：2021-11-19
CPC分类号： G01N35/025 , G01N21/11 , G01N21/82 , G01N33/86 , G01N35/00584 , G01N35/00693 , G01N35/0092 , G01N35/1004 , G01N2021/115 , G01N2035/00425 , G01N2035/00673 , G01N2035/0094 , G01N2035/0097 , G01N2035/0437 , G01N2035/0453
摘要： A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.
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公开(公告)号：US20230251182A1
公开(公告)日：2023-08-10
申请号：US18303073
申请日：2023-04-19
CPC分类号： G01N21/03 , B01L3/5027 , B01L3/502723 , G01N21/11 , G01N21/253 , B01L2200/143 , B01L2200/146 , B01L2300/0851 , B01L2300/0858 , B01L2300/0877 , B01L2400/0622 , G01N2021/0346 , G01N2021/0357
摘要： Reusable network of spatially-multiplexed microfluidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid. System and method for photometric measurements of multiple fluid samples employing such network of channels.
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公开(公告)号：US20180168556A1
公开(公告)日：2018-06-21
申请号：US15383187
申请日：2016-12-19
申请人： David R. Hall , Dan Allen , Jared Reynolds , Joshua Larsen , Terrece Pearman
发明人： David R. Hall , Dan Allen , Jared Reynolds , Joshua Larsen , Terrece Pearman
CPC分类号： A61B10/007 , G01N21/11 , G01N21/3577 , G01N2021/0346
摘要： We disclose a device and method for collecting a urine sample as a user urinates into a toilet. The device further conducts analytical measurements which may include spectral, colorimetric, and chemical assays. The user need only urinate normally into the toilet. A urine collection trap, which includes a vertical slit, may capture a urine sample which has a volume in the microliter range. Pumps may divert the urine from the vertical slit into a conduit that is connected to spectral analysis devices and other devices for analyzing the urine sample. The disclosed device is both convenient and prevents unsanitary urine spills.
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公开(公告)号：US20180113068A1
公开(公告)日：2018-04-26
申请号：US15570958
申请日：2015-07-24
发明人： Timothy L. Weber
CPC分类号： G01N21/05 , B01L3/50273 , B01L2300/0816 , B01L2400/0442 , G01N21/11 , G01N21/59 , G01N21/6428 , G01N2021/0328 , G01N2021/0346 , G01N2021/6439 , G01N2021/7783 , G01N2021/7786 , G01N2201/0221 , G01N2201/024 , G01N2201/0873
摘要： In one example, testing cells extend along a length of a slot. Each testing cell includes a microfluidic channel extending from the slot, a pump to move fluid from the slot into the channel, a discharge nozzle through which fluid exits the channel, a fluid discharger to discharge fluid from the channel through the nozzle and a photosensor. A light guide is provided to receive light from an external light source and is to serially transmit the light to the microfluidic channel of each of the plurality of testing cells.
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公开(公告)号：US20180088025A1
公开(公告)日：2018-03-29
申请号：US15677459
申请日：2017-08-15
IPC分类号： G01N21/03
CPC分类号： G01N21/03 , B01L3/502723 , B01L2200/143 , B01L2200/146 , B01L2300/0851 , B01L2300/0858 , B01L2300/0877 , B01L2400/0622 , G01N21/11 , G01N21/253 , G01N2021/0346 , G01N2021/0357
摘要： Reusable network of spatially-multiplexed microfluidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid. System and method for photometric measurements of multiple fluid samples employing such network of channels.
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公开(公告)号：US20180052101A1
公开(公告)日：2018-02-22
申请号：US15242733
申请日：2016-08-22
申请人： Yuguang Cai
发明人： Yuguang Cai
IPC分类号： G01N21/3577 , G01N21/03 , G01N21/11 , G01N33/14
CPC分类号： G01N21/3577 , G01N21/0303 , G01N21/11 , G01N33/14 , G01N33/143 , G01N2021/0364
摘要： The present invention discloses an apparatus and a method for measuring components in fluidic samples in a non-invasive fashion using Infrared (IR) transmission spectroscopy. Fluidic samples are sealed in flexible IR-transparent bags that are then fixed on a supporting bed. The supporting bed is then mounted between the front and back plates of the apparatus so that the bag is squeezed by two IR transparent windows from opposite directions until the windows contact the spacer sheet mounted on the back plate. The thickness of the spacer sets the gap distance between the two windows and thereby sets the optical path for the measurement in the transmissive mode.
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公开(公告)号：US09696329B2
公开(公告)日：2017-07-04
申请号：US14402906
申请日：2013-05-24
CPC分类号： G01N35/025 , G01N21/11 , G01N21/82 , G01N33/86 , G01N35/00584 , G01N35/00693 , G01N35/0092 , G01N35/1004 , G01N2021/115 , G01N2035/00425 , G01N2035/00673 , G01N2035/0094 , G01N2035/0097 , G01N2035/0437 , G01N2035/0453
摘要： A high-throughput automatic analyzer integrates a biochemical analysis section and a blood coagulation analysis section. The analyzer is capable of achieving a reduction in size, system cost, and lifecycle cost. The automatic analyzer includes: a reaction disk; a first reagent dispensing mechanism that dispenses a reagent to reaction cells on the reaction disk; a photometer that irradiates a reaction solution in the reaction cell with light; a reaction cell cleaning mechanism; a reaction vessel supply unit that supplies a disposable reaction vessel for mixing and reacting a sample and a reagent with each other; a second reagent dispensing mechanism that dispenses a reagent to the disposable reaction vessel; a blood coagulation time measuring section that irradiates a reaction solution in the disposable reaction vessel with light to detect transmitted or scattered light; and a sample dispensing mechanism that dispenses a sample to the reaction cell and the disposable reaction vessel.
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公开(公告)号：US09429571B2
公开(公告)日：2016-08-30
申请号：US14452082
申请日：2014-08-05
发明人： Albert Hendrik Jan Immink , Jozef Franciscus Elisabeth Gootzen , Dirk Jan Nelly Vananderoye , Petrus Johannes Wilhelmus Van Lankvelt
IPC分类号： G01N33/558 , G01N33/543 , G01N21/03 , G01N21/11 , G01N21/552
CPC分类号： G01N33/54373 , B01L2200/027 , B01L2200/04 , B01L2300/048 , B01L2300/0627 , B01L2300/0816 , B01L2300/087 , B01L2300/14 , B01L2400/0481 , G01N21/03 , G01N21/11 , G01N21/552 , G01N2021/0346
摘要： The invention relates to a sensing device for sensing a fluid. The sensing device comprises an inlet port (20) for receiving the fluid (100) and a measurement chamber (25) for sensing the fluid (100). The sensing device further comprises a fluid channel (30) coupling the inlet port (20) and the measurement chamber (25) for transporting the fluid (100) from the inlet port (20) to the measurement chamber (25) and a fluid stop unit (50) for stopping and controllably releasing the flow of fluid between the inlet port (20) and the measurement chamber (25). This allows stopping the fluid before reaching the measurement chamber (25) and controllably releasing the fluid for allowing the fluid to flow into the measurement chamber (25), if the sensing device is ready for analyzing the fluid.
摘要翻译： 本发明涉及一种感测流体的感测装置。 感测装置包括用于接收流体（100）的入口（20）和用于感测流体（100）的测量室（25）。 感测装置还包括连接入口（20）和测量室（25）的流体通道（30），用于将流体（100）从入口（20）输送到测量室（25）和流体停止 单元（50），用于停止和可控地释放入口（20）和测量室（25）之间的流体流。 这允许在到达测量室（25）之前停止流体，并且如果感测装置准备好用于分析流体，则可控地释放流体以允许流体流入测量室（25）。
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