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公开(公告)号：US20250066434A1
公开(公告)日：2025-02-27
申请号：US18943130
申请日：2024-11-11
Applicant: Sangamo Therapeutics, Inc.
Inventor： Joseph F. Nabhan , Amrutha Pattamatta , Mohammad Samie
Abstract: The present disclosure provides compositions and methods for modulating transcription of mutant C9orf72 gene alleles in patients in need thereof, including patients having a C9orf72-related disease such as amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD).
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公开(公告)号：US20250066433A1
公开(公告)日：2025-02-27
申请号：US18942681
申请日：2024-11-09
Applicant: Sangamo Therapeutics, Inc.
Inventor： Joseph F. Nabhan , Amrutha Pattamatta , Mohammad Samie
Abstract: The present disclosure provides compositions and methods for modulating transcription of mutant C9orf72 gene alleles in patients in need thereof, including patients having a C9orf72-related disease such as amyotrophic lateral sclerosis (ALS) or frontotemporal dementia (FTD).
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公开(公告)号：US20250044296A1
公开(公告)日：2025-02-06
申请号：US18294301
申请日：2022-08-03
Applicant: SEIKAGAKU CORPORATION
Inventor： Hikaru MIZUMURA , Yuki KOBAYASHI , Naoki TAKESHITA , Toshio ODA
IPC: G01N33/579 , C07K14/435 , C12N9/64
Abstract: A reagent for β-glucan measurement without requiring a horseshoe crab hemocyte extract by using horseshoe crab-derived factor D in the reagent for β-glucan measurement.
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公开(公告)号：US20250034282A1
公开(公告)日：2025-01-30
申请号：US18717882
申请日：2022-12-08
Applicant: Vesigen, Inc.
Inventor： Robert Millman , Joseph Nabhan , Nicholas Buffinger
IPC: C07K16/44 , C07K14/005 , C07K14/435
Abstract: This invention relates generally to ARRDC1 fusion proteins, ARRDC1-mediated microvesicles (ARMMs) degrading systems, and their uses.
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公开(公告)号：US12209269B2
公开(公告)日：2025-01-28
申请号：US18199056
申请日：2023-05-18
Applicant: BIOMADISON, INC.
Inventor： Ward C Tucker
IPC: C12N1/20 , C07K14/435 , C12Q1/37
Abstract: Cells are described that are useful in rapid, sensitive, and accurate cell-based assays for enzyme activity, particularly for enzyme activities associated with botulinum toxins. Such cell expresses a construct that includes an anchor region, a cleavage site, and a reporting region having two or more identical reporter peptides. Enzymatic activity at the cleavage site releases the reporter region into the cytosol of the cell, where multiple degradation events occur. The observed change in the signal is proportional to the enzymatic activity.
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Patent Agency Ranking
公开(公告)号：US20250026798A1
公开(公告)日：2025-01-23
申请号：US18906893
申请日：2024-10-04
Applicant: UTI Limited Partnership
Inventor： Raymond W. TURNER
IPC: C07K14/435 , A61K31/155 , A61K31/351 , A61K31/65 , A61K38/00 , A61P43/00 , C07K14/005
Abstract: The present disclosure relates generally to the treatment of Fragile X Syndrome using a recombinant fusion polypeptide comprising or consisting of a cell penetrating polypeptide, such as HIS or tat, and a Fragile X Mental Retardation protein (FMRP (298)).
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公开(公告)号：US12203932B2
公开(公告)日：2025-01-21
申请号：US18322480
申请日：2023-05-23
Applicant: Howard Hughes Medical Institute
Inventor： Jonathan S. Marvin , Loren Looger
IPC: G01N33/557 , C07K14/195 , C07K14/245 , C07K14/435 , G01N33/58 , G01N33/68
Abstract: The present disclosure provides, inter alia, genetically encoded recombinant peptide biosensors comprising analyte-binding framework portions and signaling portions, wherein the signaling portions are present within the framework portions at sites or amino acid positions that undergo a conformational change upon interaction of the framework portion with an analyte.
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公开(公告)号：US20250018025A1
公开(公告)日：2025-01-16
申请号：US18670211
申请日：2024-05-21
Applicant: BAYLOR RESEARCH INSTITUTE
Inventor： SangKon OH , Dapeng LI , Jacques Banchereau , Gerard Zurawski , Sandra Zurawski
IPC: A61K39/145 , A61K39/00 , A61K47/68 , A61K51/10 , C07K14/005 , C07K14/195 , C07K14/37 , C07K14/405 , C07K14/435 , C07K16/28 , C12N5/0784 , C12N7/00
Abstract: The present invention includes compositions and methods for making and using anti DC-ASGPR antibodies that can, e.g., activate DCs and other cells.
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公开(公告)号：US20250012785A1
公开(公告)日：2025-01-09
申请号：US18735719
申请日：2024-06-06
Applicant: Promega Corporation
Inventor： Jamison GRAILER , Richard A. Moravec , James R. Hartnett , Mei Cong
IPC: G01N33/53 , C07K14/435 , C12N9/02 , C12N9/12
Abstract: Provided herein are compositions comprising a double-stranded RNA (dsRNA) binding domains linked to components of a complementation system. Upon binding of a pair of dsRNA binding domains to a dsRNA, a detectable complex of the complementation components is formed, and the dsRNA can be detected/quantified.
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公开(公告)号：US20250011378A1
公开(公告)日：2025-01-09
申请号：US18754355
申请日：2024-06-26
Inventor： Dong Soo HWANG , Hyung Bin KIM
IPC: C07K14/435 , C09D189/00
Abstract: The present disclosure relates to a novel protein derived from mussel periostracum and a use thereof, and the mussel periostracum protein was isolated and purified, named Antifoulin, the entire sequence was derived, a recombinant antifouling protein was prepared therefrom, and an antifouling function was confirmed, and thus the protein can be usefully used as a coating model system for surface coating agents, especially biocompatible medical devices.
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