公开(公告)号：US20230338114A1

公开(公告)日：2023-10-26

申请号：US18027576

申请日：2021-09-22

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Alex Siu Lun FOK ,  Yung-Chung CHEN, II ,  Jose Antonio OLIVARES TREVINO ,  Hooi Pin CHEW

IPC: A61C1/08 ,  A61C13/34 ,  A61C9/00 ,  G06F30/23 ,  G16H50/50

CPC classification number: A61C1/082 ,  A61C13/34 ,  A61C9/0053 ,  A61C9/0006 ,  G06F30/23 ,  G16H50/50

Abstract: A dental preparation block guide comprises a chamber that is customized to receive at least one tooth of a patient for a shape-optimized restoration of the at least one tooth; and a channel formed in a surface of the block guide at a location selected relative to the shape-optimized restoration to be performed, the channel comprising an aperture extending through the surface to the chamber such that a dental handpiece can be inserted into and guided within the channel while a tool of the dental handpiece can interact with the at least one tooth in the chamber through the aperture to form a shape-optimized preparation in the at least one tooth to receive the shape-optimized restoration. Related methods and system, as well as other devices, also are disclosed.

公开(公告)号：US20250162879A1

公开(公告)日：2025-05-22

申请号：US18743688

申请日：2024-06-14

Applicant: Regents of the University of Minnesota

Inventor： Matthew Mickel Jacob ,  Aditya Bhan

IPC: C01B32/50

Abstract: A feed stream is contacted with a metal oxide catalyst disposed within a reactor. The feed stream includes a mixture of gases. The mixture of gases includes acetylene. The metal oxide catalyst includes a metal oxide. In response to contacting the feed stream with the metal oxide catalyst, the acetylene of the feed stream is selectively oxidized to produce at least one of carbon monoxide or carbon dioxide. A product stream is discharged from the reactor. The product stream includes the at least one of the carbon monoxide or the carbon dioxide produced.

公开(公告)号：US12297593B2

公开(公告)日：2025-05-13

申请号：US17756605

申请日：2020-12-02

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  UNITED STATES GOVERNMENT ADMINISTRATOR OF NASA

Inventor： Rachael Granberry ,  Santo Padula, II ,  Bradley Holschuh ,  Julianna Abel ,  Charles Weinberg ,  Justin Barry

IPC: D07B1/00

Abstract: Yarns incorporating filaments of shape memory materials are described herein that enable the creation of fabrics, garments, and other materials with tunable force absorption or exertion capabilities, as well as creating complex shapes and structures upon actuation. Systems and methods described herein enable selective buckling, recruitment, compression, and other desirable phenomena by actuating fibers in knitted patterns, whether used as isolated filaments or in twisted yarns.

公开(公告)号：US20250129434A1

公开(公告)日：2025-04-24

申请号：US18901167

申请日：2024-09-30

Applicant: Regents of the University of Minnesota

Inventor： Scott Dehm ,  Todd Knutson

IPC: C12Q1/6886

Abstract: Provided herein is a circulating tumor DNA assay for plasma cell-free DNA that can be used to prognosticate outcomes of metastatic castration-resistant prostate cancer (mCRPC) patients for being treated with androgen receptor (AR) inhibitors.

公开(公告)号：US20250114355A1

公开(公告)日：2025-04-10

申请号：US18289047

申请日：2022-05-09

Applicant: Mayo Foundation for Medical Education and Research ,  Regents of the University of Minnesota

Inventor： Vijay H. Shah ,  Sheng Cao ,  Mengfei Liu ,  Joseph Topczewski ,  William C.K. Pomerantz ,  Angela S. Carlson ,  Huarui Cui ,  Anand Divakaran

IPC: A61K31/506 ,  A61K31/4545 ,  A61P1/16

Abstract: This document relates to methods and materials for treating liver diseases (e.g., an alcohol-induced liver disease (ALD) such as alcoholic hepatitis (AH)). For example. one or more inhibitors of a bromodomain-containing protein 4 (BRD4) polypeptide can be administered to a mammal (e.g., a human) having a liver disease (e.g., an ALD such as AH) to treat the mammal.

公开(公告)号：US20250114350A1

公开(公告)日：2025-04-10

申请号：US18907040

申请日：2024-10-04

Applicant: Regents of the University of Minnesota ,  Duke University

Inventor： Mark Dewey Distefano ,  Feng Xu ,  Lorena S. Beese ,  Homme W. Hellinga ,  You Wang ,  Andrew A. Alspaugh

IPC: A61K31/496 ,  A61P31/10

Abstract: The invention provides competitive inhibitors of farnesyl transferase, compositions comprising the competitive inhibitors of farnesyl transferase, and their use as antifungal agents and as agents for the prevention of the formation or growth of biofilms.

公开(公告)号：US12261598B2

公开(公告)日：2025-03-25

申请号：US18349246

申请日：2023-07-10

Applicant: Regents of the University of Minnesota

Inventor： Hyung-il Kim ,  William Moy

IPC: H03K19/00 ,  H03K3/03

Abstract: A coupled ring oscillator circuit includes a first ring oscillator, a second ring oscillator and a coupling circuit. The first ring oscillator includes a series of delay stages, each delay stage including an inverter gate. The second ring oscillator includes a series of delay stages, each delay stage including an inverter gate. The coupling circuit includes a coupling cell having a first modified tri-state inverter connected in parallel with one of the inverter gates of the first ring oscillator, and a second modified tri-state inverter connected in parallel with one of the inverter gates of the second ring oscillator.

公开(公告)号：US20250090601A1

公开(公告)日：2025-03-20

申请号：US18961073

申请日：2024-11-26

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Matthew J. HAMILTON ,  Alexander KHORUTS ,  Michael J. SADOWSKY ,  Christopher M. STALEY

IPC: A61K35/74 ,  A01N1/02 ,  A61K9/00 ,  A61K9/16 ,  A61K9/19 ,  A61K9/20 ,  A61K31/43 ,  A61P31/04

Abstract: The present disclosure provides compositions and methods for treating Clostridium difficile infection (CDI) including primary and recurrent CDI. In particular, the compositions and methods described herein are capable of achieving a CDI clearance rate of at least 80% through a single oral dose of a pharmaceutical composition comprising a freeze-dried fecal microbiota preparation.

公开(公告)号：US12233073B2

公开(公告)日：2025-02-25

申请号：US16620382

申请日：2018-06-08

Applicant: Regents of the University of Minnesota

Inventor： Ann M. Bode ,  Zigang Dong ,  Eunmiri Roh

IPC: A61K35/04 ,  A61K9/00 ,  A61K31/573 ,  A61K31/58 ,  A61P35/04 ,  A61K45/06

Abstract: An example technique for treating a skin cancer condition includes administering a therapeutically effective amount of a p53-related protein kinase (PRPK) inhibitor to a patient having skin cancer or having a high risk of developing skin cancer. An example composition includes a therapeutically effective amount of a PRPK inhibitor for treating a skin cancer condition. An example composition includes a pharmaceutically effective amount of at least one anti-solar ultraviolet (anti-sUV) combination for preventing a skin cancer condition. The at least one anti-sUV combination is chosen from the combinations: avobenzone and octinoxate; octocrylene and zinc oxide; avobenzone, octocrylene, and titanium dioxide; or avobenzone, octocrylene, and zinc oxide.

公开(公告)号：US20250061618A1

公开(公告)日：2025-02-20

申请号：US18720261

申请日：2022-12-14

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Steen MOELLER ,  Mehmet AKÇAKAYA ,  Kamil UGURBIL

IPC: G06T11/00 ,  G01R33/56 ,  G06T5/70

Abstract: Denoised magnetic resonance images are generated using a two-step process. An initial set of images is first denoised on a per channel basis using a locally low-rank-based denoising technique. The denoised coil channel images are transformed back into k-space and the denoised k-space data are then applied to a nonlinear image reconstruction. In some instances, the nonlinear image reconstruction can be implemented using a trained neural network. The neural network may be trained using a self-supervised learning technique.