公开(公告)号：US20240329381A1

公开(公告)日：2024-10-03

申请号：US18295206

申请日：2023-04-03

申请人： ARACELI BIOSCIENCES INC.

发明人： Shiou-jyh Ja

IPC分类号： G02B21/36 ,  G02B21/16 ,  G02B21/18 ,  G02B21/24 ,  G06T7/00 ,  G06T7/80 ,  H04N17/00

CPC分类号： G02B21/362 ,  G02B21/16 ,  G02B21/18 ,  G02B21/244 ,  G02B21/367 ,  G06T7/0002 ,  G06T7/80 ,  H04N17/002 ,  G06T2207/10056 ,  G06T2207/10148 ,  G06T2207/30168

摘要： Methods and systems are provided for a microscope system. In one example, a method for image-based detection of optical alignment for the microscope system comprises acquiring a plurality of contrast samples of a field of view of a subject, determining a contrast distribution for a plurality of divided sub-regions for the field of view based on the plurality of contrast samples, and generating an amount of angular discrepancy based on an in-focus position derived from the contrast distribution for each of the plurality of divided sub-regions. In one example, the method further comprises adjusting the microscope system based on the amount of angular discrepancy.

公开(公告)号：US12076195B2

公开(公告)日：2024-09-03

申请号：US16980848

申请日：2019-02-01

申请人： Sony Olympus Medical Solutions Inc.

发明人： Yoshiyuki Kamata

IPC分类号： A61B90/25 ,  A61B90/00 ,  B25J13/08 ,  G02B21/00 ,  G02B21/24

CPC分类号： A61B90/25 ,  B25J13/085 ,  A61B2090/067 ,  G02B21/0012 ,  G02B21/24

摘要： A medical holding apparatus includes: an arm including a plurality of links mutually coupled through one of joints, the arm having at least six degrees of freedom due to rotational motion about a rotation axis, the arm being configured to function as a balanced arm with a counterweight and support a medical device; and an arm controller configured to control motion of the arm, in which at least three of the joints in the arm each are provided with an angular sensor that detects a rotation angle of the rotation axis and an actuator that gives the joint an assist force of assisting the rotational motion, and the arm controller controls, based on respective detected results of the angular sensors, the respective assist forces of the actuators such that an amount of force in operation necessary when an operator moves the medical device supported by the arm remains in a predetermined range.

公开(公告)号：US12061329B2

公开(公告)日：2024-08-13

申请号：US17906363

申请日：2021-03-15

申请人： SONY GROUP CORPORATION

发明人： Takeshi Matsui ,  Hirokazu Tatsuta ,  Mitsunori Ueda ,  Seiji Wada

IPC分类号： H04N23/74 ,  G02B21/00 ,  G02B21/08 ,  G02B21/24 ,  H04N23/67 ,  H04N23/71

CPC分类号： G02B21/241 ,  G02B21/0032 ,  G02B21/008 ,  G02B21/08 ,  H04N23/673 ,  H04N23/71 ,  H04N23/74

摘要： A microscope system includes: a light source unit that emits linear illumination parallel to a first direction; an objective lens that condenses the linear illumination onto a measurement target region; an acquisition unit that acquires a first optical signal indicating a light intensity value of light emitted from the measurement target region by the linear illumination; and a focus control unit that controls at least one of a relative position or a relative posture of the light source unit and an imaging unit that generates the first optical signal on a basis of a light intensity distribution of the first optical signal.

公开(公告)号：US12055380B2

公开(公告)日：2024-08-06

申请号：US17375110

申请日：2021-07-14

申请人： Carl Zeiss Microscopy GmbH

发明人： Manuel Amthor ,  Daniel Haase

IPC分类号： G01B11/14 ,  G02B21/24 ,  G02B21/26 ,  G02B21/36

CPC分类号： G01B11/14 ,  G02B21/241 ,  G02B21/26 ,  G02B21/365

摘要： A method for determining a distance of a sample reference plane of a sample carrier from a reference plane of a microscope, the microscope including a sample stage for the sample carrier and a camera, comprises the following steps: taking an overview image of the sample carrier by means of the camera; evaluating the overview image and thus detecting at least one characteristic of the sample carrier; ascertaining contextual data of the characteristic from a data set; and determining the distance of the sample reference plane from the reference plane based on the characteristic and the contextual data of the sample carrier. A microscope configured to determine the distance of the sample reference plane of the sample carrier from the reference plane is also described.

公开(公告)号：US20240221123A1

公开(公告)日：2024-07-04

申请号：US18523039

申请日：2023-11-29

申请人： InnoLux Corporation

发明人： Jia-Hong SU ,  Chong-Lin HUANG

IPC分类号： G06T5/50 ,  G02B21/24 ,  G02B21/26 ,  G06T5/20 ,  H04N23/56

CPC分类号： G06T5/50 ,  G02B21/241 ,  G02B21/26 ,  G06T5/20 ,  G06T5/94 ,  H04N23/56 ,  G06T2207/10056 ,  G06T2207/20212

摘要： In a method for acquiring image using an image acquiring system, a first image data at a first position is acquired in a first direction of the image acquiring system, wherein the first image data corresponds to a plurality of pixel positions and includes a plurality of first sub-image data; a second image data at a second position is acquired in the first direction, wherein the second image data corresponds to the plurality of pixel positions and includes a plurality of second sub-image data; a larger value among values of the first sub-image data and the second sub-image data corresponding to one of the plurality of pixel positions is selected as a combination sub-image data of a combination image data.

公开(公告)号：US20240210670A1

公开(公告)日：2024-06-27

申请号：US18422785

申请日：2024-01-25

申请人： Carl Zeiss Meditec AG

发明人： Jonathan Essig ,  Andre Mueller ,  Christian Beder

IPC分类号： G02B21/24 ,  G02B21/00

CPC分类号： G02B21/24 ,  G02B21/0012

摘要： A contactless visualization system for a microscope for eye surgery includes an ophthalmic loupe positionable in front of a patient's eye and supplies a real and vertically and laterally inverted image of the fundus in an intermediate image plane observable by the microscope. The loupe includes a first and a second lens element. Positioned in front of the eye, the first lens element is closer to the eye than the second. A wall extending from the first to the second lens element has a free end in a form of a mount which holds the second lens element. The wall has a passage opening formed therein for removing liquid possibly present in an intermediate space between the first and second lens element. The first lens element has a boundary surface facing the second. The passage opening includes a lower edge bordering on the boundary surface of the first lens element.

公开(公告)号：US12013525B2

公开(公告)日：2024-06-18

申请号：US17574590

申请日：2022-01-13

申请人： Keyence Corporation

发明人： Shingo Matsumura ,  Suguru Sekiya

IPC分类号： G02B21/36 ,  G02B21/02 ,  G02B21/24 ,  G02B21/26 ,  H04N23/63 ,  H04N23/67

CPC分类号： G02B21/367 ,  G02B21/025 ,  G02B21/244 ,  G02B21/245 ,  G02B21/26 ,  G02B21/368 ,  H04N23/635 ,  H04N23/67

摘要： A magnified observation apparatus includes an FOV changer, an in-focus degree evaluator, and a focus sequence executor. The in-focus degree evaluator calculates in-focus degree feature quantities, which represent in-focus degrees of image data corresponding to images to be displayed by a display controller on a display. The focus sequence executor executes an FOV-moving focus sequence in which a focusing device adjusts a relative distance between a focus position of the objective lens and an observation object in accordance with in-focus degree feature quantities of image data that are successively calculated by the in-focus degree evaluator corresponding to images of the observation object that are captured during movement of an observation FOV by the FOV changer so that a live image of the observation object is displayed on the display based on image data that is obtained during the movement of an observation FOV by the display controller.

公开(公告)号：US12013522B2

公开(公告)日：2024-06-18

申请号：US17267879

申请日：2019-08-12

申请人： Miltenyi Biotec B.V. & CO. KG

发明人： Rainer Uhl

IPC分类号： G02B21/00 ,  G02B21/02 ,  G02B21/08 ,  G02B21/24 ,  G02B21/26 ,  G02B27/14

CPC分类号： G02B21/241 ,  G02B21/02 ,  G02B21/08 ,  G02B21/26 ,  G02B27/141

摘要： A microscope device includes an objective (1); an actuator (6) for adjustment of a distance in a focusing direction z, an absolute z-position detector (7) for measuring a z-position. The device further includes an autofocus light source (11); a first optical arrangement (12, 13) for generating a focused spot (31) of autofocus light from the light source in the backfocal plane (14) of the objective (1) at a position offset from the optical axis of the objective by a lateral offset distance (d) The objective generates a collimated incoming beam (22) of autofocus light, which is directed at an oblique angle (β) relative to the optical axis (15) of the objective onto the substrate. The microscope may further include a second optical arrangement (13, 16) for generating collimated outgoing beams (34, 35) of autofocus light and directing the collimated outgoing beam onto a detector-array (17).

公开(公告)号：US12007548B2

公开(公告)日：2024-06-11

申请号：US18059490

申请日：2022-11-29

申请人： OPTOFLUIDICS, INC.

发明人： Colby Ashcroft ,  Brian DiPaolo ,  Gjergji Konica ,  Thomas Castner ,  Bernardo Cordovez ,  Christopher Earhart ,  David Erickson ,  Robert Hart

IPC分类号： G01B21/24 ,  G01N15/02 ,  G01N15/0227 ,  G01N15/14 ,  G01N15/1429 ,  G01N15/1434 ,  G01N21/64 ,  G02B21/12 ,  G02B21/16 ,  G02B21/24 ,  G02B21/36 ,  G01N15/00 ,  G01N15/10 ,  G01N21/35 ,  G01N21/65

CPC分类号： G02B21/367 ,  G01N15/0227 ,  G01N15/0272 ,  G01N15/1425 ,  G01N15/1429 ,  G01N15/1434 ,  G01N15/1436 ,  G01N15/1463 ,  G01N15/147 ,  G01N15/1475 ,  G01N21/6456 ,  G02B21/12 ,  G02B21/16 ,  G02B21/24 ,  G01N2015/0011 ,  G01N2015/003 ,  G01N2015/0053 ,  G01N2015/0065 ,  G01N2015/0294 ,  G01N2015/1006 ,  G01N2015/1493 ,  G01N2015/1497 ,  G01N2021/3595 ,  G01N21/6452 ,  G01N21/65 ,  G01N2201/062

摘要： A system for characterizing at least one particle from a fluid sample is disclosed. The system includes a filter disposed upstream of an outlet, and a luminaire configured to illuminate the at least one particle at an oblique angle. An imaging device is configured to capture and process images of the illuminated at least one particle as it rests on the filter for characterizing the at least one particle. A system for characterizing at least one particle using bright field illumination is also disclosed. A method for characterizing particulates in a fluid sample using at least one of oblique angle and bright field illumination is also disclosed.

公开(公告)号：US11994662B2

公开(公告)日：2024-05-28

申请号：US16746633

申请日：2020-01-17

申请人： Techcyte, Inc.

发明人： Benjamin Cahoon ,  Shane Swenson ,  Benjamin S. Larson

IPC分类号： G02B21/00 ,  G02B21/24 ,  G02B21/26 ,  G02B21/36 ,  G02B21/06 ,  G02B21/34

CPC分类号： G02B21/26 ,  G02B21/006 ,  G02B21/241 ,  G02B21/36 ,  G02B21/06 ,  G02B21/34

摘要： Systems, methods, and devices for identifying a reference focal surface in connection with light microscopy. A method includes identifying a fiducial marker printed on a surface of a coverslip or a slide used in connection with optical microscopy. The method includes focusing the optical microscope on the fiducial marker to calculate a focal distance of the fiducial marker. The method includes calculating a reference focal surface defining the surface of the coverslip or the slide based on the focal distance of the fiducial marker.