-
1.发明公开公开(公告)号：US20240358790A1
公开(公告)日：2024-10-31
申请号：US18684922
申请日：2022-08-19
发明人： Michael Agrez
CPC分类号： A61K38/08 , A61K9/0019 , A61K9/0053 , A61P37/04 , G01N33/6866 , G01N33/6869 , G01N2333/55 , G01N2333/57 , G01N2333/7155
摘要： The present invention related to methods and compositions for maintaining IL-2 homeostasis, including low levels CN of IL-2, in a subject, for treating autoimmune disorders. In a preferred embodiment, the composition comprises 2-amino-dodecanoic acid (2Adod)-conjugated peptides selected from RSKAKNPLYR-(2Adod)2-NH2, RSKAKNPLYR-(2ADod)4-NH2, or peptides with the same sequence where all residues are substituted with D-amino acids, conjugated to two or four 2Adod.
-
公开(公告)号：US12129313B2
公开(公告)日：2024-10-29
申请号：US17350795
申请日：2021-06-17
发明人： Bengt Ingemar Samuelsson , Ming Gu
摘要： Provided a peptide of the sequence Ala-Lys-Pro-Ser-Tyr-Hyp-Hyp-Thr-DOPA-Lys or a salt thereof for use in the treatment of inflammation, of an inflammatory disorder and/or of ion thea condition characterized by inflammation, including wounds, burns, psoriasis, acne and atopic dermatitis.
-
公开(公告)号：US20240325504A1
公开(公告)日：2024-10-03
申请号：US18619958
申请日：2024-03-28
发明人： Niall Macquaide , George Baillie
CPC分类号： A61K38/465 , A61K38/08
摘要： Described herein are molecules and compounds for use in medicine, as medicaments and for the treatment or prevention of cardiac diseases.
-
公开(公告)号：US20240317805A9
公开(公告)日：2024-09-26
申请号：US18343599
申请日：2023-06-28
发明人： Ji Hoon Hong
摘要： The present disclosure relates to a wafer level chip scale package with a rhombus shape which includes a semiconductor chip with a rhombus shape and a solder ball array including a plurality of solder balls formed on one surface of the semiconductor chip. Among four interior angles of the semiconductor chip, two of the four interior angles facing each other in a short diagonal direction are approximately 120°, and two of the four interior angles facing each other in a long diagonal direction are approximately 60°.
-
公开(公告)号：US20240299552A1
公开(公告)日：2024-09-12
申请号：US18039992
申请日：2021-12-16
申请人： Zealand Pharma A/S
CPC分类号： A61K47/542 , A61K38/08 , A61K47/10
摘要： The present invention relates to pharmaceutical compositions comprising particular preservatives.
-
公开(公告)号：US20240293500A1
公开(公告)日：2024-09-05
申请号：US18574671
申请日：2022-06-28
发明人： Min Jeong SHIN , In Hyeok JEONG
摘要： The present invention relates to a novel anticancer peptide. The anticancer peptide inhibits cancer cell proliferation and metastasis, induces cell death, and relieves drug resistance, and thus may be utilized for an anticancer use and an anticancer adjuvant.
-
公开(公告)号：US20240293499A1
公开(公告)日：2024-09-05
申请号：US18572826
申请日：2022-06-24
发明人： Jean Gariepy , Vivian Ma , Amanda Sparkes , Esther Matus
摘要： Described herein is a VISTA agonist for inhibiting an immune response, wherein the VISTA agonist causes at least one of the following: an increase in IL-10 expression; a decrease in proliferation of CD4+ T cells; a decrease in proliferation of CD8+ T cells; a decrease in IL-2 expression; a decrease in IFN-γ expression; and a decrease in IL-17 expression.
-
公开(公告)号：US12076365B2
公开(公告)日：2024-09-03
申请号：US17929958
申请日：2022-09-06
申请人： Gal Markel
发明人： Gal Markel
IPC分类号： A61K39/00 , A23L3/34 , A23L3/3526 , A23L33/135 , A23L33/195 , A61K38/08 , C07K7/06
CPC分类号： A61K38/08 , A23L3/34 , A23L3/3526 , A23L33/135 , A23L33/195 , C07K7/06 , Y02A50/30
摘要： Prophylactic and/or therapeutic antipathogen agents are provided that disrupt or prevent the formation of at least one homotypic and/or heterotypic protein-protein interaction that has at least one CEA-family protein and that is involved in the establishment and colonization of a pathogen in a suitable host.
-
公开(公告)号：US20240285569A1
公开(公告)日：2024-08-29
申请号：US18651154
申请日：2024-04-30
申请人： ResQ Pharma, Inc.
发明人： Guy Weinberg
IPC分类号： A61K31/201 , A61K9/00 , A61K9/107 , A61K31/202 , A61K38/08 , A61P9/00
CPC分类号： A61K31/201 , A61K31/202 , A61K38/085 , A61K9/0019 , A61K9/107 , A61P9/00
摘要： The present disclosure provides methods for decreasing injuries associated with intraoperative hypotension by intravenously administering to a subject a therapeutically effective amount of a fat emulsion, following a period of intraoperative hypotension and after the subject's mean arterial blood pressure has recovered. The disclosure also provides methods for preventing injuries associated with intraoperative hypotension, particularly for surgical candidates that have an increased risk for intraoperative hypotension. Non-limiting examples of injuries contemplated herein include myocardial injury, myocardial infarction, and acute kidney injury.
-
10.发明公开公开(公告)号：US20240279279A1
公开(公告)日：2024-08-22
申请号：US18582848
申请日：2024-02-21
发明人： Weihong MIN , Fanrui ZHAO
CPC分类号： C07K7/06 , A61K36/49 , A61K38/08 , A61P31/14 , A61K2236/39
摘要： In some embodiments, the disclosure provides a hazelnut-derived peptide with an inhibitory activity against a 2019 novel coronavirus main protease (2019-nCoV M-pro), including an amino acid sequence of Trp-Trp-Asn-Leu-Asn (WWNLN). In other embodiments, the disclosure provides use of the hazelnut-derived peptide with an inhibitory activity against a 2019-nCoV M-pro in preparation of a drug, a health product, or a food supplementary for inhibiting a 2019-nCoV infection. In further embodiments, the derived peptide WWNLN in the disclosure has a high 2019-nCoV M-pro inhibitory activity, with an inhibition rate of 74.13%±1.93% and a half maximal inhibitory concentration (IC50) value of 6.695 μM. In some embodiments, the derived peptide may be used to prepare drugs, health products, or foods supplementary that inhibit 2019-nCoV infections, and may show desirable application prospects.
-
-
-
-
-
-
-
-
-
搜索结果
7025 条记录 (耗时 0.03 秒)
