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    Self-Calibrating and Directional Focusing Systems and Methods for Infinity Corrected Microscopes
    2.
    发明公开
    Self-Calibrating and Directional Focusing Systems and Methods for Infinity Corrected Microscopes 审中-公开

    公开(公告)号：US20230359013A1

    公开(公告)日：2023-11-09

    申请号：US18132273

    申请日：2023-04-07

    Applicant: Molecular Devices, LLC

    Inventor： Matthew Chan

    IPC: G02B21/24 ,  G02B7/09

    CPC classification number: G02B21/245 ,  G02B7/09

    Abstract: A method and system for autofocusing an objective lens in a microscope system are disclosed. A decentered aperture is disposed in an optical path between an objective lens and an image plane of an image capturing device and a plurality of reference images are captured. Each reference image is captured when the objective lens is positioned at a corresponding z-position of a plurality of z-positions along an axis of travel of the objective lens and the optical path is at least partially occluded by the decentered aperture. At least one reference image of the plurality of the reference images is associated with a best focus position. The plurality of reference images are analyzed to develop a plurality of pattern locations, wherein each pattern location represents a position of a pattern formed on the image plane when a corresponding reference image was captured. The objective lens is positioned in accordance with the best focus position and the plurality of pattern locations.

    High-resolution microscope and image splitter arrangment
    4.
    发明授权
    High-resolution microscope and image splitter arrangment 有权

    公开(公告)号：US10078206B2

    公开(公告)日：2018-09-18

    申请号：US15087177

    申请日：2016-03-31

    Applicant: Carl Zeiss Microscopy GmbH

    Inventor： Thomas Kalkbrenner ,  Michael Goelles

    IPC: G02B21/36 ,  G02B21/00 ,  G01N21/64 ,  G02B21/18 ,  G02B17/02 ,  G02B21/16 ,  G02B27/10 ,  G02B27/14 ,  G02B27/58 ,  G02B7/38 ,  G02B21/24

    CPC classification number: G02B21/361 ,  G01N21/6458 ,  G02B7/38 ,  G02B17/023 ,  G02B21/0032 ,  G02B21/0072 ,  G02B21/0076 ,  G02B21/0088 ,  G02B21/16 ,  G02B21/18 ,  G02B21/245 ,  G02B21/367 ,  G02B27/106 ,  G02B27/1066 ,  G02B27/141 ,  G02B27/144 ,  G02B27/145 ,  G02B27/58

    Abstract: The invention relates to a microscope having an illumination beam path with wide field illumination of a sample and a first detection beam path having a spatially resolved surface receiver, which is reached by a first part of the detection light coming from the sample via the first detection beam path, or an image divider assembly for a microscope. In order to lengthen the optical path length, at least a second part of the detection light coming from the sample is masked out of the detection beam path and, via deflection means belonging to the detection beam path, is led into a second detection beam path and, preferably via further deflection means, is deflected back in the direction of the detection in such a way that detection light is applied to at least two partial regions beside one another on the surface receiver. At least the second part of the detection light runs in an optical element having an optical density that is increased as compared with the first detection beam path, in order to lengthen the optical path length, and the optical element is designed to be displaceable at an angle, preferably perpendicular, to the optical axis of the first detection beam path in order to adjust the optical path length, and has flat surfaces, at least on the light entry and light exit side thereof; a prism is provided, preferably a glass prism, preferably at least in the second detection beam path after a first beam deflection, for deflection in a direction parallel to the first detection beam path, in order to increase the path length and for reverse deflection.

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