公开(公告)号：US12181385B2

公开(公告)日：2024-12-31

申请号：US16632060

申请日：2018-07-18

Applicant: BECTON DICKINSON AND COMPANY

Inventor： Ryan Callaghan ,  Clark M Whitehead ,  William Alan Fox

IPC: G01N1/30 ,  G01N1/28 ,  G01N1/31 ,  G02B21/34

Abstract: A biological sample is provided, wherein the biological sample is a liquid-based cytology sample. A slide is placed in a holder. The slide is pre-coated with a composition that will cause cells to adhere to the slide. A settling chamber is placed over the slide and the settling chamber is locked onto the holder. The settling chamber has openings in both proximate and distal ends. The opening in the distal end of the settling chamber is positioned over the slide. A density reagent is then dispensed into the settling chamber. The liquid-based cytology sample is then dispensed into the settling chamber over the reagent. The assembly formed by the holder, slide and settling chamber (and its liquid contents) is placed in a centrifuge. The density reagent and the liquid thereover are decanted from the settling chamber. The settling chamber is removed from over the slide.

公开(公告)号：US12174358B2

公开(公告)日：2024-12-24

申请号：US17931414

申请日：2022-09-12

Applicant: Alentic Microscience Inc.

Inventor： Alan Marc Fine ,  Joel Ironstone ,  Christopher Gillespie

IPC: G02B21/26 ,  G02B21/00 ,  G02B21/06 ,  G02B21/34

Abstract: A base assembly includes an imaging sensor having a sensor surface to receive a sample, and a platform connected to the base assembly. The base assembly includes (a) an aperture configured to receive a lid surface of a lid in a position to define an imaging space between the sensor surface and the lid surface and (b) a movement portion movable toward and away from the base assembly. The platform and the base assembly are configured to limit contact between the sample and the base assembly other than at the sensor surface.

公开(公告)号：US12140745B2

公开(公告)日：2024-11-12

申请号：US18104363

申请日：2023-02-01

Applicant: Ventana Medical Systems, Inc.

Inventor： Anindya Sarkar ,  Chibuya Siame

IPC: G06T7/73 ,  G02B21/26 ,  G02B21/34 ,  G02B21/36 ,  G06T7/13 ,  G06V10/24 ,  G06V20/69

Abstract: A method and system for measuring the alignment between a substrate and a platform upon which it is disposed by using image processing algorithms are described herein. These algorithms automate the detection of edges of a microscope slide and the platform in a digital image. A reference line pattern in an image of the platform can be used to detect platform edges based on a computed location of the reference line pattern in the image.

公开(公告)号：US20240337570A1

公开(公告)日：2024-10-10

申请号：US18747240

申请日：2024-06-18

Applicant: Agilent Technologies, Inc.

Inventor： Adrienne McCampbell ,  Victor Lim

IPC: G01N1/40 ,  G01N1/44 ,  G02B21/34

CPC classification number: G01N1/40 ,  G01N1/4022 ,  G01N1/44 ,  G01N2001/4038 ,  G02B21/34

Abstract: Paraffin-embedded tissue is prepared removing paraffin from the tissue. The paraffin is removed by generating an electric field effective to produce plasma and direct charged species of the plasma to the paraffin, thereby rendering the paraffin responsive to the electric field. The electric field may move the paraffin out from the tissue due to electrostatic force. Movement of the paraffin may be assisted by moving an electrode utilized to generate the electric field relative to the paraffin. Movement of the paraffin also may be assisted by applying a solvent and/or heat energy to the tissue.

公开(公告)号：US12105273B2

公开(公告)日：2024-10-01

申请号：US18079930

申请日：2022-12-13

Applicant: cytena GmbH

Inventor： Agnes Johansson ,  Nathanael Dögel ,  David Rauch ,  Lena Lautscham

IPC: G02B21/36 ,  G02B21/26 ,  G02B21/34

CPC classification number: G02B21/362 ,  G02B21/26 ,  G02B21/34

Abstract: A microscope comprises a housing having a receiving portion for receiving at least one biological sample, an optics module comprising several objectives and an illumination system for illuminating at least one biological sample and/or an acquiring system for acquiring light coming from at least one biological sample, wherein the optics module is arranged in an inner space of the housing. The microscope is characterized in that the microscope comprises a replacement system for replacing an objective by one of the other objectives wherein the replacement system is configured to replace the objective by means of moving the optics module relative to the housing and/or by means of moving the housing relative to the optics module.

公开(公告)号：US20240254322A1

公开(公告)日：2024-08-01

申请号：US18610942

申请日：2024-03-20

Applicant: FUJIFILM Corporation

Inventor： Takato SUZUKI ,  Miyoko HARA ,  Yasuyuki SASADA

IPC: C08L1/12 ,  C08L31/08 ,  C08L67/00 ,  G02B1/04 ,  G02B21/34

CPC classification number: C08L1/12 ,  C08L31/08 ,  C08L67/00 ,  G02B1/04 ,  C08L2203/16 ,  G02B21/34

Abstract: The present invention provides a cover film having excellent storage stability. The cover film of the present invention includes a cellulose acetate support and a polymer layer containing a polymer, in which the support contains an additive A other than cellulose acetate, and in a case where the support contains one kind of the additive A, a molecular weight of the one kind of the additive A is 500 or more, and in a case where the support contains two or more kinds of the additives A, an average molecular weight of the two or more kinds of the additives A is 500 or more.

公开(公告)号：US20240226903A1

公开(公告)日：2024-07-11

申请号：US18618338

申请日：2024-03-27

Applicant: Mikroscan Technologies

Inventor： Jeffrey Ross Gray ,  James Clail Crowe

IPC: B01L9/00 ,  G01N35/00 ,  G02B21/26 ,  G02B21/34

CPC classification number: B01L9/52 ,  G01N35/00029 ,  G02B21/26 ,  G02B21/34 ,  B01L2300/0822 ,  G01N2035/00039 ,  G01N2035/00138

Abstract: A method of positioning a slide for examination is disclosed. The method includes the steps of placing the slide in a carrier configured to retain the slide, placing the carrier in a cartridge configured to accept the carrier, coupling the cartridge to a microscope, and activating the microscope to automatically extract the carrier from the cartridge and position the carrier such that a portion of the slide is disposed within a field of view (FOV) of the microscope.

公开(公告)号：US11988585B2

公开(公告)日：2024-05-21

申请号：US16641193

申请日：2018-09-11

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Adam York ,  Eric Welch ,  Daniel Cash

IPC: G01N1/36 ,  C08K3/30 ,  C08K5/09 ,  G01N1/30 ,  G02B21/34

CPC classification number: G01N1/36 ,  C08K3/30 ,  C08K5/09 ,  G01N1/30 ,  G01N2001/364 ,  G02B21/34

Abstract: Refractive index matching (RIM) formulations, their use for mounting biological specimens (e.g., cells and tissues) to a substrate, and methods of visualizing biological specimens embedded in RIM formulations are described.

公开(公告)号：US11982802B2

公开(公告)日：2024-05-14

申请号：US17710103

申请日：2022-03-31

Applicant: Chung Yuan Christian University

Inventor： Cheng-An Lin ,  Tzu-Yin Hou ,  You-Wei Li ,  Yuh-Show Tsai ,  Ming-Chen Wang

IPC: G02B21/34 ,  G02B21/06 ,  G01N21/47

CPC classification number: G02B21/34 ,  G02B21/06 ,  G01N21/47

Abstract: Disclosed herein are device and method for performing a total internal reflection scattering (TIRS) measurement to a sample slide. The device comprises a first reflective plate having a first opening; a second reflective plate having second and third openings and disposed on top of the first reflective plate thereby forming a slot therebetween for accommodating the sample slide, wherein the first opening of the first reflective plate is disposed directly underneath the second opening of the second reflective plate; a white light source disposed in the space formed by the third opening of the second reflective plate and configured to emit a white light into the slot; and a first blackout layer disposed on top of the third opening thereby covering the white light source and keeping the emitted white light from leaking. When the sample slide is inserted into the slot, the white light source illuminates the sample slide so as to achieve the TIRS measurement to the sample slide.

公开(公告)号：US11971531B2

公开(公告)日：2024-04-30

申请号：US17285103

申请日：2019-10-18

Applicant: LEICA MICROSYSTEMS CMS GMBH

Inventor： Alexander Weiss ,  Christian Schumann ,  Ronja Capellmann

IPC: G01B11/06 ,  G02B21/02 ,  G02B21/34 ,  G02B21/00

CPC classification number: G02B21/34 ,  G01B11/06 ,  G02B21/02 ,  G02B21/0088

Abstract: A method is useable for determining a thickness of a cover slip or object carrier in a microscope, which has an objective facing toward a sample chamber. Two optical media border two opposing surfaces of the cover slip or object carrier and form two partially reflective interfaces, which are arranged at different distances from the objective. The method includes: deflecting a measurement light beam by the objective with oblique incidence on the cover slip or object carrier; generating two reflection light beams spatially separated from one another by the measurement light beam being partially reflected on each of the two interfaces; receiving the two reflection light beams by the objective and conducting them onto a position-sensitive detector; registering the incidence locations on the position-sensitive detector; and determining the thickness of the cover slip or object carrier based on the registered incidence locations.