公开(公告)号：US10024873B2

公开(公告)日：2018-07-17

申请号：US15606119

申请日：2017-05-26

申请人： Undercover Colors, Inc.

发明人： Nicolas Letourneau ,  Aly Khalifa ,  Michael Gorczynski ,  Catherina Gomes ,  Ronald Smith ,  Sarah Paluskiewicz ,  Stephen Gray ,  Tyler Confrey-Maloney

IPC分类号： G01N33/558 ,  G01N33/94 ,  G01N33/543 ,  G01N33/14

摘要： Described herein are apparatus and methods for detecting substances of abuse or other analytes in liquids. For example, the apparatus and methods described herein can be used for real-time detection of analytes, such as substances of abuse. The methods comprise providing a detection area comprising a chromatographic membrane capable of receiving the liquid and allowing for migration of the liquid, the chromatographic membrane comprising an anti-analyte antibody-particle conjugate, an analyte-conjugate protein at a test line; exposing at least the first location of the apparatus to the liquid; and determining whether an interaction between the analyte-conjugate protein and the liquid occurs to detect the presence of the analyte. The chromatographic membrane may further comprise an anti-species antibody at a control line. Specific buffers are disclosed, and these buffers may be used in the preparation of the apparatus to overcome challenges associated with miniaturization and challenges associated with exposure to beverages.

公开(公告)号：US20170209313A1

公开(公告)日：2017-07-27

申请号：US15449721

申请日：2017-03-03

申请人： Undercover Colors, Inc.

发明人： Nicolas Letourneau ,  Aly Khalifa ,  Michael Gorczynski ,  Catherina Gomes ,  Ronald Smith ,  Sarah Paluskiewicz ,  Stephen Gray ,  Tyler Confrey-Maloney

IPC分类号： A61F13/42 ,  G01N33/52 ,  G01N33/53 ,  A61F13/15

CPC分类号： G01N33/94 ,  A61F13/00055 ,  A61F13/15 ,  A61F13/42 ,  A61F13/84 ,  A61F2013/422 ,  A61F2013/429 ,  A61F2013/8473 ,  G01N21/78 ,  G01N33/146 ,  G01N33/52 ,  G01N33/525 ,  G01N33/53 ,  G01N33/54366 ,  G01N33/558 ,  G01N2021/775 ,  G01N2021/7763 ,  G01N2021/7766

摘要： Described herein are a wearable apparatus and methods for detecting the presence of a targeted substance in a liquid. For example, the wearable apparatus can be a fingernail that detects illicit drugs in a beverage. The wearable apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the wearable apparatus can include a lateral flow assay.

公开(公告)号：US20180321212A1

公开(公告)日：2018-11-08

申请号：US15508182

申请日：2017-01-27

申请人： Undercover Colors, Inc.

发明人： Nicolas Letourneau ,  Aly Khalifa ,  Michael Gorczynski ,  Catherina Gomes ,  Ronald Smith ,  Sarah Paluskiewicz ,  Stephen Gray ,  Tyler Confrey-Maloney

IPC分类号： G01N33/14 ,  G01N21/78 ,  G01N33/53 ,  G01N33/52 ,  G01N33/543 ,  G01N33/558 ,  G01N33/94 ,  G01N33/531

CPC分类号： A61F13/42 ,  A61B5/6826 ,  A61F13/00055 ,  A61F13/15 ,  A61F13/84 ,  A61F2013/422 ,  A61F2013/429 ,  A61F2013/8473 ,  G01N21/78 ,  G01N33/146 ,  G01N33/52 ,  G01N33/525 ,  G01N33/53 ,  G01N33/5306 ,  G01N33/531 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/558 ,  G01N33/94 ,  G01N33/9426 ,  G01N2001/007 ,  G01N2021/775 ,  G01N2021/7763 ,  G01N2021/7766

摘要： Described herein are apparatus and methods for detecting substances of abuse or other analytes in liquids. For example, the apparatus and methods described herein can be used for real-time detection of analytes, such as substances of abuse. The methods comprise providing a detection area comprising a chromatographic membrane capable of receiving the liquid and allowing for migration of the liquid, the chromatographic membrane comprising an anti-analyte antibody-particle conjugate, an analyte-conjugate protein at a test line; exposing at least the first location of the apparatus to the liquid; and determining whether an interaction between the analyte-conjugate protein and the liquid occurs to detect the presence of the analyte. The chromatographic membrane may further comprise an anti-species antibody at a control line. Specific buffers are disclosed, and these buffers may be used in the preparation of the apparatus to overcome challenges associated with miniaturization and challenges associated with exposure to beverages.

公开(公告)号：US10016315B2

公开(公告)日：2018-07-10

申请号：US15449721

申请日：2017-03-03

申请人： Undercover Colors, Inc.

发明人： Nicolas Letourneau ,  Aly Khalifa ,  Michael Gorczynski ,  Catherina Gomes ,  Ronald Smith ,  Sarah Paluskiewicz ,  Stephen Gray ,  Tyler Confrey-Maloney

IPC分类号： G01N33/14 ,  G01N33/02 ,  A61F13/42 ,  A61F13/15 ,  G01N33/52 ,  G01N33/53 ,  A61F13/84 ,  A61F13/00

摘要： Described herein are a wearable apparatus and methods for detecting the presence of a targeted substance in a liquid. For example, the wearable apparatus can be a fingernail that detects illicit drugs in a beverage. The wearable apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the wearable apparatus can include a lateral flow assay.

公开(公告)号：US20180318145A1

公开(公告)日：2018-11-08

申请号：US15508178

申请日：2017-01-27

申请人： Undercover Colors, Inc.

发明人： Nicolas Letourneau ,  Aly Khalifa ,  Michael Gorczynski ,  Catherina Gomes ,  Ronald Smith ,  Sarah Paluskiewicz ,  Stephen Gray ,  Tyler Confrey-Maloney

IPC分类号： A61F13/42 ,  G01N21/78 ,  G01N33/94 ,  G01N33/14 ,  A61B5/00

CPC分类号： A61F13/42 ,  A61B5/6826 ,  A61F13/00055 ,  A61F13/15 ,  A61F13/84 ,  A61F2013/422 ,  A61F2013/429 ,  A61F2013/8473 ,  G01N21/78 ,  G01N33/146 ,  G01N33/52 ,  G01N33/525 ,  G01N33/53 ,  G01N33/5306 ,  G01N33/531 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/558 ,  G01N33/94 ,  G01N33/9426 ,  G01N2001/007 ,  G01N2021/775 ,  G01N2021/7763 ,  G01N2021/7766

摘要： Described herein are a wearable apparatus and methods for detecting the presence of a targeted substance in a liquid. For example, the wearable apparatus can be a fingernail that detects illicit drugs in a beverage. The wearable apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the wearable apparatus can include a lateral flow assay.

公开(公告)号：US20210330516A1

公开(公告)日：2021-10-28

申请号：US16320294

申请日：2017-01-27

申请人： UNDERCOVER COLORS, INC.

发明人： Nicolas Letourneau ,  Aly Khalifa ,  Michael Gorczynski ,  Catherina Gomes ,  Ronald Smith ,  Sarah Paluskiewicz ,  Stephen Gray ,  Tyler Confrey-Maloney

IPC分类号： A61F13/42 ,  A61B5/00 ,  G01N21/78 ,  A61F13/00 ,  G01N33/53

摘要： Described herein are apparatus, methods, and systems for detecting the presence of a targeted substance. The apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the apparatus can include a top layer coupled to a top surface of the detection layer and a bottom layer coupled to a bottom surface of the detection layer.

公开(公告)号：US20170269108A1

公开(公告)日：2017-09-21

申请号：US15606119

申请日：2017-05-26

申请人： Undercover Colors, Inc.

发明人： Nicolas Letourneau ,  Aly Khalifa ,  Michael Gorczynski ,  Catherina Gomes ,  Ronald Smith ,  Sarah Paluskiewicz ,  Stephen Gray ,  Tyler Confrey-Maloney

IPC分类号： G01N33/94 ,  G01N33/558 ,  G01N33/14 ,  G01N33/543

CPC分类号： G01N33/94 ,  A61F13/00055 ,  A61F13/15 ,  A61F13/42 ,  A61F13/84 ,  A61F2013/422 ,  A61F2013/429 ,  A61F2013/8473 ,  G01N21/78 ,  G01N33/146 ,  G01N33/52 ,  G01N33/525 ,  G01N33/53 ,  G01N33/54366 ,  G01N33/558 ,  G01N2021/775 ,  G01N2021/7763 ,  G01N2021/7766

摘要： Described herein are apparatus and methods for detecting substances of abuse or other analytes in liquids. For example, the apparatus and methods described herein can be used for real-time detection of analytes, such as substances of abuse. The methods comprise providing a detection area comprising a chromatographic membrane capable of receiving the liquid and allowing for migration of the liquid, the chromatographic membrane comprising an anti-analyte antibody-particle conjugate, an analyte-conjugate protein at a test line; exposing at least the first location of the apparatus to the liquid; and determining whether an interaction between the analyte-conjugate protein and the liquid occurs to detect the presence of the analyte. The chromatographic membrane may further comprise an anti-species antibody at a control line. Specific buffers are disclosed, and these buffers may be used in the preparation of the apparatus to overcome challenges associated with miniaturization and challenges associated with exposure to beverages.

公开(公告)号：US20170242045A1

公开(公告)日：2017-08-24

申请号：US15449701

申请日：2017-03-03

申请人： Undercover Colors, Inc.

发明人： Nicolas Letourneau ,  Aly Khalifa ,  Michael Gorczynski ,  Catherina Gomes ,  Ronald Smith ,  Sarah Paluskiewicz ,  Stephen Gray ,  Tyler Confrey-Maloney

IPC分类号： G01N33/94 ,  G01N33/558 ,  G01N33/543 ,  G01N33/14

摘要： Described herein are apparatus and methods for detecting substances of abuse or other analytes in liquids. For example, the apparatus and methods described herein can be used for real-time detection of analytes, such as substances of abuse. The methods comprise providing a detection area comprising a chromatographic membrane capable of receiving the liquid and allowing for migration of the liquid, the chromatographic membrane comprising an anti-analyte antibody-particle conjugate, an analyte-conjugate protein at a test line; exposing at least the first location of the apparatus to the liquid; and determining whether an interaction between the analyte-conjugate protein and the liquid occurs to detect the presence of the analyte. The chromatographic membrane may further comprise an anti-species antibody at a control line. Specific buffers are disclosed, and these buffers may be used in the preparation of the apparatus to overcome challenges associated with miniaturization and challenges associated with exposure to beverages.