公开(公告)号：US20240115344A1

公开(公告)日：2024-04-11

申请号：US18543190

申请日：2023-12-18

申请人： Inscopix, Inc.

发明人： Koen VISSCHER ,  Pei Sabrina XU ,  Shay NEUFELD

IPC分类号： A61B90/20 ,  A61B5/00 ,  G01N21/64 ,  G02B21/00 ,  G02B21/02 ,  G02B21/06 ,  G02B21/16 ,  G02B21/32

CPC分类号： A61B90/20 ,  A61B5/0059 ,  A61B5/0071 ,  A61B5/4064 ,  G01N21/6458 ,  G02B21/0004 ,  G02B21/0096 ,  G02B21/025 ,  G02B21/06 ,  G02B21/16 ,  G02B21/32 ,  G02B3/14

摘要： An adapter configured to be optically coupled to a plurality of microscopes and having (i) a first microscope interface configured to optically couple a first microscope system to an optical element that is in optical communication with an optical probe to provide first imaging data of a sample, and (ii) a second microscope interface configured to optically couple a second microscope system to the optical element to provide second imaging data of the sample. An optical imaging apparatus and method utilizing such adapter.

公开(公告)号：US20230285107A1

公开(公告)日：2023-09-14

申请号：US18198486

申请日：2023-05-17

申请人： Inscopix, Inc.

发明人： Mark O. TRULSON ,  Alice STAMATAKIS ,  Koen VISSCHER

IPC分类号： A61B90/20 ,  G01N21/64 ,  G02B21/16 ,  G02B21/06 ,  A61B5/00 ,  G02B21/02 ,  G02B21/00 ,  G02B21/32

CPC分类号： A61B90/20 ,  G01N21/6458 ,  G02B21/16 ,  G02B21/06 ,  A61B5/0071 ,  G02B21/025 ,  A61B5/0059 ,  A61B5/4064 ,  G02B21/0004 ,  G02B21/0096 ,  G02B21/32 ,  G02B3/14

摘要： Systems and methods configured for simultaneous imaging and stimulation using a microscope system. The microscope system can have a relatively small size compared to an average microscope system. The microscope can comprise in part an imaging light source and a stimulation light source. Light from the imaging light source and the stimulation light source can be spectrally separated to reduce cross talk between the stimulation light and the imaging light.

公开(公告)号：US20230228672A1

公开(公告)日：2023-07-20

申请号：US17570302

申请日：2022-01-06

申请人： Rocky G. MORALES ,  Aileen O. HUI ,  De-Ling LIU

发明人： Rocky G. MORALES ,  Aileen O. HUI ,  De-Ling LIU

IPC分类号： G01N21/21 ,  B64G1/66 ,  G02B21/00 ,  G02B21/34

CPC分类号： G01N21/211 ,  B64G1/66 ,  G02B21/0004 ,  G02B21/34

摘要： A multi-purpose in-situ contamination sampler includes an inner frame surrounded by a plurality of removable or attachable pieces, each of which include of a single witness surface configured to collect both particulate and molecular contamination within an environment on a payload or a spacecraft.

公开(公告)号：US11668917B2

公开(公告)日：2023-06-06

申请号：US17396740

申请日：2021-08-08

申请人： Dan Slater

发明人： Dan Slater

IPC分类号： G01H9/00 ,  G02B21/10 ,  G01H3/12 ,  G02B21/32 ,  G02B21/00 ,  H04R23/00 ,  G02B21/36

CPC分类号： G02B21/10 ,  G01H3/125 ,  G02B21/0004 ,  G02B21/32 ,  G02B21/36 ,  H04R23/008

摘要： A system and method for using a microscope to at least haptically observe a specimen in a fluid is provided. In one embodiment of the present invention, an audio frequency modulation sensing (AFMS) device is used to convert an optical signal from the specimen into an electrical signal. A haptic feedback device is then used to convert the electrical signal in at least vibrations, thereby providing a user with haptic feedback associated with the optical signal from the specimen. In another embodiment, a second electrical signal can be provided to a second haptic feedback (e.g., shaker, piezo electric, electric current inducing, etc.) device in the fluid, thereby allowing for bidirectional haptic feedback between the user and the specimen. In other embodiments, aural data can be extracted from the electrical signal and presented to the user either alone in in synchronization with video data (e.g., from a video camera).

公开(公告)号：US10007103B2

公开(公告)日：2018-06-26

申请号：US15342615

申请日：2016-11-03

申请人： Carl Zeiss Microscopy GmbH

发明人： Christian Soeller ,  David Michael Baddeley ,  Mark Bryden Cannell

IPC分类号： G02B21/36 ,  G02B21/00 ,  G02B21/14 ,  G02B21/16 ,  H04N13/02 ,  G06T7/194 ,  G06T7/00 ,  H04N17/00 ,  G06T5/00 ,  G06T7/73 ,  G06K9/62 ,  G06K9/46 ,  G01N21/64

CPC分类号： G02B21/365 ,  G01N21/6458 ,  G02B21/0004 ,  G02B21/0092 ,  G02B21/14 ,  G02B21/16 ,  G02B21/36 ,  G02B21/367 ,  G02B27/58 ,  G06K9/4661 ,  G06K9/4671 ,  G06K9/6267 ,  G06K2009/4666 ,  G06T5/00 ,  G06T7/0002 ,  G06T7/194 ,  G06T7/73 ,  G06T2207/10056 ,  H04N13/204 ,  H04N17/002

摘要： A 3D localization microscopy system, 4D localization microscopy system, or an emitter tracking system arranged to cause a phase difference between light passing to or from one part of the objective relative to light passing to or from another part of the objective, to produce a point emitter image which comprises two lobes, a separation between which is related to the position of the emitter relative to the objective of the imaging system, and in the 4D system a further property of the image or of the light to or from the objective is related to another location independent property of the emitter.

公开(公告)号：US09869852B2

公开(公告)日：2018-01-16

申请号：US14994835

申请日：2016-01-13

申请人： Thorlabs, Inc.

发明人： Alex Cable ,  Jörn Wollenzin ,  Ross Johnstone ,  Kirk Gossage ,  Jeffrey S. Brooker ,  Jason Mills ,  James Jiang ,  Dierck Hillmann

IPC分类号： G02B21/24 ,  G02B21/26 ,  G02B5/12 ,  G02B21/08 ,  G01B9/02 ,  G02B7/28 ,  G02B21/00

CPC分类号： G02B21/245 ,  G01B9/02059 ,  G01B9/02063 ,  G01B9/02077 ,  G01B9/0209 ,  G02B7/28 ,  G02B21/0004 ,  G02B21/26

摘要： Disclosed are several technical approaches of using low coherence interferometry techniques to create an autofocus apparatus for optical microscopy. These approaches allow automatic focusing on thin structures that are positioned closely to reflective surfaces and behind refractive material like a cover slip, and automated adjustment of focus position into the sample region without disturbance from reflection off adjacent surfaces. The measurement offset induced by refraction of material that covers the sample is compensated for. Proposed are techniques of an instrument that allows the automatic interchange of imaging objectives in a low coherence interferometry autofocus system, which is of major interest in combination with TDI (time delay integration) imaging, confocal and two-photon fluorescence microscopy.

公开(公告)号：US20180003935A1

公开(公告)日：2018-01-04

申请号：US15630240

申请日：2017-06-22

申请人： Hayong E. LIM

发明人： Hayong E. LIM

IPC分类号： G02B21/00

CPC分类号： G02B21/0004 ,  G02B21/0008 ,  G02B21/0016 ,  G02B21/0032 ,  G02B21/0036 ,  G02B21/0052 ,  G02B21/008 ,  G02B21/0088 ,  G02B21/26 ,  G02B21/361 ,  G02B21/365

摘要： A microscope that comprises a unibody core having a unibody front and a unibody side, a carrier ring rotatably coupled to said unibody front to rotate components from an upright to an inverted configuration, wherein said carrier ring has the general form of a torus, an objective turret coupled within said carrier ring, a condenser lens coupled within said carrier ring, gliding rails coupled to said unibody core, a camera coupled to said unibody core, a gliding stage extensibly coupled to said gliding rails and an attachment node coupled to said unibody side and moveably coupled to said gliding rails to modulate said gliding stage.

公开(公告)号：US20170370833A1

公开(公告)日：2017-12-28

申请号：US15543752

申请日：2016-01-19

申请人： The Research Foundation for The State University of New York

发明人： Andrea G. MARKELZ ,  Gheorghe ACBAS ,  Katherine A. NIESSEN

IPC分类号： G01N21/3581 ,  G01N21/23

CPC分类号： G01N21/3581 ,  G01N21/03 ,  G01N21/23 ,  G01N21/3586 ,  G01N2201/06113 ,  G01N2201/0683 ,  G02B21/0004

摘要： An apparatus and method for Crystal Anisotropy Terahertz Microscopy (“CATM”) is provided. The apparatus includes an emitter configured to emit a THz pulse and a detector configured to detect the THz pulse after the pulse is transmitted through a sample disposed on a sample surface of the detector. A pulsed radiation generator generates a probe beam to interrogate the detector. The detector may include an electro-optical (“EO”) crystal configured to change in birefringence according to the THz pulse. The sample surface of the detector may have a dielectric coating which is transmissive to THz and reflective to the probe beam. The sample is disposed on the dielectric coating.

公开(公告)号：US20170356884A1

公开(公告)日：2017-12-14

申请号：US15532210

申请日：2015-12-08

申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION

发明人： Song HU ,  Rui CAO ,  John A. HOSSACK ,  Joseph P. KILROY

IPC分类号： G01N29/24 ,  G02B21/02 ,  G01N29/28 ,  G02B21/00 ,  G02B27/00

CPC分类号： G01N29/2425 ,  G01N29/28 ,  G01N2291/104 ,  G02B21/0004 ,  G02B21/02 ,  G02B27/0025 ,  G02B27/005

摘要： A reflection-mode multispectral photoacoustic microscopy (PAM) system and related method is disclosed, based on an optical-acoustic objective in communication with an ultrasonic transducer. In some embodiments of the disclosed technology, when aligned and positioned in a predetermined manner, little to no chromatic aberration is provided, and with convenient confocal alignment of the optical excitation and acoustic detection.

公开(公告)号：US09804029B2

公开(公告)日：2017-10-31

申请号：US15120792

申请日：2015-01-16

申请人： HITACHI HIGH-TECHNOLOGIES CORPORATION

发明人： Tsuyoshi Sonehara ,  Hiromi Kusaka ,  Akira Fujii ,  Shuhei Yamamoto ,  Takeshi Ooura ,  Michiru Fujioka

IPC分类号： G01J3/30 ,  G01J3/42 ,  G01J3/24 ,  G01J3/44 ,  G02B7/28 ,  G02B7/32 ,  G01N21/65 ,  G02B21/36 ,  G01N21/64 ,  G01J3/02 ,  G01J3/10 ,  G02B21/00 ,  G02B21/16 ,  G02B21/24 ,  G02B27/14

CPC分类号： G01J3/44 ,  G01J3/0208 ,  G01J3/021 ,  G01J3/0229 ,  G01J3/0248 ,  G01J3/10 ,  G01J3/4406 ,  G01N21/6458 ,  G01N21/65 ,  G02B7/28 ,  G02B7/32 ,  G02B21/0004 ,  G02B21/16 ,  G02B21/244 ,  G02B21/36 ,  G02B21/365 ,  G02B27/141

摘要： With a microspectroscopy device provided with an objective lens with a high numerical aperture, a defocus arises from thermal drift, etc., necessitating auto-focusing. Conventional auto-focus based on through-focus image acquisition takes time, and thus, it cannot be applied to continuous measurement over a long time wherein high-speed sampling is carried out. The present invention addresses this problem by having a defocus-sensing beam that has either defocus or astigmatism fall incident on the objective lens. Since how the image of the spot of the beam for defocus sensing blurs differs depending on the orientation of the defocus, real-time detection of the amount and orientation of defocus becomes possible, and high-speed realtime auto-focus becomes possible.