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    Sample analysis tool, method for producing sample analysis tool, and method for inhibiting decrease in liquid permeability of development member
    3.
    发明授权
    Sample analysis tool, method for producing sample analysis tool, and method for inhibiting decrease in liquid permeability of development member 有权

    公开(公告)号：US09903864B2

    公开(公告)日：2018-02-27

    申请号：US13263729

    申请日：2010-04-05

    申请人： Kazuhiro Ohmiya ,  Tomoko Hirayama

    发明人： Kazuhiro Ohmiya ,  Tomoko Hirayama

    IPC分类号： B01L3/00 ,  B23P11/00 ,  G01N33/558 ,  G01N33/52

    CPC分类号： G01N33/558 ,  G01N33/525 ,  Y10T29/49826

    摘要： Provide is a sample analysis tool whose reactivity and reproducibility in analysis can be prevented from decreasing. The sample analysis tool 10 of the present invention includes a development member 11 and a plastic base 16, and at least part of the development member 11 is in contact with the plastic base 16. The sample analysis tool 10 further includes a hydrophilic component layer 15, and the hydrophilic component layer 15 is formed on part or the whole of at least one of a surface of the plastic base 16 and a surface of the development member 11. It is particularly preferable that the hydrophilic component layer 15 contains sucrose or N-methyl glucosamine. In the sample analysis tool 10 of the present invention, since the hydrophilic component layer 15 is formed on part or the whole of at least one of the surface of the plastic base 16 and the surface of the development member 11, it is possible to prevent the adhesion of a hydrophobic component(s) derived from the plastic base 16.

    Sensing module and sensing method
    4.
    发明授权
    Sensing module and sensing method 有权

    公开(公告)号：US09891171B2

    公开(公告)日：2018-02-13

    申请号：US15220402

    申请日：2016-07-27

    申请人： Personal Genomics, Inc.

    发明人： Sheng-Fu Lin

    IPC分类号： G01N21/64 ,  G01N21/25 ,  G01N33/543 ,  G01N33/52

    CPC分类号： G01N21/645 ,  G01N21/253 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/648 ,  G01N33/525 ,  G01N33/54373

    摘要： A sensing module including a sample loading layer, a sensing layer and an optical resonance layer locating between the sample loading layer and the sensing layer is provided. The sample loading layer includes at least a sample loading depression, and the sample loading depression exposes part of the optical resonance layer, and the sample loading depression is adapted to load sample. A surface of the optical resonance layer has optical resonance structures, and the optical resonance structures are located beside bottom of the sample loading depression or below the bottom of the sample loading depression. The sensing layer is configured to receive light and turn it into electrical signals. A sensing method is also provided.

    METHOD AND APPARATUS FOR BIOMOLECULE ANALYSIS
    6.
    发明申请
    METHOD AND APPARATUS FOR BIOMOLECULE ANALYSIS 审中-公开

    公开(公告)号：US20170138943A1

    公开(公告)日：2017-05-18

    申请号：US15419973

    申请日：2017-01-30

    申请人： Junyu Mai

    发明人： Junyu Mai

    IPC分类号： G01N33/543 ,  G01N1/40

    CPC分类号： G01N33/54393 ,  G01N1/4077 ,  G01N33/525 ,  G01N33/542 ,  G01N33/54386 ,  G01N2001/4088

    摘要： Disclosed are devices or apparatus and methods for membrane-, bead- or cell-based biomolecule analysis, where a detectable signal can be measured after affinity binding and/or enzymatic reaction occurs on the membranes, beads or cells. The apparatus or device can rapidly separate the beads or cells from the liquid solution without using centrifugation, vacuum, or magnetic force. The apparatus or device includes a sample well for receiving a sample containing cells or beads, as well as other aqueous solutions, a porous filter membrane at the bottom of the well which is capable of retaining the cells or beads on its upper surface by size exclusion, and an absorbing plug in touch with the filter membrane for removing the liquid solution. Multiple devices can be arranged in a multi-well array in a plate so that signals from multiple assays can be directly analyzed in a plate reader or an imaging instrument.

    DYNAMIC BIOLOGICAL AND CHEMICAL SENSOR INTERFACES
    8.
    发明申请
    DYNAMIC BIOLOGICAL AND CHEMICAL SENSOR INTERFACES 审中-公开
    动态生物和化学传感器界面

    公开(公告)号：US20170071536A1

    公开(公告)日：2017-03-16

    申请号：US15358415

    申请日：2016-11-22

    申请人： BIOINK CORPORATION

    发明人： Skylar Jackson Eagle Tibbits ,  Carlos Edel Olguin ,  Marcelo Henrique Coelho ,  Tal Danino

    IPC分类号： A61B5/00 ,  G01N31/22 ,  G01N33/52 ,  B01L3/00

    CPC分类号： A61B5/4845 ,  A61K8/0208 ,  A61Q1/025 ,  B01L3/502715 ,  B01L2300/041 ,  B01L2300/0663 ,  B01L2300/0887 ,  G01N31/22 ,  G01N33/525

    摘要： A dynamic sensor interface is provided. Such a dynamic sensor interface may include a reaction layer that includes a biological-based or chemical-based ink that reacts in response to a molecule of interest, a porous membrane that allows for the molecule of interest to pass through to a side that is in contact with the reaction layer, and an adhesive substrate. The reaction of the ink may include a change in a visual appearance of the ink, such as a change in color, transparency, movement within the reaction layer, three-dimensional expansion, three-dimensional contraction, or a tactile change. The reaction layer may include one or more microfluidic channels arranged in a predetermined arrangement such that movement through the microfluidic channels visually indicates detection of the molecule of interest. The reaction of the ink may further include a change in an olfactory property or a thermal property.

    摘要翻译： 提供动态传感器接口。 这种动态传感器界面可以包括反应层，其包括响应于感兴趣分子而反应的基于生物的或基于化学的油墨，允许感兴趣的分子通过到一侧的多孔膜 与反应层接触，以及粘合剂基材。 油墨的反应可以包括油墨的视觉外观的变化，例如颜色变化，透明度，反应层内的移动，三维膨胀，三维收缩或触觉变化。 反应层可以包括以预定布置布置的一个或多个微流体通道，使得通过微流体通道的移动可视地指示感兴趣的分子的检测。 油墨的反应可以进一步包括嗅觉特性或热性能的变化。

    SENSING MODULE AND SENSING METHOD
    9.
    发明申请
    SENSING MODULE AND SENSING METHOD 有权
    感应模块和感应方法

    公开(公告)号：US20170030832A1

    公开(公告)日：2017-02-02

    申请号：US15220402

    申请日：2016-07-27

    申请人： Personal Genomics, Inc.

    发明人： Sheng-Fu Lin

    IPC分类号： G01N21/64

    CPC分类号： G01N21/645 ,  G01N21/253 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/648 ,  G01N33/525 ,  G01N33/54373

    摘要： A sensing module including a sample loading layer, a sensing layer and an optical resonance layer locating between the sample loading layer and the sensing layer is provided. The sample loading layer includes at least a sample loading depression, and the sample loading depression exposes part of the optical resonance layer, and the sample loading depression is adapted to load sample. A surface of the optical resonance layer has optical resonance structures, and the optical resonance structures are located beside bottom of the sample loading depression or below the bottom of the sample loading depression. The sensing layer is configured to receive light and turn it into electrical signals. A sensing method is also provided.

    摘要翻译： 提供了一种感测模块，其包括样品加载层，感测层和定位在样品加载层和感测层之间的光学共振层。 样品加载层至少包括样品加载凹陷，并且样品加载凹陷暴露部分光学共振层，并且样品加载凹陷适于加载样品。 光学共振层的表面具有光学共振结构，并且光学共振结构位于样品负载凹陷的底部旁边或低于样品负载凹陷的底部。 感测层被配置为接收光并将其转换成电信号。 还提供了感测方法。