公开(公告)号：US20240301507A1

公开(公告)日：2024-09-12

申请号：US18657048

申请日：2024-05-07

Applicant: TORAY INDUSTRIES, INC. ,  NATIONAL CANCER CENTER

Inventor： Hiroko SUDO ,  Hitoshi NOBUMASA ,  Satoko KOZONO ,  Satoshi KONDOU ,  Junpei KAWAUCHI ,  Atsushi OCHIAI ,  Motohiro KOJIMA

IPC: C12Q1/6886 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/574 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: It is intended to provide a kit or a device for the detection of esophageal cancer and a method for detecting esophageal cancer. The present invention provides a kit or a device for the detection of esophageal cancer, comprising nucleic acid(s) capable of specifically binding to miRNA(s) in a sample of a subject, and a method for detecting esophageal cancer, comprising measuring the miRNA in vitro.

公开(公告)号：US12066440B2

公开(公告)日：2024-08-20

申请号：US17082979

申请日：2020-10-28

Applicant: Labrador Diagnostics LLC

Inventor： Chinmay Pangarkar ,  Karan Mohan ,  James R. Wasson

IPC: B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C08L5/08 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  G01N1/30 ,  G01N15/10 ,  G01N21/03 ,  G01N21/05 ,  G01N21/17 ,  G01N21/27 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/487 ,  G01N33/49 ,  G01N33/50 ,  G01N33/53 ,  G01N33/564 ,  G01N33/569 ,  G01N33/58 ,  G01N33/68 ,  G02B7/09 ,  G02B21/00 ,  G02B21/08 ,  G02B21/12 ,  G02B21/16 ,  G02B21/24 ,  G02B21/36

CPC classification number: G01N33/56972 ,  B01L3/502715 ,  G01N1/30 ,  G01N15/1012 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/17 ,  G01N21/27 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/487 ,  G01N33/49 ,  G01N33/5005 ,  G01N33/53 ,  G01N33/5308 ,  G01N33/56966 ,  G01N33/582 ,  G02B7/09 ,  G02B21/0076 ,  G02B21/088 ,  G02B21/125 ,  G02B21/16 ,  G02B21/244 ,  G02B21/365 ,  G01N2015/1014 ,  G01N2021/1738 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2201/12 ,  G01N2333/70589 ,  G01N2333/70596

Abstract: Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples.

公开(公告)号：US12064763B2

公开(公告)日：2024-08-20

申请号：US17770643

申请日：2020-10-21

Applicant: Conservation X Labs, Inc

Inventor： Alex Dehgan ,  Paul Bunje ,  Hallie Holmes ,  David Baisch ,  Cifeng Fang ,  Gareth Fotouhi ,  Misa Winters ,  Sam Kelly ,  Brad Zamft

IPC: B01L3/00 ,  B01L7/00 ,  G01N21/03 ,  G01N21/25 ,  G01N33/53 ,  G01N35/00

CPC classification number: B01L3/502715 ,  B01L3/5085 ,  B01L7/52 ,  G01N21/0332 ,  G01N21/253 ,  G01N33/53 ,  B01L2200/0684 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  G01N2035/00376

Abstract: A cartridge for providing a target analyte for detection is described. One such exemplar cartridge includes a base portion including: (1) a receiving area disposed at or near a center region of the base portion; (2) multiple reaction wells disposed outside the center region or radially disposed at or near a perimeter of the base portion; and (3) multiple connecting tracks that substantially linearly extend from a region at or proximate to the receiving area to the multiple reaction wells and designed to convey a sample including the target analyte from the receiving area to the multiple reaction wells, each of which are configured to transform the sample to a detectable sample.
Systems and methods of reacting and detecting the sample including the target analyte are also described.

公开(公告)号：US20240263245A1

公开(公告)日：2024-08-08

申请号：US18606093

申请日：2024-03-15

Applicant: TORAY INDUSTRIES, INC. ,  NATIONAL CANCER CENTER

Inventor： Satoko KOZONO ,  Hitoshi NOBUMASA ,  Satoshi KONDOU ,  Hiroko SUDO ,  Junpei KAWAUCHI ,  Atsushi OCHIAI ,  Motohiro KOJIMA

IPC: C12Q1/6886 ,  C12M1/00 ,  C12N15/09 ,  C12N15/113 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/574

CPC classification number: C12Q1/6886 ,  C12M1/00 ,  C12N15/09 ,  C12N15/113 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/574 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: It is intended to provide a kit or a device for the detection of colorectal cancer and a method for detecting colorectal cancer. The present invention provides a kit or a device for the detection of colorectal cancer, comprising a nucleic acid capable of specifically binding to a miRNA in a sample from a subject, and a method for detecting colorectal cancer, comprising measuring the miRNA in vitro.

公开(公告)号：US20240240235A1

公开(公告)日：2024-07-18

申请号：US18614970

申请日：2024-03-25

Applicant: President and Fellos of Harvard College

Inventor： George M. Church ,  Jehyuk Lee ,  Daniel Levner ,  Michael Super

IPC: C12Q1/6806 ,  C12P19/34 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6837 ,  C12Q1/6844 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N33/53

CPC classification number: C12Q1/6806 ,  C12P19/34 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6837 ,  C12Q1/6844 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N33/53 ,  G01N2458/10

Abstract: Methods of analyzing nucleic acids of a cell are provided.

公开(公告)号：US20240230644A1

公开(公告)日：2024-07-11

申请号：US18382562

申请日：2023-10-23

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： Brian Bettencourt

IPC: G01N33/566 ,  C07D263/57 ,  C07K1/00 ,  C12N15/113 ,  G01N33/50 ,  G01N33/53 ,  G01N33/567 ,  G01N33/68

CPC classification number: G01N33/566 ,  C07D263/57 ,  C12N15/113 ,  G01N33/50 ,  G01N33/53 ,  G01N33/567 ,  G01N33/6896 ,  C07K1/00 ,  C12N2310/14

Abstract: Disclosed herein are methods for reducing or arresting an increase in a Neuropathy Impairment Score (NIS) or a modified NIS (mNIS+7) in a human subject by administering an effective amount of a transthyretin (TTR)-inhibiting composition.

公开(公告)号：US20240190941A1

公开(公告)日：2024-06-13

申请号：US18554625

申请日：2022-04-07

Applicant: REPERTOIRE IMMUNE MEDICINES, INC.

Inventor： Thomas J. MALIA ,  Joanna F. SWAIN ,  Andrew G. HAMEL ,  Ellen M. WHITE

IPC: C07K14/74 ,  A61P37/06 ,  C07K14/52 ,  C07K14/705 ,  C07K16/28 ,  C12N15/63 ,  G01N33/53

CPC classification number: C07K14/70539 ,  A61P37/06 ,  C07K14/52 ,  C07K14/70596 ,  C07K16/2803 ,  C12N15/63 ,  G01N33/53 ,  C07K2319/30

Abstract: Multimers are provided in which a Major Histocompatibility Complex (MHC) class I or class II molecule, optionally complexed with an MHC-binding peptide, is attached to a multimerization moiety from immunoglobulin M or A (IgM or IgA) to thereby create a multivalent peptide-MHC-Ig multimer composition. The multimers can be used, for example, to determine the binding specificity of T cell receptors, such as for particular MHC-peptide complexes. The multimers can also be used, for example, to modulate an immune response in a subject by administering the multimer to the subject. Methods of making the peptide-MHC-Ig multimers are also provided.

公开(公告)号：US20240175876A1

公开(公告)日：2024-05-30

申请号：US18522521

申请日：2023-11-29

Applicant: UNIVERSITY OF MIAMI

Inventor： Daniel Isom ,  Jacob Rowe

IPC: G01N33/68 ,  C07K14/395 ,  C12N1/18 ,  G01N21/64 ,  G01N33/53

CPC classification number: G01N33/6845 ,  C07K14/395 ,  C12N1/185 ,  G01N21/6486 ,  G01N33/53

Abstract: Disclosed herein are engineered yeast cells, systems, and methods for screening for a ligand that modulates a receptor function and for determining functional consequences of receptor-ligand binding.

公开(公告)号：US20240165620A1

公开(公告)日：2024-05-23

申请号：US18521062

申请日：2023-11-28

Applicant: VANDERBILT UNIVERSITY

Inventor： Sinead E. MILLER ,  Charleson S. BELL ,  Todd D. GIORGIO ,  Andrew L. COOK

IPC: B01L3/00 ,  A61K38/12 ,  A61K38/14 ,  A61M5/165 ,  G01N33/48 ,  G01N33/53 ,  G01N33/543

CPC classification number: B01L3/502753 ,  A61K38/12 ,  A61K38/14 ,  A61M5/165 ,  B01L3/502715 ,  B01L3/502776 ,  G01N33/48 ,  G01N33/53 ,  G01N33/543 ,  B01L2300/0861 ,  B01L2300/16

Abstract: The present disclosure relates to a fluidic device to detect, capture, and/or remove disease material in a biological fluid. The present invention also relates to methods for the treatment/prevention of sepsis through the use of the claimed device.

公开(公告)号：US11976318B2

公开(公告)日：2024-05-07

申请号：US18064956

申请日：2022-12-13

Applicant: President and Fellows of Harvard College

Inventor： George M. Church ,  Jehyuk Lee ,  Daniel Levner ,  Michael Super

IPC: C12Q1/68 ,  C12P19/34 ,  C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6816 ,  C12Q1/6837 ,  C12Q1/6844 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N33/53

CPC classification number: C12Q1/6806 ,  C12P19/34 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/6837 ,  C12Q1/6844 ,  C12Q1/6869 ,  C12Q1/6874 ,  G01N33/53 ,  G01N2458/10

Abstract: Methods of analyzing nucleic acids of a cell are provided.