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公开(公告)号：US12071664B2
公开(公告)日：2024-08-27
申请号：US17939760
申请日：2022-09-07
Applicant: Pacific Biosciences of California, Inc.
Inventor： Adrian Fehr , Nathaniel Joseph McCaffrey , Stephen Turner
IPC: C12Q1/6874 , B01L3/00 , B82Y20/00 , C12Q1/6825 , C12Q1/6869 , G01N21/03 , G01N21/05 , G01N21/64 , G01N21/75 , G01N21/77 , G01N33/543 , G02B6/122
CPC classification number: C12Q1/6874 , B01L3/502707 , B01L3/502715 , B82Y20/00 , C12Q1/6825 , C12Q1/6869 , G01N21/03 , G01N21/0303 , G01N21/05 , G01N21/64 , G01N21/6428 , G01N21/645 , G01N21/6452 , G01N21/6454 , G01N21/6456 , G01N21/648 , G01N21/75 , G01N21/77 , G01N33/54373 , G02B6/1226 , B01L2300/0654 , B01L2300/0663 , B01L2300/0816 , B01L2300/168 , G01N2021/0346 , G01N2021/6434 , G01N2021/6439 , G01N2021/6441 , G01N2021/6463 , G01N2021/757 , G01N2021/7786 , G01N2201/067 , G01N2201/068 , G01N2201/08 , Y10T436/143333
Abstract: Optics collection and detection systems are provided for measuring optical signals from an array of optical sources over time. Methods of using the optics collection and detection systems are also described.
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公开(公告)号：US12013332B2
公开(公告)日：2024-06-18
申请号：US13435885
申请日：2012-03-30
Applicant: Nicholas Anderson , Jeffery Debad , Eli N. Glezer , Sudeep Kumar , Noel Lawrence , Kenneth Page , George Sigal , Sharon West
Inventor： Nicholas Anderson , Jeffery Debad , Eli N. Glezer , Sudeep Kumar , Noel Lawrence , Kenneth Page , George Sigal , Sharon West
IPC: G01N21/05 , B01L3/00 , B01L7/00 , B01L9/00 , G01F23/02 , G01F23/292 , G01N1/10 , G01N21/03 , G01N21/69 , G01N21/76
CPC classification number: G01N21/05 , B01L3/5027 , G01F23/02 , G01F23/292 , G01N1/10 , G01N21/03 , G01N21/0303 , G01N21/69 , G01N21/76 , B01L3/502723 , B01L3/502746 , B01L3/502784 , B01L7/00 , B01L9/527 , B01L2200/025 , B01L2200/04 , B01L2200/0605 , B01L2200/0684 , B01L2200/0689 , B01L2200/12 , B01L2200/141 , B01L2200/147 , B01L2200/16 , B01L2300/021 , B01L2300/024 , B01L2300/027 , B01L2300/044 , B01L2300/0645 , B01L2300/0654 , B01L2300/0809 , B01L2300/0874 , B01L2300/0877 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/0487 , B01L2400/0672 , B01L2400/0683 , B01L2400/0688 , G01N2021/0346 , G01N2021/054 , Y10T137/0396 , Y10T137/8593
Abstract: Assay cartridges are described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain embodiments, these cartridges are adapted to receive and analyze a sample collected on an applicator stick. Also described are kits including such cartridges and a cartridge reader configured to analyze an assay conducted using an assay cartridge.
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公开(公告)号：US20240151584A1
公开(公告)日：2024-05-09
申请号：US18053246
申请日：2022-11-07
Applicant: Endress+Hauser Optical Analysis, Inc.
Inventor： Nicholas Skriba , James Tedesco , Joseph Slater
CPC classification number: G01J3/4412 , G01N21/65 , G01N2021/0346
Abstract: Flowcells and Raman analysis systems provide improved signal collection dynamics through increased solid-angle geometries and improved numerical aperture for near-diffraction-limited performance. A combined excitation/collection beam passes through a first optical material, a sample conduit and a second optical material. A concave reflective aspheric surface focuses and re-collimates the combined beam to and from a region of the sample within the conduit. The optical materials may comprise separate windows or may integrally form sidewalls the conduit. The reflective surface may be spaced apart from the second window or may be integrally formed with the second optical material. The focused region in the sample may approximate a point or a line, and at least a portion of the interior wall of the conduit may be reflective, causing the combined beam to pass through the sample region more than once to enhance collection efficiency.
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公开(公告)号：US20240035975A1
公开(公告)日：2024-02-01
申请号：US18265361
申请日：2021-12-17
Applicant: Carl Zeiss Jena GmbH
Inventor： Alexandre Gatto , Michael Totzeck
IPC: G01N21/64
CPC classification number: G01N21/645 , G01N2201/0873 , G01N2021/0346
Abstract: A lab-on-a-chip system (100) comprises an optical detection waveguide (122) that has an at least partially periodic structure (123, 501, 502, 503, 504) that is configured to couple light (152) from surroundings of the optical detection waveguide (122) into the optical detection waveguide (122). The lab-on-a-chip system (100) furthermore also comprises a microfluidic network (212), wherein the microfluidic network (212) has multiple lines and at least one reaction chamber (211, 211-1, 211-2, 211-3).
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公开(公告)号：US11644409B2
公开(公告)日：2023-05-09
申请号：US17689648
申请日：2022-03-08
Applicant: THE GENERAL HOSPITAL CORPORATION
Inventor： Ramin Haghgooie , Kenneth T. Kotz , Robert Granier , Anne Celia Petrofsky
CPC classification number: G01N21/03 , B01L3/5027 , B01L3/502723 , G01N21/11 , G01N21/253 , B01L2200/143 , B01L2200/146 , B01L2300/0851 , B01L2300/0858 , B01L2300/0877 , B01L2400/0622 , G01N2021/0346 , G01N2021/0357
Abstract: Reusable network of spatially-multiplexed microfliuidic channels each including an inlet, an outlet, and a cuvette in-between. Individual channels may operationally share a main or common output channel defining the network output and optionally leading to a disposable storage volume. Alternatively, multiple channels are structured to individually lead to the storage volume. An individual cuvette is dimensioned to substantially prevent the formation of air-bubbles during the fluid sample flow through the cuvette and, therefore, to be fully filled and fully emptied. The overall channel network is configured to spatially lock the fluidic sample by pressing such sample with a second fluid against a closed to substantially immobilize it to prevent drifting due to the change in ambient conditions during the measurement. Thereafter, the fluidic sample is flushed through the now-opened valve with continually-applied pressure of the second fluid. System and method for photometric measurements of multiple fluid samples employing such network of channels.
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公开(公告)号：US20180348137A1
公开(公告)日：2018-12-06
申请号：US15778116
申请日：2016-11-23
Applicant: CellTool GmbH
Inventor： Karin SCHÜTZE , Raimund SCHÜTZE
CPC classification number: G01N21/65 , G01N21/03 , G01N21/64 , G01N21/645 , G01N33/5014 , G01N33/5094 , G01N2021/0193 , G01N2021/0346 , G01N2021/157 , G01N2021/651 , G21K1/003
Abstract: The invention relates to a device for analyzing biological objects comprising a Raman spectroscopy system for capturing at least one Raman spectrum. The device comprises an arresting apparatus, which is designed to at least temporarily arrest the biological objects. An electronic computing apparatus is designed to determine a reaction of a biological object arrested by the arresting apparatus to at least one substance in accordance with an evaluation of the at least one Raman spectrum.
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公开(公告)号：US20180333720A1
公开(公告)日：2018-11-22
申请号：US16047512
申请日：2018-07-27
Applicant: Schlumberger Technology Corporation
Inventor： Vincent Joseph Sieben , Cedric Floquet , Farshid Mostowfi
IPC: B01L3/00 , G01N21/82 , G01N33/22 , G01N33/28 , G01N35/00 , G01N21/25 , C10G75/04 , G01N21/07 , G01N21/65 , G01N21/64 , C09K8/524 , G01N21/03 , G01N21/77
CPC classification number: B01L3/50273 , B01F13/0059 , B01F15/0233 , B01L3/5027 , B01L2200/10 , B01L2300/0627 , B01L2300/0803 , B01L2300/0867 , B01L2300/087 , B01L2400/0409 , C09K8/524 , C09K2208/20 , C10G75/04 , G01N21/0332 , G01N21/07 , G01N21/253 , G01N21/645 , G01N21/65 , G01N21/82 , G01N33/22 , G01N33/2823 , G01N33/2835 , G01N35/00069 , G01N35/025 , G01N2021/0328 , G01N2021/0346 , G01N2021/7783 , G01N2021/7786 , G01N2035/0449
Abstract: A microfluidic device for evaluation of an organic/inorganic scale inhibitor is provided. The device comprises a substrate mountable to a disc for rotation about an axis. The device further comprises a proximal end and a distal end. The substrate defines a sample reservoir, a solvent reservoir, an inhibitor reservoir, and a precipitant reservoir at the proximal end and an analysis chamber at the distal end in fluid communication with the sample, solvent, inhibitor, and precipitant reservoirs. The substrate is constructed to direct one or more of fluids in the sample reservoir, solvent reservoir, inhibitor reservoir, and precipitant reservoir radially outwardly towards the analysis chamber under the influence of centrifugal force when the microfluidic device rotates.
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公开(公告)号：US10082507B2
公开(公告)日：2018-09-25
申请号：US14042606
申请日：2013-09-30
Applicant: President and Fellows of Harvard College
Inventor： Samuel K. Sia , Vincent Linder , Babak Parviz , Adam Siegel , George M. Whitesides
IPC: G01N33/569 , B01L3/00 , G01N21/05 , G01N21/59 , G01N33/53 , G01N33/58 , G01N33/543 , G01N21/03
CPC classification number: G01N33/56988 , B01L3/502707 , B01L2300/0822 , B01L2300/168 , G01N21/05 , G01N21/59 , G01N33/5302 , G01N33/543 , G01N33/585 , G01N2021/0346 , Y10T436/11 , Y10T436/117497 , Y10T436/118339
Abstract: An assay method is described, which comprises the steps of immobilizing a binding partner (e.g., an antigen or antibody) for an analyte to be detected (e.g., an antibody or antigen) on a portion of a surface of a microfluidic chamber; passing a fluid sample over the surface and allowing the analyte to bind to the binding partner; allowing a metal colloid, e.g., a gold-conjugated antibody, to associate with the bound analyte; flowing a metal solution, e.g., a silver solution, over the surface such as to form an opaque metallic layer; and detecting the presence of said metallic layer, e.g., by visual inspection or by measuring light transmission through the layer, conductivity or resistance of the layer, or metal concentration in the metal solution after flowing the metal solution over the surface.
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公开(公告)号：US20180120302A1
公开(公告)日：2018-05-03
申请号：US15714713
申请日：2017-09-25
Applicant: Vanderbilt University
Inventor： Darryl J. Bornhop
IPC: G01N33/53
CPC classification number: G01N33/53 , G01N21/05 , G01N21/45 , G01N2021/0346 , G01N2021/058 , G01N2021/4709 , G01N2201/06113
Abstract: Disclosed are methods, systems, and apparatuses for the free solution measurement of molecular interactions by backscattering interferometry. In one aspect, the invention relates to method and systems for detecting molecular interaction between analytes in free-solution wherein the analytes are label-free and detection is performed by back-scattering interferometry. Also disclosed are label-free, free-solution, and/or real-time measurements of characteristic properties and/or chemical events using the disclosed techniques. The disclosed methods can have very low detection limits and/or very low sample volume requirements. Also disclosed are various biosensor applications of the disclosed techniques. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US09952144B2
公开(公告)日：2018-04-24
申请号：US15046082
申请日：2016-02-17
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： M. Lizabeth Alexander , James F. Kelly , Robert L. Sams , James J. Moran , Matthew K. Newburn , Thomas A. Blake
IPC: G01J3/30 , G01N21/3504 , G01N21/59 , G01J3/433 , G01N21/31 , G01N21/39 , G02B6/42 , G01N21/71 , G02B6/02 , G01N21/03 , G01N21/05 , G01N21/85
CPC classification number: G01N21/3504 , G01J3/4338 , G01N21/3103 , G01N21/39 , G01N21/59 , G01N21/718 , G01N2021/0346 , G01N2021/052 , G01N2021/3125 , G01N2021/399 , G01N2021/8578 , G01N2201/06113 , G02B6/02328 , G02B6/4296
Abstract: A capillary absorption spectrometer and process are described that provide highly sensitive and accurate stable absorption measurements of analytes in a sample gas that may include isotopologues of carbon and oxygen obtained from gas and biological samples. It further provides isotopic images of microbial communities that allow tracking of nutrients at the single cell level. It further targets naturally occurring variations in carbon and oxygen isotopes that avoids need for expensive isotopically labeled mixtures which allows study of samples taken from the field without modification. The process also permits sampling in vivo permitting real-time ambient studies of microbial communities.
