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公开(公告)号：US20230348536A1
公开(公告)日：2023-11-02
申请号：US18316496
申请日：2023-05-12
发明人： Bengt Ingemar SAMUELSSON , Ming GU
CPC分类号： C07K7/06 , A61P29/00 , A61K9/1676 , A61K31/47 , A61K38/00
摘要： There is provided a peptide-containing compound that comprises a peptide component which is an amino acid sequence of from 2 to 45 (e.g. from 6 to 15) amino acids, which peptide component is covalently bonded to one or more compounds of the formula I:
wherein:
R1 is selected from the group consisting of —C(CH3)2OH, —COCH3, —C(CH3)═CH2 and —C(CH3)2H; and
n is 0, 1 or 2,
as well as regioisomers, stereoisomers, and pharmaceutically- or cosmetically-acceptable salts of said peptide-containing compound. The compound of formula I is preferably montelukast, montelukast styrene or hydrogenated montelukast styrene. The peptide-containing compound is particularly useful in the treatment of conditions characterised by inflammation, including wounds, hemorrhoids, burns, psoriasis, acne, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, chronic obstructive pulmonary disease, inflammatory bowel disease (such as ulcerative colitis). Compounds of the invention are also useful in the treatment of idiopathic pulmonary fibrosis.-
公开(公告)号：US20240182520A1
公开(公告)日：2024-06-06
申请号：US18282362
申请日：2022-03-17
CPC分类号： C07K7/06 , A61K51/088 , A61K38/00
摘要： Provided is a modified peptide compound comprising one or more of the peptide components (a), (b) or (c): (a) a peptide component of formula I, A-Q-B I A and B represent Z or represent A1-1-B1, A1 and B1 independently represent Z or A2-Q2-B2, A2 and B2 independently represent Z or Z-Q3-Z, Q1, Q2 and Q3 represent, for example, Lys and Z represents a peptide component of the amino acid sequence: [W-Lys-X1-Ser-U-X2-Y] n-W-Lys-X1-Ser-U-X2-Y- (SEQ ID No: 3) (b) a peptide component of the amino acid sequence: [Ala-Lys-X1-Ser-U-X2-Y] p-Ala-Lys-X1-Ser-U-X2-Y-G (SEQ ID No: 4); or (c) a peptide component of the amino acid sequence: W1-Lys-X1-Ser-U1-X2-Y-G (SEQ ID No: 5) wherein: n p, W, W1, X1, U, U1, X2, Y and G have meanings given in the description, and wherein the peptide component is modified to include a labelling groups or labelling components that is/are capable of medical imaging of internal regions of the body non-invasively, and/or of diagnosing and/or therapeutically treating one or more diseases (such as cancers) in a patient.
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公开(公告)号：US11680082B2
公开(公告)日：2023-06-20
申请号：US16645355
申请日：2019-09-14
发明人： Bengt Ingemar Samuelsson , Ming Gu
CPC分类号： C07K7/06 , A61K9/1676 , A61K31/47 , A61P29/00 , A61K38/00
摘要： There is provided a peptide-containing compound that comprises a peptide component which is an amino acid sequence of from 2 to 45 (e.g. from 6 to 15) amino acids, which peptide component is covalently bonded to one or more compounds of formula I:
wherein:
R1 is selected from the group consisting of —C(CH3)2OH, —COCH3, —C(CH3)═CH2 and —C(CH3)2H; and
n is 0, 1 or 2,
as well as regioisomers, stereoisomers, and pharmaceutically- or cosmetically-acceptable salts of said peptide-containing compound. The compound of formula I is preferably montelukast, montelukast styrene or hydrogenated montelukast styrene. The peptide-containing compound is particularly useful in the treatment of conditions characterised by inflammation, including wounds, hemorrhoids, burns, psoriasis, acne, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, chronic obstructive pulmonary disease, inflammatory bowel disease (such as ulcerative colitis). Compounds of the invention are also useful in the treatment of idiopathic pulmonary fibrosis.-
公开(公告)号：US20240316029A1
公开(公告)日：2024-09-26
申请号：US18681447
申请日：2022-08-05
摘要： The use of montelukast or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of an immunodeficiency disorder and also for the treatment of a disorder characterized by inflammation in a patient that has, or is vulnerable to, a condition characterized by immunosuppression. Particular disorders that may be mentioned include those brought on by radiation therapy as part of e.g. cancer treatment, such as radiation proctitis. Montelukast and salts thereof are preferably administered topically and locally, for example anorectally.
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5.发明公开公开(公告)号：US20230404992A1
公开(公告)日：2023-12-21
申请号：US18310020
申请日：2023-05-01
发明人： Bengt Ingemar SAMUELSSON , Ming GU
CPC分类号： A61K31/47 , A61P17/02 , A61P17/04 , A61K9/0014 , A61K9/0075 , A61K9/06 , A61K38/08 , A61K38/1767 , A61K47/10
摘要： There is provided topical pharmaceutical formulations comprising montelukast, or a pharmaceutical acceptable salt of solvate thereof, as well as combination products comprising (a) at least one mussel adhesive protein or a derivative thereof; and (b) montelukast, or a pharmaceutically-acceptable salt or solvate thereof. The formulations and combination products find particular utility in direct topical administration for the treatment of inflammation, of inflammatory disorders and/or of condition characterized by inflammation, including wounds, burns, psoriasis, acne and atopic dermatitis.
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公开(公告)号：US20230113836A1
公开(公告)日：2023-04-13
申请号：US17781543
申请日：2020-12-02
摘要： Provided is a conjugate formed between one or more linear polysaccharide chains and a peptide selected from one or more of the peptide components (a), (b), (c) or (d) as defined below: (a) a peptide component of formula (I), A-Q-B I wherein Q represents a structural fragment of formula (II), wherein: the squiggly lines and m have meanings given in the description and A and B have meanings given in the description, but may represent a peptide component of the amino acid sequence: [W-Lys-X1-Ser-U-X2-Y] n-W-Lys-X1-Ser-U-X2-Y--- (SEQ ID No: 3), wherein the dashed line, n, W, X1, U, X2 and Y have meanings given in the description; (b) a peptide component of the amino acid sequence: [Ala-Lys-X1-Ser-U-X2-Y] p-Ala-Lys-X1-Ser-U-X1-Y-G (SEQ ID No: 4) wherein p, G, X1, U, X2 and Y have meanings given in the description; (c) a peptide component of the amino acid sequence: W-Lys-X1-Ser-U-X2-Y-G (SEQ ID No: 5), wherein W, X1, U, X2, Y and G have meanings given in the description; or (d) a peptide component of the amino acid sequence: K-W1-Lys-X1-Ser-U1-X2-Y1-I-J (SEQ ID No: 6), wherein K, W1, U1, Y1, I, J, X1 and X2 have meanings as well as regioisomers, stereoisomers, and pharmaceutically- or cosmetically-acceptable salts of said conjugates, which conjugates are particularly useful in the treatment of conditions characterised by inflammation, including wounds, burns, and disorders of the mucosa, such as anorectal diseases, inflammatory bowel diseases, gynaecological diseases and dental diseases. Preferred linear polysaccharides include hyaluronic acid.
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公开(公告)号：US12129313B2
公开(公告)日：2024-10-29
申请号：US17350795
申请日：2021-06-17
发明人： Bengt Ingemar Samuelsson , Ming Gu
摘要： Provided a peptide of the sequence Ala-Lys-Pro-Ser-Tyr-Hyp-Hyp-Thr-DOPA-Lys or a salt thereof for use in the treatment of inflammation, of an inflammatory disorder and/or of ion thea condition characterized by inflammation, including wounds, burns, psoriasis, acne and atopic dermatitis.
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公开(公告)号：US20240124521A1
公开(公告)日：2024-04-18
申请号：US17642764
申请日：2020-09-11
摘要： Provided is a peptide compound comprising the amino acid sequence: G-W-Lys-X1-Ser-U-X2-Y-Z-Q wherein: G represents an optional N-terminal a 3,4-dihydrocinnamic acid group; W represents Ala or Ser, or is absent; U represents Tyr, DOPA or a single bond; X1 and X2 independently represent Pro, Hyp or diHyp; Y represents a single bond or represents a 1 to 5 amino acid sequence, in which the amino acids are selected from one or more of the group Pro, Hyp, diHyp, Thr, DOPA and Tyr; Z represents Pro, Hyp, diHyp, Thr, DOPA or Tyr; and Q represents Lys or is absent, as well as regioisomers, stereoisomers, and pharmaceutically- or cosmetically-acceptable salts of said peptide compound, provided that when G is not present, W represents Ala or is absent and Q represents Lys, then Z represents Pro, Hyp, diHyp or Thr. The compounds are particularly useful in the treatment of conditions characterised by inflammation, including wounds, burns, and disorders of the mucosa, such as anorectal diseases, inflammatory bowel diseases, gynaecological diseases and dental diseases.
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公开(公告)号：US20230331792A1
公开(公告)日：2023-10-19
申请号：US17781438
申请日：2020-12-02
IPC分类号： C07K14/435 , A61P17/02 , C07K7/06
CPC分类号： C07K14/43504 , A61P17/02 , C07K7/06 , C07K7/08
摘要： There is provided a compound of formula (I), A-Q-B I wherein Q represents a structural fragment of formula (II), wherein: the squiggly lines and m have meanings given in the description, and wherein A and B have meanings given in the description, but may represent a peptide component of the amino acid sequence: [W-Lys-X1-Ser-U—X2—Y]n—W-Lys-X1-Ser-U—X2—Y— (SEQ ID No: 3) wherein the dashed line, n, W, X1, U, X2 and Y have meanings given in the description, which compounds are useful in medicine, including as pharmaceutical excipients, adhesives and film-forming materials and/or are useful in the treatment of conditions characterised by inflammation, including wounds, burns, and disorders of the mucosa, such as anorectal diseases, inflammatory bowel diseases, gynaecological diseases and dental diseases.
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10.发明授权公开(公告)号：US11672792B2
公开(公告)日：2023-06-13
申请号：US16628170
申请日：2018-07-04
发明人： Bengt Ingemar Samuelsson , Ming Gu
IPC分类号： A61K38/00 , A61K31/47 , A61P17/02 , A61P17/04 , A61K9/00 , A61K9/06 , A61K38/08 , A61K38/17 , A61K47/10
CPC分类号： A61K31/47 , A61K9/0014 , A61K9/0075 , A61K9/06 , A61K38/08 , A61K38/1767 , A61K47/10 , A61P17/02 , A61P17/04
摘要： There is provided topical pharmaceutical formulations comprising montelukast, or a pharmaceutical acceptable salt of solvate thereof, as well as combination products comprising (a) at least one mussel adhesive protein or a derivative thereof; and (b) montelukast, or a pharmaceutically-acceptable salt or solvate thereof. The formulations and combination products find particular utility in direct topical administration for the treatment of inflammation, of inflammatory disorders and/or of condition characterized by inflammation, including wounds, burns, psoriasis, acne and atopic dermatitis.
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