公开(公告)号：US12216133B2

公开(公告)日：2025-02-04

申请号：US17218638

申请日：2021-03-31

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christopher Espy ,  Yin Cai

IPC: B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C07K14/705 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N21/77 ,  G01N21/78 ,  G01N27/414 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01N33/74 ,  G01N35/00 ,  G01N35/10 ,  G06K7/10 ,  G06K7/14 ,  G06K19/06 ,  G06K19/07 ,  G06T7/00 ,  G06T7/90 ,  H10K10/46 ,  H10K85/00 ,  H10K85/20

Abstract: A sample handling system for handling samples is disclosed. The sample handling system comprises sample holders, each receives a sample container; a sample transport device for moving the sample holders; a control unit for controlling functionality of the sample handling system, and a monitoring system for monitoring the samples during movement. The monitoring system comprises a camera module for continuously capturing images of a part of the sample transport device, wherein the camera module is at a distance from the sample transport device such that the camera module has a free field of view to the sample transport device, and a processor for processing the captured images and determining an item of information about the sample transport device and/or the sample container and/or the sample from the captured images. The control unit retrieves the item of information from the processor. The controlling is based on the retrieved item of information.

公开(公告)号：US12135292B2

公开(公告)日：2024-11-05

申请号：US17142129

申请日：2021-01-05

Applicant: Roche Diabetes Care, Inc.

Inventor： Max Berg ,  Daniel Sieffert ,  Volker Tuerck ,  Simon Wetzel ,  Momme Winkelnkemper

IPC: B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C07K14/705 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N21/77 ,  G01N21/78 ,  G01N27/414 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01N33/74 ,  G01N35/00 ,  G01N35/10 ,  G06T7/00 ,  G06T7/90 ,  H10K10/46 ,  H10K85/00 ,  H10K85/20

Abstract: A method for detecting an analyte in a sample is disclosed. The method includes providing a mobile device having a camera and an illumination source. A test strip having a test field with at least one test chemical for performing an optical detection reaction in the presence of the analyte is provided. The sample is applied to the test field. Several images of a region of the test strip are captured. The region includes at least part of the test field to which sample is applied. The images are captured before and after the sample is applied and with the illumination source turned on and off. The images captured are compared and differences in light intensities are determined. Analyte concentration is determined using the images captured and the determined light intensities.

公开(公告)号：US12099060B2

公开(公告)日：2024-09-24

申请号：US16839623

申请日：2020-04-03

Applicant: Seoul National University R&DB Foundation

Inventor： Tai Hyun Park ,  Seung Hun Hong ,  Hyun Seok Song ,  Hye Jun Jin ,  Sae Ryun Ahn

IPC: G01N21/64 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C07K14/705 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N27/414 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/68 ,  G01N33/74 ,  H10K10/46 ,  H10K85/00 ,  H10K85/20

CPC classification number: G01N33/5438 ,  C07K14/705 ,  G01N27/4145 ,  G01N33/5308 ,  G01N33/54373 ,  G01N33/74 ,  H10K10/46 ,  H10K85/761 ,  G01N2333/705 ,  G01N2333/726 ,  G01N2400/00 ,  H10K85/225

Abstract: The present invention relates to a nanovesicle comprising a heterodimeric G-protein coupled receptor, a method for preparing the nanovesicle, a field effect transistor-based taste sensor comprising the nanovesicle, and a method for manufacturing the taste sensor. The field effect transistor based taste sensor functionalized by the nanovesicle comprising the heterodimer G-protein coupled receptor according to the present invention has excellent sensitivity and selectivity and may highly specifically detect a sweet taste substance in real time, by using the heterodimeric G-protein coupled receptor and the nanovesicle comprising the same.

公开(公告)号：US12085562B2

公开(公告)日：2024-09-10

申请号：US17293220

申请日：2019-11-11

Applicant: GREAT NORTH RESEARCH AND INNOVATION LTD

Inventor： Georgios Gerardos ,  Dan Haworth ,  Paul Scott ,  Will Harris ,  Leigh Shelford

IPC: B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  C12Q1/686 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/543 ,  G01N33/68 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N33/54386 ,  G01N35/04 ,  G01N35/1009 ,  G01N35/1079 ,  G01N2035/0441 ,  G01N2035/1032 ,  G01N2035/1062

Abstract: The present invention relates to a biochemical assay apparatus in which a sample processing device is controlled by a detection instrument through a series of linear and rotary actuations to execute a biochemical assay on a biological fluid sample.

公开(公告)号：US11994519B2

公开(公告)日：2024-05-28

申请号：US16772034

申请日：2018-12-13

Applicant: GLX Analytix ApS

Inventor： Brian William Della Valle ,  Casper Hempel ,  Marie Agnete Larsen

IPC: B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C08L5/08 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/564 ,  G01N33/68

CPC classification number: G01N33/564 ,  C08L5/08 ,  G01N2400/40 ,  G01N2800/285

Abstract: The present invention relates to biomarkers associated with multiple sclerosis (MS), particular GLX molecules, and teven more particular GLX-related glycosaminoglycans (GAGs) and GLX-related proteoglycans (PGs).

公开(公告)号：US11971394B2

公开(公告)日：2024-04-30

申请号：US17047606

申请日：2019-04-16

Applicant: SHARP KABUSHIKI KAISHA

Inventor： Shohei Komaru ,  Tadashi Iwamatsu

IPC: G01N30/70 ,  G01N27/66 ,  H01J49/08

CPC classification number: G01N30/70 ,  G01N27/66 ,  H01J49/08

Abstract: The electron capture detector (100) is a device for detecting a sample (α1). The electron capture detector (100) includes a detection cell (1), a sample inlet (2), and an electron emitting element (20). The detection cell (1) forms a reaction chamber (6). The sample inlet (2) introduces a first carrier gas containing the sample (α1) into the reaction chamber (6). The electron emitting element (20) emits electrons (β) into the reaction chamber (6). An ion (α2) derived from the sample component is generated as a result of the electron emitting element (20) emitting electrons (β) into the reaction chamber (6).

公开(公告)号：US11542449B2

公开(公告)日：2023-01-03

申请号：US16110470

申请日：2018-08-23

Applicant: United Color Manufacturing, Inc.

Inventor： Michael P. Hinton ,  Justin J. Frederico

IPC: C10L1/00 ,  G01N30/68 ,  G01N30/70 ,  G01N21/31 ,  G01N21/3504 ,  G01N21/65 ,  C09B11/08 ,  G01N30/02 ,  G01N30/88

Abstract: The present disclosure provides compositions, methods, and systems for identifying marked hydrocarbon fluids. These compositions, methods, and systems utilize a gas chromatography marker including a non-pyrrolidinone nitrogen-containing compound. The methods and systems can identify the presence or absence of the gas chromatography marker and/or the non-pyrrolidinone nitrogen-containing compound. The compositions, methods, and systems can optionally utilize a spectroscopic marker.

公开(公告)号：US20050272166A1

公开(公告)日：2005-12-08

申请号：US11122533

申请日：2005-05-05

Applicant: Li Jin ,  Joseph Therrien

Inventor： Li Jin ,  Joseph Therrien

IPC: G01N30/02 ,  G01N30/34 ,  G01N30/70 ,  G01N30/72 ,  G01N33/00 ,  G01N33/50

CPC classification number: G01N30/02 ,  C07H17/08 ,  G01N30/34 ,  G01N30/70 ,  G01N30/7233 ,  G01N2030/027 ,  Y10T436/143333 ,  B01D15/426 ,  B01D15/325

Abstract: The present invention relates to reverse-phase high performance liquid chromatography (RP-HPLC) methods and systems for detecting macrolides as well as detecting, identifying and quantifying impurities in samples containing a macrolide.

Abstract translation: 本发明涉及用于检测大环内酯类的反相高效液相色谱（RP-HPLC）方法和系统，以及检测，鉴定和定量含有大环内酯的样品中的杂质。

公开(公告)号：US4680472A

公开(公告)日：1987-07-14

申请号：US818635

申请日：1986-01-14

Applicant: Claude Mendes

Inventor： Claude Mendes

IPC: G01N27/66 ,  G01N30/70

CPC classification number: G01N30/70 ,  G01N27/66

Abstract: When using an electron capture detector for the molecular identification of electrophilic compounds, the sensitivity of the detector is made reproducible by controlling the voltage or frequency of the pulses applied to it to maintain a reference current whose set value is produced automatically by the device after determination of the characteristics of the state of the detector, namely a so-called saturation current CM and a so-called spontaneous current CS, according to a law of proportionality between these two currents.In addition, knowledge of these state characteristics gives information on the physical and physicochemical anomalies of the analysis device having an effect on the sensitivity of the detector, and consequently enables them to be remedied.

Abstract translation: 当使用电子捕获检测器进行亲电子化合物的分子鉴定时，通过控制施加到其上的脉冲的电压或频率来维持检测器的灵敏度，使得检测器的灵敏度可以重现，以保持参考电流，其设定值在确定后由器件自动产生 的检测器状态的特性，即所谓的饱和电流CM和所谓的自发电流CS，根据这两个电流之间的比例定律。 此外，这些状态特征的知识提供了对分析装置的物理和物理化学异常的信息，其对检测器的灵敏度具有影响，并且因此使得它们得到补救。

公开(公告)号：US4535620A

公开(公告)日：1985-08-20

申请号：US522791

申请日：1983-08-12

Applicant: Richard D. Cunningham

Inventor： Richard D. Cunningham

IPC: G01N30/70 ,  G01N30/88 ,  G01N33/22 ,  G01N31/08

CPC classification number: G01N30/88 ,  G01N30/70 ,  G01N33/225

Abstract: A method for analyzing various components in a natural gas pipeline with the aid of a computer controlled gas chromatograph comprising the steps of: (a) providing the computer control unit with a data base for operating the gas chromatograph including at least: (1) periodically causing a sample of the natural gas to be supplied to the gas chromatograph; (2) operating the gas chromatograph to analyze the various components in the natural gas stream; (3) computing the amount of the various components in the natural gas stream; and (4) reporting the amount of components in the natural gas stream.

Abstract translation: 一种借助于计算机控制的气相色谱仪分析天然气管道中的各种组分的方法，包括以下步骤：（a）向计算机控制单元提供用于操作气相色谱仪的数据库，该数据库至少包括：（1）周期性地 使天然气样品供给气相色谱仪; （2）运行气相色谱仪分析天然气流中的各种成分; （3）计算天然气流中各种成分的量; 和（4）报告天然气流中的组分数量。