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1.发明授权公开(公告)号：US09241663B2
公开(公告)日：2016-01-26
申请号：US13815764
申请日：2013-03-15
申请人： Jana Care Inc.
发明人： Sidhant Jena , Michal Depa
IPC分类号： A61B5/15 , A61B5/00 , A61B5/1455 , G01N21/84 , A61B5/145
CPC分类号： A61B5/150358 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/6898 , A61B2560/0443 , A61B2562/0295 , F04C2270/041 , G01N21/8483 , G01N2021/8488
摘要： A system and method for analysis of colorimetric test strip strips and disease management. The system can include an accessory that is operably coupled to a mobile device, the mobile device acquiring and/or analyzing images of the colorimetric test strips. The light box accessory can be detachably attached to the mobile device, or made to remain attached to the mobile device, but with the capability of having the light box accessory removed from the field of view of the camera for general photography purposes. In other embodiments, an image containing known calibration color(s) and reagent area(s) is obtained sans the light box for comparison with a previous calibration image to model changes in ambient lighting conditions and determine a color correction function. The correction can be applied to the detected reagent area color(s) for matching between the detected reagent area color(s) and reference color(s) on the reference chart. Optionally, the information can be processed and displayed to provide feedback, as well as transmitted to a health provider for analysis.
摘要翻译： 用于分析测色条带和疾病管理的系统和方法。 该系统可以包括可操作地耦合到移动设备的附件，移动设备获取和/或分析比色测试条的图像。 灯箱附件可以可拆卸地附接到移动设备，或者被制成保持附接到移动设备，但是具有从照相机的视野中去除灯箱附件的能力以用于一般摄影目的。 在其他实施例中，无光源盒获得包含已知校准颜色和试剂区域的图像，以与先前的校准图像进行比较，以模拟环境照明条件的变化并确定颜色校正功能。 可以对检测到的试剂区域颜色进行校正，以在参考图上检测到的试剂区域颜色和参考颜色之间进行匹配。 可选地，可以处理和显示信息以提供反馈，以及传送给卫生提供者进行分析。
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公开(公告)号：US20240361341A1
公开(公告)日：2024-10-31
申请号：US18627199
申请日：2024-04-04
申请人： Jana Care, Inc.
发明人： Daniel B. Lookadoo , Ashok A. Kumar , Jeremy E. Schonhorn , Christopher M. Uherek , Michal Depa
CPC分类号： G01N33/70 , G01N33/535 , G01N33/6893 , G01N35/00069 , G16C20/10 , H04W84/18
摘要： Platforms for enzymatic assays for biomarkers, including systems, methods, and measuring devices by which a biomarker, such as creatinine, is measured using a small amount of biological fluid, such as blood, plasma, or serum. The measuring device or biosensor can be a test strip including a layered active component assembly positioned between two outer layers which enables multi-step enzymatic reactions operating in kinetic and/or endpoint (in which the reaction is allowed to near completion), and generally includes multiple layers with primary enzyme(s), coupling enzyme(s), and reagents to produce an optical signal correlated to the concentration of a biomarker in the sample. The test strip can be read using a portable optical reader coupled to a smart phone or tablet.
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3.发明申请公开(公告)号：US20200096501A1
公开(公告)日：2020-03-26
申请号：US16593099
申请日：2019-10-04
申请人： Jana Care, Inc.
发明人： Michal Depa , Sidhant Jena , Gaurav Rohatgi , Aron O. Zingman
IPC分类号： G01N33/52 , A61B5/00 , A61B5/145 , A61B10/00 , B01L3/00 , G01N21/78 , G01N21/84 , A61B5/157 , G01N33/50 , A61B5/15
摘要： A mobile device based multi-analyte testing analyzer for use in medical diagnostic monitoring and screening, and a method of manufacturing the same are disclosed. A reflectance based, colorimetric test strip reader for use with a mobile device having a jack plug receiving socket, said test strip reader adapted for removably receiving a test strip having a test strip longitudinal axis, comprising a housing; a jack plug operably coupled to and extending from said housing and adapted for operable coupling with said jack plug receiving socket; a test strip adapter including structure defining a test strip receiving channel; a light source oriented within said housing for directing light toward said test strip receiving channel to illuminate a test strip arranged within said test strip adapter; and a light sensor oriented within said housing to sense light reflected from a test strip carried by said test strip receiving channel.
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公开(公告)号：US20230176079A1
公开(公告)日：2023-06-08
申请号：US18078688
申请日：2022-12-09
申请人： Jana Care, Inc.
发明人： Daniel B. Lookadoo , Ashok A. Kumar , Jeremy E. Schonhorn , Christopher M. Uherek , Michal Depa
CPC分类号： G01N33/70 , G01N33/6893 , H04W84/18 , G16C20/10 , G01N33/535 , G01N35/00069
摘要： Platforms for enzymatic assays for biomarkers, including systems, methods, and measuring devices by which a biomarker, such as creatinine, is measured using a small amount of biological fluid, such as blood, plasma, or serum. The measuring device or biosensor can be a test strip including a layered active component assembly positioned between two outer layers which enables multi-step enzymatic reactions operating in kinetic and/or endpoint (in which the reaction is allowed to near completion), and generally includes multiple layers with primary enzyme(s), coupling enzyme(s), and reagents to produce an optical signal correlated to the concentration of a biomarker in the sample. The test strip can be read using a portable optical reader coupled to a smart phone or tablet.
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5.发明申请公开(公告)号：US20220252577A1
公开(公告)日：2022-08-11
申请号：US17582811
申请日：2022-01-24
申请人： Jana Care, Inc.
发明人： Michal Depa , Sidhant Jena , Gaurav Rohatgi , Aron O. Zingman
IPC分类号： G01N33/52 , A61B5/00 , A61B5/145 , A61B10/00 , G01N21/84 , A61B5/157 , G01N33/50 , A61B5/15 , B01L3/00 , G01N21/78
摘要： A mobile device based multi-analyte testing analyzer for use in medical diagnostic monitoring and screening, and a method of manufacturing the same are disclosed. A reflectance based, colorimetric test strip reader for use with a mobile device having a jack plug receiving socket, said test strip reader adapted for removably receiving a test strip having a test strip longitudinal axis, comprising a housing; a jack plug operably coupled to and extending from said housing and adapted for operable coupling with said jack plug receiving socket; a test strip adapter including structure defining a test strip receiving channel; a light source oriented within said housing for directing light toward said test strip receiving channel to illuminate a test strip arranged within said test strip adapter; and a light sensor oriented within said housing to sense light reflected from a test strip carried by said test strip receiving channel.
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公开(公告)号：US10436773B2
公开(公告)日：2019-10-08
申请号：US14997749
申请日：2016-01-18
申请人： Jana Care, Inc.
发明人： Michal Depa , Sidhant Jena , Gaurav Rohatgi , Aron O. Zingman
IPC分类号： G01N33/00 , G01N33/52 , B01L3/00 , G01N21/78 , A61B5/00 , A61B10/00 , A61B5/145 , G01N21/77 , H04M1/21 , H04M1/725
摘要： A mobile device based multi-analyte testing analyzer for use in medical diagnostic monitoring and screening, and a method of manufacturing the same are disclosed. A reflectance based, colorimetric test strip reader for use with a mobile device having a jack plug receiving socket, said test strip reader adapted for removably receiving a test strip having a test strip longitudinal axis, comprising a housing; a jack plug operably coupled to and extending from said housing and adapted for operable coupling with said jack plug receiving socket; a test strip adapter including structure defining a test strip receiving channel; a light source oriented within said housing for directing light toward said test strip receiving channel to illuminate a test strip arranged within said test strip adapter; and a light sensor oriented within said housing to sense light reflected from a test strip carried by said test strip receiving channel.
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7.发明申请公开(公告)号：US20190187154A1
公开(公告)日：2019-06-20
申请号：US16222463
申请日：2018-12-17
申请人： Jana Care, Inc.
发明人： Ashok A. Kumar , Jeremy E. Schonhorn , Daniel B. Lookadoo , Abha Patil , Lara Murray , Harshit Harpaldas , Sidhant Jena , Michal Depa
CPC分类号： G01N33/6854 , G01N21/17 , G01N33/48771 , G01N33/49 , G01N33/538 , G01N33/6893 , G01N33/74 , G01N33/92 , G01N2333/58 , G01N2800/325
摘要： Systems and methods directed to a monoclonal antibody covalently conjugated to latex in a two-step process to be used with a test strip and mobile-phone connected fluorimeter device. The test strip is combined with a method of analysis for quantitative detection of NT pro-BNP using the mobile device. A method for NT-proBNP testing system includes reading the test at an initial time point and at specific intervals during development of the test result, the dynamic behavior of the test can be used to distinguish differences between samples that would otherwise be difficult to differentiate by an end-point measurement due to the hook effect. Using two fluorescent tags with different excitation wavelength or emission wavelengths, or two colored beads with different absorption wavelengths, the test and the control line can simultaneously be read as they develop and dynamic formation can be used to distinguish high levels.
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8.发明申请公开(公告)号：US20170234858A1
公开(公告)日：2017-08-17
申请号：US14997749
申请日：2016-01-18
申请人： Jana Care, Inc.
发明人： Michal Depa , Sidhant Jena , Gaurav Rohatgi , Aron O. Zingman
摘要： A mobile device based multi-analyte testing analyzer for use in medical diagnostic monitoring and screening, and a method of manufacturing the same are disclosed. A reflectance based, colorimetric test strip reader for use with a mobile device having a jack plug receiving socket, said test strip reader adapted for removably receiving a test strip having a test strip longitudinal axis, comprising a housing; a jack plug operably coupled to and extending from said housing and adapted for operable coupling with said jack plug receiving socket; a test strip adapter including structure defining a test strip receiving channel; a light source oriented within said housing for directing light toward said test strip receiving channel to illuminate a test strip arranged within said test strip adapter; and a light sensor oriented within said housing to sense light reflected from a test strip carried by said test strip receiving channel.
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9.发明公开公开(公告)号：US20240230544A1
公开(公告)日：2024-07-11
申请号：US18563835
申请日：2022-05-31
申请人： Jana Care, Inc.
发明人： Daniel B. Lookadoo , Ashok A. Kumar , Jeremy E. Schonhorn , Harshit Harpaldas , Chrisptoher M. Uherek , Michal Depa
CPC分类号： G01N21/78 , G01N33/525 , G01N33/84 , G01N2021/7759 , G01N2201/0221
摘要： Systems, methods, and measuring devices by which an analyte, and more specifically electrolytes such as, for example, potassium, can be selectively extracted and measured easily and in a minimally invasive manner using a small amount of biological fluid, such as blood, plasma, or serum. The measuring device or chemical sensor is a test strip including a layered active component assembly sandwiched between two optional film or support layers. The layered active component assembly includes ion-sensitive membranes for performing ion-selective extraction methods. The test strips can be utilized with an optical reader connected to a smartphone or other mobile device for remote monitoring of an analyte level associated with conditions of a disease.
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公开(公告)号：US11982680B2
公开(公告)日：2024-05-14
申请号：US18078688
申请日：2022-12-09
申请人： Jana Care, Inc.
发明人： Daniel B. Lookadoo , Ashok A. Kumar , Jeremy E. Schonhorn , Christopher M. Uherek , Michal Depa
CPC分类号： G01N33/70 , G01N33/535 , G01N33/6893 , G01N35/00069 , G16C20/10 , H04W84/18
摘要： Platforms for enzymatic assays for biomarkers, including systems, methods, and measuring devices by which a biomarker, such as creatinine, is measured using a small amount of biological fluid, such as blood, plasma, or serum. The measuring device or biosensor can be a test strip including a layered active component assembly positioned between two outer layers which enables multi-step enzymatic reactions operating in kinetic and/or endpoint (in which the reaction is allowed to near completion), and generally includes multiple layers with primary enzyme(s), coupling enzyme(s), and reagents to produce an optical signal correlated to the concentration of a biomarker in the sample. The test strip can be read using a portable optical reader coupled to a smart phone or tablet.
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